protein synthesis – Page 3 – Communicable Diseases Research

SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis

Research

Published on 2021-05-122022-10-05
Journal: Nature [Category] SARS, 유전자 메커니즘,

The SARS‐unique domain (SUD) of SARS‐CoV and SARS‐CoV‐2 interacts with human Paip1 to enhance viral RNA translation

Article

Published on 2021-04-202022-10-31
Journal: The EMBO Journal [Category] COVID-19, SARS,

Targeting the DEAD-Box RNA Helicase eIF4A with Rocaglates—A Pan-Antiviral Strategy for Minimizing the Impact of Future RNA Virus Pandemics

Review

Published on 2021-03-052022-10-29
Journal: Microorganisms [Category] COVID-19,

[키워드] Antiviral broad-spectrum antiviral broad-spectrum antivirals candidate caused cellular complex Compound coronavirus COVID-19 CR-31-B drug eIF4A eukaryotic translation exhibiting fraction Future Helicase highlight host mRNA Impact increase in inhibitors inhibitory effect interactions Intervention limit maintaining mechanism of action mRNA outbreak pan-antiviral Pandemics protein synthesis Region Replication resulting RNA RNA secondary structure RNA virus RNA viruses rocaglates safety profile sequence Side effects silvestrol Strategy targeting therapeutic translation translation initiation unique Vaccine viral mRNA zoonotic origin Zotatifin
[DOI] 10.3390/microorganisms9030540 PMC 바로가기 [Article Type] Review

Saporin, a Polynucleotide-Adenosine Nucleosidase, May Be an Efficacious Therapeutic Agent for SARS-CoV-2 Infection

폴리뉴클레오티드-아데노신 뉴클레오시다아제인 사포린은 SARS-CoV-2 감염에 효과적인 치료제가 될 수 있습니다

Article

Published on 2021-03-012022-09-11
Journal: SLAS discovery : advancing life sciences R & D [Category] 진단, 치료제,

[키워드] (rRNA abasic site acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adenine agent Apoptosis Cell characteristic conserved coronavirus Coronavirus 2019 COVID-19 drug efficacious therapeutic enzymatic activity eukaryotic cells focus Genomic DNA high stability Hyperactivation Immunotherapy induce Infection inhibitor N-glycosidase Nucleosidase Pathways polymerase Protein protein synthesis residue respiratory ribosomal RNA RNA rRNA saporin. SARS-CoV-2 severe acute respiratory syndrome Coronavirus Signal transduction Stress stress response therapeutic therapeutic agents toxin Treatment type I
[DOI] 10.1177/2472555220970911 PMC 바로가기 [Article Type] Article

mTOR inhibition: a double-edged sword in patients with COVID-19?

mTOR 억제: COVID-19 환자의 양날의 검?

Article

Published on 2021-03-012022-08-31
Journal: Human Cell [Category] MERS, 신약개발,

Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient virus replication

코로나바이러스 엔도리보뉴클레아제 nsp15에 의한 항바이러스 스트레스 과립 형성 억제로 효율적인 바이러스 복제 보장

Research Article

Published on 2021-02-262022-08-13
Journal: PLoS Pathogens [Category] Biochemistry, MERS, 치료법,

[키워드] accumulation Activation affected aggregation Analysis antagonist antagonists Anti-viral Antiviral array cells conserved coronavirus Coronavirus infection Coronaviruses Critical Crosstalk decrease demonstrated Depletion dsRNA eIF2α ENCODE endoribonuclease Evidence Factors function Heat shock Host host antiviral response host cell host response IBV IBV infection IFN response IFN-β immune response immunofluorescence analysis include increase infected cells Infection Infectious Bronchitis Virus inhibiting inhibition innate immune interfere Interference intrinsic IRF3 knowledge mechanism mRNAs NaCl Nsp15 overcome overexpressed Pattern recognition pattern recognition receptor Pattern recognition receptors PEDV Phosphorylation PKR prevalent Prevent Protein protein synthesis provided PRRs Recognition recruitment reducing Replication reported responsible RNA viruses SARS-CoV SARS-CoV-2 scaffold proteins shown Signaling sodium sodium arsenite Stress stress granule stress response suppression TGEV Transcription translation Trigger triggered turn Viral viral dsRNA virus virus replication viruses wild type
[DOI] 10.1371/journal.ppat.1008690 PMC 바로가기 [Article Type] Research Article

Effects of Cell Proteostasis Network on the Survival of SARS-CoV-2

Review

Published on 2021-02-222022-10-27
Journal: Biological Procedures Online [Category] COVID-19,

[키워드] addition Apoptosis association Autoimmune Autoimmunity Cell chaperone chaperones contribute coronavirus COVID-19 Degradation Effect Endoplasmic reticulum ENhance epitope ER stress Evidence expression Factor Gene Expression heat shock protein Host Hsps immune system include increase in induce infect Infection Interaction macromolecules molecular Necrosis network Part Protein protein synthesis Proteins proteolytic Proteostasis Reactions replicate SARS-CoV-2 SARS-COV-2 infection severe SARS-CoV-2 Spread Stress target cells unfolded protein response UPR viral infection Viral protein virus
[DOI] 10.1186/s12575-021-00145-9 PMC 바로가기 [Article Type] Review

Dynamic competition between SARS-CoV-2 NSP1 and mRNA on the human ribosome inhibits translation initiation

SARS-CoV-2 NSP1과 인간 리보솜의 mRNA 간의 동적 경쟁은 번역 개시를 억제합니다

408

Published on 2021-02-092022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, 유전자 메커니즘,

[키워드] 40S absence accommodation acute respiratory syndrome acute respiratory syndrome coronavirus beta-CoV beta-CoVs bind binding biochemical biochemically causative agent cellular complexes coronavirus COVID-19 pandemic determine disrupt downstream dynamic eukaryotic translation eukaryotic translation initiation facilitate Factor Factors focus Host human pathogen human ribosome Infection inhibit initiation factors Interaction Messenger RNA modulate modulated molecular MONITOR mRNA mRNAs nsp1 open Prevent Protein protein synthesis real time required respiratory ribosomal subunit ribosome RNA SARS-CoV-2 SARS-CoV-2 NSP1 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Significance single-molecule fluorescence start codon subunit Support translation translation initiation virulence virulence factor virus viruses
[DOI] 10.1073/pnas.2017715118 PMC 바로가기 [Article Type] 408

Off-Target In Vitro Profiling Demonstrates that Remdesivir Is a Highly Selective Antiviral Agent

오프 타겟 시험관 내 프로파일링은 렘데시비르가 고도로 선택적인 항바이러스제임을 보여줍니다

Article

Published on 2021-01-202022-09-11
Journal: Antimicrobial Agents and Chemotherapy [Category] 치료제,

[키워드] 50% effective concentration addition adenosine aerobic agent Anti-SARS-CoV-2 Activity Antiviral Antiviral agents assays biochemical biochemical assay cells cellular cellular respiration Concentration coronavirus COVID-19 cytotoxicity demonstrated DNA DNA and RNA Effect elicit epithelial cells evaluated Filovirus filoviruses GS-5734 human airway human airway epithelial human airway epithelial cells human cell human cell line human cell lines human cells inhibitor Interaction Last MERS MERS-CoV metabolic conditions metabolite Mitochondria mitochondrial mitochondrial DNA mitochondrial respiration nucleoside nucleoside analogs oxygen polymerases primary cells Profiling protein synthesis ranged RDV reactive oxygen species Remdesivir reported resulting safety profile SARS-CoV SARS-CoV-2 selective selectivity indices target tested Toxicity Treatment triphosphate turn Viral Viral RNA
[DOI] 10.1128/AAC.02237-20 PMC 바로가기 [Article Type] Article

A Review on Plant Bioactive Compounds and Their Modes of Action Against Coronavirus Infection

Pharmacology

Published on 2021-01-112022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] 3CL pro Action affected Against Anti-viral anti-viral drug Antiviral treatment Chinese clinician combating Compound compounds coronavirus disease Coronavirus infection COVID-19 criteria cysteine protease database demonstrated described drug help Herb host immunity Houttuynia cordata identify in silico in vitro in vivo include mechanism medication medicinal plant Medicine mode MOST natural products outbreak Papain-like protease pathway penetration plant Protein protein synthesis Region researcher review Sambucus SARS SARS-CoV-2 screened selected Symptoms therapeutic drug Traditional traditional Chinese medicine (TCM) treat Treatment vaccine candidate viral illnesses viral infection Viral RNA virus
[DOI] 10.3389/fphar.2020.589044 PMC 바로가기 [Article Type] Pharmacology