Rescue therapy with inhaled nitric oxide and almitrine in COVID-19 patients with severe acute respiratory distress syndromeResearch Published on 2020-11-042022-10-28 Journal: Annals of Intensive Care [Category] COVID-19, [키워드] acute respiratory distress Almitrine ARDS association baseline Blood caused Combination Compliance conducted COVID-19 COVID-19 patient evaluate females hemodynamic highlight hypoxic increase in Inhaled iNO intubated patient male mechanism median median age nitric oxide no correlation Oxygenation PaO pathophysiology Patient patients performed pilot study preserved primary endpoint proning rescue respiratory Respiratory system Result severe COVID-19 severe hypoxemia syndrome therapy Variation vascular dysfunction Vascular function vasoconstriction were assessed [DOI] 10.1186/s13613-020-00769-2 PMC 바로가기 [Article Type] Research
Rescue of SARS-CoV-2 from a Single Bacterial Artificial ChromosomeResearch Article Published on 2020-09-252022-10-29 Journal: mBio [Category] COVID-19, SARS, [키워드] activity acute respiratory syndrome animal model Antiviral approach approved artificial BAC Bacterial biology of SARS-CoV-2 caused cDNA China chromosome clone comparable contribute coronavirus CoV COVID-19 COVID-19 disease cultured cell develop disease drug effort exhibited facilitate Factor feasibility feature food genetics growth hamsters Health impacted in viral in vitro in vivo involved knowledge lung nasal turbinate pandemic pandemic coronavirus Pathogenesis phenotype public health question recombinant recombinant virus Replication rescue rescued reverse genetics SARS-CoV-2 SARS-COV-2 infection shown Spread the SARS-CoV-2 Treatment triggered USA-WA1/2020 Vaccine Vaccine development VERO E6 cells Wuhan [DOI] 10.1128/mBio.02168-20 PMC 바로가기 [Article Type] Research Article
Case Report: Opportunities for Treatment of Severe COVID-19 Patients—Lessons From a Death CaseMedicine Published on 2020-08-142022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory syndrome Affect anti-SARS-CoV-2 approach Cardiopulmonary condition coronavirus coronavirus disease COVID-19 COVID-19 cases Critical critical condition diagnosed died help hospital incidence increase Infection Invasive mechanical ventilation involved medical condition non-invasive ventilation opportunity Patient performed Prognosis progressed required rescue risk SARS-CoV-2 severe severe COVID-19 patients Spread Symptoms the patient threat transfer treated treating COVID-19 Treatment [DOI] 10.3389/fmed.2020.00533 PMC 바로가기 [Article Type] Medicine
CytoResc – “CytoSorb” Rescue for critically ill patients undergoing the COVID-19 Cytokine Storm: A structured summary of a study protocol for a randomized controlled trialCytoResc – COVID-19 사이토카인 폭풍을 겪고 있는 중환자를 위한 "CytoSorb" 구조: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2020-06-262022-08-13 Journal: Trials [Category] SARS, 임상, [키워드] 1:1 24 hour 24 hours Acute kidney injury Acute respiratory failure Administered analysis Antibiotics arterial arterial pressure Bacterial Berlin blinded Blinding block blocks Blood C-reactive protein C-reactive protein (CRP catecholamine cause center Chain Reaction Charité clinical Clinical course Clinical practice clinical trials clinically clinician comparator concentrations condition conducted contraindication COVID-19 COVID-19 patient COVID-19 patients Critical care Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients cytokine Cytokine storm Cytokines Cytosorb CytoSorb® data set death defined dissemination dose element elevated Endpoint extracorporeal cytokine elimination feasibility Filter Formal Germany Hemodynamics hospital discharge Hospitalization hospitalized patient hospitalized patients hyperinflammation Hyperinflammatory ICU-treatment ICUs IIb IL-6 IMPROVE Inc. Inclusion inclusion criteria indication intensive care unit intensive care units interleukin interleukin-6 intervention effect mean arterial pressure mechanical ventilation molecular weight Mortality multicenter New Norepinephrine number objective observational study occur Open-label other conditions outcome parallel group participant Patient patients PCR PCT performed phase pilot study polymerase chain polymerase chain reaction polystyrene positive pressure Prevent primary endpoint procalcitonin Proinflammatory cytokine proinflammatory cytokines protocol randomization Randomized Randomized controlled trial reason for receive recruited reducing Registered registry renal replacement therapy replacement therapy rescue Respiratory failure Safety Safety assessment Sample size SARS-CoV-2 secondary Secondary outcomes Shock shown Standard of care statistician status stratified Study design Study protocol Suspected therapy toxin Treatment Trial Trial registration USA vasoplegic shock Vasopressor vasopressors website [DOI] 10.1186/s13063-020-04501-0 PMC 바로가기 [Article Type] Letter
COVID-19 and SARS Coronavirus 2: Antibodies for the Immediate Rescue and Recovery PhaseImmunology Published on 2020-05-292022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] antibody protection for Covid-19 antibody therapy for Covid-19 convalescent plasma for COVID-19 therapy COVID-19 gamma globulin for Covid-19 protection human volunteer testing for Covid-19 protection Immediate phase rescue SARS Coronavirus 2 and Covid-19 immunity SARS-CoV-2 immunity vaccine and therapeutics testing for Covid-19 [DOI] 10.3389/fimmu.2020.01196 PMC 바로가기 [Article Type] Immunology
Two-By-One model of cytoplasmic incompatibility: Synthetic recapitulation by transgenic expression of cifA and cifB in Drosophila세포질 비호환성의 Two-By-One 모델: 초파리에서 cifA 및 cifB의 형질전환 발현에 의한 합성 요약Research Article Published on 2019-06-262022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence Bacteria caused comparable cytoplasmic Dengue dengue viruses Drosophila Drosophila melanogaster dual Embryo embryonic embryos expression female functional gene expression analysis Genes Genetic genetic model hypothese hypotheses implication incompatibility induce infect infections kill lethality male mechanism methodology Modification phage Population predict Release Replication reported rescue rescued responsible robust Spread Strains Support synthetic These data transgenic uninfected vector control virus viruses wild type Wolbachia Zika [DOI] 10.1371/journal.pgen.1008221 PMC 바로가기 [Article Type] Research Article