SARS-CoV-2 infection reduces human nasopharyngeal commensal microbiome with inclusion of pathobiontsSARS-COV-2 감염Comparative Study Published on 2021-12-152022-09-10 Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] Analysis archaeal bacterial species bacterial specy collected Computational biology and bioinformatics COVID-19 COVID-19 patients determined by diagnostics Diseases Effect feature fraction functional gene genetics genomic healthy healthy control healthy controls host immunity in viral Inclusion information Interaction mapped metabolic functions metabolic pathway metabolic pathways metagenomic Microbiology Microbiome microbiota Molecular biology nasopharyngeal Nasopharyngeal swab nasopharyngeal swab sample Nasopharyngeal swab samples pandemic disease pathophysiology progression reduce respiratory RNAseq SARS-CoV-2 SARS-COV-2 infection Therapeutics Viral [DOI] 10.1038/s41598-021-03245-4 PMC 바로가기 [Article Type] Comparative Study
The crosstalk between viral RNA- and DNA-sensing mechanisms바이러스 RNA 및 DNA 감지 메커니즘 간의 누화Review Published on 2021-12-012022-09-11 Journal: Cellular and Molecular Life Sciences [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] adaptors amplify Antiviral COVID-19 Crosstalk Cytokines cytosolic detect Diseases DNA DNA and RNA DNA sensing endosomal highlight Host Human induce Infection innate immune system Innate immunity innate response interferon-stimulated gene interferon-stimulated genes mechanism nucleic acids overlap pandemic disease proinflammatory cytokines receptor recognize restrict RNA RNA sensing significantly Type type I interferon Viral diseases viral infection viral infections viral nucleic acid viral nucleic acids Viral RNA virus [DOI] 10.1007/s00018-021-04001-7 PMC 바로가기 [Article Type] Review
A large margin piecewise linear classifier with fusion of deep features in the diagnosis of COVID-19COVID-19 진단에 깊은 특징을 융합한 큰 마진 조각별 선형 분류기Article Published on 2021-12-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 치료기술, [키워드] Accuracy canonical Chest chest X-ray Chest X-ray images Classifier computer-aided diagnosis (CAD) Coronavirus infection Coronavirus infections Correlation analysis COVID-19 deep Deep feature extraction detect diagnose Diagnosis diagnosis of COVID-19 early stage Epidemics feature fused high accuracy highest introduced Large margin classifier linear linear classifier margin Medical imaging MERS pandemic disease Pneumonia reached recent SARS shown transfer Viral pneumonia was performed X-ray [DOI] 10.1016/j.compbiomed.2021.104927 PMC 바로가기 [Article Type] Article
In Silico End-to-End Protein-Ligand Interaction Characterization Pipeline: The Case of SARS-CoV-2In Silico 종단 간 단백질-리간드 상호 작용 특성 분석 파이프라인: SARS-CoV-2 사례Article Published on 2021-11-192022-09-11 Journal: ACS synthetic biology [Category] SARS, 치료제, [키워드] atomic level AutoDock AutoDock vina characterization complex conformational COVID-19 Data analysis database disease docking Dynamics effective Gromacs guideline HADDOCK help homology in silico include inhibitor Interaction Interpretation M pro methodology molecular molecular docking molecular dynamics molecular dynamics simulations pandemic disease problem protease protein-ligand protocol provided PyMol robust SARS-CoV-2 SARS-CoV-2 main protease target three-dimensional structure Treatment triggered urgency Viral proteins Virtual screening were used worldwide pandemic [DOI] 10.1021/acssynbio.1c00368 PMC 바로가기 [Article Type] Article
Pathogenesis of taste impairment and salivary dysfunction in COVID-19 patientsReview article Published on 2021-11-012022-10-05 Journal: Japanese Dental Science Review [Category] 변종, [키워드] ACE2 acute illness acute respiratory distress acute respiratory syndrome caused cell entry Characteristics Complication complications coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients death described dysfunction effort Express extrapulmonary organs eyes Factor Gustatory Gustatory impairment impairment include Infection Long COVID Mild mild pneumonia Occurrence oral disease oral tissue pandemic disease Pathogenesis problems reported required salivary salivary gland Salivary gland disorder SARS-CoV-2 Symptom syndrome Taste Taste impairment the cell the disease TMPRSS2 Xerostomia [DOI] 10.1016/j.jdsr.2021.07.001 [Article Type] Review article
Clinical Characteristics and Perioperative Complication Profiles of COVID-19–Positive Patients Undergoing Hip Fracture SurgeryResearch Article Published on 2021-10-152022-10-29 Journal: JAAOS Global Research & Reviews [Category] COVID-19, MERS, SARS, [키워드] 95% CI 95% confidence interval adverse event adverse events adverse outcome age Analysis Care classification clinical Comorbidities Comorbidity Complication confounding variables controlling Coronavirus 2019 COVID-19 COVID-19 infection demographic demonstrated events Fracture global pandemic groups Healthcare systems hip identify IMPROVE incidence increased risk information National Occurrence Odds ratio pandemic disease Patient Perioperative positive postoperative profile revision risk risk factor selected Serious Adverse Event Sex significant difference Stress surgery variables was performed [DOI] 10.5435/JAAOSGlobal-D-21-00104 PMC 바로가기 [Article Type] Research Article
COVID-19 detection in chest X-ray images using deep boosted hybrid learning딥 부스트 하이브리드 학습을 사용하여 흉부 X선 이미지에서 COVID-19 감지Article Published on 2021-10-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 치료기술, [키워드] affected applied caused Chest chest X-ray Chest X-ray image chest X-rays Classifier CNN CNNs Convolutional neural network COVID-19 COVID-19 patients dataset deep deep learning Deep learning and SVM detect DHL early diagnosis effective evaluated expected experiment f-score Features healthcare help homogeneity hybrid Hybrid learning learning pandemic disease Region required Society transfer transfer learning treat while X-ray [DOI] 10.1016/j.compbiomed.2021.104816 PMC 바로가기 [Article Type] Article
Association of HLA genotypes, AB0 blood type and chemokine receptor 5 mutant CD195 with the clinical course of COVID-19HLA 유전자형, AB0 혈액형 및 케모카인 수용체 5 돌연변이 CD195와 COVID-19의 임상 경과와의 연관성Observational Study Published on 2021-09-162022-09-10 Journal: European Journal of Medical Research [Category] 변종, 임상, 진단, [키워드] ABO blood group absence Adaptive immune response addition addressed age Analysis anti-S IgG anti-S IgG levels Antigen antigens antiviral immune response association benefit Blood Blood Group carriers caused CCR5 Chemokine receptor Clinical course clinical courses Cohort Composite courses COVID-19 COVID-19 convalescent patient Cox regression deletion mutant disease disease severity DRB1 exploratory fatal disease Follow-up genetics genotypes Group antigen heterozygous Hierarchical HLA HLA allele HLA alleles HLA class I HLA class I genotypes HLA class II Human human leukocyte antigen humoral immune responses immunogenetic background infection with SARS-CoV-2 investigated leukocyte median Mild Moderate COVID-19 morbidity mutant Mutation Neutralizing antibodies neutralizing capacity observation observational study pandemic disease parameter patient cohort patient population pauci-symptomatic potential risk presence or absence progression prolonged disease Prospective Protective protective effect reduced required Result SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severe disease severity significantly supplementary material the patient vaccination response virus was performed [DOI] 10.1186/s40001-021-00560-4 PMC 바로가기 [Article Type] Observational Study
Novel ACE2 protein interactions relevant to COVID-19 predicted by evolutionary rate correlationsBioinformatics Published on 2021-09-152022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] ACE2 ACE2 protein ACE2 receptor affecting androgen approach bind biological interaction candidate caused cell receptor Chronic illness clusterin Coagulation coagulation pathways coevolution component connection contributing to coronavirus coronavirus SARS-CoV-2 correlated correlation COVID-19 cytokine signaling Cytokine storms detect disease manifestation enzyme ERC Evolution Evolutionary inference Evolutionary rate Extracellular factor V FGA FGB FGG fibrinogen function GPR141 human cells identify IFNAR2 immune response Immunity infect Inflammatory response information interact Interaction interactions involved mammalian mammalian protein novel organ systems pandemic disease pathogen Pathologies pathology pathway predict predicted Protein protein interaction Protein networks Proteins reported Respiratory disease SARS-COV-2 infection severe COVID-19 suggestion the disease TLR8 Treatment XCR1 [DOI] 10.7717/peerj.12159 PMC 바로가기 [Article Type] Bioinformatics
Testosterone in COVID-19: An Adversary Bane or Comrade BoonCellular and Infection Microbiology Published on 2021-09-082022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] activating acute lung injury acute respiratory distress acute SARS-CoV-2 infection addition Affect anti-inflammatory cytokines ARDS article caused cleaving COVID-19 COVID-19 severity Direct Effect Endothelial dysfunction Google Scholar immune response Injury manifestation modulation MOST oxidative stress pandemic disease pro-inflammatory cytokines protease Respiratory Coronavirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein Science serine 2 severity of COVID-19 syndrome Testosterone TMPRSS2 TMPRSS2 transmembrane was done Web of Science [DOI] 10.3389/fcimb.2021.666987 PMC 바로가기 [Article Type] Cellular and Infection Microbiology