Mutation Profile of SARS-CoV-2 Genome Sequences Originating from Eight Israeli Patient IsolatesGenome Sequences Published on 2021-01-072022-10-29 Journal: Microbiology Resource Announcements [Category] COVID-19, [키워드] acute respiratory syndrome Care clinical sample collected coronavirus eight FIVE Frame Genetic variation genome sequence individual infirm isolate Nasopharyngeal swab nonsynonymous profile reported Sample SARS-CoV-2 sequence symptomatic and asymptomatic [DOI] 10.1128/MRA.01387-20 PMC 바로가기 [Article Type] Genome Sequences
SARS-CoV-2 variants evolved during the early stage of the pandemic and effects of mutations on adaptation in Wuhan populationsSARS-CoV-2 변종은 전염병 초기 단계에서 진화했으며 돌연변이가 우한 인구의 적응에 미치는 영향Review Published on 2021-01-012022-09-10 Journal: International Journal of Biological Sciences [Category] MERS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect affected alteration Amino acid amino acid sequence bioinformatics caused Characteristics China Chinese coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 develop early phase early stage Effect effort Evolution Frequency genomes help increase in infections initial L-type less Mutation mutations nonsynonymous Older outbreak pandemic phylogenetically Population prevalent prevention strategies Proteins reported researcher respiratory risk S-type SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 variant sequence sequenced severe acute respiratory syndrome Coronavirus Transmissibility Treatment variant variants Variation variations Viral virulence virus Virus evolution Wuhan Wuhan, China [DOI] 10.7150/ijbs.47827 PMC 바로가기 [Article Type] Review
Simulation of the Clinical and Pathological Manifestations of Coronavirus Disease 2019 (COVID-19) in a Golden Syrian Hamster Model: Implications for Disease Pathogenesis and Transmissibility골든 시리아 햄스터 모델에서 코로나바이러스 질병 2019(COVID-19)의 임상 및 병리학적 징후 시뮬레이션: 질병 발병 및 전염성에 대한 의미Article Published on 2020-12-032022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 진단, 치료법, [키워드] ACE2 Activation adaptive airway alveolar damage angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animal Antibody titer Antibody titers Apoptosis atrophy binding Blood change chemokine clinical Clinical sign Clinical signs Contact convalescent serum coronavirus COVID-19 Diffuse alveolar damage docking expression hamster hamsters histopathological Histopathology immunoprophylaxis initial intestinal involvement with Koch's postulates Laboratory lung Lung pathology lung viral load lymphoid mammal manifestation molecular docking Mortality Mutation Neutralizing antibody titer nonsynonymous option organ Pathogenesis pathological pathology performed physiological proliferative rapid breathing Receptor-binding domain resulting SARS-CoV-2 Serum neutralizing antibody significant decrease Simulation Spike protein spleen suggested the receptor-binding domain tissue tissue repair titer Transmission Treatment vaccination Viral Viral load viral nucleocapsid protein virus virus titer viruses weight loss [DOI] 10.1093/cid/ciaa325 PMC 바로가기 [Article Type] Article
Positive selection within the genomes of SARS-CoV-2 and other Coronaviruses independent of impact on protein functionBioinformatics Published on 2020-10-162022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] acute respiratory disease addition Affect changed changes in Characteristics COVID-19 Critical detect effort Evolution gene encoding genes encoding Genetic genetic code Genome genomes highlight highlighting Host humans identify in viral independent indicate innate immune system molecular Mutation nonsynonymous Novel coronavirus Perspective positive Positive selection Protein Region Result RNA molecules RNA stability SARS-CoV-2 spike synonymous target Test the SARS-CoV-2 genome Transcription translation unique viral life cycle [DOI] 10.7717/peerj.10234 PMC 바로가기 [Article Type] Bioinformatics
Impact of lockdown on Covid-19 case fatality rate and viral mutations spread in 7 countries in Europe and North AmericaResearch Published on 2020-09-022022-10-30 Journal: Journal of Translational Medicine [Category] COVID-19, SARS, [키워드] acute respiratory syndrome adjusted adopted Analysis analyzed biological significance calculated Case fatality rate caused China Confirmed COVID-19 infection coronavirus disease correlated country COVID-19 death death case diagnostic Europe Fatality rate France GenBank database genomes sequenced genomic sequence Germany GISAID database Impact International Italy lockdown lockdown restriction Lockdown strategy muscle Mutation NC_045512.2 nonsynonymous normalized North America outbreak Pairwise comparison pandemic Patient PCR PCR testing positive proportion public health emergency Rate reported Result SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 reference genome selected Spain Spread Standard testing capacity the spike protein two group US USA viral mutation virus was obtained was performed WHO [DOI] 10.1186/s12967-020-02501-x PMC 바로가기 [Article Type] Research
The origin and underlying driving forces of the SARS-CoV-2 outbreakSARS-CoV-2 발병의 기원과 근본적인 원동력Research Published on 2020-06-072022-08-13 Journal: Journal of Biomedical Science [Category] Biochemistry, COVID-19, SARS, [키워드] adaptive Analysis analyzed China collected concerning coronavirus Critical determine driving effective Effectiveness Epidemic Evolution excess Frequency genetic diversity had more Haplotype haplotypes hospital HPD Human humans impacted interior Intervention lockdown low frequency Mutation Mutational bias mutations network analysis nonsynonymous observation occurred ORF8 protein outbreak pandemic pangolin Population genetics Population size Positive selection Protein Receptor binding domain Relaxation reported required Result SARS-CoV SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequence sequence similarity social distancing Spike receptor binding domain Spread synonymous the SARS-CoV-2 Variation virus Wuhan [DOI] 10.1186/s12929-020-00665-8 PMC 바로가기 [Article Type] Research
SARS-CoV-2 and ORF3a: Nonsynonymous Mutations, Functional Domains, and Viral PathogenesisObservation Published on 2020-05-052022-10-29 Journal: mSystems [Category] COVID-19, [키워드] 3a protein acute respiratory syndrome amino acid substitution Analysis conserved coronavirus coronavirus disease COVID-19 defined disease pathogenesis domain functional isolate nonsynonymous nonsynonymous mutation Nonsynonymous mutations observation ORF3a orf3a gene pandemic Pathogenesis Protein reported SARS-CoV SARS-CoV-2 SARS-CoV-2 strains subpopulations the SARS-CoV-2 unique viral life cycle virulence virus [DOI] 10.1128/mSystems.00266-20 PMC 바로가기 [Article Type] Observation
De novo and inherited private variants in MAP1B in periventricular nodular heterotopia심실주위 결절성 이형에서 MAP1B의 드 노보 및 유전된 사적 변이체Research Article Published on 2018-05-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abnormality affected allele Analysis arising association Author Brain brain development caused chance Collapsing controls cortical de novo de novo mutation de novo mutations detrimental Diseases disorder driven by ENCODE epilepsy Exome exome sequencing expected explain fetal Genetic genetic risk Genetic variant genetic variants genome-wide significant heterozygous variant identify implicated incomplete penetrance indicate individual initial involved leads list of gene loci loss-of-function malformation MAP1B Migration Mutation Neuron neurons nonsynonymous occur one patient parent parents patients performed predominant Protein responsible sequence sequenced Sequencing the disease the patient transmitted variant variants [DOI] 10.1371/journal.pgen.1007281 PMC 바로가기 [Article Type] Research Article