Using a “systems therapeutic for physiological renormalization” approach to vaccine development. Covid-19 as an example백신 개발에 "생리학적 재정규화를 위한 시스템 치료" 접근 방식을 사용합니다. 코로나19를 예로 들어Article Published on 2022-11-302022-09-11 Journal: Human vaccines & immunotherapeutics [Category] 변종, [키워드] adaptive immune system approach current example induce infectious agent mimicry Mutation physiological Prevent Recombination replicate respiratory tract respiratory tracts sera Spread the disease therapeutic Vaccine Vaccine development variant virions virulent [DOI] 10.1080/21645515.2022.2043105 PMC 바로가기 [Article Type] Article
Evidence of co-infections during Delta and Omicron SARS-CoV-2 variants co-circulation through prospective screening and sequencingArticle Published on 2022-11-012022-11-15 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Analysis chimeric circulation Co-infection collected COVID-19 Delta Delta and Omicron VOC Epidemic epidemiologically evidence of France generate Genetic Health Infection K417N L452R Mutation nasopharyngeal sample omicron Pandemics pathogenic patients PCR assay polymorphism primer sets profile Recombination recombination event Respiratory samples S-gene mutation Sample SARS-CoV-2 SARS-CoV-2 co-infection SARS-CoV-2 genome SARS-CoV-2 variant screened sequence Sequencing single nucleotide Single nucleotide polymorphism Single nucleotide polymorphism screening SNP SNPs submitted Surveillance variant virus VoC was performed WGS whole genome Whole genome sequencing [DOI] 10.1016/j.cmi.2022.06.030 PMC 바로가기
An antibody from single human VH-rearranging mouse neutralizes all SARS-CoV-2 variants through BA.5 by inhibiting membrane fusionArticle Published on 2022-10-282022-11-15 Journal: Science Immunology [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] antibodies antibody approved B cell BCR binding epitope blocked CDR3 contribute described elicited Health humanized immunogen inhibiting Last Lattice mechanism of action membrane fusion mice Modification mouse model neutralization activity neutralize neutralized Neutralizing antibodies neutralizing antibody omicron Pathogens RBD receptor receptor-binding motif Recombination SARS-CoV-2 SARS-CoV-2 neutralizing antibody SARS-CoV-2 variant sequence Spike protein therapeutic therapeutic potential Vaccine Wuhan-Hu-1 [DOI] 10.1126/sciimmunol.add5446 PMC 바로가기
Dynamic analysis and optimal control considering cross transmission and variation of informationArticle Published on 2022-10-272022-11-16 Journal: Scientific Reports [Category] 변종, [키워드] Analysis analyzed applied asymptotic basic reproduction number calculated COVID-19 transmission cross dynamic generate IMPROVE information knowledge Local parameters promote Recombination sensitivity stability Support Transmission variant Variation viral recombination virus [DOI] 10.1038/s41598-022-21774-4 PMC 바로가기
Potential intervariant and intravariant recombination of Delta and Omicron variantsDelta 및 Omicron 변이체의 잠재적인 intervariant 및 intravariant 재조합Article Published on 2022-10-012022-09-11 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 coronavirus Delta Delta-Omicron XD disease-causing Evidence genomes new SARS-CoV-2 omicron pathogenic Potential raising Recombination SARS-CoV-2 SARS-CoV-2 genomes variant variants [DOI] 10.1002/jmv.27939 PMC 바로가기 [Article Type] Article
Genomic characteristics and recombination patterns of swine hepatitis E virus in ChinaArticle Published on 2022-09-012023-06-10 Journal: Transboundary and emerging diseases [Category] E형 간염, [키워드] China genetic diversity Phylogenetic analysis Recombination swine hepatitis E virus zoonosis [DOI] 10.1111/tbed.14585
Co-existence and co-infection of influenza A viruses and coronaviruses: public health challengesReview article Published on 2022-08-172022-10-05 Journal: The Innovation [Category] 비임상, [키워드] acute respiratory syndrome affecting aggravate Alter both virus caused circulation co-existence Co-infection coronavirus CoV CoVs Cross-species transmission disease disease transmission Evolution facilitate FIVE Genetic host range hosts Human IAV influenza A virus maintain Pandemics public health public health challenges Recombination risk SARS-CoV-2 Surveillance variant virus [DOI] 10.1016/j.xinn.2022.100306 [Article Type] Review article
Variation in synonymous nucleotide composition among genomes of sarbecoviruses and consequences for the origin of COVID-19사베코바이러스 게놈 간 동의 염기 조성의 변이와 코로나19의 기원에 대한 영향Article Published on 2022-08-152022-09-11 Journal: Gene [Category] COVID19(2023년), SARS, 치료기술, [키워드] analysed bat bat virus Bulgaria China Codons consequence coronavirus COVID-19 COVID-19 pandemic cytosine degenerate diagnosed dinucleotides distribution eight Evidence evidence of explain feature FIVE Genome genomes group horseshoe bat Host host cell host cells include independent intermediate intermediate host Japan Kenya less Manis javanica mutations nucleotide pangolin pangolins RdRP RdRp selection Recombination reservoir Reservoir host responsible sarbecovirus Sarbecoviruses SARS epidemic SARS-CoV SARS-CoV-2 subgenus synonymous synonymous mutations the SARS epidemic uracil viral replication viruses [DOI] 10.1016/j.gene.2022.146641 PMC 바로가기 [Article Type] Article
Pandemic-Scale Phylogenomics Reveals The SARS-CoV-2 Recombination Landscape Research Published on 2022-08-112022-10-05 Journal: Nature [Category] SARS, 변종, 치료기술, [키워드] Analysis approach breakpoint detectable Epidemic events exceeded Genetic variation Genome genomic data highlight identify landscape Lineage lineages occur pandemic Phylogenetic Phylogenomics Recombination SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 phylogeny sequenced Spread the SARS-CoV-2 the spike protein Transmissibility variants of interest viral recombination virulence virus [DOI] 10.1038/s41586-022-05189-9 [Article Type] Research
Emergence and widespread circulation of a recombinant SARS-CoV-2 lineage in North America북미에서 재조합 SARS-CoV-2 계통의 출현 및 광범위한 유통Article Published on 2022-08-102022-09-11 Journal: Cell Host & Microbe [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis circulation Cluster coronavirus Deletion distribution Effect emergence Evolution Genome geographical region Lineage lineages molecular Molecular epidemiology non-structural protein North America NSP6 ORF3a Phylogenetic Phylogenetic analysis phylogenetics Protein question raise Recombination recombination event SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 lineage shown spatiotemporal spike supported USA virus widespread [DOI] 10.1016/j.chom.2022.06.010 PMC 바로가기 [Article Type] Article