mTOR regulation of metabolism limits LPS-induced monocyte inflammatory and procoagulant responses Research Published on 2022-08-262022-10-05 Journal: Communications Biology [Category] 바이오마커, 진단, [키워드] activate Analysis cardiovascular disease catalytic Coagulopathy expression gene product IL-1β IL-6 immune cell type Inflammatory Inflammatory response limit LPS mechanism metabolism monocyte Monocytes mTOR inhibitor NAD+ pathway polyfunctional responses primary human monocyte pro-inflammatory pro-inflammatory cytokine procoagulant Regulation response risk Support tested tissue TLR4 transcriptional activity transcriptional response Treatment with HIV [DOI] 10.1038/s42003-022-03804-z [Article Type] Research
Withania somnifera (L.) Dunal (Ashwagandha) for the possible therapeutics and clinical management of SARS-CoV-2 infection: Plant-based drug discovery and targeted therapyArticle Published on 2022-08-152022-11-15 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 치료제, [키워드] ACE2 ACE2 receptors acute respiratory syndrome Analysis Anti-viral antiviral activity article Ashwagandha build Clinical management Compound coronavirus Coronavirus disease 2019 COVID-19 Critical disease drug Drug discovery flu help Immune homeostasis implicated Infection Inflammation information inhibit knowledge management MPro multiple organs organs other compounds pandemic parameter Patient patients Population pro-inflammatory cytokine protease provided Regulation SARS-CoV-2 SARS-COV-2 infection secure Side effect Standardization targeted therapy the patient Treatment Vaccine virus was performed Withania somnifera [DOI] 10.3389/fcimb.2022.933824 PMC 바로가기
Circulating microRNA signatures associated with disease severity and outcome in COVID-19 patientsArticle Published on 2022-08-112022-11-15 Journal: Frontiers in Immunology [Category] SARS, 치료제, [키워드] 95% CI adaptive immune responses Angiogenesis antiviral response antiviral responses asymptomatic infection AUROC Biomarker Biomarkers chemokines circulating miRNA clinical condition collected Combination COVID-19 COVID-19 pathogenesis COVID-19 patient DE miRNA death differentially expressed disease disease severity downregulation driven by experiment Genes healthy control heart failure highlighting Hospital admission human cell impairment in vitro induce Inflammation inhibit Innate immunity interferon involved leukocyte life threatening Lung disease Lung epithelial cells Lung fibrosis microRNA Mild miR-4433b-5p miRNA miRNA signature miRNAs moderate modulated Mortality organ damage outcome Patient predicted pro-inflammatory cytokine pro-inflammatory factors provided RNA-sequencing SARS-CoV-2 SARS-COV-2 infection Sensitivity and specificity serum serum sample severe COVID-19 severe disease severity Stress subset the cytokine storm upregulation Vascular damage was performed with COVID-19 [DOI] 10.3389/fimmu.2022.968991 PMC 바로가기
T-cell recovery and evidence of persistent immune activation 12 months after severe COVID-19심각한 COVID-19 이후 12개월 동안 T 세포 회복 및 지속적인 면역 활성화의 증거Article Published on 2022-08-012022-09-11 Journal: Allergy [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] accompanied acute infection administration analyzed assays Asymptomatic CD38 CD4 CD8 Characteristics clinical recovery coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine Critical Cytometry dysregulated immune response enrolled Evidence evidence of exhibited exhibiting expression flow cytometry Follow-up functional hallmark HLA-DR immune activation impairment independent independent of individual Infection investigated lymphopenia Mild Most patients normalization Patient persistent phenotype phenotypic Post-infection pro-inflammatory cytokine proteomics recovery SARS-CoV-2 severe COVID-19 severe COVID-19 patient severe COVID-19 patients subgroup of patient T cell T cells T-cell T-cell activation T-cell Response These cells timepoint viral antigens [DOI] 10.1111/all.15372 PMC 바로가기 [Article Type] Article
JAK inhibition as a new treatment strategy for patients with COVID-19Review article Published on 2022-08-012022-10-05 Journal: Biochemical pharmacology [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료법, [키워드] AAK1 ACE-2 acute respiratory syndrome adverse outcomes angiotensin-converting enzyme 2 Bacterial infection blockers caused clinical trial clinical trials Combination coronavirus coronavirus disease Corticosteroids Course COVID-19 Critical cytokine Cytokine storm Cytokines Cytokines storm develop discharge Disease progression dysregulated effective Epidemic Future GAK greater herpes zoster Host ICU admission IL-2 IL-6 IL-6 receptor immune improve clinical outcome increased risk Infection Inflammation inhibit inhibiting involved Jak JAK inhibition JAK inhibitor Jak-STAT JAK/STAT JAK/STAT signaling janus medication medications Mortality MOST new treatment strategy offer pathway Patient patients with COVID-19 pro-inflammatory cytokine raised regulate released SARS-CoV-2 severe pneumonia significantly Spread Thromboembolic events TNF-α Transcription transmembrane protein Treatment upregulated viral endocytosis virus virus infection WHO guideline [DOI] 10.1016/j.bcp.2022.115162 [Article Type] Review article
The Prospective Effect of Allopurinol on the Oxidative Stress Index and Endothelial Dysfunction in Covid-19코로나19의 산화 스트레스 지수와 내피 기능 장애에 대한 알로퓨리놀의 전향적 효과Article Published on 2022-08-012022-09-11 Journal: Inflammation [Category] COVID19(2023년), SARS, 바이오마커, [키워드] addition Admission allopurinol antioxidant Biomarker Biomarkers clinical outcomes cohort study correlated COVID-19 patients COVID-19 severity CRP CT scan Cytokines Cytopathic effect D-dimer dimer discharge Effect endothelial Endothelial dysfunction Endothelin Endothelin-1 enzyme ET-1 evaluated ferritin Gout Hospitalization index Inflammatory Inflammatory biomarker inflammatory biomarkers inflammatory disorder inflammatory disorders inflammatory disorders. inflammatory reaction LDH lymphocyte metabolism neutrophil NLR oxidative oxidative stress Patient pro-inflammatory cytokine pro-inflammatory cytokines procalcitonin procalcitonin) Propagation Prospective protective effect purine recruited reduced reported SARS-CoV-2 Serum level severe COVID-19 severe COVID-19 patients severity significantly single-center Standard therapy standard treatment standard treatment alone three groups Treatment triggered uric acid Viral viral infections xanthine [DOI] 10.1007/s10753-022-01648-7 PMC 바로가기 [Article Type] Article
Human surfactant protein D facilitates SARS-CoV-2 pseudotype binding and entry in DC-SIGN expressing cells, and downregulates spike protein induced inflammation인간 계면활성제 단백질 D는 DC-SIGN 발현 세포에서 SARS-CoV-2 유사형 결합 및 진입을 촉진하고 스파이크 단백질 유도 염증을 하향 조절합니다Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] ACE2 Analysis Anti-viral binding carbohydrate cause Cell cell interaction cell line cell surface receptor cells chemokine chemokines collectins controls COVID-19 cytokine cytokine response Cytokines DC-SIGN dendritic cell domain downregulate downregulated eight epithelial expressing facilitate fragment of HEK 293T HEK293T cell HEK293T cells help Human IFN-α IL- 6 IL-1β IL-8 immune function immune response immunomodulatory effect increase independent independent of infection assay infection assays Inflammation inhibit SARS-CoV-2 innate immune innate immune system Interaction intercellular involved Macrophage macrophages MHC class MHC class II modulating mRNA expression mRNA level mRNA levels N-terminal naïve T cell naïve T cells NF-κB pathogen Pathogens pro-inflammatory cytokine pro-inflammatory cytokines Protein pseudotype RANTES receptors Replication rfhSP-D. RNA virus RT-qPCR SARS- CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 spike protein shown SIGN spike Spike protein surface receptor T cells the Spike THP-1 TNF-α treated Treatment Vero Cell Vero cells viral entry viruses [DOI] 10.3389/fimmu.2022.960733 PMC 바로가기 [Article Type] Article
Melatonin: Regulation of Viral Phase Separation and Epitranscriptomics in Post-Acute Sequelae of COVID-19멜라토닌: COVID-19의 급성 후유증에서 바이러스 상 분리 및 Epitranscriptomics의 조절Review Published on 2022-07-232022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료법, [키워드] Activation acute infection alteration antiviral immune response blockade change changes Concentration COVID-19 DDX3X depolarization derepression distress early infection ENhance envelope protein Epigenetic Evolution G3BP1 Genome genomic Glycolysis GSK-3 herd immunity Host host cell host genome human host immune immune responses Immunity induce Infection influence LINE1 liquid-liquid phase separation m6A maintain manifestation mechanisms melatonin membrane microenvironment mitochondrial modifications morphology nuclear nucleocapsid outcome oxidative oxidative stress PASC phase Prevent pro-inflammatory cytokine promote PROTECT regulate resulting RNA SARS-CoV-2 virus separation sequestration Signaling signaling cascades significantly Stress stress granule stress granules Support suppress switching the SARS-CoV-2 the SARS-CoV-2 virus Transcription transcriptomic viral genome viral persistence viral replication Viral RNA virus [DOI] 10.3390/ijms23158122 PMC 바로가기 [Article Type] Review
Nasal-spraying Bacillus spores as an effective symptomatic treatment for children with acute respiratory syncytial virus infectionRandomized Controlled Trial Published on 2022-07-202022-10-06 Journal: Scientific Reports [Category] 진단, [키워드] Bacillus children clinical study demonstrated effective Efficacy faster Impact Infection Inflammation nasopharyngeal sample pro-inflammatory cytokine Randomized reducing respiratory respiratory syncytial virus RSV spore Symptom Symptomatic treatment Symptoms tract Treatment Vaccine viral infection Viral load virus was reduced [DOI] 10.1038/s41598-022-16136-z PMC 바로가기 [Article Type] Randomized Controlled Trial
Clinical, laboratory data and inflammatory biomarkers at baseline as early discharge predictors in hospitalized SARS-CoV-2 infected patients입원한 SARS-CoV-2 감염 환자의 조기 퇴원 예측인자로 기준선에서의 임상, 실험실 데이터 및 염증성 바이오마커Article Published on 2022-07-142022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Admission AUC baseline Beta C-reactive protein category CD25 clinical collected Corticosteroid Corticosteroids cytokine Cytokines D-dimers dehydrogenase Determination discharge discharged Factor group help hospital Hospitalization Hospitalized hospitals identify IMPROVE independent Inflammatory Inflammatory biomarker interferon interleukin laboratory data laboratory parameter Lactate lactate dehydrogenase logistic regression models Macrophage Male sex Mild mild patient mild patients Negative predictive value neutrophil NLR not need NPV oxygen oxygen saturation Oxygen therapy Patient performed plasma plasma sample plasma samples Positive predictive value PPV predict Predictive Predictive value predictor pro-inflammatory cytokine pro-inflammatory cytokines Protein receptor Regression model SARS-CoV-2 infected patient SARS-COV-2 infection SARS-CoV-2 pandemic sensitivity severity Spanish specificity Transmission Treatment variable virus worsening [DOI] 10.1371/journal.pone.0269875 PMC 바로가기 [Article Type] Article