Coronavirus Disease 2019 Management Strategies in Solid Organ Transplant RecipientsArticle Published on 2023-03-212024-09-05 Journal: Infectious disease clinics of North America [Category] update2024, [키워드] anti-spike monoclonal antibodies coronavirus disease-2019 COVID-19 molnupiravir Nirmatrelvir Remdesivir transplantation [DOI] 10.1016/j.idc.2023.03.003 PMC 바로가기 [Article Type] Article
Nirmatrelvir exerts distinct antiviral potency against different human coronavirusesArticle Published on 2023-02-142024-09-05 Journal: Antiviral Research [Category] update2024, [키워드] antiviral activity disparity Nirmatrelvir pan-coronavirus [DOI] 10.1016/j.antiviral.2023.105555 PMC 바로가기 [Article Type] Article
Structural basis of nirmatrelvir and ensitrelvir activity against naturally occurring polymorphisms of the SARS-CoV-2 main proteasearticle Published on 2023-02-102024-09-05 Journal: Brain stimulation [Category] update2024, [키워드] COVID DMSO, dimethyl sulfoxide drug ensitrelvir M main protease MPro Mutation Nirmatrelvir Paxlovid resistance SARS-CoV-2 Structure X-ray xocova [DOI] 10.1016/j.jbc.2023.103004 PMC 바로가기 [Article Type] article
Paxlovid (Nirmatrelvir/Ritonavir): A new approach to Covid-19 therapy?Review Published on 2023-02-062024-09-05 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] update2024, [키워드] 3 C-like protease COVID-19 Nirmatrelvir Paxlovid Ritonavir SARS-CoV-2 [DOI] 10.1016/j.biopha.2023.114367 PMC 바로가기 [Article Type] Review
SARS-CoV-2 proteases Mpro and PLpro: Design of inhibitors with predicted high potency and low mammalian toxicity using artificial neural networks, ligand-protein docking, molecular dynamics simulations, and ADMET calculationsArticle Published on 2023-02-012023-07-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), [키워드] ADMET COVID-19 heterocyclic compounds in silico drug design molecular docking Molecular dynamics simulation Mpro/PLpro inhibitors Nirmatrelvir Pyrazolopyridazines Tetrazoles. [DOI] 10.1016/j.compbiomed.2022.106449 PMC 바로가기
Nirmatrelvir and COVID-19: development, pharmacokinetics, clinical efficacy, resistance, relapse, and pharmacoeconomicsReview Published on 2023-01-022024-09-05 Journal: International journal of antimicrobial agents [Category] update2024, [키워드] Bexovid® COVID-19 main protease Nirmatrelvir Paxlovid® PF-00835231 PF-07321332 protease inhibitors Ritonavir small-chemical antivirals [DOI] 10.1016/j.ijantimicag.2022.106708 PMC 바로가기 [Article Type] Review
Generation of a VeroE6 Pgp gene knock out cell line and its use in SARS-CoV-2 antiviral studyArticle Published on 2022-12-012023-07-10 Journal: Antiviral Research [Category] COVID19(2023년), [키워드] knockout Nirmatrelvir PGP SARS-CoV-2 Vero cells. [DOI] 10.1016/j.antiviral.2022.105429 PMC 바로가기
Combination therapy with nirmatrelvir and molnupiravir improves the survival of SARS-CoV-2 infected miceArticle Published on 2022-12-012023-07-10 Journal: Antiviral Research [Category] COVID19(2023년), [키워드] combination therapy in vivo molnupiravir Nirmatrelvir Remdesivir SARS-CoV-2 [DOI] 10.1016/j.antiviral.2022.105430 PMC 바로가기
Nirmatrelvir/ritonavir as a potential treatment for prolonged SARS-CoV-2 infection in immunocompromised patientsArticle Published on 2022-12-012023-07-10 Journal: Revista española de quimioterapia : publicación [Category] COVID19(2023년), [키워드] Combination COVID-19 Nirmatrelvir Ritonavir rituximab SARS-CoV-2 [DOI] 10.37201/req/078.2022 PMC 바로가기
Simultaneous quantification of nirmatrelvir and ritonavir by LC-MS/MS in patients treated for COVID-19Article Published on 2022-12-012023-07-10 Journal: Journal of chromatography. B, Analytical technolog [Category] COVID19(2023년), [키워드] LC-MS/MS Nirmatrelvir Ritonavir Therapeutic Drug Monitoring [DOI] 10.1016/j.jchromb.2022.123510 PMC 바로가기