Primary Care implementation of Germ Defence, a digital behaviour change intervention to improve household infection control during the COVID-19 pandemic: A structured summary of a study protocol for a randomised controlled trialCOVID-19 전염병 동안 가정 감염 통제를 개선하기 위한 디지털 행동 변화 개입인 Germ Defence의 1차 진료 구현: 무작위 통제 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2021-04-092022-09-10 Journal: Trials [Category] MERS, 임상, [키워드] 1:1 antibiotic Behaviour change blinded Blinding block blocks Bristol Care clinical Cluster collaboration Commission comparator Contact Controlled trial coronavirus COVID-19 COVID-19 symptom detect diagnose Digital health Digital medicine dissemination Effect effect size Effectiveness element engage England enrolment Gastrointestinal infection gastrointestinal infections general practices Germ group hand washing help Hospital admission hygiene identity implementation IMPROVE incidence incidence of COVID-19 include independent individual Infection infection control Infectious disease Intervention intervention arm involved ISRCTN ISRCTN registry management measure number objective outcome overcome participant Patient personalised Prevalence primary care Primary outcome Principal Investigators problem problem solving protection protocol randomisation randomised randomised controlled trial Randomly receive reduce Registered respiratory respiratory tract infection Sample size secondary outcome Secondary outcomes Spread Stata Statistical Software statistical statistician Study protocol supplementary material Symptom Trial Trial registration Two-arm usual care website [DOI] 10.1186/s13063-021-05188-7 PMC 바로가기 [Article Type] Letter
Robotics, microfluidics, nanotechnology and AI in the synthesis and evaluation of liposomes and polymeric drug delivery systems리포솜 및 고분자 약물 전달 시스템의 합성 및 평가에서 로봇 공학, 미세 유체 공학, 나노 기술 및 AIArticle Published on 2021-04-012022-08-31 Journal: Drug delivery and translational research [Category] 치료제, [키워드] approach artificial artificial intelligence automated Automation cell type cell types changes in COVID-19 pandemic database drastic Efficiency experiments extension globe Laboratory Liposome Microfluidics Nanotechnology patients personalised Personalised medicine Perspective robotics therapeutic traditional methods translational unique [DOI] 10.1007/s13346-021-00929-2 PMC 바로가기 [Article Type] Article
Adjunctive IgM-enriched immunoglobulin therapy with a personalised dose based on serum IgM-titres versus standard dose in the treatment of septic shock: a randomised controlled trial (IgM-fat trial)패혈성 쇼크 치료에서 혈청 IgM 역가 대 표준 용량을 기반으로 한 개인 맞춤 용량을 사용한 보조 IgM 강화 면역글로불린 요법: 무작위 대조 시험(IgM 지방 시험)Randomized Controlled Trial Published on 2021-02-112022-09-12 Journal: BMJ Open [Category] MERS, 임상, 진단, [키워드] 1:1 all-cause mortality approved Area assigned Biomarkers circulating Clinical outcome Clinical severity Committee Critical care daily dose dosage dose effective enrolled enrolment Ethics EudraCT Host immune response hypothesised IgM Immunoglobulin immunology Infection Infectious diseases information Intensive intensive & intensive care unit Intravenous immunoglobulin investigator Italian Mortality multicentre Patient per day personalised polyclonal primary endpoint randomised randomised controlled trial Randomly receive Registered Sepsis Septic shock serum Standard dose standard treatment Study protocol the ethics committee therapy threshold titre Treatment Trial trial protocol vasoactive drug [DOI] 10.1136/bmjopen-2019-036616 PMC 바로가기 [Article Type] Randomized Controlled Trial
Nursing Interventions to Prevent Delirium in Critically Ill Patients in the Intensive Care Unit during the COVID19 Pandemic—Narrative OverviewReview Published on 2020-12-212022-10-31 Journal: International journal for equity in health [Category] COVID-19, [키워드] approach concerning COVID19 Critical care delirium greater ICU Ill improvement intensive care unit intensive care units knowledge management Nurses Nursing pandemic patients patients with COVID-19 personalised Personalized medicine SARS-CoV-2 standard measure the SARS-CoV-2 [DOI] 10.3390/healthcare8040578 PMC 바로가기 [Article Type] Review
COVID-19 and cancer: From basic mechanisms to vaccine development using nanotechnologyReview Published on 2020-12-022022-10-04 Journal: International immunopharmacology [Category] MERS, SARS, 유전자 메커니즘, [키워드] ACE acute respiratory syndrome administration affecting albumin Alter assist association Cancer cancer patient Cancer patients caused condition contribute coronavirus Coronavirus disease 2019 COVID COVID-19 COVID-19 vaccine distribution effective effective vaccine Effective vaccines Efficacy exacerbated faster global pandemic highlighting immune system Immunocompromised immunocompromised individuals Immunocompromised patient implementation Interaction lack limitation Lipid nanoparticles mechanism mortality rate mRNA vaccine Nanomaterial Nanotechnology Neutrophils pandemic Patient personalised Pharmaceutics Prevalence required SARS-CoV-2 show the vaccine Treatment Vaccine Vaccine development vaccine platform viral spike protein viral strains Viral vector virus [DOI] 10.1016/j.intimp.2020.107247 PMC 바로가기 [Article Type] Review
Prediction of survival odds in COVID-19 by zinc, age and selenoprotein P as composite biomarker복합 바이오마커로서 아연, 연령 및 셀레노단백질 P에 의한 COVID-19의 생존 확률 예측Clinical Trial Published on 2020-10-202022-08-13 Journal: Redox Biology [Category] MERS, SARS, 바이오마커, 임상, [키워드] age an area Analysis AUC Biomarker characteristic collected Concentration contribute convalescence coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients deficiency deficit different time point different time points EpiC EPIC cohort European healthy subject healthy subjects Hypothesis immune response immune system Inflammation information investigation majority Micronutrient non-survivor Non-survivors nutrition pandemic Patient personalised prediction Prevalence prognostic Prospective provide receiver operating characteristic reference range reference ranges ROC SARS-COV-2 infection SARS-CoV-2 infections Se transporter selenoprotein P Selenium SELENOP Selenoprotein P serum serum sample serum samples status Support survival survival odd survivor tested threshold Trace element trace elements was determined were used yielding Zinc [DOI] 10.1016/j.redox.2020.101764 PMC 바로가기 [Article Type] Clinical Trial
Personalised health education against health damage of COVID-19 epidemic in the elderly Hungarian population (PROACTIVE-19): protocol of an adaptive randomised controlled clinical trialStudy Protocol Published on 2020-09-292022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] adaptive Admission affecting age alcohol approved assessment attenuate boost caused change clinical trial complex concerning condition COVID-19 COVID-19 epidemic detrimental effect Effect ethics committee Follow-up group Health Health Assessment Hospital admission ICU ICU admission incidence include intensive care Intervention lack life-threatening Medical Research Council mental health Mortality nCOV-2019 older population outcome overall mortality pandemic participant personalised pharmacological physical activity Pragmatic prevention primary endpoint protocol public health randomised randomised controlled randomised controlled trial receive reduce Registered Sample size SARS-CoV-2 smoking subject therapy Treatment WHO World Health Organization [DOI] 10.1186/s13063-020-04733-0 PMC 바로가기 [Article Type] Study Protocol
Drug Repositioning: New Approaches and Future Prospects for Life-Debilitating Diseases and the COVID-19 Pandemic OutbreakReview Published on 2020-09-222022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] approach approved assessments COVID-19 Cushing’s syndrome cushing’s syndrome de novo developmental disease Diseases drug Drug discovery drug personalisation drug repositioning Efficacy and safety Future HIV HIV infection margin New novel novel diseases orphan diseases outbreak pandemic personalised Regulatory Authorities repositioning Research risk treat Treatment [DOI] 10.3390/v12091058 PMC 바로가기 [Article Type] Review
Monocytopenia, monocyte morphological anomalies and hyperinflammation characterise severe COVID ‐19 in type 2 diabetes단핵구 감소증, 단핵구 형태 이상 및 과염증은 제2형 당뇨병에서 중증 COVID-19의 특징입니다Observational Study Published on 2020-09-112022-09-11 Journal: EMBO Molecular Medicine [Category] MERS, SARS, 바이오마커, 임상, [키워드] COVID‐19 SARS‐CoV-2 aetiology Affect aggravate Anomaly Care Cell change changes in circulating classical Cohort condition contribute COVID diabetes Diabetic disease course Evidence expression gene expression profile group hospitalised hyperinflammation Hyperinflammatory identifying IL 6 Immune cell immune cells immune response immune responses immunology immunophenotype Increased increased expression Inflammation Inflammatory Inflammatory marker inflammatory markers intensive care interferon leucocyte lymphocyte Lymphocytes lymphocytopenia metabolism Microbiology, Virology & Host Pathogen Interaction mitigate monocyte Monocytes monocytopenia Morphological morphology Mortality observational study pandemic pathway Patient patients peripheral circulation personalised Population precision therapy quantified risk factor severe disease severity T2D target therapeutic target type 1 interferon type 2 diabete type 2 diabetes Variation variations [DOI] 10.15252/emmm.202013038 PMC 바로가기 [Article Type] Observational Study
Covid-19 pandemic by the “real-time” monitoring: the Tunisian case and lessons for global epidemics in the context of 3PM strategies"실시간" 모니터링을 통한 코로나19 대유행: 3PM 전략의 맥락에서 튀니지 사례 및 글로벌 전염병에 대한 교훈Letter to the Editor Published on 2020-04-252022-08-13 Journal: The EPMA Journal [Category] Biochemistry, COVID-19, [키워드] “Real-time” monitoring a minor affected Analysis Anti-body Anti-gene approach Bottle-neck China Comorbidities Comparative analysis country COVID-19 COVID-19 disease Depression disease distribution Economy effective Epidemic Epidemics Ethics Europe Evolution exponential phase heterogeneous Home isolation individual Individual outcomes Infection Laboratory medicine Laboratory test Laboratory tests lack lead leads measure minor mortality rate Multi-professional expertise pandemic personalised Policymaking Population Population screening Predictive Predictive preventive personalised (3P) medicine Prevent preventive measures Protective provided Psychotic attitude Qualitative Quantitative randomised reached Region Related mortality Research Salami-tactic SARS-CoV-2 significant delay Strategy Suicide Suppressed immune defence Targeted protective measures Test the epidemic therapeutic Titanic Triage vaccination Violence Viral [DOI] 10.1007/s13167-020-00207-0 PMC 바로가기 [Article Type] Letter to the Editor