Discovering common pathogenetic processes between COVID-19 and diabetes mellitus by differential gene expression pattern analysis차등 유전자 발현 패턴 분석에 의한 COVID-19와 당뇨병 사이의 일반적인 병원성 과정 발견Case Study Published on 2021-11-172022-09-01 Journal: Briefings in Bioinformatics [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] analyses Analysis biological processe biological processes blood gene expression caused characterized Comorbidity coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient dataset DEGs diabete diabetes Diabetes Mellitus Differential gene expression differentially expressed gene downregulated dysregulated followed by functional Functional assessment Gene ontology GO term identify implicated Increased Infectious disease involved islets modulated molecular pathways mononuclear cell mononuclear cells Ontology Organoid pancrea pancreas pathway Pathways patients with diabete PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells prediction RELA SARS-CoV-2 severity of COVID-19 T1D T2D transcription factor transcription factors transcriptional transcriptional signatures transcriptomic Treatment Type 1 diabetes type 2 diabete type 2 diabetes upregulated upregulation whole-genome [DOI] 10.1093/bib/bbab262 PMC 바로가기 [Article Type] Case Study
Prevalence of hepatopancreatic injury and clinical outcomes in patients with COVID-19 in USAOriginal Research Published on 2021-11-062022-10-30 Journal: International Journal of Emergency Medicine [Category] COVID-19, [키워드] 95% CI 95%CI age albumin alkaline phosphatase Analysis Bilirubin Clinical outcome Cohort coronavirus disease COVID-19 COVID-19 patient Critical determine disease severity hospital increase in Injury lactate dehydrogenase liver Liver cirrhosis Liver injury medication Mortality pancreas pancreatic Patient patients patients with COVID-19 Prevalence Prothrombin time Result SARS-CoV2 Sex significantly higher transaminases USA [DOI] 10.1186/s12245-021-00393-2 PMC 바로가기 [Article Type] Original Research
National survey on deceased donor organ transplantation during the COVID-19 pandemic in JapanOriginal Article Published on 2021-10-232022-10-29 Journal: Surgery today [Category] COVID-19, MERS, [키워드] affected average Brain-dead donors COVID-19 COVID-19 pandemic death Deceased Donor Donors after cardiac death investigated Japan kidney less liver lung network organ Organ donation pancrea pancreas questionnaire reducing response Result significantly significantly lower small intestine solid organ transplantation Transplant website [DOI] 10.1007/s00595-021-02388-1 PMC 바로가기 [Article Type] Original Article
Acute pancreatitis associated with severe acute respiratory syndrome coronavirus-2 infection: a case report and review of the literatureCase Report Published on 2021-09-092022-10-30 Journal: Journal of Medical Case Reports [Category] COVID-19, SARS, [키워드] abdominal pain absence acute pancreatitis acute respiratory syndrome Alpha association attack bilious Case report chymotrypsin Computed tomography conducted coronavirus Coronavirus-2 Course COVID-19 determine discharged elevated etiology Fever healthy hospital Infection intravenous knowledge Lactate male Mild Nasopharyngeal swab Pain pancreas pancreatic Patient patients per day polymerase chain positive presenting reported respiratory symptoms risk factor SARS-CoV-2 serum severe symptoms Symptom typical symptom vomiting was done [DOI] 10.1186/s13256-021-03026-7 PMC 바로가기 [Article Type] Case Report
Application of Human Induced Pluripotent Stem Cell-Derived Cellular and Organoid Models for COVID-19 ResearchCell and Developmental Biology Published on 2021-09-062022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] acute respiratory syndrome application Brain caused cellular cellular model complex coronavirus coronavirus disease COVID-19 Drug screening dysregulation Efficiency experiments eyes function global public health Human human cell IMPROVE in vitro include induced Induced pluripotent stem cell Interaction International intestines kidneys liver mechanisms microenvironment Model Organoid other organ outbreak pancreas Pandemics pathology pluripotent stem cell Prevent Respiratory failure SARS-CoV-2 SARS-COV-2 infection Spread STEM viral infection viral life cycle [DOI] 10.3389/fcell.2021.720099 PMC 바로가기 [Article Type] Cell and Developmental Biology
Computational analysis of TMPRSS2 expression in normal and SARS-CoV-2-infected human tissues정상 및 SARS-CoV-2에 감염된 인간 조직에서 TMPRSS2 발현의 전산 분석Article Published on 2021-09-012022-09-11 Journal: Chemico-biological interactions [Category] 유전자 메커니즘, [키워드] acute respiratory illnesses Analysis analyzed B cells Cancer CD8 Cell cell growth co-expression correlated correlation cytokine datasets epididymis expression female G-CSF gene co-expression network Gene expression profiles Gene ontology growth healthy individuals high expression level highest human host cells human tissue human tissues IFN-α IL-1 IL-12 IL-18 IL-2 IL-4 IL-7 IL-8 immune immune signature Immune signatures in healthy individual interferon interferon response investigated involved IP-10 kidneys Lungs male MCP-1 mechanism metabolism Nasopharyngeal swab nasopharyngeal swabs NK cells no significant difference normal lung tissue not significantly different Older older patients older population other diseases pancreas parathyroid Parathyroid gland pathway Pathway and gene ontology Pathways Patient performed Population positive positively correlated potential mechanism proliferation Prostate salivary salivary gland SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected patient SARS-CoV-2-infected patients seminal vesicle Serine serine protease significantly lower small intestine stomach T cells tissue tissues TMPRSS2 TMPRSS2 expression TMPRSS2 expression level TMPRSS2 expression levels TMPRSS2 protein TNF-α transmembrane serine protease transmembrane serine protease 2 Vesicle [DOI] 10.1016/j.cbi.2021.109583 PMC 바로가기 [Article Type] Article
Mapping single-cell data to reference atlases by transfer learningAnalysis Published on 2021-08-302022-10-04 Journal: Nature biotechnology [Category] MERS, SARS, 신약개발, [키워드] Analysis batch effect batch effects Brain Cell computational resource coronavirus disease COVID-19 Data integration dataset datasets de novo deep learning disease example facilitate healthy immune information iterative machine learning magnitude mapping pancreas parameter raw data single-cell transfer Variation [DOI] 10.1038/s41587-021-01001-7 PMC 바로가기 [Article Type] Analysis
SARS-CoV-2 infection of the pancreas promotes thrombofibrosis and is associated with new-onset diabetes췌장의 SARS-CoV-2 감염은 혈전 섬유증을 촉진하고 새로운 발병 당뇨병과 관련이 있습니다Research Article Published on 2021-08-232022-09-12 Journal: JCI Insight [Category] MERS, SARS, 진단, [키워드] ACE2 acute respiratory syndrome Admission angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 association Cell cell entry cells coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients data sets diabete diabetes died dysfunction endothelial Endothelial cell endothelial cells examined exhibited expression Factor female fibrosis humans Infection islet male NHP NHPs Occurrence pancrea pancreas pancreatic pancreatic islet Patient promote SARS-CoV-2 SARS-COV-2 infection Serine Severe acute respiratory syndrome Single-cell RNA sequencing thrombosis tissue TMPRSS2 transmembrane serine protease transmembrane serine protease 2 Vascular [DOI] 10.1172/jci.insight.151551 PMC 바로가기 [Article Type] Research Article
Elevated Pancreatic Enzymes in ICU Patients With COVID-19 in Wuhan, China: A Retrospective StudyMedicine Published on 2021-08-172022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] addition Admission All participant amylase Analysis baseline characteristics caused Complication conditions cough COVID-19 COVID-19 patient COVID-19 patients critical COVID-19 patient Degradation discharge elevated enrolled enzyme Enzymes Fever hospital ICU incidence Increased information Injury intensive care Kidney injury life threatening Lipase Logistic management mechanical ventilation medical resource Mortality multiple organ failure multivariable myalgia no statistical difference Odds ratio Oxygenation pancreas pancreatic pancreatic enzyme pancreatic enzymes Pancreatitis pandemic Patient patients patients with COVID-19 poor prognosis progressed reported risk factor Symptom Treatment Wuhan [DOI] 10.3389/fmed.2021.663646 PMC 바로가기 [Article Type] Medicine
Imaging of abdominal complications of COVID-19 infectionReview Article Published on 2021-07-052022-10-28 Journal: BJR Open [Category] COVID-19, [키워드] abdominal pain acute respiratory syndrome Asymptomatic Atypical base bowel caused China complications of COVID-19 coronavirus Coronavirus disease 2019 cough COVID-19 described diagnosis of COVID-19 diarrhoea Dyspnea fatigue Fever Gallbladder Gastrointestinal symptom imaging Infection kidneys Laboratory test liver loss of appetite lung pancreas pandemic patients patients with COVID-19 patients with SARS-CoV-2 Pneumonia radiological features reported RT-PCR SARS-CoV-2 SARS-COV-2 infection spleen Symptom syndrome Typical vomiting Wuhan [DOI] 10.1259/bjro.20200052 PMC 바로가기 [Article Type] Review Article