Cycle Threshold Values from Severe Acute Respiratory Syndrome Coronavirus-2 Reverse Transcription-Polymerase Chain Reaction Assays: Interpretation and Potential Use Cases중증 급성 호흡기 증후군 코로나바이러스-2 역전사-중합효소 연쇄 반응 분석의 주기 임계값: 해석 및 잠재적 사용 사례Review Published on 2022-06-012022-09-11 Journal: Clinics in laboratory medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 approved Caregiver Caregivers chain Chain Reaction clinical care Concentration coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 Ct value Ct values cycle cycle threshold Cycle threshold value determine Infection polymerase chain reaction Potential progression reaction reflect respiratory reverse transcription Reverse transcription-polymerase chain reaction RNA RT-PCR SARS-CoV-2 Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus the patient threshold value Variability Viral RNA virus [DOI] 10.1016/j.cll.2022.02.003 PMC 바로가기 [Article Type] Review
A Novel Approach on Deep Learning-Based Decision Support System Applying Multiple Output LSTM-Autoencoder: Focusing on Identifying Variations by PHSMs’ Effect over COVID-19 Pandemic다중 출력 LSTM-Autoencoder를 적용한 딥 러닝 기반 의사 결정 지원 시스템에 대한 새로운 접근 방식: COVID-19 팬데믹에 대한 PHSM의 영향에 따른 변이 식별을 중심으로Article Published on 2022-06-012022-09-11 Journal: International Journal of Environmental Research an [Category] 변종, 치료기술, [키워드] addition Analysis Anomaly Applying approach caused changes in confirmed case COVID-19 COVID-19 pandemic decision decision support system deep deep learning demonstrated Effect Effectiveness Effects expected failure Focusing identifying implementation increase in information limitation LSTM-Autoencoder measure methodology Multiple novel outbreak output overcome Previous studies previous study provide provided Public public health public health and social measures (PHSMs). reflect Research restriction statistical model Support Support System System transfer Usability utilization variant Variation variations virus [DOI] 10.3390/ijerph19116763 PMC 바로가기 [Article Type] Article
Extracellular vesicles in kidney disease Reviews Published on 2022-05-312022-10-05 Journal: Nature reviews. Nephrology [Category] 바이오마커, [키워드] addition administration Alter amplification body fluids candidate Cell cell type cell-to-cell communication chronic kidney diseases circulating diagnostic Efficacy Evidence extracellular vesicle fibrosis gene expression profile glomerular Increasing Inflammation investigated involved kidney kidney damage Kidney disease majority mechanism modulate molecular organ pathology pathophysiological preclinical data prognostic promote reduce reflect regenerative released robust Standardization stem cell target cells thought tubular cell urinary Vesicle [DOI] 10.1038/s41581-022-00586-9 [Article Type] Reviews
Characterization of Immune Response Diversity in Rodents Vaccinated with a Vesicular Stomatitis Virus Vectored COVID-19 Vaccine수포성 구내염 바이러스 벡터가 적용된 COVID-19 백신을 접종한 설치류의 면역 반응 다양성 특성화Article Published on 2022-05-242022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated acute respiratory syndrome Administered animal model animal models applied BALB/c mice candidate Cellular immune response cellular immunity challenge characterization coronavirus coronavirus disease COVID-19 COVID-19 vaccine Diversity effective Efficacy evaluated hamsters humoral immune response immune response immunization immunization routes intramuscular intranasal Neutralizing neutralizing antibody Protective protective immunity provide public health recombinant COVID-19 vaccine recombinant vesicular stomatitis virus reflect response robust rodent SARS-CoV-2 significantly higher stomatitis susceptible Syrian Golden hamsters T cell Th1 Th2 triggered Vaccine vaccine candidate vesicular vesicular stomatitis virus VSV [DOI] 10.3390/v14061127 PMC 바로가기 [Article Type] Article
Peak value of serum KL-6 may be useful for predicting poor prognosis of severe COVID-19 patients혈청 KL-6의 피크 값은 심각한 COVID-19 환자의 나쁜 예후를 예측하는 데 유용할 수 있습니다Observational Study Published on 2022-05-192022-09-11 Journal: European Journal of Medical Research [Category] MERS, 바이오마커, 임상, [키워드] 95% CI Accuracy adjusted odds ratio Admission age alveolar Analysis analyzed Area AUC baseline characteristics best Biomarker Biomarkers Comorbidities Concentration COVID-19 COVID-19 patient COVID-19 patients criteria cut-off value defined determine discrimination early phase epithelial evaluate examination help high risk high-flow oxygen therapy higher risk Hospitalization hospitalized patient identify inclusion criteria indicated initial Injury Invasive mechanical ventilation KL-6 LDH Logistic regression analyses minimum multivariate logistic regression non-survivor observational study once a week oxygen Oxygen therapy Patient patients peak performed Pneumonitis poor prognosis predict Prognosis Prognostic value progression reflect reported required Respiratory failure retrospective sensitivity serum severe COVID-19 patient Sex single-center supplemental oxygen survivor Treatment U/mL [DOI] 10.1186/s40001-022-00690-3 PMC 바로가기 [Article Type] Observational Study
Severe Acute Respiratory Syndrome Coronavirus 2 Viremia Is Associated With Coronavirus Disease 2019 Severity and Predicts Clinical Outcomes중증 급성 호흡기 증후군 코로나바이러스 2 바이러스혈증은 코로나바이러스 질병 2019 심각도와 연관되어 있으며 임상 결과를 예측합니다Observational Study Published on 2022-05-032022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, 진단, 치료기술, [키워드] 19 outcome 2 RNAemia 2 viremia acute respiratory syndrome acute respiratory syndrome coronavirus Admission Antibody titers bloodstream Care clinical clinical outcomes Cohort coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 CoV COVID COVID-19 COVID-19 patient COVID-19 severity cross-sectional discharge disease severity electron tomography hazard ratio Health Organization Hospitalized Host immune response host immune responses ICU ICU Patients immune responses immunostaining indicate Inflammatory biomarker Inpatients Level Mortality Neutralizing antibody titer neutralizing antibody titers non-ICU outcome outcomes Outpatient outpatients Patient pellet plasma plasma sample plasma samples quantified reflect respiratory SARS SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly significantly higher Viral Viral RNA Viremia virion virions virus particle virus particles Visualization vRNA WHO World Health Organization [DOI] 10.1093/cid/ciab686 PMC 바로가기 [Article Type] Observational Study
Pandemic, Epidemic, Endemic: B Cell Repertoire Analysis Reveals Unique Anti-Viral Responses to SARS-CoV-2, Ebola and Respiratory Syncytial Virus유행성, 전염병, 풍토병: B 세포 레퍼토리 분석을 통해 SARS-CoV-2, 에볼라 및 호흡기 세포융합 바이러스에 대한 독특한 항바이러스 반응이 밝혀졌습니다Article Published on 2022-05-032022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] age Analysis B cell Characteristics class-switch recombination (CSR) cohorts COVID-19 COVID-19 patient disease Ebola Ebolavirus Effects Endemic Epidemic event Evidence example Fever germinal centre heterogeneity humoral humoral immune response Hypothesis IgG1 IGH IGHV4-39 immature Immunity infections lack Lineage morbidity and mortality Mutation pandemic patients Recombination reflect repertoire respiratory response risk RSV RSV (respiratory syncytial virus) SARS-CoV-2 Sequencing significant difference Support survivor switching unique vaccination Vaccine viral challenge viral infection Zaire [DOI] 10.3389/fimmu.2022.807104 PMC 바로가기 [Article Type] Article
Stratification of COVID-19 patients based on quantitative immune-related gene expression in whole blood전혈의 면역 관련 유전자 발현량을 기반으로 한 코로나19 환자 계층화Article Published on 2022-05-012022-09-11 Journal: Molecular immunology [Category] COVID19(2023년), SARS, 바이오마커, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 added amplification Analysis analyzed Biomarker Blood carried cause clinically coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 cases COVID-19 disease COVID-19 patient Critical Critically ill Critically ill patient critically ill patients dcRT-MLPA. Determination differentially expressed gene Differentially expressed genes disease severity expression gene encoding Gene Expression healthy controls healthy individuals identify immune immune response immune-related gene immune-related genes Immunity immunopathology in some individual infected individuals infected with SARS-CoV-2 Intervention life-threatening lower expression lymphocyte lymphocyte counts majority marker mechanism Mild Mild symptom mild symptoms multiplex notable Patient Peripheral blood Predictive probe provide Quantitative reduced reflect reverse transcriptase risk stratification SARS-CoV-2 separated several genes severe acute respiratory syndrome Coronavirus severity of COVID-19 subgroup symptom onset Symptoms transcript transcriptase transcriptional Treatment Whole blood whole blood sample [DOI] 10.1016/j.molimm.2022.03.004 PMC 바로가기 [Article Type] Article
Generation time of the alpha and delta SARS-CoV-2 variants: an epidemiological analysis알파 및 델타 SARS-CoV-2 변종 생성 시간: 역학 분석Article Published on 2022-05-012022-09-11 Journal: The Lancet. Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] 95% CI Alpha alpha and delta variants Alpha variant analysed Analysis assumed B.1.1.529 B.1.617.2 Contact tracing Council credible interval decrease delta variant Delta variants determine dominant dominant variant effective Effectiveness Engineering epidemiological faster Generation Generation time genomic sequencing household Households index case Infection Innovation intrinsic Isolation less mathematical occur participant Participants positive PCR test posterior probability recruited reflect responsible SARS-CoV-2 SARS-CoV-2 variant Science security susceptible susceptible individual susceptible individuals Transmissibility Transmission Transmission model transmissions variant virus was used [DOI] 10.1016/S1473-3099(22)00001-9 PMC 바로가기 [Article Type] Article
The Analysis of Patterns of Two COVID-19 Outbreak Clusters in China중국의 두 가지 COVID-19 발병 클러스터의 패턴 분석Article Published on 2022-04-172022-09-11 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 치료기술, [키워드] analyzed Beijing center Characteristics China Chinese compared and analyzed confirmation confirmed case COVID-19 COVID-19 epidemic COVID-19 outbreak demonstrated distance District Emergency Epidemic epidemiological FIVE foci Home isolation infected individual infected individuals Infection initiated Intervention Isolation Local local outbreak MOST nucleic acid outbreak outbreak in clusters pattern periphery precautions Prevention and control rapid detection method reflect spatiotemporal spatiotemporal evolution Spread spread to Standard deviation System dynamics modeling the timing Tianjin transfer Transmission Workplace [DOI] 10.3390/ijerph19084876 PMC 바로가기 [Article Type] Article