Pharmacophore based virtual screening for natural product database revealed possible inhibitors for SARS-COV-2 main protease천연물 데이터베이스에 대한 약전 기반 가상 스크리닝을 통해 SARS-COV-2 주요 프로테아제에 대한 가능한 억제제가 밝혀졌습니다.Article Published on 2022-05-012022-09-11 Journal: Virology [Category] COVID19(2023년), SARS, 치료제, [키워드] absence antiviral drug approved candidate Candidates Compound compounds COVID-19 COVID-19 pandemic COVID-19 virus database diterpene drug effort eight Ent-kaurane enzyme Health Infection inhibitor inhibitors main protease inhibitors molecular docking MPro Nature nucleus overcome pharmacophore positive problems protease protease inhibitors proteinase provide reported SARS-CoV-2 SARS-CoV-2 main protease suggested terpenoids triggered Virtual screening virus infection [DOI] 10.1016/j.virol.2022.03.003 PMC 바로가기 [Article Type] Article
Covalent narlaprevir- and boceprevir-derived hybrid inhibitors of SARS-CoV-2 main proteaseSARS-CoV-2 주요 프로테아제의 공유 narlaprevir 및 boceprevir 파생 하이브리드 억제제Article Published on 2022-04-272022-09-11 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] active site Antiviral antiviral property antivirals appear binding boceprevir candidate characterization comparable comparison complex component COVID-19 vaccines Critical Cys145 drug target Effectiveness explain Hepatitis hepatitis C in vitro inhibitor inhibitors of SARS-CoV-2 Interaction intrinsic joint M pro narlaprevir performed PF-07321332 protease Protease inhibitor protease inhibitors Protonation reaction relative residue SARS-CoV-1 SARS-CoV-2 variant Therapeutic treatment virus replication [DOI] 10.1038/s41467-022-29915-z PMC 바로가기 [Article Type] Article
Progress on SARS-CoV-2 3CLpro Inhibitors: Inspiration from SARS-CoV 3CLpro Peptidomimetics and Small-Molecule Anti-Inflammatory CompoundsSARS-CoV-2 3CLpro 억제제에 대한 진행 상황: SARS-CoV 3CLpro 펩티드 모방체 및 소분자 항염 화합물에서 영감Review Published on 2022-04-082022-09-11 Journal: Drug design, development and therapy [Category] Coronavirus, COVID19(2023년), SARS, 치료제, [키워드] 3CLpro accelerate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-inflammatory anti-inflammatory agents anti-inflammatory effect Anti-inflammatory effects Antiviral antiviral target caused Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Health inhibitor inhibitors inspiration life cycle pathophysiological peptidomimetics Progress protease protease inhibitors Protein proteinase SARS-CoV SARS-CoV-2 sequence homology Sequencing severe acute respiratory syndrome Coronavirus similarity small-molecule inhibitors. viral life cycle whole-genome sequencing [DOI] 10.2147/DDDT.S359009 PMC 바로가기 [Article Type] Review
There is nothing exempt from the peril of mutation – The Omicron spike돌연변이의 위험에서 예외는 없다 - 오미크론 스파이크Review Published on 2022-04-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] ACE2 angiotensin angiotensin-converting enzyme 2 antibody approach approved binding caused Corona Corona virus COVID-19 COVID-19 therapy elevated entry pathway enzyme followed by Health Organization healthcare Healthcare system Interaction kinase inhibitors manuscript mutated Mutation omicron Omicron variant pandemic protease inhibitors RBD Receptor binding domain referred to researcher responsible risk spike Spike protein target the spike protein therapy Transmission Treatment Vaccine variant variant of concern verge Virus Disease VoC WHO World Health Organization [DOI] 10.1016/j.biopha.2022.112756 PMC 바로가기 [Article Type] Review
Multiple SARS-CoV-2 Variants Exhibit Variable Target Cell Infectivity and Ability to Evade Antibody Neutralization다양한 SARS-CoV-2 변이체가 다양한 표적 세포 감염성과 항체 중화 회피 능력을 나타냄Article Published on 2022-03-162022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 진단, [키워드] Ability addition antigenicity B.1.617.2 BBIBP-CorV BBIBP-CorV vaccine binding affinity blocked changed CoronaVac CoronaVac vaccine coronavirus disease Coronavirus disease 2019 COVID-19 D614G elicited Evolution of SARS-CoV-2 exacerbated host cell host cells Immune escape immune evasion in viral infect Infection Infectivity inhibit inhibitors less mAb mAbs monoclonal antibody Multiple Mutation Neutralizing Neutralizing antibodies neutralizing antibody pandemic polyclonal antibodies polyclonal antibody Protease inhibitor protease inhibitors Protein proteolytic provide pseudovirus receptor S protein SARS-coronavirus SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sera significantly stomatitis susceptible cell target the S protein therapeutic vaccination variable variant variants variants of concern vesicular stomatitis vesicular stomatitis virus Viral viral entry viral infection viral infectivity virus infection VoC was used were assessed [DOI] 10.3389/fimmu.2022.836232 PMC 바로가기 [Article Type] Article
Oral antivirals for the prevention and treatment of SARS-CoV-2 infectionSARS-CoV-2 감염 예방 및 치료를 위한 경구용 항바이러스제Article Published on 2022-03-012022-09-11 Journal: AIDS reviews [Category] SARS, 변종, 치료제, [키워드] advent Antiviral antiviral therapy antivirals benefit classical combination therapies combination therapy complications COVID-19 COVID-19 disease COVID-19 pandemic Disease progression dissemination Each early treatment Emergency use authorization escape mutant Formulation Infection landscape life-threatening Long-ActingAntivirals manifestation medications Medicine molnupiravir monoclonal antibodies monoclonal antibody Mutagenesis Nirmatrelvir offer oral Oral Remdesivir parenteral administration polymerase Prevent Prophylaxis protease protease inhibitors PROTECT provided reduce regulatory agencies regulatory agency Remdesivir required SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease small molecule treat Treatment Vaccine variant viral illnesses waning immunity [DOI] 10.24875/AIDSRev.22000001 PMC 바로가기 [Article Type] Article
A multi-stage virtual screening of FDA-approved drugs reveals potential inhibitors of SARS-CoV-2 main proteaseFDA 승인 약물의 다단계 가상 스크리닝은 SARS-COV-2 주 프로테아제의 잠재적 억제제를 보여줍니다.Article Published on 2022-03-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis antiviral target applied approach approved binding mode caused Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment crystal structure crystal structures docking drug drug candidate drug candidates Drug repurposing extension FDA-approved drug filtration FIVE flavonoid followed by free energy functional protein H-bond health emergency identify inhibitor inhibitors inhibitors of SARS-CoV-2 M pro maturation MD simulations molecular molecular docking molecular dynamics pharmacophore Potential protease protease inhibitors protein-ligand interaction protocol reported repurposing respiratory responsible reveal RMSD SARS-CoV-2 SARS-CoV-2 main protease severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 trajectory Treatment Viral Virtual screening [DOI] 10.1080/07391102.2020.1837680 PMC 바로가기 [Article Type] Article
Identification of Potential Antiviral Inhibitors from Hydroxychloroquine and 1,2,4,5-Tetraoxanes Analogues and Investigation of the Mechanism of Action in SARS-CoV-2Article Published on 2022-02-042022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, COVID19(2023년), SARS, [키워드] 6M0J ACE2 receptor Action analogue antimalarial Antiviral binding affinity biological activity carcinogenicity compounds COVID-19 database evaluated FIVE identification identify in vitro in vivo inhibitor Interaction intestinal investigated investigation mechanism of action molecular molecular docking molecular docking studies MPro PDB penetration pharmacokinetic Potential protease inhibitors receptor Receptor-binding domain risk SARS-CoV-2 selected Structure structures Virtual screening was performed was used were used [DOI] 10.3390/ijms23031781 PMC 바로가기 [Article Type] Article
In Silico Molecular Characterization of Human TMPRSS2 Protease Polymorphic Variants and Associated SARS-CoV-2 SusceptibilityArticle Published on 2022-02-032022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] 2019 coronavirus disease acute respiratory syndrome addition Alter Analysis analyzed Camostat mesylate cell entry characterization complex coronavirus COVID-19 develop docking drug examined global pandemic glycoprotein Health care system high affinity host susceptibility Human Infection inhibitors Interaction interactions intermolecular interaction investigated molecular molecular docking nafamostat pandemic Polymorphic Polymorphisms predicted protease inhibitors Protective proteolytic cleavage reported responsible S glycoprotein SARS-CoV-2 SARS-CoV-2 spike serine protease serine protease inhibitors Spike protein Spread Structural analysis susceptibility the SARS-CoV-2 TMPRSS2 transmembrane serine protease treating COVID-19 patients Type variant variants Variation [DOI] 10.3390/life12020231 PMC 바로가기 [Article Type] Article
Targeting SARS-CoV-2 Proteases for COVID-19 Antiviral DevelopmentChemistry Published on 2022-02-032022-10-31 Journal: Frontiers in Chemistry [Category] COVID-19, [키워드] 3CLpro acute respiratory syndrome adopted antiviral drug antivirals approved biochemical assay candidate cells coronavirus COVID-19 Critical curtail death development Disease progression drug effective Evolution facilitate food highly pathogenic hospitalized patients Host IMPROVE Infection inhibition inhibitor inhibitory effect innate immune responses main protease maturation moderate MPro Occurrence Papain-like protease Peptide inhibitor PLPro Potential Prophylactic protease protease inhibitors Research SARS-CoV-2 SARS-CoV-2 protease sustained targeting targets therapeutic efficacy Treatment vaccination rate Vaccine Viral protein viral replication viral variant virus [DOI] 10.3389/fchem.2021.819165 PMC 바로가기 [Article Type] Chemistry