Enhanced Label-Free Nanoplasmonic Cytokine Detection in SARS-CoV-2 Induced Inflammation Using Rationally Designed Peptide AptamerArticle Published on 2022-11-022022-11-15 Journal: ACS applied materials & interfaces [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome Analysis Antibody-derived peptide aptamer (ADPA) applied aptamer Biomarker coronavirus COVID-19 patients cytokine detection Detection limit Disease progression disorders enhanced IL-6 immune pathway Immune status immunoassay immunoassays in vitro induced Inflammation inflammatory status information interleukin 6 (IL-6 Interluekin-6 (IL-6) Interpretation limit of detection localized surface plasmon resonance (LSPR) magnitude nanoplasmonic immunoassay pandemic pathogenic inflammation Patient peptide Predictive profile Prognosis provide quantification Rapid SARS-CoV-2 serum serum cytokine Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). [DOI] 10.1021/acsami.2c14748 PMC 바로가기
Virtual screening of quinoline derived library for SARS-COV-2 targeting viral entry and replicationArticle Published on 2022-11-012022-11-15 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] added antibiotic antimalarial Antiviral approved binding domain Bruton tyrosine kinase inhibitors China claimed contagious Control country COVID-19 pandemic Dependent disease domain drug drug design FDA in viral in-depth analysis increase Infection inhibiting inhibitor Interaction interfere M pro MD simulation number of infected outbreak Papain Population protease provide Psychological distress quinoline based FDA approved Drugs. RBD Remdesivir Replication required resource RNA RNA dependent RNA polymerase RNA polymerase RNA virus SARS-CoV-2 selected Spike protein spread to target Vaccines viral entry viral replication Virtual screening [DOI] 10.1080/07391102.2021.1913228 PMC 바로가기
Accurate identification of SARS-CoV-2 variant delta using graphene/CRISPR-dCas9 electrochemical biosensorArticle Published on 2022-11-012022-11-15 Journal: Talanta [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Accurate identification amplified B.1.617.2 Beta clinical samples clinical sensitivity clinical specificity CRISPR-dCas9 Delta Detection limit develop electrochemical biosensor Gamma identify other variants probe provide reproducibility SARS-CoV-2 SARS-CoV-2 variant selective the SARS-CoV-2 variant Variant delta. variant of SARS-CoV-2 [DOI] 10.1016/j.talanta.2022.123687 PMC 바로가기
Understanding and combating COVID-19 using the biology and chemistry of SARS-CoV-2Article Published on 2022-11-012022-11-15 Journal: Bioprocess and biosystems engineering [Category] SARS, 치료기술, [키워드] ACE acute respiratory syndrome angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) Asymptomatic binding caused combating contributed coronavirus coronavirus disease COVID-19 enzyme high affinity host receptor hydrophobic Infection Interaction lead to fatality Like molnupiravir Mutation Nanotechnology omicron pandemic pathogenic viruses PAXLOVID™ provide quercetin Remdesivir responsible SARS-CoV-2 spike glycoprotein suggested Transmissibility understanding vaccine. Vaccines viability virus [DOI] 10.1007/s00449-022-02788-8 PMC 바로가기
Updates on Coronavirus Disease 2019 in Children in JapanArticle Published on 2022-11-012022-11-16 Journal: The Pediatric Infectious Disease Journal [Category] 변종, [키워드] affected age approach changed children clinical feature Clinical outcome coronavirus disease COVID-19 COVID-19 pandemic COVID-19 vaccine European country Government IMPROVE incidence Inflammatory Japan lack obesity Older Outbreaks over physical predominant provide syndrome The United States vaccination rate variants [DOI] 10.1097/INF.0000000000003641 PMC 바로가기
An overview of pivotal trials and real-world evidence for CD20-depleting therapy in multiple sclerosis : Immunotherapy with rituximab, ocrelizumab, and ofatumumabArticle Published on 2022-11-012022-11-15 Journal: Wiener medizinische Wochenschrift (1946) [Category] 바이오마커, 진단, [키워드] addition Autoimmunitiy brain tissue Central nervous system chronic inflammatory disease COVID-19 pandemic Demyelination disadvantage disease effective Evidence MRI Multiple multiple sclerosis neurodegeneration Neuroimmunology Patient primary mechanism Primary progressive multiple sclerosis provide Relapsing-remitting multiple sclerosis. Research T cell therapeutic Therapeutic approach Therapies therapy Treatment Trial [DOI] 10.1007/s10354-022-00939-w PMC 바로가기
A triple-RBD-based mucosal vaccine provides broad protection against SARS-CoV-2 variants of concernArticle Published on 2022-11-012022-11-15 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibodies antigenic chimeric correlated Delta effective elicit flagellin Flagellin adjuvant human ACE2 IgA immunization Infection initial intranasal intranasal immunization Lower lung mucosal mucosal vaccine Mutation nasal neutralizing antibody neutralizing immunity omicron pathology Protein provide RBD reduce SARS-CoV-2 SARS-CoV-2 variant secretory IgA significantly specificity Spread tissue pathology transgenic mice transmission potential Triple-RBD Vaccine vaccine candidate variant Variant of concern. Viral RNA [DOI] 10.1038/s41423-022-00929-3 PMC 바로가기
Potent monoclonal antibodies neutralize Omicron sublineages and other SARS-CoV-2 variantsArticle Published on 2022-11-012022-11-15 Journal: Cell Reports [Category] SARS, 변종, 진단, [키워드] Analysis antibodies antibody Beta breadth complementary conserved CP: Immunology CP: Microbiology Efficacy Hamster model human monoclonal antibodies immune Immune escape in vivo interact monoclonal antibody mutations neutralization neutralize Neutralizing activity omicron Omicron sublineages BA.1., BA.2, BA.2.12.1, and BA.4 overcome potent Protective provide raise reduced SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein Spread the receptor-binding domain the SARS-CoV-2 therapeutic therapeutic antibodies therapeutic efficacy Vaccine variant variants variants of concern variants of concern. [DOI] 10.1016/j.celrep.2022.111528 PMC 바로가기
An external quality assessment for the molecular testing of the SARS-CoV-2 virus genome in Zhejiang Province, ChinaArticle Published on 2022-11-012022-11-15 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 진단, [키워드] Accuracy Asymptomatic CDC China Combination Concentration concentrations Concordance COVID-19 COVID-19 pandemic Culture diagnostics external quality assessment false-negative False-positive Genome infected individual Laboratory medium molecular molecular diagnostics. negative sample nucleic acid extraction organized participated PCR Population positive sample provide public health rapid expansion reagents SARS-CoV-2 SARS-CoV-2 test SARS-CoV-2 tests serial dilution the SARS-CoV-2 virus viral titer Zhejiang [DOI] 10.1016/j.diagmicrobio.2022.115766 PMC 바로가기
Single-cell transcriptomic atlas reveals distinct immunological responses between COVID-19 vaccine and natural SARS-CoV-2 infectionArticle Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome alteration analysis antibody production Apoptosis B cell caused collected CoronaVac coronavirus COVID-19 COVID-19 infected patient COVID-19 patients COVID-19 vaccine cytotoxicity downregulation Emergency use authorization expression expression of gene feature greater HLA class II IL21R immune Immune cell immune cell types immune response immunization immunized immunological Immunological response immunological responses inactivated Inactivated vaccine individual individuals Infection Inflammatory cytokine innate immune cell interferon response magnitude mechanism Migration mononuclear cells naïve B cell naïve B cells pandemic PBMC Peripheral blood phenotype plasma profile Proinflammatory cytokine proportion provide reveal SARS-CoV-2 SARS-COV-2 infection scRNA-seq Sequencing severe disease single-cell Single-cell RNA sequencing single-cell sequencing. Sinovac systemic immune response T cell thrombosis transcriptomic upregulation vaccine-induced immune response [DOI] 10.1002/jmv.28012 PMC 바로가기