Current and novel biomarkers of thrombotic risk in COVID-19: a Consensus Statement from the International COVID-19 Thrombosis Biomarkers ColloquiumCOVID-19의 혈전 위험에 대한 현재 및 신규 바이오마커: 국제 COVID-19 혈전증 바이오마커 콜로키움의 합의 성명Review Published on 2022-07-012022-09-11 Journal: Nature reviews. Cardiology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, 치료기술, 치료법, [키워드] Activation aggregation Biomarker Biomarkers Clinical use Coagulation Coagulopathy Consensus coronavirus disease Coronavirus disease 2019 COVID-19 current D-dimer disease disease severity Elevation elevations Endothelial cell excessive inflammation fibrinogen fibrinolysis hypercoagulability in-hospital mortality Injury Intervention marker pandemic Patient patients Platelet platelet activation platelet aggregation platform Post-vaccine predict Prognosis prothrombotic recommendation Research risk risk stratification syndrome thrombocytopenia thromboembolic Thromboembolic events thrombosis thrombotic thrombotic and thromboembolic events thrombotic risk with COVID-19 [DOI] 10.1038/s41569-021-00665-7 PMC 바로가기 [Article Type] Review
Anti-severe acute respiratory syndrome coronavirus-2 adenoviral-vector vaccines trigger subclinical antiplatelet autoimmunity and increase of soluble platelet activation markersArticle Published on 2022-07-012023-07-09 Journal: British Journal of Haematology [Category] COVID19(2023년), [키워드] anti-SARS-CoV-2 vaccines antiplatelet autoantibodies blood clotting platelet activation platelet-derived microvesicles. [DOI] 10.1111/bjh.18245
Potential Autoimmunity Resulting from Molecular Mimicry between SARS-CoV-2 Spike and Human ProteinsSARS-CoV-2 스파이크와 인간 단백질 간의 분자 모방으로 인한 잠재적 자가면역Article Published on 2022-06-282022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Adverse reactions AlphaFold2 antibody Antibody binding Asymptomatic Autoimmune Autoimmunity calcium cardiac disease cause coronavirus coronavirus SARS-CoV-2 COVID-19 COVID-19 complication COVID-19 complications COVID-19 pathogenesis COVID-19 patients cross-reacting antibodies disease disorder Epitopes example explanation highlight host protein host proteins hotspot Human human proteins implication induce investigated involved machine learning mimicry molecular molecular dynamics molecular mimicry motif omicron outcomes platelet activation Potential PRKG1 Protein protein structure protein structure comparison reduce Regulation resulting SARS-CoV-2 SARS-CoV-2 spike spike Symptom therapeutic intervention therapeutic interventions thrombocytopenia Thrombopoietin tropomyosin Vaccine Vaccine design variant Viral Viral antigen viral antigens [DOI] 10.3390/v14071415 PMC 바로가기 [Article Type] Article
Shining a light on platelet activation in COVID-19COVID-19에서 혈소판 활성화에 빛을 비추다Article Published on 2022-06-012022-09-12 Journal: Journal of thrombosis and haemostasis : JTH [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] COVID-19 platelet activation [DOI] 10.1111/jth.15678 PMC 바로가기 [Article Type] Article
Weighted Gene Co-Expression Network Analysis to Identify Potential Biological Processes and Key Genes in COVID-19-Related StrokeCOVID-19 관련 뇌졸중의 잠재적 생물학적 과정 및 주요 유전자를 식별하기 위한 가중 유전자 공동 발현 네트워크 분석Article Published on 2022-05-092022-09-11 Journal: Oxidative Medicine and Cellular Longevity [Category] 유전자 메커니즘, [키워드] Analysis Biological biological processe Cell coronavirus disease COVID-19 Critical Cytoscape Cytoscape software cytosolic database dataset datasets elevated enrichment analysis Extracellular matrix FIVE Functional enrichment analysis gene co-expression network Gene Expression Omnibus Gene ontology Genes GEO hub genes identify indicated integrin integrin signaling Interaction Intervention involved ITGA2B ITGB3 KEGG Kyoto Lineage network pathway Pathways PI3K PI3K-Akt signaling Platelet platelet activation Potential receptor Research screened stroke target was used [DOI] 10.1155/2022/4526022 PMC 바로가기 [Article Type] Article
Integrated analysis of transcriptomic data reveals the platelet response in COVID-19 disease전사 데이터의 통합 분석은 COVID-19 질병에서 혈소판 반응을 나타냅니다Article Published on 2022-04-272022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] ACE-2 Activation aggregation Analysis Complication COVID-19 COVID-19 disease etiology expressed expressed gene expressed genes healthy controls healthy controls; increased risk infected with SARS-CoV-2 Infection inflammatory condition inflammatory state Invasion involved membrane Pathogenesis Patient Platelet platelet activation Platelets receptor reveal SARS-COV-2 infection severe COVID-19 single-cell systemic inflammatory thrombotic Thrombotic events transcriptomic data virus [DOI] 10.1038/s41598-022-10516-1 PMC 바로가기 [Article Type] Article
Platelet-monocyte interaction amplifies thromboinflammation through tissue factor signaling in COVID-19Research article Published on 2022-04-142022-10-05 Journal: Blood advances [Category] SARS, 바이오마커, 비임상, [키워드] activated Activation aggregate amplification amplify amplifying Analysis approach assays binding CD16 Coagulation Combination COVID-19 Critically ill patient driving Evidence Ex vivo exhibited expression fibrinogen function functional high risk highlight HLA-DR hypercoagulability hyperinflammation identify in vitro indicated Inflammation Inflammatory Inflammatory cytokine Inflammatory mediators inflammatory monocyte Interaction interleukin-1β life-threatening mechanism mechanisms monocyte P-selectin pathogenesis of COVID-19 Patient pharmacological Platelet platelet activation Platelets presenting proinflammatory cytokines receptor response RNA-sequencing SARS-COV-2 infection secretion severe COVID-19 Signaling single-cell subset thromboembolic complications Thromboinflammation tissue tumor necrosis factor-α with COVID-19 [DOI] 10.1182/bloodadvances.2021006680 [Article Type] Research article
SARS-CoV-2 Spike Protein Expression In Vitro and Hematologic Effects in Mice Vaccinated With AZD1222 (ChAdOx1 nCoV-19)AZD1222(ChAdOx1 nCoV-19) 백신을 접종한 쥐의 시험관 내 SARS-CoV-2 스파이크 단백질 발현 및 혈액학적 효과Article Published on 2022-04-122022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Adenovirus Adenovirus-vectored vaccine AZD1222 AZD1222 (ChAdOx1 nCoV-19) blood cell cells ChAdOx1 ChAdOx1 nCoV-19 change cleavage cleaved COVID-19 COVID-19 vaccination COVID-19 vaccine detectable Disease progression Effect Evidence expected expression hematologic hematology parameter Hematology parameters host cell host cells Host immune response host immune responses immediate effect immediate effects immune responses immunization immunohistochemistry in vitro in vivo Infection innate immune response intramuscular intravenous investigated mice morbidity morbidity and mortality nCoV neutrophil occurred parameters plasma concentration Platelet platelet activation platelet and white blood cell parameters. produced promote Protein prothrombotic state Respiratory failure response risk S1 protein S1 subunit SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein sera severe COVID-19 spike spike glycoprotein Spike protein the S1 subunit undetectable vaccination vectored vaccine vehicle Viral Viral particles White blood cell [DOI] 10.3389/fimmu.2022.836492 PMC 바로가기 [Article Type] Article
Platelet and immune signature associated with a rapid response to the BNT162b2 mRNA COVID-19 vaccineBNT162b2 mRNA COVID-19 백신에 대한 신속한 반응과 관련된 혈소판 및 면역 신호Article Published on 2022-04-012022-09-12 Journal: Journal of thrombosis and haemostasis : JTH [Category] COVID19(2023년), SARS, 진단, [키워드] aggregates B cells Biomarker BNT162b2 BNT162b2 mRNA CD31 circulating platelet COVID-19 COVID-19 vaccine Critical cytokine response dose effective Efficacy elevated enrolled eosinophils expressed feature females first dose healthy volunteer humoral identify immune response immune signature immune system Immunity inhibitory leukocyte median motif mounted mRNA-based COVID-19 vaccine mRNA-based vaccine neutralizing antibody non-classical monocyte of BNT162b2 participant Platelet platelet activation Platelet count rapid immune response rapid response reactive receptor responders second dose stability stimulate the vaccine Vaccine Vaccines Vascular [DOI] 10.1111/jth.15648 PMC 바로가기 [Article Type] Article
Treatment of vaccine-induced immune thrombotic thrombocytopenia (VITT)백신 유발 면역 혈전성 혈소판 감소증(VITT)의 치료Review Published on 2022-04-012022-09-12 Journal: Seminars in hematology [Category] MERS, 진단, [키워드] Adenovirus antibodies antibody anticoagulation Atypical ChAdOx1 nCoV-19 characterized Concentration coronavirus disease Corticosteroids COVID-19 disorder Disseminated intravascular coagulation ENhance Frequency heparin heparin-induced thrombocytopenia High-dose High-dose immune globulin (IVIG) immune in vitro inhibit inhibited intravenous Long Long VITT much higher Patient pharmacological plasma platelet activation prothrombotic recipient resulting Therapeutic plasma exchange Therapeutic plasma exchange (TPE) thrombosis thrombotic thrombotic complication Treatment Vaccine Vaccine-induced immune thrombotic thrombocytopenia (VITT). [DOI] 10.1053/j.seminhematol.2022.03.002 PMC 바로가기 [Article Type] Review