Comparison of Binding Site of Remdesivir and Its Metabolites with NSP12-NSP7-NSP8, and NSP3 of SARS CoV-2 Virus and Alternative Potential Drugs for COVID-19 TreatmentNSP12-NSP7-NSP8, NSP3와 렘데시비르의 결합 부위와 SARS CoV-2 바이러스 및 COVID-19 치료를 위한 대체 잠재 약물의 비교Comparative Study Published on 2020-12-012022-09-11 Journal: The protein journal [Category] SARS, 치료제, [키워드] administration ADP-ribose agent Analysis approach approved binding site cause children Compound compounds coronavirus COVID-19 crystal structure crystal structures D614G mutation docking docking scores drug Efficacy Emergency use food GS-441524 Hospitalized immunization increase interfere metabolite monophosphate Mutation non-structural protein Non-structural protein 3 (NSP3) of SARS CoV-2 virus Nsp12 Nsp3 Nsp7 NSP8 Potential protein 3 reduce released Remdesivir Replication reported ribose SARS CoV SARS CoV-2 SARS-CoV-2 virus screened selected severe disease Site Spike protein the SARS-CoV-2 virus the spike protein treat Treatment treatment method Vaccine viable treatment Virtual screening virus [DOI] 10.1007/s10930-020-09942-9 PMC 바로가기 [Article Type] Comparative Study
SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls Research Published on 2020-07-152022-10-05 Journal: Nature [Category] SARS, 치료기술, 치료법, [키워드] acute respiratory syndrome Affect Betacoronavirus CD4 CD8 T cell Clinical severity conserved Contact coronavirus coronavirus disease Coronaviruses COVID-19 COVID-19 pandemic cross-reactivity Donor exhibited General population homology Human Immunity immunodominance individual individuals induce Infection long-lasting management memory T cell N protein Nsp7 nucleocapsid ORF1 outbreak pathogen pathogenesis of SARS-CoV-2 Patient Protein reactive recognize Region robust SARS-CoV SARS-CoV infection SARS-CoV-2 SARS-CoV-2-specific T cell subsequent susceptibility T cell T cell response the disease the N protein understanding uninfected uninfected control [DOI] 10.1038/s41586-020-2550-z [Article Type] Research
Mutational Frequencies of SARS-CoV-2 Genome during the Beginning Months of the Outbreak in USAArticle Published on 2020-07-132022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] accumulate accumulated accumulated mutations America Analysis analyzed bioinformatics changes in circulating conserved COVID-19 determine functions Genetic variation Genome Helicase help Limited majority Month Mutation nsp10 NSP11 Nsp7 ORF3a ORF6 ORF7b ORF8 pandemic potential therapeutic target Protein Proteins provide RdRP Receptor binding domain Region Replication reported RNA virus SARS-CoV-2 SARS-CoV-2 genome SARS-CoV2 spike Spread submitted USA viral gene viral genome Viral protein virus propagation WHO [DOI] 10.3390/pathogens9070565 PMC 바로가기 [Article Type] Article