neutralizing monoclonal antibodies – Page 3 – Communicable Diseases Research

Tracking cryptic SARS-CoV-2 lineages detected in NYC wastewater

Article

Published on 2022-02-032022-10-04
Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종,

The use of neutralizing monoclonal antibodies and risk of hospital admission and mortality in patients with COVID-19: a systematic review and meta-analysis of randomized trials

COVID-19 환자의 중화 단일클론항체 사용과 입원 및 사망 위험: 무작위 시험의 체계적인 검토 및 메타 분석

Meta-Analysis

Published on 2022-02-012022-09-11
Journal: Immunopharmacology and immunotoxicology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료제,

[키워드] 95% CI 95% confidence interval administration all-cause mortality antibody Clinical outcome clinical outcomes database death determine eligible evaluated Evidence Future Hospital admission identify Meta-analysis monoclonal monoclonal antibody Mortality Neutralizing Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibodies neutralizing monoclonal antibody nine no statistically significant difference Odds ratio outcome Patient patients with COVID-19 random-effects model Randomized controlled trials randomized trial reduced risk Repository risk Risk of bias Sample size SARS-CoV-2 serostatus Spike protein statistically significant difference statistically significant reduction systematic literature search systematic review the timing Trial was performed was used
[DOI] 10.1080/08923973.2021.1993894 PMC 바로가기 [Article Type] Meta-Analysis

Experience of Rwanda on COVID-19 Case Management: From Uncertainties to the Era of Neutralizing Monoclonal Antibodies

COVID-19 사례 관리에 대한 르완다의 경험: 불확실성에서 단일 클론 항체 중화 시대까지

Article

Published on 2022-01-182022-09-10
Journal: International Journal of Environmental Research an [Category] SARS, 진단, 치료기술,

[키워드] Anti-inflammatory drugs Antibiotic therapy anticoagulation Antiviral effect approach Asymptomatic bamlanivimab broad-spectrum antibiotic Care Case fatality rate Clinical management COVID-19 COVID-19 case COVID-19 cases COVID-19 pandemic COVID-19 patient COVID-19 patients COVID-19 therapeutics COVID-19 vaccine eligible patient Eligible patients experience Fatality rate Favipiravir guidelines Healthcare system hyperglycemia index case Intervention interventions management management guidelines measure Mild monoclonal antibodies neutralizing monoclonal antibodies neutralizing monoclonal antibody outcomes Patient provided receiving remained Rwanda therapeutic Therapeutic approach Therapeutics treated treatment for COVID-19 Uncertainty Viral viral clearance
[DOI] 10.3390/ijerph19031023 PMC 바로가기 [Article Type] Article

Humoral response to mRNA anti-COVID-19 vaccines BNT162b2 and mRNA-1273 in patients with chronic lymphocytic leukemia

만성 림프구성 백혈병 환자에서 mRNA 항-COVID-19 백신 BNT162b2 및 mRNA-1273에 대한 체액 반응

Article

Published on 2022-01-112022-09-12
Journal: Blood advances [Category] SARS, 진단,

[키워드] absence acute respiratory syndrome age anti-CD20 Antibody Response BNT162b2 CLL Combination coronavirus COVID-19 dose evaluate highest Humoral response immune response independent predictor individual inhibitor leukemia monoclonal antibody monotherapy mRNA mRNA-1273 mRNA-1273 vaccine multivariable analysis neutralizing monoclonal antibodies Older Patient post-dose Prophylactic provide receiving response rate risk SARS-CoV-2 second dose Seroconversion seronegative seronegative patient significantly higher single dose therapy treated Treatment treatment-naïve patient tyrosine vaccination Vaccine venetoclax
[DOI] 10.1182/bloodadvances.2021006215 PMC 바로가기 [Article Type] Article

Murine monoclonal antibodies against RBD of the SARS-CoV-2 spike protein as useful analytical tools for subunit vaccine development and clinical trials

소단위 백신 개발 및 임상 시험을 위한 유용한 분석 도구로서 SARS-CoV-2 스파이크 단백질의 RBD에 대한 뮤린 모노클로날 항체

Article

Published on 2022-01-012022-09-11
Journal: Journal of Immunological Methods [Category] MERS, SARS, 비임상, 임상, 진단,

[키워드] ACE2-RBD binding Additivity index affinities affinity Alpha Anti-RBD antibodies antibody Antigen Beta binding breath characterization clinical trial COVID-19 D614G demonstrated determine Epitopes FIVE high affinity hybridoma technology infect mAbs monoclonal monoclonal antibodies monoclonal antibody murine neutralized Neutralizing neutralizing capacity neutralizing monoclonal antibodies nine pandemic pharmacokinetic purified RBD Receptor binding domain Recognition recombinant antigens sandwich ELISA SARS-CoV-2 SARS-CoV-2 spike protein solution Spike protein stability strain subunit Subunit vaccine subunit vaccines the RBD the SARS-CoV-2 trials Vaccine development Vero cells virus was used
[DOI] 10.1016/j.jim.2021.113195 PMC 바로가기 [Article Type] Article

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Patients

사설: 입원하지 않은 환자의 SARS-CoV-2 감염에 대한 경구용 항바이러스제 치료 현황

Editorial

Published on 2022-01-012022-09-11
Journal: Medical science monitor : international medical jo [Category] SARS, 변종, 신약개발, 진단, 치료제,

[키워드] administration antiviral drug antiviral drug treatment antiviral drugs approval approved bamlanivimab can be used Casirivimab children Community community setting costly COVID-19 current drug drug treatments early stage early stages editorial effective Emergency use authorization etesevimab EUA FDA healthcare facility Healthcare Products Regulatory Agency Hospitalization Imdevimab increased risk intravenous Intravenous administration Medicine Medicines MHRA Mild Moderate COVID-19 molnupiravir neutralizing monoclonal antibodies Nirmatrelvir oral Paxlovid positive priority product progression Regulatory Remdesivir Ritonavir SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 test SARS-CoV-2 virus severe COVID-19 status the SARS-CoV-2 virus therapeutic Treatment variants of concern
[DOI] 10.12659/MSM.935952 PMC 바로가기 [Article Type] Editorial

Animal Models of COVID-19: Transgenic Mouse Model

Article

Published on 2022-01-012022-11-15
Journal: Methods in molecular biology (Clifton, N.J.) [Category] SARS, 변종, 진단,

[키워드] acute respiratory syndrome animal animal model Antiviral Brain C57BL/6 cause caused changes in concern coronavirus coronavirus disease COVID-19 COVID-19 disease cytokeratin 18 promoter death described ELISA enzyme-linked immunosorbent evaluated expressing global public health hACE2 hallmark Histopathology human Angiotensin-converting enzyme IHC immune response immunohistochemistry infected intranasally Infection K18 K18 hACE2 transgenic mice lung Lungs Model morbidity Mortality mouse mouse model nasal nervous system neutralizing monoclonal antibodies pathogenesis of SARS-CoV-2 pathogenicity pathology Prophylactic protocol respiratory tracts responses SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain spleen Spread survival the cytokine storm therapeutic tissues transgenic transgenic mice Treatment Vaccine viral pathogenesis viral replication virus Wuhan, China
[DOI] 10.1007/978-1-0716-2111-0_16 PMC 바로가기

Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2

SARS-COV-2에 대한 항 -RBD 인간 단일 클론 항체의 구조 및 치료 가능성

Research Paper

Published on 2022-01-012022-09-01
Journal: Theranostics [Category] SARS, 변종, 유전자 메커니즘, 진단,

[키워드] In vitro and in vivo function abrogated ACE2 Analysis anti-RBD Anti-RBD antibody anti-receptor-binding domain antibodies antibody antibody cocktail Antibody-antigen complex attenuate B.1.1.7 B.1.351 B.1.617.2 binding cocktail convalescent patient Convalescent patients COVID-19 Cryo-electron microscopy Crystallography curtail dissect effective Efficacy electron microscopy epitope Epitopes evaluate feature Formulation hamster hamsters Hospitalization Human monoclonal antibody in vitro in vivo Infection leads lung viral load mechanism mechanism of action monoclonal antibodies monoclonal antibody Mutation neutralization Neutralizing neutralizing monoclonal antibodies non-overlapping epitope non-overlapping epitopes patients with SARS-CoV-2 Prevent Prophylactic pulmonary inflammation RBD Receptor-binding domain epitope reduce reported residue reveal SARS-CoV-2 SARS-COV-2 infection shown somatic mutations Structural analysis Structure structure-function subsequent Support the RBD therapeutic therapeutic potential unique variable region variant variants variants of concern Viral viral RBD viral shedding virus weight loss wild type
[DOI] 10.7150/thno.65563 PMC 바로가기 [Article Type] Research Paper

Influence of treatment with neutralizing monoclonal antibodies on the SARS-CoV-2 nasopharyngeal load and quasispecies

Article

Published on 2022-01-012023-07-02
Journal: Clinical microbiology and infection : the official [Category] SARS,

[키워드] Coronavirus disease 2019 mutations neutralizing monoclonal antibodies Quasispecies Receptor-binding domain severe acute respiratory syndrome coronavirus 2 Single-molecular real-time sequencing Spike protein
[DOI] 10.1016/j.cmi.2021.09.008 PMC 바로가기

Antibody Response against SARS-CoV-2 Infection: Implications for Diagnosis, Treatment and Vaccine Development

SARS-CoV-2 감염에 대한 항체 반응: 진단, 치료 및 백신 개발에 미치는 영향

Review

Published on 2022-01-012022-09-12
Journal: International reviews of immunology [Category] SARS, 진단,