Serum KL-6 Could Represent a Reliable Indicator of Unfavourable Outcome in Patients with COVID-19 Pneumonia혈청 KL-6은 COVID-19 폐렴 환자에서 불리한 결과의 신뢰할 수 있는 지표를 나타낼 수 있습니다Article Published on 2021-02-202022-08-31 Journal: International Journal of Environmental Research an [Category] MERS, 바이오마커, [키워드] Accuracy antibody Antigen blood sample Blood samples chemiluminescence collected Concentration COVID-19 COVID-19 pneumonia cut-off value death died elevated enrolled enrolment enzyme enzyme immunoassay evaluated Fujirebio IL-6 immunoassay Indicator Interstitial lung diseases interstitial pneumonia KL-6 Lung diseases median Mortality outcome P/F ratio parameter Patient patients with COVID-19 Pneumonia Positive predictive value Predictive value prognostic Pulmonary function Respiratory failure risk SARS-CoV-2 SARS-CoV2 infection serum severe respiratory failure significantly lower those who survived U/mL were measured with COVID-19 [DOI] 10.3390/ijerph18042078 PMC 바로가기 [Article Type] Article
Optimal use of tocilizumab for severe and critical COVID-19: a systematic review and meta-analysis심각하고 중대한 COVID-19에 대한 토실리주맙의 최적 사용: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2021-02-042022-09-11 Journal: F1000Research [Category] 임상, 진단, [키워드] administration all-cause mortality approved baseline benefit clinical benefit clinical benefits conducted COVID-19 COVID-19 patients COVID-19 pneumonia criteria Critical Critically ill CRP CRP level cytokine Cytokine release syndrome death demonstrated eligibility criteria enrolled evaluate event hospital Intervention Meta-analysis mmHg no difference outcome P/F ratio Patient Pneumonia positive Prospective Study randomised controlled trial retrospective risk SARS-COV-2 infection searched severe severe and critically ill COVID-19 patients Standard of care subgroup analysis systematic review the patient therapy Tocilizumab treated treating COVID-19 Treatment [DOI] 10.12688/f1000research.45046.1 PMC 바로가기 [Article Type] Meta-Analysis
Efficacy of canakinumab in mild or severe COVID‐19 pneumonia경증 또는 중증 COVID-19 폐렴에서 카나키누맙의 효능Comparative Study Published on 2021-01-192022-09-10 Journal: Immunity, Inflammation and Disease [Category] MERS, SARS, 진단, 치료제, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration Beta canakinumab cause caused collected collected data coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 enrolled Hospitalized Human monoclonal antibody ICU IL1‐β IMPROVE Inflammation intensive care laboratory parameter Laboratory parameters Lopinavir Lopinavir/ritonavir lopinavir/ritonavir) Mild monoclonal antibody oxygen oxygen flow oxygen support Oxygenation P/F ratio pandemic Patient patients treated Pneumonia rapid increase reduced reduction in reported respiratory Respiratory function Result Ritonavir Safety SARS CoV2 SARS‐CoV‐2 SARS‐CoV‐2 infection severe acute respiratory syndrome Coronavirus severe adverse events single dose Standard therapy supply therapeutic option therapeutic strategy therapy treat [DOI] 10.1002/iid3.400 PMC 바로가기 [Article Type] Comparative Study
Real Time PCR and Culture-Based Virus Isolation Test in Clinically Recovered Patients: Is the Subject Still Infectious for SARS-CoV2?Article Published on 2021-01-152022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] absence age Analysis Asymptomatic asymptomatic patient average Biosafety Level 3 Cell culture chain clearance clinically conducted contagious COVID-19 COVID-19 disease criteria Culture discharge hospitalized patient hospitalized patients in vitro Laboratory N gene nasopharyngeal Nasopharyngeal swab P/F ratio PaO Patient patients hospitalized PCR performed persistence Pneumonia positive positive RT-PCR public health reaction recovered RT-PCR SARS-CoV-2 Severe case specimen Still subject supernatant Swab swabbing Symptoms Test time viral clearance viral culture viral fragment viral growth Viral transmission virus [DOI] 10.3390/jcm10020309 PMC 바로가기 [Article Type] Article
The Effect of Exogenous Surfactant on Moderate and Severe Stages of COVID-19 Induced ARDS: the Pilot Study of a Clinical TrialOriginal Article Published on 2021-01-012022-10-30 Journal: Iranian Journal of Pharmaceutical Research : IJPR [Category] COVID-19, [키워드] alleviate alveolar cells Analysis ARDS Blood clinical Clinical outcome clinical trial control arm COVID-19 COVID-19 adult patients COVID-19 pandemic COVID-19 patient COVID-19 patients dose Effect Effects Exogenous Face mask form Health ICU induced Inflammatory Intubated lung dysfunction moderate P/F ratio Patient pilot study Potential treatment potential treatments previous study pulmonary involvement severe COVID-19 significantly Stage surfactant treatment arm trials virus with COVID-19 [DOI] 10.22037/ijpr.2021.115390.15347 PMC 바로가기 [Article Type] Original Article
Clinical characteristics and outcomes of critically ill patients with COVID-19 admitted to an intensive care unit in London: A prospective observational cohort studyObservational Study Published on 2020-12-152022-10-04 Journal: PLoS ONE [Category] MERS, SARS, 임상, [키워드] Admission affected age Characteristics clinical clinical decision Cohort collected conducted country Critically ill patient death described determinant died discharged Factor Follow-up globe Health healthcare ICU ICUs Infection intensive care intensive care unit Intubated lowest male mechanical ventilation multivariable logistic regression Multivariable models neuromuscular blockade obese obesity outcome P/F ratio Patient patients with COVID-19 prevalent Prone position prospective observational cohort renal replacement therapy required Research Respiratory failure Result severely ill patient severity Support survival understanding United Kingdom with COVID-19 [DOI] 10.1371/journal.pone.0243710 PMC 바로가기 [Article Type] Observational Study
Efficacy of therapeutic plasma exchange in the treatment of penn class 3 and 4 cytokine release syndrome complicating COVID-19Clinical Trial Published on 2020-12-012022-10-05 Journal: Respiratory medicine [Category] SARS, 임상, 치료법, [키워드] average C-reactive protein (CRP complication of COVID-19 COVID-19 Critically ill CRP CRS cytokine Cytokine release syndrome demonstrated determine Efficacy eight GM-CSF Hypothesis IFNγ IL-10 IL-6 IL-8 improving oxygenation majority mechanically ventilated patient mechanically ventilated patients non-ventilated patients Oxygen requirement Oxygenation oxygenation index P/F P/F ratio paO2/fiO2 Patient patient safety patients pharmacologic agent pilot study plasma reducing reduction in reductions in respiratory Respiratory failure resulting Serum level study period subset supplemental oxygen syndrome Therapeutic benefit Therapeutic plasma exchange TNFα TPE Treatment Trial Volume was measured were measured [DOI] 10.1016/j.rmed.2020.106188 PMC 바로가기 [Article Type] Clinical Trial
Possible silent hypoxemia in a COVID-19 patient: A case reportCase Report Published on 2020-11-242022-10-28 Journal: Annals of Medicine and Surgery [Category] COVID-19, [키워드] Analysis ARDS blood gas blood pressure body temperature breath breathing difficulty Case report circulation cough COVID-19 COVID-19 patient COVID-19 patients decrease Deterioration died Early sign of deterioration endothelial injury FiO2 hypothese Hypoxemia intervene intrapulmonary intravascular microthrombi Intubated male mandatory mechanism morbidity and mortality nasal occur oxygen oxygen saturation P/F ratio PaCO2 PaO2 patients with COVID-19 positive presentation progressive respiratory failure pulse Respiratory failure with severe hypoxia respiratory rate RT-PCR severe hypoxia Shortness of breath silent Silent hypoxemia SpO2 strained suffered Support Ventilation ventilator vital sign worsening [DOI] 10.1016/j.amsu.2020.11.053 PMC 바로가기 [Article Type] Case Report
The effect of surfactant on clinical outcome of patients with COVID-19 under mechanical ventilation: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-11-112022-10-29 Journal: Trials [Category] Coronavirus, SARS, [키워드] 1:1 6 hour accompany acute respiratory distress syndrome addition adjusted Administered age anticipated approach ARDS Assessing auxiliary Bacterial blinded Care Clinical outcome control group COVID-10 COVID-19 COVID-19 patient discharge disease dissemination dose doses ECMO element etiology Existence extracorporeal membrane oxygenation Face mask Healthcare provider hospital hospital discharge rate Randomised controlled trial Hospital length of stay ICU information intervention group intubation investigator Iran less lung involvement mechanical ventilation moderate Mortality much lower number objective outcome P/F ratio parallel group participant Patient patient mortality patients with COVID-19 Pneumonia protocol pulmonary disease pulmonary involvement random randomisation randomised randomised controlled trial receive Registration researchers Sample size SARS-CoV-2 second dose sequence severe ARDS status Study protocol surfactant Tehran the patient time Trial ventilator Version Volume website written consent [DOI] 10.1186/s13063-020-04815-z PMC 바로가기 [Article Type] Letter
Comparison of Efficacy of Dexamethasone and Methylprednisolone in Improving PaO2/FiO2 Ratio Among COVID-19 PatientsInternal Medicine Published on 2020-10-122022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome administration anti-inflammatory treatment Antiviral C-reactive protein calculated Clinicians coronavirus coronavirus disease covid induced ards COVID-19 COVID-19 patients CRP cytokines release syndrome Dexamethasone distress drug effective Effectiveness eight global pandemic group Host immune reaction Improving inflammation markers inflammatory markers initial less Methylprednisolone Oxygenation P/F P/F ratio PaO paO2/fiO2 participant Participants Patient Ratio ratio of partial pressure of arterial oxygen and fraction of inspired oxygen recorded reduced Result retrospective SARS-CoV-2 serum ferritin level significantly steroid therapy Study design syndrome t-test two group viral replication was used Wuhan, China [DOI] 10.7759/cureus.10918 PMC 바로가기 [Article Type] Internal Medicine