Proinflammatory response – Page 3 – Communicable Diseases Research

Intestinal Host Response to SARS-CoV-2 Infection and COVID-19 Outcomes in Patients With Gastrointestinal Symptoms

위장 증상이 있는 환자의 SARS-CoV-2 감염 및 COVID-19 결과에 대한 장 숙주 반응

Multicenter Study

Published on 2021-06-012022-09-11
Journal: Gastroenterology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술,

Distinct cytokine profiles associated with COVID-19 severity and mortality

Clinical Trial

Published on 2021-06-012022-10-05
Journal: The Journal of Allergy and Clinical Immunology [Category] SARS, 임상,

[키워드] Accuracy acute respiratory syndrome Analysis Antigen association characteristic Combination coronavirus coronavirus disease correlated COVID-19 COVID-19 patient Critical cytokine Cytokine concentration cytokine profile determine dominant ECMO elevated exhibited extracorporeal membrane oxygenation Hospital admission Hospitalization IFN-α IFN-β IL-10 IL-6 IL-8 independent interferon interferon response interferons mechanical ventilatory support Mortality oxygen support Patient patients Predictive principal-component analysis profiles Proinflammatory cytokine Proinflammatory response reported respiratory severity resulting risk serum serum cytokines severity symptomatic patient TNF-α Treatment Type-I interferons validation cohort was used were measured with COVID-19
[DOI] 10.1016/j.jaci.2021.03.047 PMC 바로가기 [Article Type] Clinical Trial

Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation

결함 있는 NET 제거는 COVID-19 관련 폐 혈전 염증에서 지속적인 FXII 활성화에 기여합니다

Research paper

Published on 2021-05-142022-09-11
Journal: EBioMedicine [Category] 유전자 메커니즘,

[키워드] accumulation Activation activity alveolar alveolar spaces Analysis clearance clinical Coagulation coagulation factor Coagulopathy Contact contribute coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients DNase Donor European expression Extracellular factor XII FIBRIN finding foundation funding FXII hallmark hallmarks Hamburg healthy control immunostaining in vitro increased mortality Inflammation leads lung lung parenchyma lung tissue mechanism NET NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps offer pathogenic Pathologies Patient performed plasma sample plasma samples procoagulant Proinflammatory response proteomic Proteomic analysis Pulmonary thrombo-inflammation reduced Support supported sustained targeting therapeutic strategy thrombosis union vasculature was increased
[DOI] 10.1016/j.ebiom.2021.103382 PMC 바로가기 [Article Type] Research paper

Repurposing Treatment of Wernicke–Korsakoff Syndrome for Th-17 Cell Immune Storm Syndrome and Neurological Symptoms in COVID-19: Thiamine Efficacy and Safety, In-Vitro Evidence and Pharmacokinetic Profile

Pharmacology

Published on 2021-03-022022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] Administered alcohol Anti-inflammatory clinical study condition Control COVID-19 COVID-19 cytokine storm COVID-19 patient Cytokine storm disease disorder dose doses effective Effectiveness elevated healthy volunteer humans identify IL-17 IL-22 immune in vitro study increase in Intervention literature review macrophage cell line measure metabolic conditions Neurological symptom occur pandemic Patient patients pharmacokinetic profile proinflammatory Proinflammatory cytokine Proinflammatory response repurposing respond Safe Safety Septic shock severe cases significantly storm subsequent tested Th17 Th17 response the cytokine storm Thiamine treated Treatment viral infection was performed
[DOI] 10.3389/fphar.2020.598128 PMC 바로가기 [Article Type] Pharmacology

COVID-19: Imbalanced Immune Responses and Potential Immunotherapies

COVID-19: 불균형한 면역 반응 및 잠재적 면역 요법

Review

Published on 2021-01-292022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive immune system Asymptomatic caused contrary convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 Corticosteroids COVID-19 COVID-19 vaccines Critical disease Evidence facilitate gamma globulin high infectiousness IL-6R IL-6R blockade immune function immune mechanism immunological immunomodulation Immunotherapy infected individual infected individuals Infection interferon intravenous intravenous gamma globulin majority Mild symptom mild symptoms morbidity and mortality pandemic coronavirus Pathogenesis Patient Potential Proinflammatory response respiratory response SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe SARS severe SARS-CoV-2 thymosin thymosin alpha1 tissue repair Viral
[DOI] 10.3389/fimmu.2020.607583 PMC 바로가기 [Article Type] Review

Cytokine storm in aged people with CoV-2: possible role of vitamins as therapy or preventive strategy

Review

Published on 2020-08-312022-10-28
Journal: Aging Clinical and Experimental Research [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome Antiviral ARDS arising Autoimmune disease Characteristics characterized coronavirus CoV-2 COVID-19 CRS Cytokine release syndrome deaths deficiency defined Efficacy health emergency Host hydrosoluble immune response immune system Immune system dysfunction individual induce Infection International lethality rate life-threatening mechanism Micronutrient Mortality pathological condition phenotype proinflammatory Proinflammatory response protocol Regulatory Result SARS SARS-CoV-2 SARS-COV-2 infection searched subject T-cell the epidemic therapeutic therapeutic strategy therapy Treatment Vitamin vitamins WHO
[DOI] 10.1007/s40520-020-01669-y PMC 바로가기 [Article Type] Review

Auxora versus standard of care for the treatment of severe or critical COVID-19 pneumonia: results from a randomized controlled trial

중증 또는 치명적인 COVID-19 폐렴의 치료를 위한 Auxora 대 표준 치료: 무작위 대조 시험의 결과

Research

Published on 2020-08-142022-08-13
Journal: Critical Care [Category] MERS, 임상,

[키워드] 95% CI Abstract Administered adverse event Auxora baseline blinded calcium Calcium release-activated calcium Calcium release-activated calcium channel inhibitors channel inhibitor conducted COVID-19 COVID-19 pneumonia CRAC CRAC channel inhibitor CRAC channel inhibitors Critical cytokine demonstrated died dose Efficacy Enrollment FDA Fewer patient Fewer patients Guidance intravenously Invasive mechanical ventilation mechanical ventilation median time nine novel Open-label open-label study design Ordinal Scale outcome PaO Patient patient population patients with COVID-19 placebo-controlled study Pneumonia Proinflammatory cytokine Proinflammatory response proportion Pulmonary endothelium randomization Randomized Randomized controlled trial rate ratio receive receiving Regulatory respiratory respiratory complication Respiratory complications Result resulting risk safety profile Serious Adverse Event Serious Adverse Events Severe COVID-19 pneumonia significantly Standard of care study enrollment the median Time to recovery Tolerability transition Treatment Trial registration Two patient two patients
[DOI] 10.1186/s13054-020-03220-x PMC 바로가기 [Article Type] Research

COVID-19 meets Cystic Fibrosis: for better or worse?

Research

Published on 2020-06-302022-10-05
Journal: Genes and Immunity [Category] 변종, 유전자 메커니즘, 임상, 치료제,

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

Research Article

Published on 2018-10-092022-10-29
Journal: mBio [Category] Coronavirus,

[키워드] absence Activation acute respiratory syndrome Adaptive immune response animal models ARDS Bacterial cascade chemokine chemokines complement contributed controls coronavirus Coronavirus infection Critical cytokine Defense disease distress dysfunction effective exhibited fungal infections high-titer virus Host human infection identify immune Immune cell infiltration Infection Inflammatory cytokine inflammatory monocyte inhibiting intranasal investigated less lung Lung pathology mice mouse-adapted SARS-CoV neutrophil observation outbreak outcome outcomes Pathogenesis pathologic pathology pattern recognition receptor Proinflammatory response Protective reduced regulate relative Replication respiratory Respiratory disease respiratory viruses SARS-CoV SARS-CoV infection sera Severe case Signaling significantly stimulate subsequent syndrome systemic inflammation therapeutic These data Treatment Viral load weight loss
[DOI] 10.1128/mBio.01753-18 PMC 바로가기 [Article Type] Research Article

Porcine epidemic diarrhea virus nucleoprotein contributes to HMGB1 transcription and release by interacting with C/EBP-β

Research Paper

Published on 2016-11-152022-10-28
Journal: Oncotarget [Category] Coronavirus,