no effect – Page 3 – Communicable Diseases Research

Profiling RT-LAMP tolerance of sequence variation for SARS-CoV-2 RNA detection

SARS-CoV-2 RNA 검출을 위한 서열 변이의 RT-LAMP 내성 프로파일링

Article

Published on 2022-03-242022-09-11
Journal: PLoS ONE [Category] SARS, 변종, 치료기술, 치료제,

Global evidence of expressed sentiment alterations during the COVID-19 pandemic

Research

Published on 2022-03-172022-10-05
Journal: Nature human behaviour [Category] 치료법,

Reproductive and developmental safety of nirmatrelvir (PF-07321332), an oral SARS-CoV-2 M pro inhibitor in animal models

동물 모델에서 경구용 SARS-CoV-2 M pro 억제제인 니르마트렐비르(PF-07321332)의 생식 및 발달 안전성

Article

Published on 2022-03-012022-09-11
Journal: Reproductive toxicology (Elmsford, N.Y.) [Category] 치료제,

[키워드] administration age animal model Antiviral Clinical studies clinical study clinically coronavirus COVID-19 Critical death developmental during pregnancy Effect Embryo Embryo-Fetal development embryonic embryonic development enhancer evaluated Factor female female fertility Fertility Genetic Genetic toxicity high risk Hospitalization hospitalized patient ICH in viral infected with SARS-CoV-2 information inhibitor lack limit dose M pro male mammalian cells manifestation Nirmatrelvir NMV no effect no effects oral Oral COVID-19 therapy patient population Paxlovid PF-07321332 pharmacokinetic phase Pregnancy Prevent progression protease Protein rabbit RAT Rat. RATs Replication reported reproductive risk Ritonavir SARS-CoV-2 SARS-CoV-2 main protease selective severe disease shown specific protein the SARS-CoV-2 therapeutic option therapeutic target therapy Toxicity viral replication virus
[DOI] 10.1016/j.reprotox.2022.01.006 PMC 바로가기 [Article Type] Article

Effectiveness of inactivated SARS-CoV-2 vaccine (CoronaVac) on intensive care unit survival

중환자실 생존에 대한 비활성화된 SARS-CoV-2 백신(CoronaVac)의 효과

Original Paper

Published on 2022-02-092022-09-11
Journal: Epidemiology and Infection [Category] COVID19(2023년), MERS, SARS, 변종,

[키워드] Admission admitted to ICU arterial blood arterial blood gas Blood blood gas clinical CoronaVac coronavirus disease Coronavirus disease 2019 Course COVID-19 eligible enrolled evaluated ferritin ferritin level ferritin levels genetic variants group had no hospital Hospital mortality Hospital stay ICU inactivated intensive care intensive care unit investigated Laboratory Lactate lactate dehydrogenase Length Mortality National no effect not different on admission parameters Patient patients protective effect radiological Radiological parameters SARS-CoV-2 pandemic SARS-CoV-2 vaccine Sinovac survival target population vaccination vaccination schedule Vaccine
[DOI] 10.1017/S0950268822000267 PMC 바로가기 [Article Type] Original Paper

Are angiotensin converting enzyme (ACE1/ACE2) gene variants associated with the clinical severity of COVID-19 pneumonia? A single-center cohort study

안지오텐신 전환 효소(ACE1/ACE2) 유전자 변이가 COVID-19 폐렴의 임상 중증도와 관련이 있습니까? 단일 센터 코호트 연구

Article

Published on 2022-02-012022-09-11
Journal: Anatolian journal of cardiology [Category] COVID19(2023년), SARS, 변종, 치료기술,

[키워드] abnormality ACE ACE gene ACE1 ACE1 gene ACE1/ACE2 ACE2 ACE2 gene Admission age allele Analysis angiotensin angiotensin converting enzyme automated Bioinformatics analysis Clinical characteristics Clinical severity Cohort cohort study coronavirus disease Coronavirus disease 2019 COVID-19 determine disease severity DNA domain DSP enzyme exon 1 frequencies Frequency functional Genetic Genomic DNA Genotype group I/D polymorphism ICU independent predictor independent predictors intensive care intensive care unit investigated knowledge no effect non-ICU Older age other variant pandemic Patient patients hospitalized Peripheral blood peripheral blood lymphocyte peripheral blood lymphocytes Pneumonia polymorphism Polymorphisms purified radiologic recent Sanger sequencing Science Sequencing analysis severe disease single-center statistical analysis Statistical Package variant was performed was used
[DOI] 10.5152/AnatolJCardiol.2021.502 PMC 바로가기 [Article Type] Article

Ibuprofen, Flurbiprofen, Etoricoxib or Paracetamol Do Not Influence ACE2 Expression and Activity In Vitro or in Mice and Do Not Exacerbate In-Vitro SARS-CoV-2 Infection

Article

Published on 2022-01-192022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS,

Effectiveness of low-dose radiation therapy in COVID-19 patients globally: A systematic review

전 세계적으로 코로나19 환자에서 저선량 방사선 요법의 효과: 체계적인 검토

Clinical Trial

Published on 2022-01-192022-09-11
Journal: F1000Research [Category] SARS, 임상,

[키워드] Affect article baseline benefit Case-control change CINAHL Clinical course Cohort Combination conducted confounding effect Corona COVID pneumonia COVID-19 COVID-19 patients COVID-19 pneumonia Cross-sectional studies cross-sectional study CT-scan Cytokines defined demonstrated double-blind double-blind randomized controlled trial drug drugs duplicates Google Scholar High-dose IL-1a inclusion criteria Inflammatory inflammatory disease inflammatory markers interleukin Intervention item LDRT leukocyte low-dose Low-dose radiation therapy Lungs meta-analyses Mortality multiple organs no effect novel other diseases participant Patient Pneumonia proinflammatory proinflammatory cytokines Radiation radiation therapy Radiotherapy Randomized receiving recruitment reduce Reporting Research resulting SARS-CoV-2 pneumonia status steroid Steroids Support systematic review therapy treat treated Virus Disease was used were excluded
[DOI] 10.12688/f1000research.74558.1 PMC 바로가기 [Article Type] Clinical Trial

Better COVID-19 Intensive Care Unit survival in females, independent of age, disease severity, comorbidities, and treatment

Article

Published on 2022-01-142022-10-04
Journal: Scientific Reports [Category] 임상, 치료법,

[키워드] 95%CI added adjusted administration Admission age APACHE II APACHE II score association Belgium Better chronic Comorbidities comparable comprehensive analysis coronavirus 2 country COVID-19 disease course disease severity Diseases Factor female females Germany ICU independent intensive care unit investigated less Logistic regression male mechanism Medical research Model Modification Mortality multicenter Netherlands no effect obese obesity Observational cohort study Odds ratio organ support other variables pandemic Pathogenesis Patient patients patients with SARS-CoV-2 Physiology Pneumonia prognostic random intercept respiratory Risk factors SARS-CoV-2 SARS-CoV-2 patient Seven Sex smoking survival Therapeutic approach therapy Treatment was used
[DOI] 10.1038/s41598-021-04531-x PMC 바로가기 [Article Type] Article

Inferring the stabilization effects of SARS-CoV-2 variants on the binding with ACE2 receptor

Article

Published on 2022-01-062022-10-04
Journal: Communications Biology [Category] SARS, 변종,

[키워드] ACE2 receptor acute respiratory syndrome addition African amino acid substitution Analysis antigenicity binding characteristic complex complexes contagiousness coronavirus Effect English feature greater help human ACE2 receptor Interaction molecular Molecular conformation Molecular dynamics simulation Molecular modelling MONITOR Mutation negative control no effect observation occur pandemic performed phenotype phenotypic provoke residue SARS-CoV-2 spike protein SARS-CoV-2 spike variant SARS-CoV-2 variant selected selective several variant South specific mutation spike variant spike variants Spread stability stabilizing effect Surveillance the SARS-CoV-2 the spike protein variant variants Variation viral genome virus while wild type
[DOI] 10.1038/s42003-021-02946-w PMC 바로가기 [Article Type] Article

Genome sequencing of SARS-CoV-2 reveals the prevalence of variant B 1.1.7 in Egypt

SARS-CoV-2의 게놈 시퀀싱은 이집트에서 변이 B 1.1.7의 유행을 보여줍니다

Article

Published on 2022-01-012022-09-11
Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 진단,

[키워드] acute respiratory syndrome coronavirus Alpha Alpha variant authorization B 1.1.7 B.1.1.7 case fatality rates clade compatibility convalescent coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Egypt eight Emergency expected feasibility Government Hospitalization hospitalizations majority measure Ministry of Health Monoclonal antibody treatments neutralization new SARS-CoV-2 new strain no effect outbreak Prevalence public health raised recorded respiratory reveal Sample SARS-CoV-2 SARS-CoV-2 B.1.1.7 Sequencing sera severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity shown strain susceptibility the SARS-CoV-2 transmission rate Treatment protocol Vaccine variant Viral Viral transmission
[DOI] 10.1016/j.meegid.2021.105191 PMC 바로가기 [Article Type] Article