Repurposing clinically approved drugs for COVID-19 treatment targeting SARS-CoV-2 papain-like proteaseSARS-COV-2 Papain-Like 프로테아제를 대상으로 COVID-19 치료를위한 임상 적으로 승인 된 약물을 재구성Article Published on 2021-10-012022-08-31 Journal: International journal of biological macromolecules [Category] SARS, 신약개발, 유전자 메커니즘, 치료법, 치료제, [키워드] activities application approved drug binding caused Chloroxine clinically Compound COVID-19 death develop disease docking drug drug target effort function highlight IC50 inhibitor inhibitors involved library modifications molecular molecular dynamics molecular mechanism Papain Papain-like protease PLPro protease removal repurposing SARS-CoV-2 sodium tanshinone tanshinone IIA sulfonate sodium Tanshinone IIA sulfonate sodium. Treatment Viral viral genome replication Viral proteins [DOI] 10.1016/j.ijbiomac.2021.07.184 PMC 바로가기 [Article Type] Article
Interactions between SARS coronavirus 2 papain-like protease and immune system: A potential drug target for the treatment of COVID-19SARS 코로나바이러스 2 파파인 유사 프로테아제와 면역 체계 간의 상호 작용: COVID-19 치료를 위한 잠재적 약물 표적Review Published on 2021-10-012022-09-11 Journal: Scandinavian journal of immunology [Category] SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 complex complex system Compound coronavirus CoV COVID-19 CoVs cytokine production DeISGylating deubiquitinating drug drug target DUB dysregulation Effect enzyme evade Host host immunity immune immune response immune responses immune system infections inhibit inhibitor Innate innate immune responses MAPK Mild mild to moderate moderate molecules multifunctional New coronavirus NF-κB Papain Papain-like protease pathway Pathways PLPro protease public health regulate Respiratory tract infections respiratory virus respiratory viruses SARS Coronavirus SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 STING suppress TGF-β Treatment treatment of COVID-19 upper respiratory tract upper respiratory tract infections viral spread viruses [DOI] 10.1111/sji.13044 PMC 바로가기 [Article Type] Review
Cyanobacterial metabolites as promising drug leads against the M pro and PL pro of SARS-CoV-2: an in silico analysis유망한 약물로서 시아 노 박테리아 대사 산물은 SARS-COV-2의 M Pro 및 PL PRO에 대한 이끌어 낸다 : AN Silico AnalysisArticle Published on 2021-10-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] MERS, SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis antiviral drug antiviral drugs approach binding energy binding pocket carrageenan causative agent Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cryptophycin cyanobacterial metabolites cylindrospermopsin deoxycylindrospermopsin drug-likeness effective effort exhibited facilitate followed by foundation in silico in silico analysis in vitro in vivo inhibitor inhibitory lack M pro metabolite metabolites MM-PBSA molecular molecular docking molecular dynamics Molecular dynamics simulation molecular dynamics simulations pandemic Papain Papain-like protease Pathologies Physicochemical properties physicochemical property polyprotein present protease Proteases Research research finding respiratory robust SARS-CoV-2 SARS-CoV-2 protease the SARS-CoV-2 Toxicity Treatment Viral viral replication were assessed [DOI] 10.1080/07391102.2020.1794972 PMC 바로가기 [Article Type] Article
Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potentialSARS-CoV-2 감염 중 단백질 분해를 특성화하여 치료 가능성이 있는 바이러스 절단 부위 및 세포 표적 식별Article Published on 2021-09-212022-09-10 Journal: Nature Communications [Category] SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] Anti-viral Antibody testing Antigen benefit biology of SARS-CoV-2 causative agent cell line cellular cellular protease cleavage cleavage site cleavage sites COVID-19 COVID-19 pandemic death dose-dependent reduction drugs targeting event identify in vitro infections inhibit inhibit SARS-CoV-2 mass spectrometry MYLK Papain pathogen protease Protease activity Proteases Protein proteolysis proteolytic cleavage provide resource responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease SARS-CoV-2 replication shown significant increases in siRNA SRC substrate target targets therapeutic potential titres treat tyrosine vaccinate Vaccine Viral viral infection Viral proteins [DOI] 10.1038/s41467-021-25796-w PMC 바로가기 [Article Type] Article
Repurposing of FDA-approved antivirals, antibiotics, anthelmintics, antioxidants, and cell protectives against SARS-CoV-2 papain-like proteaseFDA 승인 항바이러스제, 항생제, 구충제, 항산화제 및 SARS-CoV-2 파파인 유사 프로테아제에 대한 세포 보호제의 용도 변경Article Published on 2021-09-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, 진단, 치료제, [키워드] 6-mercaptopurine ACE acting Analysis Antacid Antibiotics anticancer drugs antimicrobial antioxidant antioxidants Antiviral antivirals approved drug benzimidazole binding affinities binding affinity binding energy binding pattern binding patterns blocker bypassing candesartan Cell contagious coronavirus coronavirus disease coronavirus disease 19 COVID-19 COVID-19 patient COVID-19 patients Critical demonstrated docking score doripenem drug Drug discovery Drug repurposing drugs expected Famotidine fatal disease FDA-approved drugs followed by Guidance highest inhibitor list losartan MD simulations mercaptopurine molecular molecular dynamics moroxydine NAD+ oxiglutatione Papain Papain-like protease pharmacokinetic Phenformin PLPro primer protease Protective provided quercetin quercitrin receptor repurposing Ritonavir Safe SARS CoV SARS-CoV-2 sulfaguanidine surface area systemically Toxicity treat Vaccine development valsartan was used zanamivir [DOI] 10.1080/07391102.2020.1784291 PMC 바로가기 [Article Type] Article
CoViTris2020 and ChloViD2020: a striking new hope in COVID-19 therapyCovitris2020 및 Chlovid2020 : Covid-19 치료에서 놀라운 새로운 희망Article Published on 2021-08-012022-08-31 Journal: Molecular diversity [Category] 신약개발, 치료제, [키워드] activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-COVID-19 drug anti-SARS-CoV-2 antioxidant binding affinities binding affinity binding energy biological assay blocker ChloViD2020 Clinical studies Compound Coronaviral Coronaviral-2 coronavirus COVID-19 COVID-19 therapy CoViTris2020 derivative disease docked docking drug Drug discovery effective enzyme exhibited Favipiravir in vitro inhibit inhibit SARS-CoV-2 inhibitory Ivermectin lead life cycle Ligand lower binding energy medication molecular docking oxadiazole Papain Papain-like protease Papain-like protease (PLpro) PLPro Polyphenolic 2,5-disubstituted-1,3,4-oxadiazole protease Protein RdRP Remdesivir repurposing required Research respiratory RNA polymerase RNA-dependent RNA polymerase RNA-dependent RNA polymerase (RdRp) robust SARS-CoV-2 SARS-CoV-2 life cycle SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus significantly the SARS-CoV-2 therapy [DOI] 10.1007/s11030-020-10169-0 PMC 바로가기 [Article Type] Article
Viral Proteases as Targets for Coronavirus Disease 2019 Drug Development코로나바이러스 질병 2019 약물 개발의 표적으로서의 바이러스성 프로테아제Review Published on 2021-08-012022-09-11 Journal: The Journal of pharmacology and experimental thera [Category] SARS, 변종, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral drug antiviral therapeutics antiviral therapies antiviral therapy caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine Critical development drug Drug development effective effort hepatitis C hepatitis C virus Human immunodeficiency virus immunodeficiency virus Infection Papain Papain-like protease Population protease Protease inhibitor protease inhibitors regimen remains uncertain respiratory SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 variant SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus target targets therapeutic Treatment treatment of COVID-19 unmet need vaccination Viral virus infections [DOI] 10.1124/jpet.121.000688 PMC 바로가기 [Article Type] Review
In silico Studies on the Interaction between Mpro and PLpro From SARS-CoV-2 and Ebselen, its Metabolites and DerivativesSARS-CoV-2와 Ebselen, 그 대사 산물 및 파생물에서 Mpro와 PLpro 간의 상호 작용에 대한 인 실리코 연구Article Published on 2021-08-012022-09-11 Journal: Molecular informatics [Category] SARS, 치료제, [키워드] active sites antiviral drugs carbonyl caused COVID-19 COVID-19 pandemic cysteine density Density functional theory derivative derivatives DFT docking Ebselen electrophilic energetics enzyme Enzyme inhibition Enzymes ethaselen in vitro inhibit inhibitor inhibitors Interaction Jin metabolite molecules MPro Nature nucleophilic organoselenium Papain Papain-like protease PLPro protease Proteases SARS-CoV-2 target tested the SARS-CoV-2 theory thiol Treatment virus replication [DOI] 10.1002/minf.202100028 PMC 바로가기 [Article Type] Article
Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19COVID-19에 대한 치료 전략으로 SARS-CoV-2 프로테아제를 표적화하기 위한 과제Article Published on 2021-06-112022-09-11 Journal: ACS Infectious Diseases [Category] MERS, SARS, 진단, 치료제, [키워드] antiviral potency cathepsin cathepsin cross-reactivity Cathepsins Cell cellular challenge Compound COVID-19 cysteine cysteine protease cysteine proteases determine effective inhibitor effort evaluated explained expressing expression focus highlight host cell identify infection assays inhibited inhibitor inhibitors lead lysosomal cathepsins M pro main protease Papain Papain-like protease potency Prevent produced protease Proteases purified reported SARS-CoV-2 SARS-CoV-2 protease SARS-CoV-2 virus screened selectivity Serine Strategy targeting the SARS-CoV-2 virus TMPRSS2 transmembrane serine protease Treatment treatment of COVID-19 Viral viral entry viral entry pathway viral infectivity viral replication [DOI] 10.1021/acsinfecdis.0c00815 PMC 바로가기 [Article Type] Article
Unraveling the unbinding pathways of SARS-CoV-2 Papain-like proteinase known inhibitors by Supervised Molecular Dynamics simulationSupervised Molecular Dynamics 시뮬레이션을 통해 알려진 SARS-CoV-2 Papain-like proteinase 억제제의 결합 해제 경로 풀기Research Article Published on 2021-05-192022-09-10 Journal: PLoS ONE [Category] SARS, 치료제, [키워드] activity Behavior can be used characterized complex COVID-19 disease Critical Dynamics enzyme event inhibitor inhibitors molecular dynamics Papain Papain-like protease pathway Pathways PLPro Potential potential molecular protease Protein proteinase recent residue residues SARS-CoV-2 SARS-CoV-2 virus targets the SARS-CoV-2 virus therapy for COVID-19 Treatment X-ray crystallographic structure [DOI] 10.1371/journal.pone.0251910 PMC 바로가기 [Article Type] Research Article