SARS-CoV-2 Infects Primary Neurons from Human ACE2 Expressing Mice and Upregulates Genes Involved in the Inflammatory and Necroptotic PathwaysArticle Published on 2022-02-172022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] ACE2 activate acute respiratory syndrome addition Brain brains CCL2 Central nervous system CNS Coronavirus-2 COVID-19 Culture cultures CXCL10 cytokeratin 18 promoter Effect evaluated expressing expression of gene Human human Angiotensin-converting enzyme IFN-α IL-6 Immunological response Infection Inflammation Innate immunity involved K18-hACE2 K18-hACE2 mice mechanism mice necroptosis Neuron neuronal neurons Neuropathogenesis occur Pathogenesis pathway replication of SARS-CoV-2 SARS-CoV-2 SARS-COV-2 infection Support tissue tropism TNF-α upregulated virus replication [DOI] 10.3390/pathogens11020257 PMC 바로가기 [Article Type] Article
Neurovascular Interactions in Malariaarticle Published on 2021-12-312024-09-01 Journal: Neuroimmunomodulation [Category] 말라리아, [키워드] astrocytes blood-brain barrier endothelial cells malaria microglia neurons [Article Type] article
Microglia Do Not Restrict SARS-CoV-2 Replication following Infection of the Central Nervous System of K18-Human ACE2 Transgenic Mice소교세포는 K18-인간 ACE2 형질전환 마우스의 중추신경계 감염 후 SARS-CoV-2 복제를 제한하지 않습니다Pathogenesis and Immunity Published on 2021-12-222022-09-10 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] accompanied ACE2 Activation addition administration Antiviral causative agent CCL19 CCL2 CCL5 Central nervous system characterized chemokine CNS colony-stimulating factor consequence contribute contributing to COVID-19 COVID-19 patient COVID-19 patients Critical CXCL10 CXCL9 cytokine Defense determined by disease eIF2 evaluate Evidence exhibited expression hACE2 Host host defense human ACE2 IFN-λ Immune cell infiltration immune response immune responses immunological immunological mechanism increased expression infect infecting Infection infection with SARS-CoV-2 infiltration Inflammatory response inhibitor K18 K18-hACE2 Lung pathology macrophages MERS MERS-CoV mice microglia Mild mind Monocytes monocytes/macrophages nervous nervous system Neuroinvasive neurologic Neuron neurons Neuropathology not affect PLX5622 Pro-inflammatory genes proinflammatory Proinflammatory cytokine receptor reduction in replicate responsible RNA sequencing SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severity Signaling survival Symptom System TNF-α transcript transgenic mice understanding Viral viral infection viral pathogen viral replication virus viruses [DOI] 10.1128/jvi.01969-21 PMC 바로가기 [Article Type] Pathogenesis and Immunity
The microglial NLRP3 inflammasome is involved in human SARS-CoV-2 cerebral pathogenicity: A report of three post-mortem cases소교세포 NLRP3 인플라마솜은 인간 SARS-CoV-2 대뇌 병원성에 관여합니다: 3건의 사후 사례 보고Case Reports Published on 2021-12-152022-09-11 Journal: Journal of neuroimmunology [Category] SARS, 진단, 치료기술, 치료법, 치료제, [키워드] ACE2 age astrocytes Brain CD68 cell entry receptor cortical COVID-19 COVID-19 cases Critical death Deceased Human Human brain human SARS-CoV-2 immunofluorescence Inflammasome involved lesion lung Macrophage macrophages microglia microglial neurons NLRP3 NLRP3 inflammasome nucleocapsid Post-mortem SARS-CoV-2 SARS-CoV-2 nucleocapsid the SARS-CoV-2 therapeutic target tissues Viral [DOI] 10.1016/j.jneuroim.2021.577728 PMC 바로가기 [Article Type] Case Reports
The Causes and Long-Term Consequences of Viral EncephalitisNeuroscience Published on 2021-11-302022-10-31 Journal: Frontiers in Cellular Neuroscience [Category] COVID-19, [키워드] Affect affected astrocytes Autoimmune disease Brain cause Cell Central nervous system clinical symptom Cognitive impairment Coma Confusion consequence contributing to Coronaviruses degenerative described Diseases disorders Encephalitis Fever Frequency headache herpesviruses Immune cell infiltration impairment individual induce Inflammation local immune response microglia Mild morbidity and mortality neurons Neuropsychiatric neurotropic pathology pediatric populations pro-inflammatory molecule public health report reported secretion Seizures shown subsequent viral clearance viral encephalitis viral infection viral infections virus weakness zone [DOI] 10.3389/fncel.2021.755875 PMC 바로가기 [Article Type] Neuroscience
Corona Virus Disease 2019 (COVID-19) as a System-Level Infectious Disease With Distinct Sex Disparities2019년 코로나 바이러스 질병(COVID-19)은 성별 격차가 뚜렷한 시스템 수준 전염병Review Published on 2021-11-292022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, [키워드] abnormality ACE2 acute respiratory syndrome coronavirus Affect angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 clotting system Coagulation Corona coronavirus COVID COVID-19 cytokine Cytokine storm Cytokine storms disparity endothelial cells endotheliopathy Endothelium explain expressed fatigue global pandemic heart help host cells hyper-inflammation hypercoagulability Immune cell immune cells immune system Immunity increased the risk interconnectedness kidney lead lung men Mortality multi-organ dysfunction neurons outcome physical physical fitness RAS recruitment reduced Renin renin-angiotensin system respiratory resulting SARS-CoV-2 SARS-CoV-2 entry severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity Sex Symptoms System Thromboembolism thrombosis Venous thrombosis [DOI] 10.3389/fimmu.2021.778913 PMC 바로가기 [Article Type] Review
COVID-19 Anosmia: High Prevalence, Plural Neuropathogenic Mechanisms, and Scarce Neurotropism of SARS-CoV-2?COVID-19 ANOSMIA : SARS-COV-2의 높은 유병률, 복수의 신경 병원성 메커니즘 및 부족한 신경 프로즘?Review Published on 2021-11-042022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus analyzed angiotensin angiotensin-converting enzyme 2 Anosmia apical surface appear causative pathogen cause Cell cellular Characteristics convalescent coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytological damages examined expression in some Infection lack mechanism molecular nasal Nasal cavity neurons Neuropathology ODs olfactory olfactory bulb olfactory dysfunction Olfactory epithelium Pathogenesis Perspective Plural Prevalence priming protease receptor respiratory respiratory epithelium respiratory virus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neurotropism SARS-CoV-2 receptor Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Structure susceptibility target transmembrane serine protease transmembrane serine protease 2 underlie Viral viral infection [DOI] 10.3390/v13112225 PMC 바로가기 [Article Type] Review
Post COVID-19 Syndrome in Patients with Asymptomatic/Mild FormReview Published on 2021-10-302022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] acute phase Affect Analysis analyzed Anosmia association Asymptomatic Autoimmune autoimmune damage autoimmune dysautonomia average Brain caused Cell chronic fatigue syndrome complex cough Course COVID-19 database described develop Factor fatigue female form Gender Glia immune response individual Mild Myalgic encephalomyelitis/chronic fatigue syndrome nervous system neurons Pathogenesis Patient patients Post COVID-19 syndrome Predictive reported Shortness of breath similarity Symptom Symptoms the disease vessels women [DOI] 10.3390/pathogens10111408 PMC 바로가기 [Article Type] Review
SARS-CoV-2 S1 Protein Induces Endolysosome Dysfunction and Neuritic DystrophyCellular Neuroscience Published on 2021-10-272022-10-31 Journal: Frontiers in Cellular Neuroscience [Category] COVID-19, [키워드] Brain Cell contribute cortical COVID-19 pandemic cross Dystrophy endocytosis endolysosomal acidification endolysosome Hypothesis incidence Incubation induce Injury lysosome membranes morphology neuritic dystrophy Neurological disorder Neuron neuronal neurons Pathogenesis released reported SARS-CoV-2 SARS-CoV-2 S1 SARS-CoV-2 S1 protein specimens tested the S1 protein undetectable with COVID-19 [DOI] 10.3389/fncel.2021.777738 PMC 바로가기 [Article Type] Cellular Neuroscience
Toll-like Receptors in Viral EncephalitisReview Published on 2021-10-142022-10-28 Journal: Viruses [Category] COVID-19, [키워드] addition Affect Astrocyte astrocytes Cell cell differentiation CNS complex interplay condition consequence Encephalitis example expressed Flaviviridae function functional herpes simplex herpes viruses highlight immune stimulation immunodeficiency implication Infection infections Intervention knowledge less microglia neurite outgrowth Neuron neuronal neurons neurotropic Paramyxoviridae Rhabdoviridae stimulated subset syndrome TLR TLR signaling TLR stimulation Toll-like receptor Toll-like receptors vaccine response varicella viral encephalitis virus viruses [DOI] 10.3390/v13102065 PMC 바로가기 [Article Type] Review