Widespread occurrence of covalent lysine-cysteine redox switches in proteins단백질에서 공유 라이신-시스테인 산화 환원 스위치의 광범위한 발생Article Published on 2022-04-012022-09-11 Journal: Nature chemical biology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 binding coronavirus cysteine cysteines database DNA domain effectors enzyme Gene Expression homeostasis human protein human proteins instances life lysine motif nitrogen NOS Occurrence oxygen Pathogens pathophysiological conditions physiological plant pathogens Protein protein structure Proteins Regulatory reported SARS-CoV-2 severe acute respiratory syndrome Coronavirus Signaling substrates sulfur trivalent variants whole protein [DOI] 10.1038/s41589-021-00966-5 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Mutations and COVID-19 Clinical Outcome: Mutation Global Frequency Dynamics and Structural Modulation Hold the KeySARS-CoV-2 돌연변이 및 COVID-19 임상 결과: 돌연변이 글로벌 주파수 역학 및 구조 변조가 핵심Article Published on 2022-03-212022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 변종, 유전자 메커니즘, 치료법, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus addition Analysis analyzed Characteristics clinical Clinical data Clinical features Clinical outcome clinical outcomes Cohort comprehensive analysis coronavirus coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 pandemic disease disease outcome disease severity distribution driving Dynamics Effect effort Frequency Genomic surveillance global frequency flip Healthcare system identify Impact management mechanism molecular molecular dynamics Molecular dynamics simulation Mortality mortality group Mutation mutation analysis mutations nucleocapsid Occurrence outcome pandemic Patient patients performed Protein protein structure provide recovered patient recovered patients SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe disease progression significantly Spectrum stability temporal dynamics the mortality group two group two groups variants variants of concern variants of interest viral genome virus VOCs [DOI] 10.3389/fcimb.2022.868414 PMC 바로가기 [Article Type] Article
Mutations and Evolution of the SARS-CoV-2 Spike ProteinSARS-CoV-2 스파이크 단백질의 돌연변이와 진화Review Published on 2022-03-192022-09-11 Journal: Viruses [Category] SARS, 변종, 유전자 메커니즘, [키워드] Alpha Alter alterations arising Beta binding can be used cellular entry COVID-19 Critical Delta Effect ENhance Evolution FIVE functions Gamma genesis Health Organization immune Immune escape Infectivity mechanism Mutation new SARS-CoV-2 occur omicron potential mechanism potential mechanisms protein structure SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 spike protein SARS-CoV-2 strain SARS-CoV-2 variants Scientific community spike Spike protein strain the SARS-CoV-2 the spike protein variant variants viral infection Virus neutralization World Health Organization [DOI] 10.3390/v14030640 PMC 바로가기 [Article Type] Review
Computational investigation reveals that the mutant strains of SARS-CoV2 have differential structural and binding properties전산 조사에 따르면 SARS-CoV2의 돌연변이 균주는 차등적인 구조 및 결합 특성을 가지고 있습니다Article Published on 2022-03-012022-09-11 Journal: Computer methods and programs in biomedicine [Category] SARS, 변종, 유전자 메커니즘, [키워드] approaches binding binding affinity caused computational method Computational methods Course docking exhibited functional genetic variants host protein Infection manifested MD simulation mechanism molecular molecular basis molecular dynamics mutant mutant strain Mutant strains network network analysis over pandemic Pathogenesis persistent infection Protein protein structure protein-protein interaction RBD Receptor binding domain reveal SARS-CoV2 Scientific community Severe acute respiratory syndrome strain Structure Transmission utility V367F V483A variant variants virus wildtype [DOI] 10.1016/j.cmpb.2021.106594 PMC 바로가기 [Article Type] Article
Conformational variability of loops in the SARS-CoV-2 spike proteinSARS-CoV-2 스파이크 단백질 루프의 구조적 가변성Article Published on 2022-03-012022-09-11 Journal: Proteins [Category] SARS, 변종, [키워드] Accuracy Analysis applied binding Characteristics Cluster cluster analysis conformation conformational conformational ensembles conformations COVID-19 decoy selection facilitate flexible identify involved loop loop modeling Protein Protein binding Protein Data Bank protein structure protein structure prediction Region SARS-CoV-2 spike sequence sequence variants. Spike protein structures targets the S protein the SARS-CoV-2 Variability variants viral infection while [DOI] 10.1002/prot.26266 PMC 바로가기 [Article Type] Article
Structure- and Interaction-Based Design of Anti-SARS-CoV-2 AptamersAnti-SARS-CoV-2 앱타머의 구조 및 상호 작용 기반 설계Article Published on 2022-02-242022-09-11 Journal: Chemistry (Weinheim an Der Bergstrasse, Germany) [Category] COVID19(2023년), SARS, 변종, [키워드] approach aptamer Aptamers binding binding affinity blueprint complexes computational method Computational methods Cytometry develop Directed mutagenesis DNA docking drug design ENhance fragment molecular orbitals method functional IMPROVE in silico Infection Interaction iterative methodology molecular molecular docking molecular dynamics molecules Mutagenesis nucleic acids offer pathogen probes Protein protein structure Receptor-binding domain SARS-CoV-2 SARS-CoV-2 spike protein SAXS scratch speed Spike protein Structure synergy target target protein tertiary structure the receptor-binding domain the SARS-CoV-2 time-consuming variants X-ray scattering [DOI] 10.1002/chem.202104481 PMC 바로가기 [Article Type] Article
Glycosylation and Serological Reactivity of an Expression-enhanced SARS-CoV-2 Viral Spike Mimetic발현이 강화된 SARS-CoV-2 바이러스 스파이크 모방체의 당화 및 혈청학적 반응성Research Article Published on 2022-01-302022-09-10 Journal: Journal of Molecular Biology [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] Abstract analysed Analysis antibody antigenic capture changes in clinical sample clinical samples COVID-19 patient COVID-19 patients detect discrepancies exhibit expression Extensive feature globe glycoprotein Glycoproteins glycosylation HexaPro IgA IgG IgM response IgM responses impacted include infected individual infected individuals Mimetic N-linked glycan N-linked glycans N-linked glycosylation observation performed Perturbation prefusion conformation proline proline substitution Protein protein structure reactivity S protein SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 S protein SARS-CoV-2 spike sera serological serological activity serological assessment serological studies serology spike stability Substitution substitutions trimeric spike Variation variations Viral viral glycoprotein viral glycoproteins virus viruses [DOI] 10.1016/j.jmb.2021.167332 PMC 바로가기 [Article Type] Research Article
SCoV2-MD: a database for the dynamics of the SARS-CoV-2 proteome and variant impact predictionsSCoV2-MD: SARS-CoV-2 단백질체의 역학 및 변이체 영향 예측을 위한 데이터베이스Article Published on 2022-01-072022-09-11 Journal: Nucleic Acids Research [Category] SARS, 변종, [키워드] Amino acid amino acid substitution Analysis analyzed antibody attributes binding affinities binding affinity build database dynamic Evolution experiment GISAID group hydrogen hydrogen bonding include Interaction interactions Local Metrics molecular molecular data molecular dynamics Mutation nine pandemic Phylogenetic Point mutation produced Protein protein structure proteome resource SARS-CoV-2 proteome sequenced solvent steric the SARS-CoV-2 trajectory variant variety Viral protein Viral proteins [DOI] 10.1093/nar/gkab977 PMC 바로가기 [Article Type] Article
Prediction of the effects of the top 10 nonsynonymous variants from 30229 SARS-CoV-2 strains on their proteins30229 SARS-CoV-2 균주의 상위 10개 동의어가 아닌 변이체가 단백질에 미치는 영향 예측Article Published on 2022-01-062022-09-11 Journal: F1000Research [Category] SARS, 변종, [키워드] addition affecting Amino acid amino acid residue Analysis analyzed bioinformatics cause co-mutation computational studies Computational study consequence COVID-19 D614G Deleterious Effect Frequency functions highest Impact in vitro in vivo Multiple studies Mutation N protein N501Y nine nonsynonymous mutation nonsynonymous mutation. Nonsynonymous mutations nonsynonymous variant Nsp12 nsp5 ORF1 ORF1a ORF1b ORF3 ORF3a outbreak P323L pathogen prediction Protein protein structure Proteins Q57H reported S protein SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genome sequences SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 strain SARS-CoV-2 virus stability Structure the SARS-CoV-2 genome wild type Wuhan Wuhan, China [DOI] 10.12688/f1000research.72904.2 PMC 바로가기 [Article Type] Article
Tracking SARS-CoV-2 Spike Protein Mutations in the United States (January 2020—March 2021) Using a Statistical Learning Strategy통계 학습 전략을 사용하여 미국에서 SARS-COV-2 스파이크 단백질 돌연변이 추적 (2020 년 1 월-2021 년 3 월)Article Published on 2021-12-212022-09-10 Journal: Viruses [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alignment Analysis analyzed applied approach complementary coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 D1118H eight false discovery rate functional genomic Genomic surveillance GISAID highlight homology homology modelling identify identifying L452R learning MONITOR mutations proportion Protein protein sequence protein structure q-value reference strain residue respiratory SARS-CoV-2 sequence severe acute respiratory syndrome Coronavirus spatiotemporal spike Spike protein Spike protein sequence statistical statistical learning strain Strains Strategy Substitution supported Surveillance temporal dynamics the United State United States unsupervised learning variant variants variants of concern variants of interest Viral viral residue variant VOCs VOIs was performed [DOI] 10.3390/v14010009 PMC 바로가기 [Article Type] Article