Deciphering underlying mechanism of Sars-CoV-2 infection in humans and revealing the therapeutic potential of bioactive constituents from Nigella sativa to combat COVID19: in-silico studyResearch Article Published on 2020-10-282023-07-02 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, [키워드] α-hederin Angiotensin-II receptor (ACE2) Nigella Sativa Protein interaction network SARS-CoV-2 [DOI] 10.1080/07391102.2020.1839560 PMC 바로가기 [Article Type] Research Article
Nigella sativa supplementation to treat symptomatic mild COVID-19: A structured summary of a protocol for a randomised, controlled, clinical trialLetter Published on 2020-08-082022-10-29 Journal: Trials [Category] COVID-19, MERS, [키워드] 1:1 absence Admission Alanine transaminase assigned Black seed Blinding block Breast feeding Chronic kidney disease chronic liver disease clinical trial clinically comparator computer-generated randomization conducted control group control groups COVID-19 COVID19 Date defined dialysis disease dissemination Efficacy element eligible patient exploratory glomerular filtration rate hospital Infection intensive care Jeddah King limit medication Mild Nigella Sativa no symptoms number objective Open-label outcome parallel-group participant Patient phytotherapy Pneumonia polymerase chain reaction Prospective protocol radiological randomisation randomised randomised controlled trial Randomly recruited renal respiratory Sample size SARS-CoV-2 Saudi Arabia Standard of care status Symptom symptomatic mild the patient throat swab transfer treat Treatment Trial Two-arm university upper respiratory tract website written Informed Consent [DOI] 10.1186/s13063-020-04647-x PMC 바로가기 [Article Type] Letter
Effect of Thymoquinone on Acute Kidney Injury Induced by Sepsis in BALB/c MiceResearch Article Published on 2020-06-162022-10-27 Journal: BioMed Research International [Category] Coronavirus, MERS, SARS, [키워드] activities AKI alteration Anti-inflammatory Antioxidative Apoptosis BALB/c BALB/c mice Blood urea nitrogen caspase-1 caspase-3 caspase-8 COVID-19 creatinine demonstrated Effect evaluated Gene Expression histopathological IL-1 β IL-6 induced ingredient inhibited investigated kidney damage Kidney injury kidney tissue male New coronavirus Nigella Sativa NLRP3 Patient Pneumonia proinflammatory protective effect Protein protein level pyroptosis Sepsis serum Serum level significantly therapeutic thymoquinone TNF- α variety was performed [DOI] 10.1155/2020/1594726 PMC 바로가기 [Article Type] Research Article
Molecular docking, simulation and MM-PBSA studies of nigella sativa compounds: a computational quest to identify potential natural antiviral for COVID-19 treatmentResearch Article Published on 2020-06-122023-07-01 Journal: Journal of biomolecular structure & dynamics [Category] SARS, [키워드] ADMET COVID-19 Dithymoquinone MM-PBSA molecular dynamic simulation Nigella Sativa [DOI] 10.1080/07391102.2020.1775129 PMC 바로가기 [Article Type] Research Article
Sambucus nigra extracts inhibit infectious bronchitis virus at an early point during replicationResearch Article Published on 2014-01-162022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] Rhodiola rosea Sambucus nigra Anti-viral drugs bronchitis Cell compounds Concentration coronavirus Cytopathic effect cytotoxicity derivative determined different Effect electron microscopy highest IBV infected cell Infection Infectious Bronchitis Virus inhibit magnitude mechanism of action membrane MOI multiplicity of infection Nigella Sativa non-infectious other coronavirus pathogenic plant Plaque assay Prevent protocol quantified reduced Replication Result Rhodiola Safe Sambucus solvent staining suggested supernatant tested tissue transmission electron microscopy treat treated Treatment trypan blue staining vaccination Vero Cell vesicles viral titer virion virus virus inhibition virus titer viruses [DOI] 10.1186/1746-6148-10-24 PMC 바로가기 [Article Type] Research Article
The effects of Nigella sativa (Ns), Anthemis hyalina (Ah) and Citrus sinensis (Cs) extracts on the replication of coronavirus and the expression of TRP genes familyArticle Published on 2014-01-122023-06-15 Journal: Molecular biology reports [Category] MERS, [키워드] Anthemis hyalina Citrus sinensis Coronavirus (CoV) Nigella Sativa TRP channels [DOI] 10.1007/s11033-014-3019-7 PMC 바로가기 [Article Type] Article