Challenges and Opportunities for Public Health Service in Oman From the COVID-19 Pandemic: Learning Lessons for a Better FuturePublic Health Published on 2021-12-092022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] adaptive approach Better Care challenge Community COVID-19 COVID-19 pandemic COVID-19 vaccination disease Disease surveillance expand Future Health Health care system health system include lack learning lesson nucleus Oman one health opportunity pandemic platform precursor provide provided Public public health regions risk service Stage Surveillance the disease [DOI] 10.3389/fpubh.2021.770946 PMC 바로가기 [Article Type] Public Health
Social Isolation, Loneliness and Generalized Anxiety: Implications and Associations during the COVID-19 QuarantineReview Published on 2021-12-082022-10-28 Journal: Brain Sciences [Category] COVID-19, [키워드] Anxiety association COVID-19 COVID-19 pandemic Evidence Generalized Health heterogenous HPA Impact implication Implications locus loneliness mechanism morbidity Mortality nucleus quarantine social isolation Solutions [DOI] 10.3390/brainsci11121620 PMC 바로가기 [Article Type] Review
The risk of transmission of the novel coronavirus (SARS-CoV-2) with human heart valve transplantation: evaluation of cardio-vascular tissues from two consecutive heart donors with asymptomatic COVID-19인간 심장 판막 이식으로 신종 코로나바이러스(SARS-CoV-2) 전파 위험: 무증상 COVID-19가 있는 2명의 연속 심장 기증자의 심혈관 조직 평가Case Reports Published on 2021-12-012022-09-11 Journal: Cell and tissue banking [Category] SARS, 치료기술, [키워드] ACE2 Allograft Aortic valve Asymptomatic Asymptomatic COVID-19 Cardiomyopathy clinically coronavirus COVID-19 cytoplasmic dilated cardiomyopathy donation Donor donors eosinophilic myocarditis heart Heart transplantation Heart valves hearts Homograft hypertrophic hypertrophic cardiomyopathy immunostaining life-threatening LIGHT light microscopy living donors Microscopy Mild mitral mitral valve myocarditis Myocardium Novel coronavirus nucleus Obstructive performed positive Presence pulmonary Pulmonary valve receiving Research risk risk of transmission RT-PCR SARS-CoV-2 SARS-CoV-2 test tested tissue Tissue banking Tissue Transplantation tissues Transmission tricuspid tricuspid valve Viral transmission virus virus transmission wall [DOI] 10.1007/s10561-021-09913-z PMC 바로가기 [Article Type] Case Reports
Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infectioncGAS에 의한 세포질 염색질 감지는 SARS-CoV-2 감염에서 타고난 면역 반응을 활성화합니다Article Published on 2021-11-032022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] ACE2 activate Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition caused Cell Cell fusion cellular cGAS chromatin contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytoplasmic cytosolic Defense DNA expression Host host antiviral response host antiviral responses host cell host cells host defense host immune system immune system induce infected cells Infectious diseases inhibit innate immune response innate immune system Innate immunity interferon knowledge MAVS mechanism nucleic acids nucleus offer pandemic pathway positive-sense RNA virus pro-inflammatory gene expression recognize reported required respiratory respond RNA virus SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Spike protein STING targeting therapeutic treating COVID-19 Trigger Viral viral infection viral replication Viral RNA [DOI] 10.1038/s41392-021-00800-3 PMC 바로가기 [Article Type] Article
Diabetes and susceptibility to infections: Implication for COVID-19당뇨병과 감염에 대한 감수성: COVID-19에 대한 시사점Review Published on 2021-11-012022-09-11 Journal: Immunology [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] activating binding Cell cell survival contribute COVID-19 COVID-19 infections diabete diabetes Diabetic differentiation dysregulated explain Factor healthcare immune immune activation Immune cell immune cells immune checkpoint blocker immune response immune-related genes in viral Infection infections Inflammation insulin insulin receptor insulin resistance involved lymphocyte Lymphocytes mechanism mTOR myeloid cell myeloid cells nucleus observation outcome pathology pathway Pathways peripheral tolerance PI3K polarization Proteins receptor regulate shown survival susceptibility susceptibility to infection the strongest Transcription translocate Viral viral infections [DOI] 10.1111/imm.13383 PMC 바로가기 [Article Type] Review
SARS-CoV-2 infection triggers widespread host mRNA decay leading to an mRNA export blockArticle Published on 2021-11-012022-10-29 Journal: RNA (New York, N.Y.) [Category] COVID-19, MERS, SARS, [키워드] Antiviral antiviral response biogenesis caused cytoplasm cytoplasmic Degradation dissemination early stage elevated expression Genes hallmark Host host mRNA IFN immune response inhibit inhibited Innate immunity interferon IRF3 limit mammalian mRNA mRNA decay mRNA export mRNAs nucleus Patient performed Protein Regulatory RNA RNase RNase L SARS-CoV-2 SARS-CoV-2 infected cells SARS-COV-2 infection SARS-CoV-2 replication second serum severe COVID-19 disease Signaling the interferon the SARS-CoV-2 Transcription transcription factor transcriptional translocation Transport Trigger type I Type III IFN viral replication widespread [DOI] 10.1261/rna.078923.121 PMC 바로가기 [Article Type] Article
S-farnesylation is essential for antiviral activity of the long ZAP isoform against RNA viruses with diverse replication strategiesResearch Article Published on 2021-10-252022-10-29 Journal: PLoS Pathogens [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Antiviral antiviral activity assist association binding broad inhibitor C-terminal C-terminal region catalytic site catalytically caused cofactor complex coronavirus CpG cysteine cytoplasm Degradation dependent on determinant dinucleotide distribution domain element Endoplasmic reticulum Factors highlight HIV-1 Human immunodeficiency virus hydrophobic in viral inactive Interaction isoform KHNYN lack membrane membranes Microscopy modulate motif N-terminal RNA-binding domain nucleus PARP physical plasma membrane polymerase post-translational modification Prevent Protein provide recruitment regulate replicate Replication required residue restored RNA RNA virus RNAs SARS-CoV-2 Structure subcellular translation TRIM25 type I Vesicle viral pathogens Viral RNA virion virus virus replication ZAP [DOI] 10.1371/journal.ppat.1009726 PMC 바로가기 [Article Type] Research Article
SARS–CoV–2 Spike Impairs DNA Damage Repair and Inhibits V(D)J Recombination In VitroSARS – COV – 2 스파이크는 DNA 손상 복구를 손상시키고 V (D) J J 재조합을 억제합니다.Article Published on 2021-10-132022-09-01 Journal: Viruses [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Adaptive immunity affecting BRCA1 cell line clinical Clinical outcome clinical outcomes Clinical studies coronavirus coronavirus disease Coronavirus disease 2019 damage DNA DNA damage DNA damage repair DNA repair effective full-length immune immune responses Immunity impede in vitro indicated Infection influence inhibit mechanism nucleus pandemic Patient patients potential molecular Protein public health Recombination recruitment repair required respiratory SARS–CoV–2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Side effect significantly spike Spike protein spike-based vaccines the spike protein V(D)J recombination Vaccine [DOI] 10.3390/v13102056 PMC 바로가기 [Article Type] Article
Design, Microwave-Assisted Synthesis and In Silico Prediction Study of Novel Isoxazole Linked Pyranopyrimidinone Conjugates as New Targets for Searching Potential Anti-SARS-CoV-2 AgentsArticle Published on 2021-10-102022-10-30 Journal: Molecules [Category] COVID-19, MERS, SARS, [키워드] agent binding energy binding score classical click chemistry co-crystallized comparable Compound condition conjugate copper catalyst COVID-19 derivative docking score in silicomolecular docking inhibitor Interaction isoxazole Ligand M pro means microwave irradiation moderate N3 inhibitor New NMR novel nucleus Potential predict prediction protease Protein pyranopyrimidinone reference standard SARS-CoV-2 SARS-CoV-2 Mpro inhibitors Structure synthesis target target protease these compound turn was used were used [DOI] 10.3390/molecules26206103 PMC 바로가기 [Article Type] Article
Molecular Mechanism of the Anti-Inflammatory Action of HeparinArticle Published on 2021-10-032022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] Action anti-inflammatory action anti-inflammatory agent applicability Autoimmune diseases bind binding biological activity Cell cellular receptor complex condition COVID-19 CRS Cytokine storm Cytokines heparin high affinity IFNγ IFNγ IL-6 Inflammation Inflammatory influence inhibit Interaction investigated LMWH low-molecular-weight heparin (LMWH) mechanism molecular dynamics molecular mechanism Molecular modelling nucleus overexpression phosphorylated resulting signalling pathway Stat1 stimulated translocation with COVID-19 [DOI] 10.3390/ijms221910730 PMC 바로가기 [Article Type] Article