Rapid and accurate nucleobase detection using FnCas9 and its application in COVID-19 diagnosisFnCas9를 이용한 신속하고 정확한 핵염기 검출 및 이를 코로나19 진단에 적용Article Published on 2021-07-012022-09-11 Journal: Biosensors & bioelectronics [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] accelerated carriers Cas9 cleavage Clinical prognosis clinical sample clinical samples Combination COVID-19 COVID-19 diagnosis COVID-19 outbreak CRISPRDx detection diagnostics disease outbreaks FELUDA FnCas9 heterozygous Infectious disease infectious disease outbreak lateral flow LFA Molecular diagnosis nucleobase nucleotide nucleotide sequence pathogenic point-of-care prototype qPCR Rapid reporter resources robust RT-RPA SARS-CoV2 semi-quantitative sensitivity sequence Sequencing Single nucleotide variant single nucleotide variants SNV SNV detection. SNVs specificity strip Traditional traditional methods trans Uniform variant variants Viral Viral load viral loads [DOI] 10.1016/j.bios.2021.113207 PMC 바로가기 [Article Type] Article
Comparative study: nonsynonymous and synonymous substitution of SARS-CoV-2, SARS-CoV, and MERS-CoV genomeOriginal Article Published on 2021-06-302022-11-01 Journal: Genomics & Informatics [Category] COVID-19, [키워드] acute respiratory syndrome Analysis analyzed Comparative coronavirus divergence time dN/dS Evolution favor Hypothesis indicate investigated likelihood MERS-CoV genome Middle East Neutral nonsynonymous nucleotide sequence positive proportion Respiratory syndrome respiratory syndrome coronavirus Result SARS-CoV SARS-CoV-2 significantly statistical strain Substitution Support syndrome synonymous synonymous and nonsynonymous change transition/transversion ratio Variation viruses [DOI] 10.5808/gi.20058 PMC 바로가기 [Article Type] Original Article
Discrimination of the SARS-CoV-2 strains using of coloured s-LASCA-imaging of GB-speckles, developed for the gene “S” nucleotide sequences유전자 "S" 뉴클레오티드 서열을 위해 개발된 GB-반점의 착색된 s-LASCA 영상을 사용한 SARS-CoV-2 균주의 구별Article Published on 2021-06-252022-09-11 Journal: F1000Research [Category] SARS, 변종, 치료기술, 치료제, [키워드] approach be positive bioinformatics classical coding component demonstrated described discrimination Effectiveness GB-speckles Gene indicate LASCA molecular target natural mutation nucleotide nucleotide sequence pathogenic viruses positive processing Result resulting SARS-CoV-2 SARS–CoV-2 spike glycoprotein spike glycoprotein gene strain the SARS-CoV-2 typing variant [DOI] 10.12688/f1000research.53214.2 PMC 바로가기 [Article Type] Article
Multiple detection and spread of novel strains of the SARS-CoV-2 B.1.177 (B.1.177.75) lineage that test negative by a commercially available nucleocapsid gene real-time RT-PCR시판되는 뉴클레오캡시드 유전자 실시간 RT-PCR로 음성 판정을 받은 SARS-CoV-2 B.1.177(B.1.177.75) 계통의 신규 균주 다중 검출 및 확산Original Article Published on 2021-06-132022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 치료기술, 치료법, [키워드] Abruzzo activity adopted Analysis B.1.177 circulating Cluster Clusters connection COVID-19 Diagnosis diagnostic epidemiological Epidemiology Genetic genomic data highlight independent involved Italy knowledge Lineage majority Molecular tests Multiple Mutation mutations N gene nucleocapsid Nucleocapsid gene nucleotide nucleotide sequence occur ORF1 ORF1ab performed Phylogeny polymerase chain reaction positive primer Primers probe real-time RT-PCR RT-PCR S gene SARS-CoV-2 sequence sequences Sequencing Spread strain Strains Support synonymous TaqPath test negative tested the SARS-CoV-2 Thermofisher turn unique [DOI] 10.1080/22221751.2021.1933609 PMC 바로가기 [Article Type] Original Article
SARS‐CoV‐2 worldwide replication drives rapid rise and selection of mutations across the viral genome: a time‐course study – potential challenge for vaccines and therapiesSARS-CoV-2 전 세계 복제는 바이러스 게놈 전반에 걸친 돌연변이의 급속한 증가 및 선택을 유도합니다: 시간 경과 연구 – 백신 및 요법에 대한 잠재적 도전Article Published on 2021-05-312022-09-11 Journal: EMBO Molecular Medicine [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] 501Y.V2 Affect B.1.1.7 B.1.351 Brazil China Chromatin, Epigenetics, Genomics & Functional Genomics Complete country Course diagnostic tests Efficacy examined facilitated France Genome Germany GISAID high incidence of C to T transitions India Influenza initiative lockdowns Microbiology, Virology & Host Pathogen Interaction mutant mutant strain mutants Mutation mutations nucleotide nucleotide sequence numerous new mutations P.1 P.2 pandemic Population Prevalence provided Replication reported resource Russia SARS‐CoV‐2 scientist sequence South Africa South African and Brazil variants Spain strain Therapies therapy time course of SARS‐CoV‐2 mutant emergence UK variant B.1.1.7 United Kingdom United States vaccination Vaccine Vaccines variant variants Viral Viral mutations viral replication viral variant waned [DOI] 10.15252/emmm.202114062 PMC 바로가기 [Article Type] Article
Predicting the animal hosts of coronaviruses from compositional biases of spike protein and whole genome sequences through machine learningResearch Article Published on 2021-04-202022-10-29 Journal: PLoS Pathogens [Category] COVID-19, [키워드] Accuracy addition Animal host applied Applying approach assist bat categories codon usage coevolution coronavirus Coronaviruses COVID-19 COVID-19 pandemic Cross-species transmission demonstrated disease Diseases effort emerging disease family Coronaviridae feature Genetic Genome genomic genomic information Health Host host-virus interaction investigated likelihood machine learning algorithm MERS-CoV methodology Model New nine nucleotide sequence Outbreaks pandemic phylogenetic analyses Phylogeny predict predicted Predictive Protein random reached resource SARS-CoV SARS-CoV-2 sequence shown Spike protein Spike protein sequence suggested tracing Variation viral genome virus whole genome whole genome sequence whole genomes widespread Yinpterochiroptera zoonotic Zoonotic coronavirus [DOI] 10.1371/journal.ppat.1009149 PMC 바로가기 [Article Type] Research Article
At Least Seven Distinct Rotavirus Genotype Constellations in Bats with Evidence of Reassortment and Zoonotic TransmissionsResearch Article Published on 2021-01-192022-10-29 Journal: mBio [Category] Coronavirus, Fulltext, 조류인플루엔자, [키워드] acute respiratory syndrome America Analysis available data backbone bat bat coronavirus bat rotavirus bats characterized Clustering collected constellation Contact coronavirus diarrheal disease equine Europe Evidence evidence of example Fecal sample form gcs genetic diversity genetics Genome Genotype genotypes Host Human humans identity Increasing majority mammal MERS-CoV Middle East nucleotide sequence pathogenic PCR-positive Phylogenetic Reassortment remained Research respiratory syndrome coronavirus risk rotavirus rotavirus genetic diversity SA11 SARS-CoV SARS-CoV-2 Spread strain viral metagenomics viral pathogens virus viruses zoonosis [DOI] 10.1128/mBio.02755-20 PMC 바로가기 [Article Type] Research Article
An Insight Into COVID-19: A 21st Century Disaster and Its Relation to Immunocompetence and Food AntioxidantsVeterinary Science Published on 2021-01-132022-11-01 Journal: Frontiers in Veterinary Science [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome affected angiotensin-converting enzyme 2 antigenicity antioxidants approach bat BatCoV RaTG13 binding biosecurity candidate cause coronavirus coronavirus disease COVID-19 Diagnosis disaster Effect effective effort Emergency epidemiological food Genome genomic health emergency Host host cell Human identity immune-competence immunocompetence Immunocompromised Immunopathogenesis indicated insight knowledge malaise mechanism MERS-CoV Middle East nucleotide sequence outbreak penetrate positive-sense single-stranded RNA preexisting comorbidities public health receptor relation respiratory droplet respiratory syndrome coronavirus risk SARS-CoV SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 vaccine Smokers Spike protein Spread the Betacoronavirus Treatment vaccination Vaccine viral infections Viral pneumonia virus WHO World Health Organization [DOI] 10.3389/fvets.2020.586637 PMC 바로가기 [Article Type] Veterinary Science
Genetic Diversity and Evolution of the Biological Features of the Pandemic SARS-CoV-2Research Article Published on 2021-01-012022-10-28 Journal: Acta Naturae [Category] COVID-19, [키워드] analyzed approach Biological biological property Characteristics confirmed case contagiousness coronavirus Coronaviruses country COVID-19 death Diversity effort etiological agent Evolution of SARS-CoV-2 exceeded genetic diversity genetic variants Health identify Infection intensive care units New coronavirus nucleotide sequence outbreak pathogenicity Prophylaxis public health measure Retrospective analysis SARS-CoV-2 Sequencing Spread the disease the SARS-CoV-2 therapy understanding viral genome virulence virus Virus evolution [DOI] 10.32607/actanaturae.11337 PMC 바로가기 [Article Type] Research Article
Randomness for Nucleotide Sequences of SARS-CoV-2 and Its Related SubfamiliesSARS-CoV-2 및 관련 서브패밀리의 뉴클레오티드 서열에 대한 무작위성Research Article Published on 2020-11-142022-09-11 Journal: Computational and Mathematical Methods in Medicine [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] candidate clinical researches Coronaviridae COVID-19 develop ENhance Evolution Evolution of SARS-CoV-2 help indicate knowledge measure mechanism mutations nucleotide nucleotide sequence predict Randomly randomness SARS-CoV-2 sequence subfamily the Coronaviridae Vaccine virus [DOI] 10.1155/2020/8819942 PMC 바로가기 [Article Type] Research Article