PD-L1 Silencing in Liver Using siRNAs Enhances Efficacy of Therapeutic Vaccination for Chronic Hepatitis BArticle Published on 2022-03-182023-06-13 Journal: Biomolecules [Category] B형 간염, [키워드] checkpoint inhibition HBV Hepatitis immunology PD-L1 RNAi Therapeutic vaccination [DOI] 10.3390/biom12030470 PMC 바로가기
A phase 2 trial of avelumab in men with aggressive-variant or neuroendocrine prostate cancer Research Published on 2022-03-152022-10-05 Journal: Prostate cancer and prostatic diseases [Category] 바이오마커, 임상, [키워드] 95% CI Activation Administered anticipated Avelumab Central nervous system Complete conducted COVID-19 COVID-19 pandemic criteria CXCR2 defined disease Efficacy Endpoint enrolled Enrollment histology immune Immune cell Immunotherapy liver median median age men Metastasis monotherapy Msh2 Mutation neuroendocrine open label Patient patients PD-L1 Peripheral blood phase 2 trial Phenotyping poor prognosis positive potential mechanism primary endpoint progression progressive disease Prostate cancer Radiographic Result Safety secondary single center subset survival T-cell Response tested therapy Toxicity Treatment while [DOI] 10.1038/s41391-022-00524-7 [Article Type] Research
Circulating Levels of PD-L1, TIM-3 and MMP-7 Are Promising Biomarkers to Differentiate COVID-19 Patients That Require Invasive Mechanical VentilationPD-L1, TIM-3 및 MMP-7의 순환 수준은 침습적 기계 환기가 필요한 COVID-19 환자를 구별하는 유망한 바이오마커입니다Article Published on 2022-03-142022-09-11 Journal: Biomolecules [Category] Coronavirus, MERS, SARS, 바이오마커, [키워드] 105 patient 105 patients acute disease Acute respiratory failure acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Biomarker Biomarkers caused Clinical data Coronavirus-2 correlated COVID-19 COVID-19 patient diagnosed with COVID-19 disease disease severity eight ELISA evaluate exhibited followed by highest Hospital stay IMV Infectious disease Invasive mechanical ventilation Level lung lesion lung lesions marker Mechanical molecules NIMV PaO Patient patients PD-L1 persistence Potential biomarker potential biomarkers quantified respiratory Respiratory failure ROC analysis RT-PCR SARS-CoV-2 sensitivity Serum level serum levels Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus significant decrease specificity T-cell T-cells two group two groups was increased [DOI] 10.3390/biom12030445 PMC 바로가기 [Article Type] Article
Recombinant human interleukin-7 reverses T cell exhaustion ex vivo in critically ill COVID-19 patientsResearch Published on 2022-03-052022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] administration Admission alteration alterations approaches Bacterial sepsis Blood Cell cell proliferation characteristic clinical setting collected COVID-19 COVID-19 patient COVID-19 patients Critically ill Critically ill patient CTLA-4 described evaluated Ex vivo Exhaustion expression feature flow cytometry hallmark Hospitalized ICU ICU admission ICU patient IFN-γ immune immunostimulation inhibited intensive care interleukin-7 lymphopenic marker mononuclear cell over-expression pathophysiology Pathways Patient PD-L1 peripheral proliferation recombinant Result reversed SARS-CoV-2 Sepsis severe coronavirus disease severe COVID-19 severe COVID-19 patient significantly supplementary material T cell T cell activation T cell proliferation T lymphocyte T lymphocyte response T lymphocytes therapeutic therapeutic strategy therapy transcriptomic profile treat [DOI] 10.1186/s13613-022-00982-1 PMC 바로가기 [Article Type] Research
SARS-CoV-2 Induces Cytokine Responses in Human BasophilsSARS-CoV-2는 인간 호염기구에서 사이토카인 반응을 유도합니다Article Published on 2022-02-242022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Activation Alter Antibody Response Antibody responses basophil basophils Caco-2 Caco-2 cells CD107a CD13 CD69 characterized COVID-19 COVID-19 patients cytokine cytokine response degranulation epithelial cell epithelial cells expression help Human IL-13 IL-3 IL-4 immune Immune cell immune cells immune responses increased expression induce Inflammation Interaction marker Orientation pandemic virus PD-L1 promote reducing reported response SARS-CoV-2 SARS-CoV-2 replication surface marker surface markers virus [DOI] 10.3389/fimmu.2022.838448 PMC 바로가기 [Article Type] Article
Case Report: A Peculiar Case of Inflammatory Colitis After SARS-CoV-2 Infection사례 보고: SARS-CoV-2 감염 후 염증성 대장염의 특이한 사례Case Reports Published on 2022-02-092022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, 치료법, [키워드] alteration appear autoinflammatory response break Cell co-morbidity Colitis Colon COVID-19 cytotoxic immune cells death demonstrated died expected expressed expression healthy Hospitalization IHC immunological alterations increasingly Inflammatory inhibitory Interaction investigated Ligand lymphocyte marker morbidity mucosal necrotizing ulcerative colitis nucleocapsid protein Patient PD-1 PD-1/PD-L1 axis PD-L1 qRT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus self-tolerance the patient the SARS-CoV-2 virus tissue undetectable [DOI] 10.3389/fimmu.2022.849140 PMC 바로가기 [Article Type] Case Reports
Combination strategies with PD-1/PD-L1 blockade: current advances and future directionsReview Published on 2022-01-212023-08-30 Journal: Molecular Cancer [Category] E형 간염, [키워드] Angiogenesis inhibitor bispecific antibody combination therapy gut microbiota PD-1 PD-L1 Radiotherapy STING [DOI] 10.1186/s12943-021-01489-2 PMC 바로가기 [Article Type] Review
A Comparative and Comprehensive Review of Antibody Applications in the Treatment of Lung DiseaseReview Published on 2022-01-172022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] ACE2 protein addition antibodies antibody Antigen application Autoimmune disease B cell benefit bioinformatics Cancer cancer patient Cancer patients Clinical use Comparative Comprehensive connection COVID-19 CTLA-4 cytokine debatable disease Diseases explain IL-1β IL-6 immune Immunotherapy Infectious disease mechanism monoclonal antibody neutralizing antibody Patient PD-L1 potential mechanism produced Protein provided review signaling pathway somatic cells subsequent therapeutic effect therapy Treatment tyrosine Vaccine VEGF virus entry [DOI] 10.3390/life12010130 PMC 바로가기 [Article Type] Review
A Practical Strategy for Exploring the Pharmacological Mechanism of Luteolin Against COVID-19/Asthma Comorbidity: Findings of System Pharmacology and Bioinformatics AnalysisCOVID-19/천식 동반 질환에 대한 루테올린의 약리학적 메커니즘 탐색을 위한 실용적인 전략: 시스템 약리학 및 생물정보학 분석 결과Immunology Published on 2022-01-072022-09-11 Journal: Frontiers in Immunology [Category] 치료제, [키워드] activities Against AKT1 ALB Anti-inflammatory Antiviral approach Asthma binding binding activity Bioactivity Bioinformatics analysis biological activity Biological functions blood circulation Cancer Cell cell growth Comorbidity coronavirus disease Coronavirus disease 2019 COVID-19 Defense disease drug candidate Effect effective EGFR enrichment analysis ErbB evaluate Evidence experiments finding growth Health HIF-1 IL-6 immune regulation immune responses indicate indicated Inflammation Luteolin MAPK mechanism molecular docking analysis molecular mechanism oxidative stress pathway Patient PD-1 PD-L1 performed Pharmacology Physicochemical properties physicochemical property poor prognosis predicted Protein–protein interaction RAGE reducing Regulation Replication Research SARS-COV-2 infection Signaling Strategy suggested susceptibility System system pharmacology target targets TNF Toll-like receptor TP53 VEGFA virus [DOI] 10.3389/fimmu.2021.769011 PMC 바로가기 [Article Type] Immunology
PD-1 blockade counteracts post–COVID-19 immune abnormalities and stimulates the anti–SARS-CoV-2 immune responsePD-1 봉쇄는 코비드 -19 면역 이상을 반대하고 항 -SARS-COV-2 면역 반응을 자극합니다.Research Article Published on 2021-12-222022-08-31 Journal: JCI Insight [Category] SARS, 바이오마커, [키워드] abnormality Alter Altered among others Anergy blockade CD8 characterized coronavirus coronavirus disease coronavirus disease-2019 counteract COVID-19 COVID-19–related symptom COVID-19–related symptoms Ex vivo healthy controls hospital discharge IL-1 IL-1 β IL-1ra IL-8 immune Immune checkpoint blockade immune response immunologically immunology Immunotherapy Infection lentivirus Methylation Neutralization assay neutralize nonspecific normalized Patient patients PD-1 PD-L1 PD1 peptides plasma Plasma level Plasma levels promoter proportion pseudotyped reduced restored SARS-CoV-2 antigens SARS-CoV-2 peptides SARS-CoV-2 spike stimulate T cell T cell response T cells [DOI] 10.1172/jci.insight.146701 PMC 바로가기 [Article Type] Research Article