Potential Use of CRISPR/Cas13 Machinery in Understanding Virus–Host InteractionMicrobiology Published on 2021-11-262022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acquisition approaches Cas13 Cas9 class component CRISPR-Cas Degradation degrade diagnostics DNA effector elements Features Genetic identify immune system Interaction modulate Nuclease nucleases nucleic acid offer Palindromic phage plasmids Potential Prokaryote Protein Proteins recognizing Repeat Research RNA RNA interference RNA-labeling sequence spacer subsequent understanding variant Viral RNA Virological virus diagnosis virus interference virus resistance [DOI] 10.3389/fmicb.2021.743580 PMC 바로가기 [Article Type] Microbiology
Alterations in the Composition of Intestinal DNA Virome in Patients With COVID-19Cellular and Infection Microbiology Published on 2021-11-242022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome addition affected alteration analyzed Bacterial bacteriome bacteriophage Bacteroidaceae changed changes in characteristic contribute coronavirus correlation COVID-19 database digestive system DNA DNA virus Gut gut virome healthy controls Hospital admission indicated Infection information intestinal intestinal flora intestinal tract investigated Myoviridae patients patients hospitalized patients with COVID-19 phage progression SARS-CoV-2 shown significantly Siphoviridae Symptoms the disease the SARS-CoV-2 Treatment virus-bacteria linkages viruses while [DOI] 10.3389/fcimb.2021.790422 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
A Mycobacteriophage-Based Vaccine Platform: SARS-CoV-2 Antigen Expression and DisplayArticle Published on 2021-11-232022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] administration Antigen characterized described display displaying Efficacy infectious agents intravenous mycobacteriophage Neutralizing antibodies phage phage display vaccine platform protein antigens recombinant safety profile SARS-CoV-2 SARS-COV-2 infection spike Vaccine Vaccine development variety [DOI] 10.3390/microorganisms9122414 PMC 바로가기 [Article Type] Article
Selection for Phage Resistance Reduces Virulence of Shigella flexneri파지 저항성 선택이 Shigella flexneri의 병원성을 감소시킨다Article Published on 2021-11-172024-07-30 Journal: Applied and Environmental Microbiology [Category] 세균성이질, [키워드] Evolution phage resistance trade-off virulence [DOI] 10.1128/AEM.01514-21 PMC 바로가기
Genomic and phenotypic comparison of two Salmonella Typhimurium strains responsible for consecutive salmonellosis outbreaks in New Zealandarticle Published on 2021-10-312024-09-01 Journal: International Journal of Medical Microbiology [Category] 살모넬라증, [키워드] Epidemic Genomics phage Plasmid Salmonella [Article Type] article
Identification of Shiga-Toxin-Producing Shigella Infections in Travel and Non-Travel Related Cases in Alberta, Canada알버타, 캐나다에서 여행 관련 및 비여행 관련 사례에서 시가 독소 생성 시겔라 감염의 확인Article Published on 2021-10-252024-07-30 Journal: Toxins [Category] 세균성이질, [키워드] global transmissions phage phylogenomic Shiga toxin Shigella flexneri [DOI] 10.3390/toxins13110755 PMC 바로가기 [Article Type] Article
Design and proof of concept for targeted phage-based COVID-19 vaccination strategies with a streamlined cold-free supply chain423 Published on 2021-07-272022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, [키워드] AAVP Administered aerosolization Antibody Response Antigen approach attributes Bacteria circulation CMV promoter coronavirus disease COVID-19 COVID-19 pandemic COVID-19 vaccination COVID-19 vaccine COVID-19 vaccine development development displaying effective vaccine elicit Emergency use authorization epitope experiments expression gene delivery Genetic highly pathogenic humans humoral immune response immunization imperative infect inherent initial injected Ligand lung lung epithelium mice Particle Particles peptide performed phage phage display plasticity platform Protein Rapid Research robust S protein S protein-specific antibody safety profile SARS-CoV-2 SARS-CoV-2 S protein Significance stability subcutaneous vaccination sustained temperature the SARS-CoV-2 transgene translational Transport unique vaccination Vaccine Vaccine development virus widespread [DOI] 10.1073/pnas.2105739118 PMC 바로가기 [Article Type] 423
Developing Recombinant Antibodies by Phage Display Against Infectious Diseases and Toxins for Diagnostics and Therapy진단 및 치료를 위한 감염성 질환 및 독소에 대한 파지 디스플레이에 의한 재조합 항체 개발Review Published on 2021-07-072022-09-12 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 진단, [키워드] Against antibodies antibody antibody fragment Autoimmune diseases Bacterial Cancer caused convalescent patient COVID-19 pandemic Developing Diagnosis diagnostic disease Diseases display DNA sequence eukaryotic Final human monoclonal antibodies immune immune systems in vitro in vivo Infectious disease limitation microbial monoclonal antibody packaged Particles pathogen Pathogens phage phage display recombinant recombinant antibodies scFv antibodies selected sera therapeutic therapy toxin toxins treat Treatment VHH antibodies while [DOI] 10.3389/fcimb.2021.697876 PMC 바로가기 [Article Type] Review
Discovery of Antivirals Using Phage Display파지 디스플레이를 사용한 항 바이러스 발견Review Published on 2021-06-102022-09-10 Journal: Viruses [Category] SARS, 치료제, [키워드] antibody Antibody therapeutics antigen-binding fragment Antiviral antiviral agent Antiviral agents antiviral potency approach approaches bacteriophage clinic coronavirus coronavirus disease COVID-19 COVID-19 treatment development disease outbreak display drug Drug discovery Emergency use ENhance expected expiration global public health Health highlight increment India intellectual property intrabody market nanobody outbreak peptide phage phage display platform predominant provide Russia screening method screening methods selected single-chain variable fragment spread of COVID-19 threat transbody Treatment Viral viral infection viral infections [DOI] 10.3390/v13061120 PMC 바로가기 [Article Type] Review
A Simple Electrostatic Precipitator for Trapping Virus Particles Spread via Droplet TransmissionArticle Published on 2021-05-062022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] aerosol bacteriophage φ6 Concentration coronavirus disease COVID-19 COVID-19 virus demonstrated develop droplet droplet transmission effective electric field electrostatic eliminating experiments FITC introduced Ion ionic wind negative negative charge negative ions opposite ozone bubbling pandemic Particle Particles phage provide Pseudomona respiratory droplet simple Spread Trapping vessel viral pathogen virus particle was used [DOI] 10.3390/ijerph18094934 PMC 바로가기 [Article Type] Article