Virus-like particles derived from bacteriophage MS2 as antigen scaffolds and RNA protective shellsReview Published on 2024-04-172024-09-05 Journal: Nanomedicine [Category] update2024, [키워드] Bionano capsid drug delivery phage protein cage protein engineering RNA delivery RT-PCR Vaccines [DOI] 10.2217/nnm-2023-0362 PMC 바로가기 [Article Type] Review
Collateral sensitivity increases the efficacy of a rationally designed bacteriophage combination to control Salmonella enterica부가적 민감성은 살모넬라 엔테리카를 제어하기 위한 합리적으로 설계된 박테리오파지 조합의 효능을 증가시킨다.Article Published on 2024-03-192024-08-21 Journal: Journal of virology [Category] 살모넬라증, [키워드] antimicrobial BtuB collateral sensitivity LPS phage TraDIS
Phage Therapy: From Biologic Mechanisms to Future DirectionsArticle Published on 2023-01-012024-09-05 Journal: Cell [Category] update2024, [키워드] bacteriophage bacteriophage therapy phage phage therapy [DOI] 10.1016/j.cell.2022.11.017 PMC 바로가기 [Article Type] Article
Discovery of a Phage Peptide Specifically Binding to the SARS-CoV-2 Spike S1 Protein for the Sensitive Phage-Based Enzyme-Linked Chemiluminescence Immunoassay of the SARS-CoV-2 AntigenSARS-CoV-2 항원의 민감한 파지 기반 효소 연결 화학발광 면역분석을 위한 SARS-CoV-2 스파이크 S1 단백질에 특이적으로 결합하는 파지 펩티드의 발견Article Published on 2022-08-232022-09-11 Journal: Analytical Chemistry [Category] SARS, 치료기술, 치료제, [키워드] albumin Amino acid amino acid sequence amplification antigen recognition binding site bovine bovine serum albumin chemiluminescence immunoassay conditions COVID-19 pandemic detect diagnose Dissociation constant Economy Effect exhibited expressing healthcare high affinity hydrogen hydrogen bond network hydrophobic immunoassay Interaction molecular docking N-terminal domain peptide peptides phage probe Protein pseudovirus S1 subunit Saliva SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 S1 SARS-CoV-2 S1 protein selective sensitive sensitivity serum albumin specificity spike Spread supported target target protein the S1 subunit the SARS-CoV-2 transducing transmembrane protein [DOI] 10.1021/acs.analchem.2c01988 PMC 바로가기 [Article Type] Article
Dysbiosis and intestinal inflammation caused by Salmonella Typhimurium in mice can be alleviated by preadministration of a lytic phagearticle Published on 2022-07-312024-09-01 Journal: Microbiological Research [Category] 살모넬라증, [키워드] 16 S rRNA gut microbiota intestinal inflammation phage Salmonella Typhimurium [Article Type] article
Personalized bacteriophage therapy to treat pandrug-resistant spinal Pseudomonas aeruginosa infection Research Published on 2022-07-222022-10-05 Journal: Nature Communications [Category] 변종, [키워드] added administer Antibiotics Bacteria Bacterial Bacterial infection bacteriophage bone Combination European expression infecting Infection Intravenous injection joint kill Local Lytic management P. aeruginosa Patient persistence phage Pseudomonas aeruginosa purified the patient therapeutic potential therapy treat treated Treatment unique variants virus [DOI] 10.1038/s41467-022-31837-9 [Article Type] Research
Peptide-Antibody Fusions Engineered by Phage Display Exhibit an Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants파지 디스플레이가 조작한 펩티드-항체 융합은 SARS-CoV-2 변이체의 초강력 및 광범위한 중화를 나타냅니다Article Published on 2022-07-152022-09-11 Journal: ACS chemical biology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] affinities affinity approach approved B.1.1.529 Bivalent bivalent IgG breadth clinically Coverage COVID-19 demonstrated display domain dominant ENhance exacerbated fused fusion fusions generate implicated IMPROVE Infection infection assay low potency Mutation N-terminal domain N-terminus NAb NAbs naïve neutralization neutralization potency neutralize neutralizing antibody NTD omicron peptide peptides phage RBD RBD mutation RBD mutations S-protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein spread of COVID-19 tetravalent the RBD the spike protein therapeutic Therapeutics trimer variant variants variants of concern vulnerability [DOI] 10.1021/acschembio.2c00411 PMC 바로가기 [Article Type] Article
Peptide Binder with High-Affinity for the SARS-CoV-2 Spike Receptor-Binding DomainSARS-CoV-2 스파이크 수용체 결합 도메인에 대한 고친화성을 갖는 펩티드 결합제Article Published on 2022-06-292022-09-11 Journal: ACS applied materials & interfaces [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity peptide albumin antigen detection assembly binder binding binding affinity Biomarker Biomarkers bovine bovine serum albumin Characteristics coronavirus Delta diagnostics dissociation Dissociation constant early diagnosis exhibited fluctuation Gamma gold Gold nanoparticle high affinity Human serum albumin identify independent Interaction interface Lambda mutant omicron Omicron variants peptide phage Rapid rapid detection method RBD Receptor-binding domain recombinants respiratory SARS-CoV-2 SARS-CoV-2 spike protein selectivity sensor sequence serum albumin severe acute respiratory syndrome Coronavirus spike Spike protein the binding affinity the RBD the receptor-binding domain the SARS-CoV-2 variants [DOI] 10.1021/acsami.2c03707 PMC 바로가기 [Article Type] Article
ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike ProteinORFeome 파지 디스플레이, SARS-CoV-2 스파이크 단백질의 S2 하위 도메인에 대한 주요 면역원성 에피토프 공개Article Published on 2022-06-172022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Amino acid amino acid sequence anti-SARS-CoV-2 antibodies antibodies antibody Antibody Response Antibody responses applied approved binding binding site blocking cell entry cleave COVID-19 COVID-19 pandemic COVID-19 patients Diseases display Efficacy epitope epitope mapping Epitopes fusion peptide genomic genomic library Host host cell identify immunogenic library Major mechanism monoclonal antibody mutate Mutation neutralization neutralize NGS Open reading frame open reading frames ORFeome ORFs Particle peptide phage phage display RBD RBD region Receptor binding domain representing SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant SARS-CoV-2 variants sequence Serine serine protease serine protease TMPRSS2 spike the cell the RBD the SARS-CoV-2 genome therapeutic therapy TMPRSS2 Vaccine virus variants [DOI] 10.3390/v14061326 PMC 바로가기 [Article Type] Article
Human Superantibodies to 3CL pro Inhibit Replication of SARS-CoV-2 across Variants3CL pro에 대한 인간 초항체는 변이체 전반에 걸쳐 SARS-CoV-2의 복제를 억제합니다Article Published on 2022-06-132022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] 3CL pro 3CLpro Betacoronavirus betacoronaviruses binding blocked catalytic activity Cell cell-penetrating antibody clone conserved Contact E. coli effective enzyme Escherichia coli Host Human human cells human single-chain antibody variable fragments (HuscFvs) in vitro infect inhibited inhibitory investigated Major major protease (3CLpro) membrane omicron Omicron variants peptide phage predicted produced protease Replication residue residues Safe SARS-CoV-2 single-chain antibody superantibody. tested the SARS-CoV-2 variant virus replication was used were used wild type Wuhan [DOI] 10.3390/ijms23126587 PMC 바로가기 [Article Type] Article