Open reading frame – Page 3 – Communicable Diseases Research

Variable levels of spike and ORF1ab RNA in post-mortem lung samples of SARS-CoV-2-positive subjects: comparison between ISH and RT-PCR

SARS-CoV-2 양성 대상자의 사후 폐 샘플에서 다양한 수준의 스파이크 및 ORF1ab RNA: ISH와 RT-PCR 간의 비교

Original Article

Published on 2022-02-012022-09-10
Journal: Virchows Archiv [Category] COVID19(2023년), MERS, SARS, 치료기술, 치료법, 치료제,

Targeting genomic SARS-CoV-2 RNA with siRNAs allows efficient inhibition of viral replication and spread

siRNA로 게놈 SARS-CoV-2 RNA를 표적화하면 바이러스 복제 및 확산을 효율적으로 억제할 수 있습니다.

AcademicSubjects/SCI00010

Published on 2022-01-112022-09-10
Journal: Nucleic Acids Research [Category] 진단, 치료제,

[키워드] 3′ end active against acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 antiviral efficacy approach cell entry conserved conserved region Coronavirus-2 COVID-19 discontinuous transcription effective Ex vivo Frame genomic genomic RNA gRNA human lung inhibited Open reading frame open reading frame 1 ORF1 Prevent Prophylactic Region replicate Replication respiratory RNA SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 RNA sequence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus sgRNA sgRNAs siRNA siRNAs Spread target targeting therapy transcript Transcription transcripts translational unique Verifying Viral viral replication Viral RNA viral transcript viral transcripts virus-induced cell death
[DOI] 10.1093/nar/gkab1248 PMC 바로가기 [Article Type] AcademicSubjects/SCI00010

Transmission cluster of COVID-19 cases from Uruguay: emergence and spreading of a novel SARS-CoV-2 ORF6 deletion

우루과이의 COVID-19 사례 전파 클러스터: 새로운 SARS-CoV-2 ORF6 결실의 출현 및 확산

Research Article

Published on 2022-01-102022-09-10
Journal: Memórias do Instituto Oswaldo Cruz [Category] 변종, 치료기술,

[키워드] accessory gene acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amino acids analysed Care changes in Cluster coding coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 case COVID-19 cases Deletion deletion variant Deletion variants detect epidemiological link epidemiological links epidemiological studies Evidence Genes genetics Genome genomic data Health Health care Illumina immune modulation include INDEL indels information nucleotide deletion Open reading frame open reading frames ORF ORF6 ORFs outbreak Outbreaks Protein regions repeat unit repeated repetitive sequence reported respiratory SARS-CoV-2 SARS-CoV-2 genome sequence sequenced severe acute respiratory syndrome Coronavirus Spread Substitution substitutions the SARS-CoV-2 genome Transmission unique
[DOI] 10.1590/0074-02760210275 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 ORF10 suppresses the antiviral innate immune response by degrading MAVS through mitophagy

SARS-CoV-2 ORF10은 미토파지를 통해 MAVS를 분해하여 항바이러스 선천 면역 반응을 억제합니다.

Article

Published on 2022-01-012022-09-11
Journal: Cellular and Molecular Immunology [Category] SARS, 유전자 메커니즘, 치료제,

[키워드] accumulation Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral signaling autophagy binding blocked caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Degradation expressed expression facilitated Frame humans IFN-I IFN-I signaling IFN-stimulated genes induce inhibit inhibited innate immune innate immune response Interaction knockdown MAVS mechanism Mitochondria mitochondrial mitophagy. morbidity and mortality NIX Open reading frame ORF10 overexpression pandemic pathway promoted Protein receptor SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus suppresse suppressed target translocated type I interferon viral genes viral replication
[DOI] 10.1038/s41423-021-00807-4 PMC 바로가기 [Article Type] Article

Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and function

독특한 SARS-CoV-2 ORF10 변이체의 출현과 단백질 구조 및 기능에 미치는 영향

Article

Published on 2022-01-012022-09-11
Journal: International journal of biological macromolecules [Category] SARS, 변종,

[키워드] acute respiratory syndrome coronavirus And ubiquitin ligase complex caused Co-occurring mutations comprehension Consequences coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic CUL2 disorder Effect ELOB ELOC emergence expected expressed Frame highlight host protein human protein human proteins interact intrinsic Intrinsic protein disorder lung tissue MAP7D1 Mutation Open reading frame ORF10 pathogenicity PPT1 predicted Protein public health RBX1 Research respiratory SARS-CoV-2 SARS-CoV-2 mutation SARS-CoV-2 mutations SARS-CoV-2 variant secondary structure severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severity single mutation THTPA TIMM8B ubiquitin ligase unique variant variants virulence virus ZYG11B
[DOI] 10.1016/j.ijbiomac.2021.11.151 PMC 바로가기 [Article Type] Article

Analysis of Clinical Characteristics and Virus Strains Variation of Patients Infected With SARS-CoV-2 in Jiangsu Province—A Retrospective Study

장쑤성 SARS-CoV-2 감염 환자의 임상적 특성 및 바이러스 균주 변이 분석 - 후향적 연구

Public Health

Published on 2021-12-242022-09-11
Journal: Frontiers in Public Health [Category] MERS, SARS, 변종, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Alpha Amino acid amino acid replacement amino acid replacements amino acid substitution Analysis association Asymptomatic asymptomatic infection Beta caused change Characteristics China clinical Clinical characteristics Clinical features Clinical severity collected concern conditions confirmed case coronavirus correlated Course Delta detect diagnosed disease Diversity dominant dominant mutation Evolution Frame Genetic genomic genomic variation help hosts imported cases infected patient Infection Jiangsu Last local outbreak local outbreaks loci men Missense mutation MONITOR Mutation mutations nine nucleotide occurred Open reading frame ORF1ab oropharyngeal swab oropharyngeal swabs Patient patients patients severity patients severity SARS-CoV-2 pedigree pharyngeal swabs Phylogeny positively correlated present Recombination respiratory risk S gene SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants Sequencing severity significantly Single nucleotide polymorphism single nucleotide polymorphisms SNP SNPs spike glycoprotein Spread strain Surveillance the SARS-CoV-2 undergo variant variety virus virus variant viruses was performed was used were infected whole genome Whole genome sequencing women
[DOI] 10.3389/fpubh.2021.791600 PMC 바로가기 [Article Type] Public Health

Coronavirus Infection-Associated Cell Death Signaling and Potential Therapeutic Targets

코로나바이러스 감염 관련 세포 사멸 신호 및 잠재적 치료 표적

Review

Published on 2021-12-092022-09-10
Journal: Molecules [Category] SARS, 치료제,

[키워드] (RdRp 3CLpro ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-apoptotic Anti-inflammatory antiviral properties Apoptosis assembly autophagy BCL-2 can be used caused celastrol cell death cell death pathways Chloroquine chloroquine/hydroxychloroquine Compound coronavirus CoV infection COVID-19 COVID-19 treatment Critical Curcumin cysteine Cytokines death deaths Effect Efficacy enzyme expression FIVE flavonoids Frame group Helicase host cell Hydroxychloroquine induce Infection Inflammation inhibiting inhibitor Inhibitory effects interactions involved L-cysteine life cycle mechanism mitigate modify molecular target molecules MPro name natural natural compounds necroptosis NF-κB NF-κB signaling NLRP3 inflammasome non-structural protein nonstructural protein 1 nsp1 Nsp12 occurred Open reading frame ORF7a outcomes Papain play roles PLPro Potential progression proliferation promote Propagation protease Protein proteinase pyroptosis RdRP Regulated cell death Replication responsible RNA RNA dependent RNA polymerase RNA polymerase SARS-CoV infection SARS-CoV-2 SARS-CoV-2-infected patients Serine serine 2 severe acute respiratory syndrome Coronavirus Signaling small molecule specific inhibitor spike Spike protein survival target targeted therapy the disease therapeutic targeting TMPRSS2 TNF transmembrane transmembrane protease serine 2 Treatment variety Viral viral entry viral infection viral life cycle virions XIAP yielding
[DOI] 10.3390/molecules26247459 PMC 바로가기 [Article Type] Review

Diagnostic performances of common nucleic acid tests for SARS-CoV-2 in hospitals and clinics: a systematic review and meta-analysis

병원 및 의원에서 SARS-CoV-2에 대한 일반적인 핵산 검사의 진단 성능: 체계적인 검토 및 메타 분석

Meta-Analysis

Published on 2021-12-012022-09-11
Journal: The Lancet. Microbe [Category] SARS, 치료기술,

[키워드] 95% CI Accuracy applied AUC authorization bioRxiv Chinese clinical sample clinical samples clinical settings Committee comparator conditions Consistency detect diagnostic diagnostic sensitivity digital PCR effort Emergency Emergency use authorization false False positive false-negative False-positive followed by Frame heterogeneity highest Hong Kong hospital isothermal amplification Laboratory LAMP latent class less Loop-mediated isothermal amplification medRxiv Meta-analysis not differ nucleic acid nucleic acid test nucleic acid tests Open reading frame open reading frame 1ab PCR PCR assay PCR assays performed Pharyngeal swab primer primer-probe sets protocol qPCR quantitative PCR random-effect reference standard reported RNA RNA extraction Sample size SARS-CoV-2 SARS-CoV-2 detection searched sensitivity Sensitivity and specificity shown significantly specimen systematic review Test true-positive university were excluded
[DOI] 10.1016/S2666-5247(21)00214-7 PMC 바로가기 [Article Type] Meta-Analysis

CRISPR-Cas12a-Based Detection for the Major SARS-CoV-2 Variants of Concern

우려의 주요 SARS-CoV-2 변이체에 대한 CRISPR-Cas12a 기반 탐지

Research Article

Published on 2021-11-172022-09-10
Journal: Microbiology Spectrum [Category] MERS, SARS, 변종, 진단, 치료기술, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Alpha Amino acid amplification approach B.1.1.7 B.1.351 B.1.617.2 Beta clinical sample clinical samples Combination concern Concordance coronavirus COVID-19 pandemic CRISPR CRISPR-Cas system D614G delta variant Delta variants described detect detection Detection sensitivity E484K emerging SARS-CoV-2 variant evaluated Frame genotyping Immunity IMPROVE indicated Infection K417N L452R Laboratory Lambda limit of detection Lineage Major multiplex Mutation N501Y nucleic acid nucleic acid amplification nucleic acid amplification tests Open reading frame ORF8 PAM PCR primer protospacer adjacent motif public health Rapid test resource respiratory reverse transcription-PCR robust RT-PCR SARS-CoV-2 SARS-CoV-2 nucleic acid SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 variants Sequencing severe acute respiratory syndrome Coronavirus Spike protein T478K unmet need vaccination variant screening variants variants of concern variants of interest variants of SARS-CoV-2 virulent VOCs VOIs wild type
[DOI] 10.1128/Spectrum.01017-21 PMC 바로가기 [Article Type] Research Article

Genome-wide covariation in SARS-CoV-2

SARS-CoV-2의 게놈 전체 공변이

Article

Published on 2021-11-012022-09-11
Journal: Mathematical biosciences [Category] SARS, 치료기술,