potential biomarkers – Page 3 – Communicable Diseases Research

In Silico Identification and Clinical Validation of a Novel Long Non-Coding RNA/mRNA/miRNA Molecular Network for Potential Biomarkers for Discriminating SARS CoV-2 Infection Severity

SARS CoV-2 감염 중증도를 판별하기 위한 잠재적 바이오마커에 대한 새로운 Long Non-Coding RNA/mRNA/miRNA 분자 네트워크의 실리코 식별 및 임상 검증

Article

Published on 2021-11-092022-09-11
Journal: Cells [Category] MERS, SARS, 바이오마커, 진단,

Transcriptomic studies revealed pathophysiological impact of COVID-19 to predominant health conditions

전사체 연구에 따르면 COVID-19가 주요 건강 상태에 미치는 병태생리학적 영향

Article

Published on 2021-11-052022-09-11
Journal: Briefings in Bioinformatics [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] ADAM8 Analysis association canakinumab Captopril Comorbidities Comorbidity coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 progression diabetes Diabetes Mellitus disease downregulation drug candidate dysregulated Factors gene expression analyses Genes genetic determinant genetic determinants health condition hypertension Inflammatory responses influence influences IRF7 lung cancer mechanism METTL7A Microarray MicroRNAs molecular basis MX2 Myocardial infarction notable outcome Pathogenesis pathophysiological Pathways patients Potential biomarker potential biomarkers PPARGC1A predominant prevalent prognostic provide Regulatory rilonacept RNA-Seq SARS-CoV-2 severity shared pathway shared pathways signaling pathway therapeutic transcription factor transcription factors upregulated gene upregulated genes upregulation
[DOI] 10.1093/bib/bbab197 PMC 바로가기 [Article Type] Article

Serum nitrite and nitrate: A potential biomarker for post-covid-19 complications?

혈청 아질산염 및 질산염: 코로나19 이후 합병증에 대한 잠재적 바이오마커?

Article

Published on 2021-11-012022-09-11
Journal: Free radical biology & medicine [Category] MERS, SARS, 바이오마커,

Elevated cytokines and chemokines in peripheral blood of patients with SARS-CoV-2 pneumonia treated with high-titer convalescent plasma

고역가 회복기 혈장으로 치료한 SARS-CoV-2 폐렴 환자의 말초혈액 내 사이토카인 및 케모카인 상승

Research Article

Published on 2021-10-292022-09-12
Journal: PLoS Pathogens [Category] MERS, SARS, 진단,

[키워드] acute respiratory distress acute respiratory distress syndrome addition administration Blood caused chemokine chemokines Clinical course clinical trial Cohort Concentration conducted contribute convalescent convalescent plasma Convalescent plasma therapy correlated Course COVID-19 COVID-19 pneumonia CRP cytokine Cytokine storm syndrome Cytokines Day Deterioration Disease progression Donor donors Efficacy elevated Elevation elevations evaluate fatality foundation healthy controls Hospitalization Hospitalized hospitalized COVID-19 hospitalized COVID-19 patient hospitalized COVID-19 patients IIa immune immune activation immune response IMPROVE increase in Inflammatory Inflammatory cytokines infusion institution Lung pathology mechanical ventilation MIP-1α MIP-1β Neutralizing antibodies neutralizing antibody Neutralizing titer observation outcomes pandemic Patient patients patients hospitalized patients with SARS-CoV-2 Peripheral blood phase plasma plasma sample plasma samples Pneumonia Potential biomarker potential biomarkers receive recipient recipients respiratory distress Respiratory distress syndrome resulting SARS-CoV-2 coronavirus SARS-COV-2 infection SARS-CoV-2 virus significant difference syndrome the cytokine storm the disease the patient the SARS-CoV-2 virus the timing track transfer treat treated Treatment unique virus while with COVID-19
[DOI] 10.1371/journal.ppat.1010025 PMC 바로가기 [Article Type] Research Article

CXCL10 levels at hospital admission predict COVID-19 outcome: hierarchical assessment of 53 putative inflammatory biomarkers in an observational study

입원 시 CXCL10 수준으로 COVID-19 결과 예측: 관찰 연구에서 추정되는 53개의 염증성 바이오마커에 대한 계층적 평가

Observational Study

Published on 2021-10-182022-09-10
Journal: Molecular Medicine [Category] MERS, SARS, 바이오마커, 임상,

[키워드] 95% CI Abstract age alarmins analysed Analysis approach AUC best Biomarker Biomarkers C-reactive protein C-reactive protein (CRP cART cause classification Combination Concentration confounding factors contribute COVID-19 COVID-19 patient COVID-19 severity predictors creatinine CXCL10 Cytokines data-driven death Decision tree determine discharge disease Growth factors healing Hierarchical hospital Hospital admission humoral hypoxia ICU identify Inflammation Inflammatory biomarker innate immune iron Iron metabolism Lactate lactate dehydrogenase LDH life-threatening lymphocyte metabolism Mild neuroendocrine neutrophil NLR outcome outcomes Patient Potential biomarker potential biomarkers predict Predictive prognostic Prognostic biomarkers Result risk Risk assessment robust SARS-COV-2 infection selected supplementary material survival survivor transfer was selected were used
[DOI] 10.1186/s10020-021-00390-4 PMC 바로가기 [Article Type] Observational Study

Upregulation of Human Endogenous Retroviruses in Bronchoalveolar Lavage Fluid of COVID-19 Patients

COVID-19 환자의 기관지폐포 세척액에서 인간 내인성 레트로바이러스의 상향 조절

Research Article

Published on 2021-10-062022-09-10
Journal: Microbiology Spectrum [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제,

[키워드] activated addition age analyzed BALF bronchial cell bronchial cells bronchial epithelial cell Bronchoalveolar lavage fluid Cancer cellular senescence changes in characterized China conditions controls Course COVID-19 COVID-19 patient COVID-19 patients COVID-19 pneumonia COVID-19 severity Disease progression disease severity dysregulated dysregulation element endogenous endogenous retroviruses epithelial cells examined explain exploration expression Families global pandemic groups HBEC HBECs healthy control healthy controls HERV HERVs Human human bronchial epithelial cells human endogenous retrovirus human endogenous retroviruses identify immune senescence increase in increasing age Infection Inflammation Inflammatory inflammatory pathway Inflammatory response Inflammatory responses Intensive lavage Local lung Lungs mechanism monocyte Monocytes Mortality Older age oncogene outcomes pathophysiological Patient PBMC PBMCs Peripheral blood peripheral blood monocytes Pneumonia populations Potential biomarker potential biomarkers potential therapeutic target provide recognize retroviral retrovirus risk factor SARS-CoV-2 senescent severe COVID-19 Severe COVID-19 pneumonia shown Transcriptome transcriptomes upregulated upregulation
[DOI] 10.1128/Spectrum.01260-21 PMC 바로가기 [Article Type] Research Article

A systematic review on SARS‐CoV‐2‐associated fungal coinfections

Review

Published on 2021-10-052022-10-04
Journal: Journal of medical virology [Category] MERS, SARS, 치료기술,

[키워드] Analysis approach B.1.1.7 B.1.351 B.1.427 Biomarker Black fungus Case report clinical settings clinician conducted contribute coronavirus 2 COVID‐19 COVID‐19 patient COVID‐19 detect Diabetes Mellitus Diagnosis diagnostic Diagnostic method eligible Factor Factors for inclusion Fungal infection globe Google Scholar help higher risk identify immune system Immunocompromised indicated Infection Intervention invasive mechanism mortality rate Mucormycosis Mutation Mycosis observational study pandemic Pandemics potential biomarkers potential risk radiological reported researcher resources respiratory response retrospective Risk factors SARS‐CoV‐2 searched severity significantly increased Strains suppressed systematic review Variation virulent were excluded WHO World Health Organization
[DOI] 10.1002/jmv.27358 PMC 바로가기 [Article Type] Review

Distinct Metabolic Profile Associated with a Fatal Outcome in COVID-19 Patients during the Early Epidemic in Italy

이탈리아의 초기 전염병 기간 동안 COVID-19 환자의 치명적인 결과와 관련된 독특한 대사 프로필

Observation

Published on 2021-09-012022-09-10
Journal: Microbiology Spectrum [Category] MERS, SARS, 바이오마커, 진단,

[키워드] alteration best change clinical condition Cohort Complete contribute coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients described Diagnosis diagnostic disease severity epicenter Fatal outcome identify independent Infection IRCCS Italian Italy lombardy metabolic metabolome metabolomics moderate moment mortality rate not correlated outcome oxygen oxygen demand pandemic Potential biomarker potential biomarkers predictive biomarkers profile Prognosis Prognostic factor Region SARS-COV-2 infection severe cases severe symptom severity starting point the disease the patient therapeutic Therapeutic treatment understanding unique
[DOI] 10.1128/Spectrum.00549-21 PMC 바로가기 [Article Type] Observation

An update comprehensive review on the status of COVID-19: vaccines, drugs, variants and neurological symptoms

Article

Published on 2021-08-302022-10-29
Journal: Turkish Journal of Biology [Category] COVID-19,

[키워드] acute respiratory syndrome addition antibody Antibody Response approval approved B.1.617 chronic disease clinical outcomes clinical trials convalescent plasma coronavirus correlation COVID-19 COVID-19 virus drugs Effect Efficacy evaluated immunization infections Lineage mAbs manifestation mutant neurological neurological manifestations Neurological symptom Neurological symptoms neutralization Neutralizing Neutralizing antibodies neutralizing monoclonal antibody P.1 potential biomarkers reported respiratory tract respiratory tract disorder SARS-CoV-2 Symptom target therapeutic drug therapy Treatment Vaccine vaccine candidate Vaccines variant variants variants of concern
[DOI] 10.3906/biy-2106-23 PMC 바로가기 [Article Type] Article

Immune characterization and profiles of SARS-CoV-2 infected patients reveals potential host therapeutic targets and SARS-CoV-2 oncogenesis mechanism

SARS-CoV-2 감염 환자의 면역 특성 및 프로필은 잠재적인 숙주 치료 표적 및 SARS-CoV-2 종양 발생 메커니즘을 나타냅니다

Article

Published on 2021-08-012022-09-11
Journal: Virus research [Category] SARS, 변종, 유전자 메커니즘,

[키워드] Analysis analyzed approved Bulk RNASeq analysis Cancer Cell Characteristics characterized clinical investigation contribute coronavirus COVID-19 COVID-19 infection COVID-19 pandemic COVID-19 patient COVID-19 patients COVID19 COVID19 patients Critical Cytokines develop differentially expressed disease pathogenesis disease severity E2F Emergency use expression FDA Gene expression analysis Host Host immune response host immune system human host identify immune Immune characterization of COVID19 patients immune factor immune profiling Immune profiling of COVID19 patients immunological immunological profile implicated Infection interferon Intervention investigated lymphopenia mechanism modulate modulated morbidity morbidity and mortality mortality rate NF-kB oncogenesis outbreak Outbreaks pandemic pathway Pathways Patient patients PKR Potential biomarker potential biomarkers Previous studies profile PROTECT protein targets Proteins RB1 reduce reveal RNAseq SARS-CoV-2 SARS-CoV-2 infected patient SARS-COV-2 infection scRNAseq severe COVID-19 patient severe COVID-19 patients severity of COVID-19 significant pathway significant pathways Single Cell Single cell scRNAseq analysis. Spread T cell T cell lymphopenia target the disease Therapeutic strategies therapeutic strategy therapeutic target therapeutic targets TNF transcription factor transcription factors treat upregulated Vaccine vaccine availability variant variants viral escape
[DOI] 10.1016/j.virusres.2021.198464 PMC 바로가기 [Article Type] Article