Dynamic Alterations in the Respiratory Tract Microbiota of Patients with COVID-19 and its Association with Microbiota in the GutArticle Published on 2022-09-012022-11-15 Journal: Advanced Science [Category] 바이오마커, [키워드] Actinomyces alteration analyzed Bacteroide Biomarker Candida contributing to coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 progression determine Diagnosis disease Disease progression disease severity dynamic Enterococcus Fecal sample Gut gut microbiota ICU ICU Patients identify immune response Increases intensive care intensive care unit metagenome microbe microbial Microbiome microbiota mononuclear cell non-ICU pathway Patient patients patients with COVID-19 PBMC Peripheral blood positive correlation reduced respiratory respiratory microbiota. respiratory tract sequenced Significant significantly sputum Stage Streptococcus tract Treatment strategies with COVID-19 [DOI] 10.1002/advs.202200956 PMC 바로가기
SARS-CoV-2 productively infects primary human immune system cells in vitro and in COVID-19 patientsSARS-CoV-2는 시험관 내 및 COVID-19 환자에서 1차 인간 면역계 세포를 생산적으로 감염시킵니다Article Published on 2022-08-172022-09-11 Journal: Journal of Molecular Cell Biology [Category] SARS, 진단, 치료기술, 치료법, [키워드] accumulating acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Apoptosis appear B and T lymphocytes B cells B lymphocyte B lymphocytes CD4+ T lymphocyte Cell circulating leukocytes coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Cytokine storm disease pathogenesis disease severity double-stranded RNA expressive flow cytometry hallmark Host Human immune system hyperinflammatory state Immune cell immune cells immune dysfunction immunofluorescence analysis implication in vitro indicated infect Infection inflammatory state leukocyte leukocytes lung tissue Lymphocytes lymphocytopenia monocyte Monocytes mononuclear cell mononuclear cells outcome patients PBMC Peripheral blood Peripheral blood mononuclear cell (PBMC) Peripheral blood mononuclear cells Prognosis progression Replication respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection in vitro severe acute respiratory syndrome Coronavirus susceptible sustained symptom onset T cell T lymphocytes Viral viral replication Viral RNA virus spread [DOI] 10.1093/jmcb/mjac021 PMC 바로가기 [Article Type] Article
Humoral and cellular response in convalescent COVID-19 lupus patients회복기 COVID-19 루푸스 환자의 체액 및 세포 반응Article Published on 2022-08-122022-09-11 Journal: Scientific Reports [Category] SARS, 진단, 치료기술, 치료법, 치료제, [키워드] accumulated adaptive Analysis analyzed antibodies antibody Antibody Response Antibody titer Antibody titers CD8 cellular response changes in collected confirmed cases confirmed COVID-19 case convalescent convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient Convalescent patients COVID-19 COVID-19 disease COVID-19 incidence COVID-19 infection COVID-19 susceptibility declined decrease died dose dysregulation evaluated flow cytometry Gene expression analysis General population Health care higher risk Hospital admission humoral Humoral and cellular responses hypocomplementemia IgG antibodies immune dysregulation immune response immunological immunological profile Immunological studies Immunosuppression immunosuppressive immunosuppressive therapy impair incidence increase in Infection intensive care lack longitudinal longitudinal changes Lupus medical record memory cell Mild Patient patients PBMC PBMCs PCR-confirmed COVID-19 Prednisone predominant prospective cohort reduction required risk factor Risk factors SARS-CoV-2 IgG SARS-CoV-2 IgG antibodies SARS-CoV-2 IgG antibody severe COVID-19 disease severe disease severity Signaling SLE Surveillance susceptibility sustained Symptom symptom onset T cell Th17 Th2 response therapy were measured [DOI] 10.1038/s41598-022-17334-5 PMC 바로가기 [Article Type] Article
SOLVx therapeutics vaccine – Activate T-cell immunity using broad surveillance epitope strategy against mutant strains SARS-COV2SOLVx 치료제 백신 - 돌연변이 균주 SARS-COV2에 대한 광범위한 감시 에피토프 전략을 사용하여 T 세포 면역 활성화Article Published on 2022-08-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha Analysis Anti-viral B cell B cells BALB/c mice biochemical biological samples cellular coronavirus cytokine levels Cytokine storm decrease Defense develop dose Effect Efficacy and safety elevated epitope eradication euthanized Evolution functional Genome HCoV HCoV-229E hematological humoral IFN-γ IL-10 IL-6 immune response Immunoglobulin Immunoglobulin G increase in interferon gamma Laboratory lung tissue Lungs mice mRNA mutable mutant mutant strain NK cell parameter PBMC PBMCs peptide peptides Prophylactic qPCR reduced SARS-COV2 mutant significantly SOLVx statistically significant suggested Surveillance T cell T-cell immunity therapeutic TNF-alpha TNF-α treated Treatment treatment group treatment groups Vaccine virus Virus evolution virus infectivity were assessed were used [DOI] 10.1016/j.biopha.2022.113212 PMC 바로가기 [Article Type] Article
Nonproductive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immune responsesSARS-CoV-2에 대한 PBMC의 비생산적 노출은 세포 고유의 타고난 면역 반응을 유도합니다Article Published on 2022-08-012022-09-11 Journal: Molecular Systems Biology [Category] SARS, 치료기술, [키워드] absence ACE2 receptor analyzed baseline bystander cell bystander cells Cell COVID-19 Culture Cytokines detectable Ex vivo experiment exposure to expression expression profile expression profiles healthy donor healthy donors human PBMC immune responses in vivo induce infected cell Infection innate immune response Interaction interferon interferon-stimulated gene interferon-stimulated genes interferon-stimulated genes. Invasion ISG ISGs Mild monocyte Monocytes mounted Particle Patient PBMC PBMCs physical proinflammatory cytokines respiratory tract response RT-PCR SARS-CoV SARS-CoV-2 severe COVID-19 Single-cell RNA sequencing STAT stimulate susceptibility triggered virus particle virus particles [DOI] 10.15252/msb.202210961 PMC 바로가기 [Article Type] Article
Circulating B10 regulatory cells are decreased in severe and critical COVID-19심각하고 치명적인 COVID-19에서 순환하는 B10 조절 세포가 감소합니다Article Published on 2022-08-012022-09-11 Journal: Journal of leukocyte biology [Category] COVID19(2023년), SARS, 치료기술, [키워드] B cell B cells B10 Bregs Cell cells clinical and laboratory parameters correlated COVID-19 COVID-19 pathogenesis Critical critical COVID-19 patient determine disease severity evaluate Evidence explained Frequency functional healthy individuals IL-10 immune response immune responses include inflammatory parameter Laboratory parameters mechanisms multiparametric flow cytometry patient groups PBMC PBMCs reduction in Regulatory regulatory cell SARS-CoV-2 severity specific antibodies specific antibody Stimulation subset the disease [DOI] 10.1002/JLB.5COVCRA0721-387RR PMC 바로가기 [Article Type] Article
Bioinformatics approach reveals the critical role of the NOD-like receptor signaling pathway in COVID-19-associated multiple sclerosis syndrome생물 정보학 접근법은 COVID-19 관련 다발성 경화증 증후군에서 NOD 유사 수용체 신호 전달 경로의 중요한 역할을 보여줍니다Article Published on 2022-08-012022-09-11 Journal: Journal of neural transmission (Vienna, Austria : [Category] 유전자 메커니즘, [키워드] Affect Analysis analyzed approach association Autoimmune disease bioinformatics Brain CASP1 Central nervous system CNS Complete coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Critical cross disease Diseases functional protein genetic information GEO database identify IFNB1 IFNg IL1B immune indicated Inflammation mechanism monocyte mononuclear cell Multiple multiple sclerosis network analysis NLR NLRP3 Occurrence P2RX7 pathway Patient patients PBMC Peripheral blood platform PPI Protein protein-protein interaction receptor receptor signaling reported reveal RNA sequencing data SARS-CoV-2 selected Signaling signaling pathway spinal cord STRING syndrome the patient TNF was collected with COVID-19 [DOI] 10.1007/s00702-022-02518-0 PMC 바로가기 [Article Type] Article
Single-cell RNA sequencing to decipher the immunogenicity of ChAdOx1 nCoV-19/AZD1222 and mRNA-1273 vaccines in patients with autoimmune rheumatic diseases자가면역 류마티스 질환 환자에서 ChAdOx1 nCoV-19/AZD1222 및 mRNA-1273 백신의 면역원성을 해독하기 위한 단일 세포 RNA 시퀀싱Article Published on 2022-08-012022-09-12 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] Analysis analyzed anti-rheumatic medications anti-SARS-CoV-2 IgG antibodies Antigen presentation Arthritis Autoimmune AZD1222 CD16 CD4 ChAdOx1 COVID-19 COVID-19 vaccine database domain dose electrochemiluminescence immunoassay enriched pathway enrolled exhibited Gene Expression Omnibus GEO healthy controls HLA-DRA immunized inhibitor Interaction Janus kinase methotrexate MHC class Moderna monocyte mononuclear cell mRNA-1273 mRNA-1273 vaccine mRNA-based vaccine Necrosis Oxford-AstraZeneca participant pathway Patient patients PBMC PBMCs Peripheral blood predominant quantified receiving rheumatic disease RNA sequencing scRNA-seq serum IgG antibody Single-cell RNA sequencing the SARS-CoV-2 vaccination Vaccine [DOI] 10.3389/fimmu.2022.920865 PMC 바로가기 [Article Type] Article
Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19통합 혈장 단백질체 및 단일 세포 면역 신호 네트워크 시그니처는 경증, 중등도 및 중증 COVID-19를 구분합니다.Article Published on 2022-07-192022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 임상, 진단, 치료기술, [키워드] addition approach AUC Cell clinical manifestation clinical manifestations coronavirus Coronavirus 2019 COVID-19 COVID-19 progression COVID-19 severity CyTOF determinant dysregulation examination feature hallmark identify immune Immunophenotyping Inflammatory JAK/STAT Ligand MAPK mass cytometry Mild moderate mTOR NF-κB nuclear Olink Patient patients PBMC Peripheral blood phenotype phosphosignaling response plasma plasma protein plasma proteins proteomic proteomics response reveal SARS-CoV-2 severe COVID-19 Signaling single-cell stacked generalization. STAT therapeutic target therapeutic targets Treatment uninfected [DOI] 10.1016/j.xcrm.2022.100680 PMC 바로가기 [Article Type] Article
Specific CD4+ T Cell Responses to Ancestral SARS-CoV-2 in Children Increase With Age and Show Cross-Reactivity to Beta Variant어린이의 조상 SARS-CoV-2에 대한 특정 CD4+ T 세포 반응은 나이가 들어감에 따라 증가하고 베타 변이체에 대한 교차 반응성을 나타냅니다Article Published on 2022-07-152022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] accompanied Activation activation induced marker (AIM) activation-induced marker activation-induced markers age ancestral Antiviral average Beta Beta variant beta variants Blood CD4+ CD4+ T cell children Control convalescent coronavirus COVID-19 cross-reactivity Cytokines cytometric disease course Effective vaccines Flow global health granzyme granzyme B HCoV Health human coronavirus human coronavirus (HCoV) IFN-γ immune response increase Infection infection rate infection rates marker Mild mononuclear cell PBMC pediatric peptide peripheral Peripheral blood Peripheral blood mononuclear cells reduced reduction response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant secreted cytokine secretion seronegative show social distancing measures Specific stimulated T cell T cell responses T cells the SARS-CoV-2 vaccination variant variant of concern (VOC) viral variant VoC was reduced were used [DOI] 10.3389/fimmu.2022.867577 PMC 바로가기 [Article Type] Article