receptor-binding motif – Page 3 – Communicable Diseases Research

Structure-guided antibody cocktail for prevention and treatment of COVID-19

코로나19 예방 및 치료를 위한 구조유도항체 칵테일

Research Article

Published on 2021-10-212022-09-10
Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 진단,

Emergence of SARS-COV-2 Spike Protein Escape Mutation Q493R after Treatment for COVID-19

COVID-19 치료 후 SARS-COV-2 스파이크 단백질 탈출 돌연변이 Q493R의 출현

Expedited

Published on 2021-10-012022-09-10
Journal: Emerging Infectious Diseases [Category] MERS, SARS, 변종,

A Novel Real-Time RT-PCR-Based Methodology for the Preliminary Typing of SARS-CoV-2 Variants, Employing Non-Extendable LNA Oligonucleotides and Three Signature Mutations at the Spike Protein Receptor-Binding Domain

Article

Published on 2021-09-272022-10-29
Journal: International Review of Cell and Molecular Biology [Category] COVID-19,

[키워드] ACE2 amino-acid amplification Analysis approach Beta blocker Delta delta variant domain Efficiency examined expand Gamma Human identify Immune escape linear LNA oligonucleotide blockers log Multiplex PCR mutated Mutation negative sample non-specific novel nucleic acid oligonucleotide other variant probe Public health interventions Rapid RBD RBM real-time RT-PCR Receptor-binding domain receptor-binding motif reduce residue resulting SARS-CoV-2 SARS-CoV-2 variant signature Spike protein Substitution TaqMan targets the SARS-CoV-2 the Spike the spike protein Transmissibility typing validation variant variant of concern variants variants of concern
[DOI] 10.3390/life11101015 PMC 바로가기 [Article Type] Article

Deamidation drives molecular aging of the SARS-CoV-2 spike protein receptor-binding motif

Research Article

Published on 2021-09-072022-10-30
Journal: The Journal of Biological Chemistry [Category] COVID-19, MERS, SARS,

[키워드] Affect antibodies asparagine backbone binding biochemical conditions consequence CoV, coronavirus Critical decrease experiment FIVE hACE2, human angiotensin-converting enzyme 2 Host immune response hotspot human Angiotensin-converting enzyme identify Infection Modification modulate molecular molecular aging positive potential mechanism Protein protein deamidation protein evolution protein–protein interaction PTM, posttranslational modification RASA, relative accessible surface area RBD, receptor-binding domain RBM, receptor-binding motif RBR, receptor binding ridge receptor Receptor binding receptor structure–function receptor-binding motif residue residues RNA virus SARS-CoV-2 SARS, Severe acute respiratory syndrome shown significantly spike Spike protein the SARS-CoV-2 the spike protein Vaccine development viral fitness viral infectivity virion virus infectivity
[DOI] 10.1016/j.jbc.2021.101175 PMC 바로가기 [Article Type] Research Article

Featuring ACE2 binding SARS-CoV and SARS-CoV-2 through a conserved evolutionary pattern of amino acid residues

Research Article

Published on 2021-09-062023-07-02
Journal: Journal of biomolecular structure & dynamics [Category] SARS,

[키워드] ACE2 Coronaviruses evolutionary pattern Receptor-binding domain receptor-binding motif SARS-CoV SARS-CoV-2
[DOI] 10.1080/07391102.2021.1965028 PMC 바로가기 [Article Type] Research Article

SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape

탈출에 대한 폭과 저항을 최대화하는 SARS-CoV-2 RBD 항체

Article

Published on 2021-09-012022-09-12
Journal: Nature [Category] Fulltext, SARS, 변종, 진단,

Mutations of SARS-CoV-2 RBD May Alter Its Molecular Structure to Improve Its Infection Efficiency

SARS-COV-2 RBD의 돌연변이는 분자 구조를 변경하여 감염 효율을 향상시킬 수 있습니다.

Article

Published on 2021-08-252022-09-10
Journal: Biomolecules [Category] Coronavirus, MERS, SARS, 변종,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme binding affinity changed compensation conformation coronavirus domain E484K E484K mutation E484K mutations FIVE flexibility free energy free energy landscape host cell human Angiotensin-converting enzyme in some Interaction L452R Local molecular molecular dynamics molecular dynamics simulations mutant mutant RBDs Mutation N439K N501Y Neutralizing antibodies Principal component principal component analysis principle component analysis RBD RBD flexibility RBD mutation RBD mutations RBD region RBDs RBM RBM region receptor Receptor-binding domain receptor-binding motif recorded respiratory rigidity S477N SARS-CoV-2 SARS-CoV-2 RBD selected severe acute respiratory syndrome Coronavirus Structure target the binding affinity the RBD Viral Viral load were used wild-type wild-type RBD
[DOI] 10.3390/biom11091273 PMC 바로가기 [Article Type] Article

Non-RBM Mutations Impaired SARS-CoV-2 Spike Protein Regulated to the ACE2 Receptor Based on Molecular Dynamic Simulation

Molecular Biosciences

Published on 2021-07-272022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

[키워드] ACE2 ACE2 receptor ACE2-RBD binding addition angiotensin-converting enzyme 2 bind binding binding free energy change changes conducted coronavirus Deterioration domain dynamic electrostatic interaction experiment higher affinity host cell hydrophobic interactions Impaired Infection interact Interaction looser molecular dynamic simulation molecular dynamics mutant Mutation mutations non-RBM mutations Novel coronavirus pathogenicity performed polar positive Protein random RBD RBM RBM region receptor Receptor binding domain receptor-binding motif Region Research residue SARS-CoV-2 SARS-CoV-2 mutation selected shown significantly Simulation spike Spike protein the epidemic the RBD V367F weakened wild-type
[DOI] 10.3389/fmolb.2021.614443 PMC 바로가기 [Article Type] Molecular Biosciences

SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity

SARS-CoV-2 스파이크 L452R 변종은 세포 면역을 회피하고 감염력을 증가시킵니다

Article

Published on 2021-07-142022-09-11
Journal: Cell Host & Microbe [Category] Coronavirus, MERS, SARS, 변종, 진단,

[키워드] ACE2 Affect affinity Antigen B.1.1.298 B.1.427/429 B.1.617 cellular cellular immunity COVID-19 entry receptor escape evade Evolution Host human leukocyte antigen Humoral immunity immune resistance increase investigated L452R leukocyte Mutation naturally occurring variants pandemic phenotype promote Receptor-binding domain receptor-binding motif SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants sensitivity Spike protein spike stability the receptor-binding domain the SARS-CoV-2 These data variant Viral viral infectivity viral replication Y453F
[DOI] 10.1016/j.chom.2021.06.006 PMC 바로가기 [Article Type] Article

Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses

Research Article

Published on 2021-07-022022-10-31
Journal: Computational and Structural Biotechnology Journal [Category] COVID-19,