Nucleic Acids Analytical Methods for Viral Infection Diagnosis: State-of-the-Art and Future Perspectives바이러스 감염 진단을위한 핵산 분석 방법 : 최첨단 및 미래의 관점Review Published on 2021-10-272022-09-01 Journal: Biomolecules [Category] MERS, SARS, 진단, 치료기술, [키워드] acid Analysis analytical methods approach approaches biological sample biological samples Chain Reaction Conventional coronavirus coronavirus disease diagnose Diagnosis Diseases DNA Evolution Future Genetic genetic material highlighting human diseases implementation Infection infections diagnosis Microfluidics NAT NATs nucleic acid nucleic acid test nucleic acids pandemic pathogen PCR performed point-of-care polymerase chain polymerase chain reaction purification Research RNA silicon silicon-based technologies Treatment Viral viral NA analysis viral nucleic acid viral nucleic acids [DOI] 10.3390/biom11111585 PMC 바로가기 [Article Type] Review
Rapid Detection of SARS-CoV-2 Using Duplex Reverse Transcription-Multienzyme Isothermal Rapid Amplification in a Point-of-Care Testing현장 진료 테스트에서 이중 역전사-다효소 등온 급속 증폭을 사용한 SARS-CoV-2의 신속한 검출Cellular and Infection Microbiology Published on 2021-10-222022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] 229E 95% CI 95% confidence interval a low volume acute respiratory syndrome Adenovirus Amplicon amplicons amplification amplify buffer caused Concentration coronavirus coronavirus 229E cross-reaction detection diagnostics duplex multienzyme isothermal rapid amplification Efficacy extraction guanidinium human parainfluenza virus Influenza influenza A influenza A virus influenza B influenza B virus isothermal amplification lateral flow lateral flow dipstick limit of detection MERS MERS-CoV N gene National Negative predictive value nucleic acid nucleic acid test nucleic acid tests ORF1 ORF1ab ORF1ab gene Pathogens point-of-care testing Positive predictive value Precision Predictive value primer Primers probe probes qPCR Rapid reaction respiratory Respiratory pathogens respiratory syncytial virus RNA extraction SARS-CoV SARS-CoV-2 Severe acute respiratory syndrome specimen Spread suspected patient suspected patients Swab target temperature Testing virus Volume were used without RNA extraction [DOI] 10.3389/fcimb.2021.678703 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
A Novel Rapid Test to Detect Anti-SARS-CoV-2 N Protein IgG Based on Shear Horizontal Surface Acoustic Wave (SH-SAW)Article Published on 2021-10-052022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Acoustic acute respiratory syndrome anti-SARS-CoV-2 antibodies antibody Antibody testing Antigen collected Concentration coronavirus Coronavirus disease 2019 COVID-19 demonstrated detect develop diagnostic ELISA enzyme-linked immunosorbent evaluated high correlation IgG immunoassay in vitro in vitro diagnostic (IVD) injection IVD novel nucleic acid test nucleocapsid outbreak pandemic pathogen detection platform Protein Rapid SARS-CoV-2 SARS-CoV-2 N protein sensitivity sera severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shear surface surface acoustic wave (SAW) Test viral culture Wave [DOI] 10.3390/diagnostics11101838 PMC 바로가기 [Article Type] Article
COVID-19 Mortality Prediction From Deep Learning in a Large Multistate Electronic Health Record and Laboratory Information System Data Set: Algorithm Development and ValidationOriginal Paper Published on 2021-09-282022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, SARS, [키워드] 95% CI age Algorithm America Analysis approach AUROC Cardiopulmonary caused characteristic clinical manifestations Clinical treatment Cohort Comorbidity covariate COVID-19 data set death deep deep learning development disease EHR Electronic health record evaluated feature fibrinogen first positive follow-up time hazard ratio Health heterogeneous indicated individual information Kera Laboratory laboratory measurement Laboratory test learning machine learning machine learning model Mayo Clinic Mild Missing data Mortality Neural network nucleic acid test objective oxygen saturation Patient patient population performed predicted prediction provide provided Record recurrent neural networks reducing reported Result retained robust SARS-COV-2 infection serum statistically significant difference Stratification survival Symptom System TensorFlow the SARS-CoV-2 virus the United State Time series Traditional treated validation [DOI] 10.2196/30157 PMC 바로가기 [Article Type] Original Paper
Clinical Characteristics of Pediatric Cases of COVID-19 in Hunan, China: A Retrospective, Multi-Center Case SeriesPediatrics Published on 2021-09-242022-10-31 Journal: Frontiers in Pediatrics [Category] COVID-19, [키워드] addition Analysis Antibiotics antiviral therapy Asymptomatic C-reactive protein changes in Characteristics Chest Chest CT chest imaging children children with COVID-19 China clinical Clinical features Cluster conducted consolidation Contact cough COVID-19 Diagnosis diarrhea discharge early stage eight elevated epidemiological Epidemiology Familial fatigue Fever Follow-up Ground glass opacity headache hospital Intravenous immunoglobulin laboratory characteristics LDH less lymphocyte Lymphocytes Methylprednisolone Mild moderate MOST nucleic acid test Other patchy Patient pediatric infection Pediatric patient Pediatric patients peripheral blood leukocyte procalcitonin Prognosis route of infection RT-PCR detection SARS-CoV-2 Sery Supportive treatment Symptom Symptoms the patient treated Treatment White blood cell [DOI] 10.3389/fped.2021.665377 PMC 바로가기 [Article Type] Pediatrics
Diagnostic classification of coronavirus disease 2019 (COVID-19) and other pneumonias using radiomics features in CT chest imagesCT 흉부 이미지에서 방사선 기능을 사용한 코로나 바이러스 질병 2019 (Covid-19) 및 기타 폐렴의 진단 분류Article Published on 2021-09-092022-09-01 Journal: Scientific Reports [Category] SARS, 임상, 진단, 치료기술, 치료법, [키워드] Accuracy AUC biomedical engineering Blood blood cell blood oxygen Bonferroni correction C-reactive protein Chest CT image Chest CT images Cohort collected conducted coronavirus disease Coronavirus disease 2019 correlated Correlation analysis COVID-19 COVID-19 patient COVID-19 patients CT chest determine diagnose diagnosis of COVID-19 diagnostic classification erythrocyte sedimentation erythrocyte sedimentation rate feature Final hypersensitive C-reactive protein identify independent Laboratory Laboratory test Lymphocytes Medical imaging multiple comparison correction Neutrophils nucleic acid nucleic acid test oxygen participant Patient patients patients with COVID-19 Pneumonia pneumonias positive positively correlated region of interest Respiratory tract diseases ROI RT-PCR sedimentation rate sensitivity specificity Support support vector machine SVM two group two groups validation cohort vector was performed was used WBC White blood cell [DOI] 10.1038/s41598-021-97497-9 PMC 바로가기 [Article Type] Article
Pre-Vaccine Positivity of SARS-CoV-2 Antibodies in Alberta, Canada during the First Two Waves of the COVID-19 PandemicCOVID-19 팬데믹의 첫 두 물결 동안 캐나다 앨버타주에서 SARS-CoV-2 항체의 백신 사전 양성Research Article Published on 2021-08-182022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 진단, 치료기술, 치료법, [키워드] 95% CI 95% confidence interval antibodies antibody best blood sample Canada clinical laboratories Cohort collected Concordance correlated correlation COVID-19 COVID-19 pandemic demographics detectable Epidemiology evaluated facilitate female followed by geographical areas group help highest highlight immunology in some individual Infection information Laboratory Local lowest male minority groups molecular molecular test NAAT no significant difference nucleic acid test nucleocapsid protein Patient population prevalence positive positive COVID-19 proportion provide public health residual SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 nucleocapsid SARS-CoV-2 virus second wave secondary school seeking serology serology testing seronegative seropositive seropositive individual seropositive individuals Seropositivity Seroprevalence Sociodemographic Spike protein Support tested the SARS-CoV-2 virus vaccination Wave [DOI] 10.1128/Spectrum.00291-21 PMC 바로가기 [Article Type] Research Article
Efficacy and Safety of Traditional Chinese Medicine in Coronavirus Disease 2019 (COVID-19): A Systematic Review and Meta-AnalysisPharmacology Published on 2021-08-062022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 95% CI 95% confidence interval acute respiratory syndrome adverse event approved ARDS articles benefit Chest chest imaging Chinese clearance Clinical deterioration clinical effectiveness Clinical efficacy clinically conducted coronavirus COVID-19 database death death rate duration of hospitalization Evidence Fever IMPROVE incidence mechanical ventilation Medicine Meta-analysis moderate negativity nucleic acid test outcome participant Patient patients with COVID-19 promote Randomized controlled trial RCT RCTs reduce reducing reduction review risk Risk of bias Safe Safety SARS-CoV-2 SARS-CoV-2 nucleic acid searched secondary selected Serious Adverse Event Seven severe disease shown significant difference significantly systematic review TCM the SARS-CoV-2 Traditional Traditional Chinese medicine treat Treatment two groups [DOI] 10.3389/fphar.2021.609213 PMC 바로가기 [Article Type] Pharmacology
Clinical relevance of serum α-l-fucosidase activity in the SARS-CoV-2 infectionSARS-CoV-2 감염에서 혈청 α-l-fucosidase 활성의 임상적 관련성Article Published on 2021-08-012022-09-12 Journal: Clinica chimica acta; international journal of cli [Category] MERS, SARS, 진단, [키워드] antibodies C-reactive protein clinical Clinical relevance Comorbidities Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) correlation COVID-19 COVID-19 patient COVID-19 patients CRP Disease progression disorder disorders enzyme highest IgG IgG antibody IgM IgM/IgG immune response Infection Invasion material Mortality mRNA Non-severe case nucleic acid nucleic acid test Odds ratio Patient reduced SAA SARS-CoV-2 Serological antibodies serum serum amyloid severe cases spike glycoprotein the SARS-CoV-2 virus α-l-fucosidase. [DOI] 10.1016/j.cca.2021.03.031 PMC 바로가기 [Article Type] Article
Evaluation and Comparison of Serological Methods for COVID-19 DiagnosisMolecular Biosciences Published on 2021-07-232022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] antibody chemiluminescence immunoassay CLIA Clinical diagnosis COVID-19 COVID-19 diagnosis diagnostic early diagnosis Effect Efficiency ELISA enzyme-linked immunosorbent global public health golden standard healthy help IMPROVE include increasingly lateral flow immunoassay LFIA Nucleic acid detection nucleic acid test Patient problem respiratory tract SARS-CoV-2 sensitivity serological serological test Serological testing spread of COVID-19 viral nucleic acid virus detection worldwide pandemic [DOI] 10.3389/fmolb.2021.682405 PMC 바로가기 [Article Type] Molecular Biosciences