Receptor-Loaded Virion Endangers GPCR Signaling: Mechanistic Exploration of SARS-CoV-2 Infections and Pharmacological Implications수용체가 장착된 Virion은 GPCR 신호 전달을 위험에 빠뜨립니다: SARS-CoV-2 감염 및 약리학적 의미의 기계적 탐색Review Published on 2021-10-112022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 치료제, [키워드] ACE2 ACE2 receptor alleviate antibody Antibody therapy arrestin binding Brain Cell cell junction cellular response COVID-19 demonstrated disrupting Disruption distribution drug Drug development E protein ENhance exploration GPCR signaling hematogenous host cells impair Infection interact Interaction intestine Invasion kidney Loss of Smell loss of smell and taste lung Lungs membrane motif multiorgan injury multiple organs NRP1 other organ other organs PALS1 pathogenic PDZ interaction penetration Protein receptor required respiratory respiratory tract SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections susceptible Taste therapeutic strategy therapy tissue Viral viral cell entry viral endocytosis viral invasion virion virtue ZO-1 [DOI] 10.3390/ijms222010963 PMC 바로가기 [Article Type] Review
Lesson by SARS-CoV-2 disease (COVID-19): whole-body CT angiography detection of “relevant” and “other/incidental” systemic vascular findingsSARS-CoV-2 질병(COVID-19)의 교훈: "관련" 및 "기타/우발적" 전신 혈관 소견의 전신 CT 혈관 조영술 검출Article Published on 2021-10-012022-09-11 Journal: European Radiology [Category] SARS, 치료기술, [키워드] Affect Aneurysm aneurysms Arterial thrombosis Brain COVID-19 COVID-19 patients CT angiography disease distribution Embolism evaluated event events Evidence Fisher exact test Frequency Gut ICU ICU patient ICU Patients in some Increasing Infarction intensive care intensive care unit investigated involved Ischemic kidney kidneys lesson liver lung management Mann-Whitney U test no significant difference no significant differences non-ICU non-ICU patients occurred other organ other organs Patient care patients evaluated Prognosis Pulmonary embolism reported retrospective cohort SARS-CoV-2 disease SARS-COV-2 infection significantly significantly higher spleen student Student T-test study groups study population systemic thrombosis Vascular venous Venous thrombosis was used were recorded [DOI] 10.1007/s00330-021-07904-y PMC 바로가기 [Article Type] Article
Neuropsychiatric Disorders and COVID-19: What We Know So FarReview Published on 2021-09-172022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] addition Admission Affect Angiotensin-converting enzyme 2 (ACE2) Brain carried Central nervous system Cerebrovascular disease CNS consequence Consequences COVID-19 COVID-19 patients cranial damaged diagnose events explain higher risk ICU Inflammatory response intensive care life-threatening limit literature review manifestation Manifestations Mortality nervous system neurological Neurological disorder neurological manifestation neurological problem Neurological symptom occur other organs Patient reduce Research respiratory SARS-CoV-2 Severe infection shown skeletal muscle injury therapy Treatment vital sign with COVID-19 [DOI] 10.3390/ph14090933 PMC 바로가기 [Article Type] Review
Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone RemodelingReview Published on 2021-09-162022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] Activation aggregation altered bone remodeling association bone characterized Coagulation Coagulopathy complications COVID-19 COVID-19 infection deficiency Endothelial dysfunction Factor Health Health status hypercoagulable immune response increase Inflammation information lung mineral metabolism Osteoporosis other organs parameter pathological conditions Platelet Platelets Potential promote relation remodeling severe COVID-19 patient severe COVID-19 patients stimulate thrombosis Vitamin D [DOI] 10.3390/ijms221810010 PMC 바로가기 [Article Type] Review
Interactions between the Gut Microbiome, Lung Conditions, and Coronary Heart Disease and How Probiotics Affect These장내 미생물군집, 폐 상태, 관상동맥 심장병 간의 상호작용과 프로바이오틱스가 이들에 미치는 영향Review Published on 2021-09-082022-09-12 Journal: International Journal of Molecular Sciences [Category] 진단, [키워드] Affect affecting can not cardiovascular disease chronic condition Clinical outcome Coronary Coronary heart disease COVID-19 COVID-19 infections disturbance effectors Factor Fatty acid fatty acids Gut gut microbiome gut–lung axis Health healthy heart Immune cell immune cells Interaction lung Lungs mechanism Microbiome occur organs other organ other organs Oxide Physiology Probiotics receptor responsible short-chain fatty acids Symptom to define variety [DOI] 10.3390/ijms22189700 PMC 바로가기 [Article Type] Review
Oxygen Sparing Effect of Bacteriotherapy in COVID-19COVID-19에서 세균 요법의 산소 절약 효과Article Published on 2021-08-232022-09-10 Journal: Nutrients [Category] MERS, 치료제, [키워드] activated addition Administered Analysis Azithromycin bacteriotherapy Blood blood gas Blood level blood levels collected COVID-19 Effect enzyme Enzymes Gas exchange heparin hypoxia intestinal cells intestine lesion lesions lung lung involvement Lungs mechanism nitric oxide Non-invasive observation period organ organs other organs oxygen Oxygen consumption Oxygen therapy Oxygenation parameter Patient performed presenting Probiotics receiving reduce reduced risk Remdesivir reported Respiratory failure SARS-CoV-2 infected patient SARS-CoV-2 infected patients severe COVID-19 patient severe COVID-19 patients significantly increased SLAB51 sparing Standard therapy subject survival Treatment [DOI] 10.3390/nu13082898 PMC 바로가기 [Article Type] Article
Clinical and Histopathologic Features of a Feline SARS-CoV-2 Infection Model Are Analogous to Acute COVID-19 in HumansArticle Published on 2021-08-052022-10-28 Journal: Viruses [Category] COVID-19, MERS, SARS, [키워드] ACE2 expression acute COVID-19 animal model ARDS clinical clinical disease controls correlation COVID-19 COVID-19 disease Diffuse alveolar damage distal domestic cats dry cough Dyspnea evaluate feline Fever genetic modification Hospitalized Host Human humans hyaline membrane formation immune response include Infection intratracheal lesion lesions lethargy Lungs Model nasal turbinates other organs pathology produced pulmonary pulmonary lesions quantified Respiratory disease Result SARS-CoV-2 SARS-COV-2 infection translational urgency viral infection were infected [DOI] 10.3390/v13081550 PMC 바로가기 [Article Type] Article
Case Report: Co-occurrence of Myocarditis and Thrombotic Microangiopathy Limited to the Heart in a COVID-19 PatientCardiovascular Medicine Published on 2021-07-292022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] Analysis anticoagulation Capillaries Combination COVID-19 death described died Diffuse alveolar damage disease etiology feature female healthy heart inflammatory reaction initial Limited Lungs microangiopathy Microthrombosis myocarditis myocarditis acute and fulminant other organs Patient positive prevalent Prophylactic required risk stratification SARS-CoV-2 Symptoms the patient Thromboinflammation Thromboprophylaxis thrombotic Thrombus [DOI] 10.3389/fcvm.2021.695010 PMC 바로가기 [Article Type] Cardiovascular Medicine
Viral mapping in COVID-19 deceased in the Augsburg autopsy series of the first wave: A multiorgan and multimethodological approachAugsburg 부검 시리즈의 첫 번째 웨이브에서 사망 한 COVID-19의 바이러스 매핑 : 다층 및 다중 방법 학적 접근Research Article Published on 2021-07-192022-09-10 Journal: PLoS ONE [Category] MERS, 진단, 치료기술, [키워드] affected alterations alveolar damage analyzed approach Autopsies Autopsy Central nervous system Chain Reaction CNS correlation COVID-19 Deceased died diffuse Diffuse alveolar damage disease distribution early phase Epidemiology Evidence exhibited fat First wave focus frequencies Germany gross examination histological change histological changes histology immunohistochemistry information internal organ internal organs inverse correlation lung Lungs mediastinal lymph node mediastinal lymph nodes Multiorgan organ organs Other other organ other organs outcome pandemic pathophysiology Patient performed polymerase polymerase chain polymerase chain reaction positive positive sample Result SARS-CoV-2 SARS-CoV-2 detection Stage the disease the stage therapy upper airway upper airways Viral viral infection Viral load virus [DOI] 10.1371/journal.pone.0254872 PMC 바로가기 [Article Type] Research Article
Insights into Pathology and Pathogenesis of Coronavirus Disease 2019 from a Histopathological and Immunological PerspectiveReview Article: COVID-19 Published on 2021-07-132022-10-30 Journal: JMA Journal [Category] COVID-19, [키워드] affected Analysis causal link contribute COVID-19 COVID-19 pathogenesis Deterioration develop disease Effect effective Epidemic histopathological Host immune response Immunity immunological Infectious disease insight lesion mechanism organ other organs pathogen Pathogenesis pathological pathological condition pathology pathophysiology Perspective provided public health reported SARS-CoV-2 Spread the SARS-CoV-2 treatments for COVID-19 Wuhan, China [DOI] 10.31662/jmaj.2021-0041 PMC 바로가기 [Article Type] Review Article: COVID-19