Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected CellsArticle Published on 2021-11-202022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] antiviral activity antiviral therapeutics cellular Characteristics Combination complex Contact COVID-19 drug Drug discovery effective Host human cells impacted inhibit inhibiting Interaction investigated Ligand molecular docking pathway property receptor Receptor binding Replication representing SA4503 SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 mutation SARS-CoV-2 protein sigma sigma-1 receptor Specific therapeutic Toxicity Treatment treatment strategy variants of concern virus virus infection [DOI] 10.3390/pathogens10111514 PMC 바로가기 [Article Type] Article
Advancing African Medicines Agency through Global Health Diplomacy for an Equitable Pan-African Universal Health Coverage: A Scoping ReviewReview Published on 2021-11-092022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] Advancing African African Medicines Agency AMA article aspect China Consensus COVID-19 Critical disease Efficacy equity European extension global health good quality Google Scholar Health health diplomacy Health services health systems highlight identify India Intellectual intellectual property rights literature review mechanism Medicine Mortality property Regulatory regulatory authority resources review right secure seeking South–South cooperation Strategy Support union Universal Universal health coverage Vaccine Vaccines was done Web of Science worsened [DOI] 10.3390/ijerph182211758 PMC 바로가기 [Article Type] Review
Broad Spectrum Antiviral Properties of Cardiotonic Steroids Used as Potential Therapeutics for Emerging Coronavirus InfectionsArticle Published on 2021-11-022022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] activity administration Analysis analyzed anti-coronavirus activity Antiviral antiviral activity antiviral drug antiviral property Calu3 cell Cardiotonic cardiotonic steroid Compound coronavirus Coronavirus infection Coronavirus infections COVID-19 death develop differentially expressed gene digitoxin dose gene expression patterns immunofluorescence indicated inhibit MERS MERS-CoV MERS-CoV infection oral bioavailability pharmacokinetics Potential property repeated SARS-CoV SARS-CoV-2 SARS-CoV-2 coronavirus Seven Spectrum stability steroid suggested therapeutic Therapeutics these compounds Toxicity treated variety virus-infected cells [DOI] 10.3390/pharmaceutics13111839 PMC 바로가기 [Article Type] Article
Tie2 activation protects against prothrombotic endothelial dysfunction in COVID-19Tie2 활성화는 COVID-19의 혈전성 내피 기능 장애로부터 보호합니다Research Article Published on 2021-10-222022-09-10 Journal: JCI Insight [Category] SARS, 유전자 메커니즘, [키워드] accompany Activation AKB-9778 alteration angiopoietin Anticoagulant Antithrombotic assessment Autopsy changes in circulating Coagulation Cohort Concentration COVID-19 demonstrated disease severity Disruption dysfunction endothelial Endothelial cell endothelial cells Endothelial dysfunction endothelial marker Endothelial markers expression Genes highest highlight Inflammation inhibit inhibited Microvascular thrombosis Mild moderate Patient patients with COVID-19 Pharmacologic phenotypic plasma procoagulant promoted property PROTECT prothrombotic prothrombotic state rationale receptor released reversed severe COVID-19 Signaling small molecule survival therapy These data thrombosis treated Trial upregulated Vascular Biology [DOI] 10.1172/jci.insight.151527 PMC 바로가기 [Article Type] Research Article
A New Transmuted Generalized Lomax Distribution: Properties and Applications to COVID-19 DataResearch Article Published on 2021-10-072022-10-31 Journal: Computational Intelligence and Neuroscience [Category] Coronavirus, MERS, SARS, [키워드] application bootstrap Characteristics Complete confidence interval COVID-19 demonstrated distribution distributions Features flexible form France Generalized include introduced likelihood maximum New Other parameter property real-world data Rényi entropy Research United Kingdom utility [DOI] 10.1155/2021/5918511 PMC 바로가기 [Article Type] Research Article
Anti-flavivirus Properties of Lipid-Lowering DrugsPhysiology Published on 2021-10-072022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] analyzed Antiviral antiviral target Antiviral treatment antivirals cholesterol drug Effect effective fatty acids FDA-approved drug Flaviviridae flavivirus Host Infection infections Lipid lipid metabolism lipids metabolic pathway metformin Pathogens property Regulation replicative required Safe shown signaling pathway statins triggered Vaccine virus ZIKV [DOI] 10.3389/fphys.2021.749770 PMC 바로가기 [Article Type] Physiology
A Bioinformatics Approach for the Prediction of Immunogenic Properties and Structure of the SARS-COV-2 B.1.617.1 Variant Spike Protein면역 원성 특성의 예측 및 SARS-COV-2의 구조 B.1.617.1 변이 스파이크 단백질의 생물 정보학 접근법Research Article Published on 2021-10-052022-09-10 Journal: BioMed Research International [Category] 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Amino acid amino acid sequence Analysis analyzed Antigen antigenic B cell B cell epitopes B- and T-cell epitopes B.1.617.1 bioinformatics chemokine Coronavirus-2 COVID-19 drug Epitopes IFN immune function immunogenic Immunological response immunological responses in silico analysis in silico Approach incidence interferon Interferon-gamma mitigate Mortality objective predicted prediction property Protective Protein protein structure provide Region respiratory Respiratory illness responsible Result S protein S protein of SARS-CoV-2 SARS-CoV 2 SARS-CoV-2 second wave sequence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 spike Structure subunit T cell T cell epitope T cell epitopes T-cell epitopes tertiary structure Vaccine variant variant of SARS-CoV-2 variant S protein was used [DOI] 10.1155/2021/7251119 PMC 바로가기 [Article Type] Research Article
A Bioinformatics Approach for the Prediction of Immunogenic Properties and Structure of the SARS-COV-2 B.1.617.1 Variant Spike ProteinResearch Article Published on 2021-10-052022-10-27 Journal: BioMed Research International [Category] [키워드] acute respiratory syndrome Amino acid Analysis analyzed Antigen antigenic B cell B cell epitopes B.1.617.1 bioinformatics chemokine Coronavirus-2 COVID-19 IFN immune function immunogenic Immunological response in silico analysis in silico Approach incidence mitigate Mortality objective predicted prediction property Protective Protein provide Region Respiratory illness responsible Result S protein SARS-CoV 2 SARS-CoV-2 second wave sequence spike Structure subunit T cell epitope T cell epitopes T-cell epitopes Vaccine variant variant of SARS-CoV-2 variant S protein was used [DOI] 10.1155/2021/7251119 PMC 바로가기 [Article Type] Research Article
A Bioinformatics Approach for the Prediction of Immunogenic Properties and Structure of the SARS-COV-2 B.1.617.1 Variant Spike ProteinResearch Article Published on 2021-10-052022-10-27 Journal: BioMed Research International [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Amino acid Analysis analyzed Antigen antigenic B cell B cell epitopes B.1.617.1 bioinformatics chemokine Coronavirus-2 COVID-19 IFN immune function immunogenic Immunological response in silico analysis in silico Approach incidence mitigate Mortality objective predicted prediction property Protective Protein provide Region Respiratory illness responsible Result S protein SARS-CoV 2 SARS-CoV-2 second wave sequence spike Structure subunit T cell epitope T cell epitopes T-cell epitopes Vaccine variant variant of SARS-CoV-2 variant S protein was used [DOI] 10.1155/2021/7251119 PMC 바로가기 [Article Type] Research Article
Biginelli Reaction Mediated Synthesis of Antimicrobial Pyrimidine Derivatives and Their Therapeutic PropertiesReview Published on 2021-10-042022-10-30 Journal: Molecules [Category] Coronavirus, SARS, [키워드] Anti-inflammatory anticancer antimicrobial antimicrobial resistance Antimicrobials antioxidant antitubercular Antiviral antiviral property Biginelli reaction blockers catalyst Compound compounds coronavirus COVID-19 derivative dihydropyrimidininones global public health Mediated pandemic property reaction reported Research resulting Structure synthesis therapeutic [DOI] 10.3390/molecules26196022 PMC 바로가기 [Article Type] Review