Identifying the molecular targets and mechanisms of xuebijing injection for the treatment of COVID-19 via network pharmacology and molecular docking네트워크 약리학 및 분자 도킹을 통한 COVID-19의 처리를위한 Xuebijing 주입의 분자 표적 및 메커니즘 식별Research Article Published on 2021-06-022022-08-31 Journal: Bioengineered [Category] 치료제, [키워드] acting affecting AKT1 alleviate baicalein clinical symptom Clinical symptoms connection COVID-19 Cytoscape disease severity enrichment analysis identify identifying IMPROVE indicated Inflammatory response ingredient inhibit injection lipopolysaccharide Luteolin mechanism modulate molecular docking molecular docking analysis molecular target network pharmacology NOS pathogenic pathway potential molecular predict quercetin R language regulate screened STRING target TCMSP therapeutic target therapeutic targets TNF treating COVID-19 Treatment UniProt was performed was used xuebijing injection [DOI] 10.1080/21655979.2021.1933301 PMC 바로가기 [Article Type] Research Article
Identifying the molecular targets and mechanisms of xuebijing injection for the treatment of COVID-19 via network pharmacology and molecular dockingResearch Article Published on 2021-06-022022-10-27 Journal: Bioengineered [Category] COVID-19, [키워드] acting affecting AKT1 alleviate baicalein clinical symptom connection COVID-19 Cytoscape disease severity enrichment analysis identify identifying IMPROVE indicated Inflammatory response ingredient inhibit injection Luteolin mechanism modulate molecular docking molecular docking analysis molecular target network pharmacology NOS pathogenic pathway potential molecular predict quercetin R language regulate screened target TCMSP therapeutic target TNF treating COVID-19 Treatment UniProt was performed was used xuebijing injection [DOI] 10.1080/21655979.2021.1933301 PMC 바로가기 [Article Type] Research Article
Identifying the molecular targets and mechanisms of xuebijing injection for the treatment of COVID-19 via network pharmacology and molecular dockingResearch Article Published on 2021-06-022022-10-27 Journal: Bioengineered [Category] Coronavirus, COVID-19, Fulltext, SARS, [키워드] acting affecting AKT1 alleviate baicalein clinical symptom connection COVID-19 Cytoscape disease severity enrichment analysis identify identifying IMPROVE indicated Inflammatory response ingredient inhibit injection Luteolin mechanism modulate molecular docking molecular docking analysis molecular target network pharmacology NOS pathogenic pathway potential molecular predict quercetin R language regulate screened target TCMSP therapeutic target TNF treating COVID-19 Treatment UniProt was performed was used xuebijing injection [DOI] 10.1080/21655979.2021.1933301 PMC 바로가기 [Article Type] Research Article
Unraveling the unbinding pathways of SARS-CoV-2 Papain-like proteinase known inhibitors by Supervised Molecular Dynamics simulationSupervised Molecular Dynamics 시뮬레이션을 통해 알려진 SARS-CoV-2 Papain-like proteinase 억제제의 결합 해제 경로 풀기Research Article Published on 2021-05-192022-09-10 Journal: PLoS ONE [Category] SARS, 치료제, [키워드] activity Behavior can be used characterized complex COVID-19 disease Critical Dynamics enzyme event inhibitor inhibitors molecular dynamics Papain Papain-like protease pathway Pathways PLPro Potential potential molecular protease Protein proteinase recent residue residues SARS-CoV-2 SARS-CoV-2 virus targets the SARS-CoV-2 virus therapy for COVID-19 Treatment X-ray crystallographic structure [DOI] 10.1371/journal.pone.0251910 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2: Pathogenesis, Molecular Targets and Experimental ModelsPharmacology Published on 2021-04-222022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE-2 acute respiratory syndrome Antiviral blood vessel organoid Calu-3 cause cell line cells clinical sample coronavirus COVID-19 develop drug design Drug discovery epithelial cell epithelial cells experimental model experimental models expression H1299 HEK-293 human Angiotensin-converting enzyme human lung inefficient Infection intestinal epithelial cells Intestinal Organoids investigated Laboratory lung organoids Model molecular molecular target Molecular targets morbidity and mortality mouse model Novel coronavirus outbreak outcomes pandemic Pathogenesis potential molecular Protein recent receptor Research researcher SARS-CoV-2 SARS-CoV-2 biology SARS-COV-2 infection sequencing data spike target targets the SARS-CoV-2 therapeutic transgenic Treatment outcome Vero cells viral genome viral life cycle viral pathogen viral pathogenesis Viral protein viral titer X-ray [DOI] 10.3389/fphar.2021.638334 PMC 바로가기 [Article Type] Pharmacology
The in-vitro effect of famotidine on sars-cov-2 proteases and virus replicationArticle Published on 2021-03-082022-10-04 Journal: Scientific Reports [Category] SARS, 신약개발, 치료제, [키워드] 3CL pro Administered analyzed antiviral activity antiviral drug approved assays bind cell lines clinical study Concentration coronavirus cough COVID-19 COVID-19 pandemic direct-acting Drug discovery function High dose hospitalized COVID-19 patients human cell improvement in silico In-vitro inhibit inhibitor intubation lack Lungs Medicine Mild moderate molecular mechanism Molecular medicine Mortality potential molecular protease Proteases reduced retrospective SARS-CoV-2 SARS-CoV-2 replication Shortness of breath Symptom target tested Treatment virus replication while [DOI] 10.1038/s41598-021-84782-w PMC 바로가기 [Article Type] Article
A network-informed analysis of SARS-CoV-2 and hemophagocytic lymphohistiocytosis genes’ interactions points to Neutrophil extracellular traps as mediators of thrombosis in COVID-19SARS-CoV-2와 hemophagocytic lymphohistiocytosis 유전자의 상호 작용에 대한 네트워크 기반 분석은 COVID-19의 혈전증 매개체로서 호중구 세포외 트랩을 가리킵니다.Research Article Published on 2021-03-082022-09-10 Journal: PLoS Computational Biology [Category] SARS, 유전자 메커니즘, [키워드] abnormal coagulation acting Adults Algorithm Algorithms Analysis approach children circulating co-morbidities co-morbidity Coagulation concert condition consequence COVID-19 described disease Diseases Endothelium environmental condition environmental conditions Epidemic extracellular trap extracellular traps favor feature Genetic genetic information H1N1 H1N1 influenza hematologic hemophagocytic lymphohistiocytosis HLH Host host gene hyperinflammation Hypothesis identify Immune cell immune cells increase increased risk individual inflammatory condition inflammatory conditions inflammatory process inflammatory signal inflammatory signals Influenza information Interaction life-threatening likelihood manuscript mechanism mediators Metabolic disorders morbidities NET NETs network neutrophil Neutrophils Pathogenesis pathogenic pathway Pathways potential mechanism potential molecular predict presenting problem Pulmonary thromboembolism regulate responsible risk SARS-CoV-2 serious complication severe COVID-19 severely ill patient severely ill patients similarities similarity tested Thromboembolism thrombosis thrombotic thrombotic complication Thrombotic complications trajectory underlying condition underlying conditions vascular thrombosis Viral protein Viral proteins [DOI] 10.1371/journal.pcbi.1008810 PMC 바로가기 [Article Type] Research Article
High frequency of cerebrospinal fluid autoantibodies in COVID-19 patients with neurological symptoms신경계 증상이 있는 코로나19 환자에서 뇌척수액 자가항체의 높은 빈도Article Published on 2021-03-012022-09-12 Journal: Brain, behavior, and immunity [Category] MERS, 진단, [키워드] absence analyzed autoantibodies autoantibody autoantigen Autoimmunity binding Brain brain tissue cerebrospinal fluid Clinical symptoms COVID-19 COVID-19 patient Critically ill CSF delirium disease Encephalitis Endothelium Epitopes explain Frequency ganglia hyperexcitability immunofluorescence Immunotherapy intensive care patient monoclonal murine neurological Neurological symptom NEUROLOGY neuronal NMDA olfactory Patient potential molecular presenting Protein receptor SARS-CoV-2 SARS-CoV-2 antibodies Seizures selected serum surface proteins Undetermined vessel Viral-triggered. virus-neutralizing antibody [DOI] 10.1016/j.bbi.2020.12.022 PMC 바로가기 [Article Type] Article
Computational Characterizations of the Interactions Between the Pontacyl Violet 6R and Exoribonuclease as a Potential Drug Target Against SARS-CoV-2Chemistry Published on 2021-01-212022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] acute respiratory syndrome Against Antiviral treatment binding candidate catalytic characterization coronavirus DEDDh exonucleases drug drug target enzyme Exoribonuclease Hydrogen bond hydrophobic interactions identify inhibitors Interaction Ligand Molecular dynamics simulation Orthocoronavirinae pontacyl violet 6R Potential potential molecular RNA-dependent RNA polymerase SARS-CoV-2 stability target Violet Virtual screening [DOI] 10.3389/fchem.2020.627340 PMC 바로가기 [Article Type] Chemistry
Inflammasome formation in the lungs of patients with fatal COVID-19치명적인 COVID-19 환자의 폐에서 Inflammasome 형성Article Published on 2021-01-012022-09-12 Journal: Inflammation research : official journal of the Eu [Category] 진단, [키워드] acute respiratory distress aggregate ARDS ASC Cardiopulmonary caspase-1 cleaved collected conducted control subject coronavirus SARS-CoV COVID-19 cytokine Cytokine release syndrome died disease domain embedded in paraffin Evidence expression fatal COVID-19 fixed formalin Hospitalized identify IL-1 in vitro Inflammasome Italy leukocytes lung Lung injury Macrophage NLRP3 NLRP3 inflammasome on mechanical ventilation Patient Pneumonia potential molecular Protein protein 3 Pulmonary infection recruitment Repository Sample SARS-CoV-2 significantly higher staining subject syndrome Trieste Trigger university viral infection [DOI] 10.1007/s00011-020-01413-2 PMC 바로가기 [Article Type] Article