Editorial: Unveiling novel aspects of SARS-CoV-2 to combat COVID-19Genetics Editorial Published on 2024-02-212024-09-05 Journal: Frontiers in Genetics [Category] update2024, [키워드] COVID-19 Evolution genome sequecing protein synthesis SARS-CoV-2 [DOI] 10.3389/fgene.2024.1383640 PMC 바로가기 [Article Type] Genetics Editorial
SARS-CoV-2 protein ORF8 limits expression levels of Spike antigen and facilitates immune evasion of infected host cellsarticle Published on 2023-06-232024-09-05 Journal: Brain stimulation [Category] update2024, [키워드] Antibody-mediated immunity COVID-19 endoplasmic reticulum (ER) ORF8 plus-stranded RNA virus protein synthesis protein-protein interaction SARS-CoV-2 spike Vaccine [DOI] 10.1016/j.jbc.2023.104955 PMC 바로가기 [Article Type] article
SARS-CoV-2 Harnesses Host Translational Shutoff and Autophagy To Optimize Virus Yields: the Role of the Envelope (E) Proteinarticle Published on 2023-01-092024-09-05 Journal: Microbiology Spectrum [Category] update2024, [키워드] autophagy ER stress HSV-1 HSV-1 γ1 34.5 protein PERK protein synthesis SARS-CoV-2 SARS-CoV-2 E protein translation control virus replication [DOI] 10.1128/spectrum.03707-22 PMC 바로가기 [Article Type] article
Hesperetin and the PI3K/AKT pathway: Could their interaction play a role in the entry and replication of the SARS-CoV-2?Article Published on 2022-09-012022-11-16 Journal: Journal of food biochemistry [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Anti-inflammatory antioxidant antiviral properties cell proliferation changes COVID-19 Effect Evidence hesperetin hesperetin. host cell host cells Inflammatory response Inflammatory responses Interaction involved molecular mechanism pathogenesis of SARS-CoV-2 pathway pharmacological PI3K/AKT Potential treatment protein synthesis Replication SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection signaling pathway subsequent therapeutic effect viral entry Viral particles [DOI] 10.1111/jfbc.14212 PMC 바로가기
Characterization and Utilization of Disulfide-Bonded SARS-CoV-2 Receptor Binding Domain of Spike Protein Synthesized by Wheat Germ Cell-Free Production System밀 배아 무세포 생산 시스템에 의해 합성된 스파이크 단백질의 이황화 결합 SARS-CoV-2 수용체 결합 도메인의 특성화 및 활용Article Published on 2022-07-012022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 receptor Analysis bind cell-free protein synthesis characterization contribute COVID-19 COVID-19 therapeutics Disulfide disulfide bond Drug screening Endoplasmic reticulum evaluate Express functional Germ immunogenicity Interaction Mutation PDI Production Protein protein disulfide isomerase protein synthesis Rapid RBD RBD protein RBD-ACE2 SARS-CoV-2 SARS-CoV-2 SP spike Spike protein System translational utilization Vaccine viral infection Viral variants wheat [DOI] 10.3390/v14071461 PMC 바로가기 [Article Type] Article
SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodiesSARS-CoV-2 숙주 차단은 타고난 NK 세포 기능에 영향을 미치지만 항체 의존적 NK 활성은 스파이크가 아닌 항체를 통해 강력하게 활성화됩니다Article Published on 2022-05-192022-09-11 Journal: eLife [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료법, [키워드] a minor activated activating Activation ADCC ADNKA Analysis antibody Cell cellular immunity correlated cytokine dependent on Depletion Disease progression dominant downregulation Effect Efficacy epithelial cells evade expression functions genetic risk factors identify immune response Immunity immunology Impact implication infected cell Infection Infectious disease Inflammation Innate immunity interferon interferon response Ligand Lung epithelial cells mechanism membrane MHC-I MICA Microbiology minor Most patients natural infection Nectin1 neutralisation NK cell NK cells nsp1 nsp14 nucleocapsid occurred ORF3a outcome overcome Pathogenesis patients pro-inflammatory cytokine protein synthesis Proteins proteomic reduction in response SARS-CoV-2 SARS-CoV2 second dose specific antibodies spike-specific antibodies Spike-specific antibody surface protein sustained the disease ULBP2 understanding vaccination Vaccine Vaccine design vaccine efficacy Vaccine-induced immunity virus viruses [DOI] 10.7554/eLife.74489 PMC 바로가기 [Article Type] Article
The “LLQY” Motif on SARS-CoV-2 Spike Protein Affects S Incorporation into Virus ParticlesSARS-CoV-2 스파이크 단백질의 "LLQY" 모티프는 S가 바이러스 입자에 통합되는 데 영향을 줍니다.Article Published on 2022-03-232022-09-11 Journal: Journal of Virology [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Affect Alter Amino acid amino acid residue amino acids antiviral drug antiviral drugs assembly biological significance Biosynthesis caused Cell culture cleavage cleavage site cleavage sites cleaved conformational conservation conserved Contact contribute coronavirus COVID-19 epidemic Critical demonstrated Effectiveness expressed glycoprotein hydrogen Hydrogen bond hydrogen bonds incorporation Infection intrachain junction key amino acid key amino acids less Lineage LLQY domain membrane fusion motif mutated Mutation Neutralizing antibodies Particle Prevent processing producer cell protease Protein protein synthesis protein synthesis and cleavage Pseudotyped virus pseudovirus pseudoviruses reduce residue S protein S1/S2 SARS-CoV-2 SARS-CoV-2 pseudoviruses SARS-CoV-2 variant SARS-CoV-2 variants sensitivity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein stability subcellular localization synthesis the S protein the SARS-CoV-2 Transmission tyrosine Vaccines viral entry viral infection virus virus assembly Virus-like particle virus-like particles [DOI] 10.1128/jvi.01897-21 PMC 바로가기 [Article Type] Article
Potential Antiviral Action of AlkaloidsReview Published on 2022-01-282022-10-30 Journal: Molecules [Category] COVID-19, [키워드] acting Action alkaloid alkaloids Antiviral antiviral activity antiviral agent antiviral drug antiviral therapeutics biological activities cause Characteristics Concentration DNA DNA and RNA Effect effective Efficacy Efficiency effort Evidence highlight humans identify Infection inhibition inhibitory concentration molecular morbidity and mortality natural products outbreak Pandemics plants Potential protein synthesis public health emergency Research RNA Safe specificity targets Treatment Vaccine Viral diseases viral entry viral replication virus viruses [DOI] 10.3390/molecules27030903 PMC 바로가기 [Article Type] Review
The Landscape of Aminoacyl-tRNA Synthetases Involved in Severe Acute Respiratory Syndrome Coronavirus 2 InfectionPhysiology Published on 2022-01-262022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] acute respiratory syndrome addition Amino acid Aminoacyl-tRNA aminoacyl-tRNA synthetase analyzed co-immunoprecipitation co-IP coronavirus coronavirus 2 correlation COVID-19 CoVs cytoplasmic database develop downregulation EARS2 enzyme eukaryotic Evolution expand experiment function HARS2 highly pathogenic human CoVs identify implicated in viral Infection Interaction Interaction network involved key factor landscape M protein mitochondrial mRNA levels Organisms pathway Perspective Phosphorylation physical protein level protein synthesis proteomic provide respiratory SARS-CoV-2 SARS-COV-2 infection Synthetase TARS2 the shortest path transcriptomic translation tRNA [DOI] 10.3389/fphys.2021.818297 PMC 바로가기 [Article Type] Physiology
Towards detection of SARS-CoV-2 RNA in human saliva: A paper-based cell-free toehold switch biosensor with a visual bioluminescent output인간 타액에서 SARS-CoV-2 RNA 검출을 향하여: 시각적 생물발광 출력이 있는 종이 기반 무세포 발가락 스위치 바이오센서Article Published on 2022-01-252022-09-11 Journal: New biotechnology [Category] SARS, 치료기술, [키워드] activated addition administration bioluminescent biosensor cell-free protein synthesis CFPS complex Concentration COVID-19 COVID-19 pandemic decrease develop diagnostic diagnostic procedure diagnostic procedures disrupt distribution equipment Express facilitate generate Health help Infection layperson less limit of detection murine nucleic acid Nucleic acid diagnostic platform point-of-care Protein protein synthesis reporter Research RNase inhibitor Saliva saliva samples SARS-CoV-2 RNA sequence Seven Support test cassette Toehold switch. Transmission TXTL while widespread [DOI] 10.1016/j.nbt.2021.09.002 PMC 바로가기 [Article Type] Article