Exponential increase in neutralizing and spike specific antibodies following vaccination of COVID-19 convalescent plasma donorsCOVID-19 회복기 혈장 기증자 백신 접종 후 중화 및 스파이크 특이적 항체의 기하급수적인 증가Article Published on 2021-07-012022-09-12 Journal: Transfusion [Category] MERS, SARS, 진단, [키워드] antibody approval candidate CCP chemiluminescence immunoassay convalescent plasma COVID-19 COVID-19 infection COVID-19 vaccines demonstrated DiaSorin Donor dramatic increase exceeded IC50 immunology immunology (other than RBC serology) increase in Infection Neutralizing neutralizing antibody Neutralizing antibody titer plaque reduction neutralization positive Practice PRNT RBC recovered recovered COVID-19 patient screened significantly significantly higher single vaccination specific antibody Spike-specific antibody subject tested transfusion practices (adult). vaccination with COVID-19 [DOI] 10.1111/trf.16401 PMC 바로가기 [Article Type] Article
Red cell distribution width is associated with mortality in non-anemic patients with COVID-19Comment Published on 2021-07-012023-06-19 Journal: Journal of medical virology [Category] MERS, SARS, [키워드] Anemia COVID-19 hemoglobin Mortality Prognosis RBC RDW [DOI] 10.1002/jmv.27011 PMC 바로가기 [Article Type] Comment
Hemozoin is a potential threat in cerebral malaria pathology through the induction of RBC-EC cytoadherencearticle Published on 2021-05-312024-09-01 Journal: Family process [Category] 말라리아, [키워드] antioxidants cerebral malaria cytoadherence endothelial cells RBC [Article Type] article
Mild anemia as a single independent predictor of mortality in patients with COVID‐19Research Article Published on 2021-05-062022-10-31 Journal: Ejhaem [Category] COVID-19, [키워드] 1.26 age Algorithm Anemia asked Asymptomatic Biomarker Blood caused Cell clinical care clinical feature clinical presentation Comorbidities confidence continuous variable coronavirus 2 coronavirus disease correlation COVID‐19 COVID‐19 death diagnosed disease evaluated females Haemoglobin hazard hazard ratio Health hemoglobin identify Impact IMPROVE independent International interval Laboratory male management Mortality New York City outcome Patient Patient care Predictive Prognosis RBC resource respiratory risk SARS‐CoV‐2 Sex the disease therapeutic treated [DOI] 10.1002/jha2.167 PMC 바로가기 [Article Type] Research Article
Neutralizing activity to SARS-CoV-2 of convalescent and control plasma used in a randomized controlled trial무작위 대조 시험에서 사용된 회복기 및 대조 혈장의 SARS-CoV-2에 대한 중화 활성Randomized Controlled Trial Published on 2021-05-012022-09-11 Journal: Transfusion [Category] MERS, SARS, 임상, 진단, 치료기술, 치료법, 치료제, [키워드] 293 T cells 293T ACE2 Administered antibody Antibody titers approach binding calculated Cell convalescent convalescent plasma COVID-19 COVID-19 infection criteria detect Donor donors excluded exhibited FDA FFP transfusion Human immunodeficiency virus IgG antibody immunochromatographic test immunology immunology (other than RBC serology) individual Infection inhibited IQR median medium neutralization titer neutralize Neutralizing activity Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers non-specific nucleocapsid protein optical optical density plasma pseudovirus random Randomized controlled trial Randomized controlled trials Randomly randomly selected samples RBC RCT SARS-CoV-2 SARS-CoV-2 pseudovirus SARS2 screened selected serology Spike protein subset T cells tested titer Viral was collected [DOI] 10.1111/trf.16283 PMC 바로가기 [Article Type] Randomized Controlled Trial
Correlation of Low Levels of α -1 Antitrypsin and Elevation of Neutrophil to Lymphocyte Ratio with Higher Mortality in Severe COVID-19 Patients중증 COVID-19 환자에서 낮은 수준의 α-1 항트립신과 호중구 대 림프구 비율 상승과 사망률의 상관관계Observational Study Published on 2021-04-282022-09-10 Journal: Mediators of Inflammation [Category] MERS, SARS, 유전자 메커니즘, 임상, [키워드] accounted Admission alterations antitrypsin arterial oxygen saturation blood count blood sugar C-reactive protein CBC Chain Reaction cohort study Comorbidities complete blood count COVID-19 COVID-19 illness COVID-19 patient CRP CRP level CRP values dysregulated immune response dysregulation Elevation erythrocyte sedimentation erythrocyte sedimentation rate ESR etiology explanation form Glutamate groups Hospitalization hospitalized patient hospitalized patients hyperinflammation immune dysregulation immune response immunomodulatory effect individual Individual differences inflammation response involved Level lymphocyte marker mechanism mortality rate MOST neutrophil NLR not significantly different O2sat Observational cohort study Oxaloacetate oxygen oxygen saturation patients PCR percentage percentages plasma protein polymerase chain polymerase chain reaction positive COVID-19 Prevalence pyruvate random Ratio RBC Result retrospective sedimentation rate serum Serum level severe COVID-19 severe COVID-19 illness severe COVID-19 patient severe COVID-19 patients severe forms of COVID-19 severe symptoms severity SGOT SGPT sugar the patient troponin troponin level troponin levels with COVID-19 [DOI] 10.1155/2021/5555619 PMC 바로가기 [Article Type] Observational Study
Early immune responses and prognostic factors in children with COVID-19: a single-center retrospective analysisResearch Article Published on 2021-04-172022-10-28 Journal: BMC Pediatrics [Category] COVID-19, MERS, [키워드] analyzed B cell Blood blood lymphocyte caused Cell cell count children children with COVID-19 concentrations conducted COVID-19 Critical critical cases cytokine Decreased diagnostic disease severity early diagnosis eosinophil ferritin group hemoglobin Hemoglobin concentration IFN-γ IL-10 IL-6 immune characteristics immune dysregulation immune response Inflammatory Inflammatory factor initial Lymphocyte count Lymphocyte subset natural killer peripheral procalcitonin procalcitonin level Prognostic factor progression RBC reduced Result Retrospective analysis Retrospective study SAA SARS-CoV-2 SARS-COV-2 infection Severe case severe disease significantly significantly increased significantly lower single-center statistically subset systemic cytokine T lymphocyte [DOI] 10.1186/s12887-021-02561-y PMC 바로가기 [Article Type] Research Article
Clinical characteristics of Egyptian male patients with COVID‐19 acute respiratory distress syndrome이집트 남성 코로나19 급성호흡곤란증후군 환자의 임상적 특징Research Article Published on 2021-04-162022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alanine alanine aminotransferase ALT Analysis ARDS aspartate Aspartate aminotransferase association AST Biomarker Biomarkers blood biochemistry Blood routine C‐reactive protein can be used caused Characteristics clinical Clinical characteristics coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 severity COVID‐19 creatinine CRP D-dimer D‐dimer disease severity ferritin ferritin levels groups hemoglobin information involved Laboratory Lactate lactate dehydrogenase LDH lymphopenia male material monocyte monocyte count not significantly different objective parameter Participants Patient patients Platelet Platelet count predict RBC RBC count reported respiratory respiratory distress Result SARS-CoV-2 Serum ferritin severe acute respiratory syndrome Coronavirus Severe case severe cases severity syndrome the disease thrombotic [DOI] 10.1371/journal.pone.0249346 PMC 바로가기 [Article Type] Research Article
Blood Donations and Transfusions during the COVID-19 Pandemic in Spain: Impact According to Autonomous Communities and HospitalsArticle Published on 2021-03-272022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] affected autonomous average Blood blood component caused Cohort Community COVID-19 COVID-19 pandemic decrease distribution donation eight Emergency Evolution hospital Impact increase in initial pandemic performed plasma Platelet Prospective Study RBC RBCs red blood cell reduction in Retrospective study significant decrease Spain state transfusion [DOI] 10.3390/ijerph18073480 PMC 바로가기 [Article Type] Article
In vitro characterization of engineered red blood cells as viral traps against HIV-1 and SARS-CoV-2Original Article Published on 2021-03-102022-10-30 Journal: Molecular Therapy [Category] COVID-19, [키워드] absence Abstract anti-viral therapeutics approach CCR5 CD4 cell line cellular co-expressed codon optimization Combination Engineered red blood cells erythrocyte Express expressing expression facilitate fusion protein high expression level HIV-1 Hoffmann Infection Interaction lack neutralization neutralize neutralized nuclei organelle Potential treatment Prevent produced progenitor cell progenitor cells Proteins RBC RBCs receptor receptors red blood cell required SARS-CoV-2 spike transgene trimeric viral entry viral infections viral replication virions [DOI] 10.1016/j.omtm.2021.03.003 PMC 바로가기 [Article Type] Original Article