Masseter muscle pressure injury: First report of a prone position complication in patients with COVID-19교근 근육 압박 부상: COVID-19 환자의 엎드린 자세 합병증의 첫 보고Case Reports Published on 2022-08-012022-09-11 Journal: Intensive & critical care nursing [Category] SARS, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome Case report Complication COVID-19 COVID-19 patients deep Deep tissue injury distress facial Injury intensive care intensive care unit intensive care units management Masseter muscle obese patients with COVID-19 pressure Pressure injury Prevent prone Prone position Prophylactic respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-COV-2 infection Side effect syndrome tissue tissue injury [DOI] 10.1016/j.iccn.2022.103251 PMC 바로가기 [Article Type] Case Reports
Multiplex protein profiling of bronchial aspirates reveals disease-, mortality- and respiratory sequelae-associated signatures in critically ill patients with ARDS secondary to SARS-CoV-2 infection기관지 흡인물의 다중 단백질 프로파일링은 SARS-CoV-2 감염에 이차적으로 ARDS가 있는 중환자에서 질병, 사망률 및 호흡기 후유증과 관련된 징후를 나타냅니다.Multicenter Study Published on 2022-07-292022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] acute respiratory distress acute respiratory distress syndrome adverse outcomes AGR2 all-cause mortality ARDS association BAS bronchial bronchial aspirate confounding factors correlated COVID-19 COVID-19 patients Cox regression model Cox regression models Critically ill Critically ill patient critically ill patients CST5 Decision making determinant disease pathogenesis DPP7 ENTPD2 expressed Factor FCRL1 highest hospital discharge host response ICU ICU – intensive care unit identify IL-1α immune IMV intensive care Invasive mechanical ventilation Kaplan-Meier curve Kaplan-Meier curves KYAT1 lung cells Lung function mechanism molecular Mortality mortality risk multicenter study NADK Non-COVID-19 Non-COVID-19 patients nonsurvivor nonsurvivors NQO2 NTF4 OSM outcomes Pathogenesis pathology Poor Protein proteomic proteomics proximity extension assay PTN quantified radiological feature radiological features random Random forest reduced respiratory respiratory distress Respiratory distress syndrome reveal risk Risk assessment SARS-COV-2 infection SRPK2 subgroup subgroups supported Survivors the disease the strongest THOP1 TRAIL TSS TYMP Viral viral infectivity were used with COVID-19 [DOI] 10.3389/fimmu.2022.942443 PMC 바로가기 [Article Type] Multicenter Study
Immunomodulation of Mesenchymal Stem Cells in Acute Lung Injury: From Preclinical Animal Models to Treatment of Severe COVID-19급성 폐 손상에서 중간엽 줄기 세포의 면역 조절: 전임상 동물 모델에서 중증 COVID-19 치료까지Review Published on 2022-07-252022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, [키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal animal model antiviral properties antiviral property caused Cell Cell therapy clinical trial clinical trials coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cytokine storm highlight immunomodulation immunomodulatory Infection lung Lung injury mass Mesenchymal stem cells Model Mortality MSC MSC therapy MSCs outcome pandemic Pathogenesis patients with COVID-19 potential mechanism potential mechanisms Preclinical public health Reinfection respiratory distress Respiratory distress syndrome risk SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus STEM stem cells syndrome the SARS-CoV-2 tissue repair treat vaccination vaccine breakthrough infection vaccine breakthrough infections Viral variants [DOI] 10.3390/ijms23158196 PMC 바로가기 [Article Type] Review
Updated Living Systematic Review and Meta-analysis of Controlled Trials of Mesenchymal Stromal Cells to Treat COVID-19: A Framework for Accelerated Synthesis of Trial Evidence for Rapid Approval-FASTER ApprovalCOVID-19를 치료하기 위한 중간엽 간질 세포의 통제된 시험에 대한 업데이트된 살아있는 체계적인 검토 및 메타 분석: 신속한 승인-빠른 승인을 위한 시험 증거의 가속화된 합성을 위한 프레임워크Meta-Analysis Published on 2022-07-202022-09-11 Journal: Stem cells translational medicine [Category] 임상, [키워드] accelerate accelerated acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 appear approval ARDS Clinical studies clinical study conducted Consistency Control Controlled controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 criteria Critical death Endpoint evaluate Evidence Exosomes Extracellular Extracellular vesicles facilitate framework heterogeneity Hospital stay identify IMPROVE ISCT Master protocol mean difference Mesenchymal stem cells Mesenchymal stromal cell Mesenchymal stromal cells Meta-analysis Microvesicles moderate Mortality MSC MSC-EVs exosomes MSCs non-randomized study outcome Oxygenation Patient Pneumonia PROSPERO protocol random-effect random-effects Random-effects meta-analysis Randomized controlled trial Rapid reduce reduce mortality Relative risk reported respiratory distress Respiratory distress syndrome review risk of bia risk of death RoB SARS-CoV-2 Sepsis severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Society stromal cell stromal cells synthesis systematic review treat Treatment [DOI] 10.1093/stcltm/szac038 PMC 바로가기 [Article Type] Meta-Analysis
Pyroptotic Patterns in Blood Leukocytes Predict Disease Severity and Outcome in COVID-19 Patients혈액 백혈구의 Pyroptotic 패턴은 COVID-19 환자의 질병 심각도와 결과를 예측합니다Article Published on 2022-07-192022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] acute respiratory distress acute respiratory distress syndrome ARDS blood leukocyte caused Clinical treatment Cluster Clustering Compound coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients deaths detrimental effects differentially expressed gene Differentially expressed genes disease effective enrichment analysis expression gene set enrichment analysis Genes GSEA hyperinflammation hyperinflammatory state IMPROVE LASSO leukocyte leukocytes operator pandemic Patient patients pattern Prognosis prognosis model prognostic model proteomic pyroptosis respiratory distress Respiratory distress syndrome syndrome therapeutic transcription factor transcription factors transcriptomic data Unsupervised clustering upstream worse prognosis [DOI] 10.3389/fimmu.2022.888661 PMC 바로가기 [Article Type] Article
Does awake prone positioning prevent the use of mechanical respiratory support or death in COVID-19 patients on standard oxygen therapy hospitalised in general wards? A multicentre randomised controlled trial: the PROVID-19 protocol깨어 있는 엎드린 자세가 일반 병동에 입원한 표준 산소 요법을 받는 COVID-19 환자의 기계적 호흡 지원 또는 사망을 방지합니까? 다기관 무작위 대조 시험: PROVID-19 프로토콜Article Published on 2022-07-082022-09-11 Journal: BMJ Open [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory distress acute respiratory distress syndrome approved ARDS Awake prone positioning body mass body mass index composite endpoint COVID-19 COVID-19 patient COVID-19 patients death death in COVID-19 decrease defined Ethics France hospitalised hypothesised hypoxaemia IMPROVE Infectious diseases Informed consent intervention group intubation investigator-initiated mechanical respiratory multicentre Non-intubated non-invasive ventilation Noninvasive ventilation Oxygenation Patient patients with ARDS peer-reviewed Prevent prone Prone position prone positioning protocol randomised randomised controlled receive registration number respiratory distress Respiratory distress syndrome respiratory infections responsible Safe severity Standard of care standard oxygen therapy Stratification submitted Support survival syndrome the ethics committee Treatment treatment failure Trial usual care usual care alone [DOI] 10.1136/bmjopen-2021-060320 PMC 바로가기 [Article Type] Article
Mechanical ventilation in COVID-19: A physiological perspectiveReview Published on 2022-07-012023-07-06 Journal: Experimental Physiology [Category] COVID19(2023년), [키워드] artificial COVID-19 Critical care Physiology Respiration respiratory Respiratory distress syndrome SARS-CoV-2 [DOI] 10.1113/EP089400 PMC 바로가기 [Article Type] Review
Alcohol Increases Lung Angiotensin-Converting Enzyme 2 Expression and Exacerbates Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Subunit 1-Induced Acute Lung Injury in K18-hACE2 Transgenic Mice알코올은 폐 안지오텐신 전환 효소 2 발현을 증가시키고 중증 급성 호흡기 증후군을 악화시킨다Article Published on 2022-07-012022-09-11 Journal: The American journal of pathology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] ACE2 Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alcohol Alcohol Abuse alcohol consumption alveolar Alveolar space angiotensin angiotensin-converting enzyme 2 Biomarker blood cell body weight Bronchoalveolar lavage fluid chronic coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Course Cytokine storm decrease dramatic increase enzyme Ethanol Express Factor human ACE2 receptor Human angiotensin-converting enzyme 2 Immune cell immune cells increase Inflammasome Interaction K18-hACE2 lung tissue mechanism mice Mortality NF-κB NLR NLRP3 overexpression pandemic parenchymal proinflammatory protein 3 recruitment reported respiratory respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus spike Spike protein STAT3 Stress subunit syndrome Therapeutic approach therapeutic approaches transgenic mice White blood cell worsening [DOI] 10.1016/j.ajpath.2022.03.012 PMC 바로가기 [Article Type] Article
Vitamin D Endocrine System and COVID-19: Treatment with Calcifediol비타민 D 내분비계와 코로나19: 칼시페디올로 치료Review Published on 2022-06-292022-09-11 Journal: Nutrients [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] 25OHD 25OHD deficiency 25OHD level 25OHD levels acute respiratory distress acute respiratory distress syndrome addition Admission angiotensin antimicrobial peptides Antiviral Antiviral agents approved ARDS association autophagy bradykinin calcifediol calcitriol Characteristics chemokine cholecalciferol coagulability complications Course Coverage COVID-19 COVID-19 pandemic Critical death described develop dose doses drug early stage early stages Effect effector mechanisms Endocrine endocrine system ENhance epithelial Evidence functional High dose Host hyperinflammatory phase ICU ICU admission include increased coagulability indication Infection integrity intensive care intensive care unit intervention study mechanical ventilation modulating mortality rate neutrophil Patient patients with SARS-CoV-2 pharmacokinetic pilot study prohormone prothrombotic public health systems RAAS reactive reduce Renin repositioning respiratory distress Respiratory distress syndrome risk SARS-CoV-2 SARS-COV-2 infection serum severe COVID-19 significantly subsequent syndrome System the disease therapeutic options Treatment treatment of COVID-19 vaccination variant VDES viral evolution Vitamin Vitamin D vitamin D endocrine system vitamin D endocrine system. [DOI] 10.3390/nu14132716 PMC 바로가기 [Article Type] Review
Host lung microbiota promotes malaria-associated acute respiratory distress syndrome호스트 폐 미생물군은 말라리아 관련 급성 호흡 곤란 증후군을 촉진한다.Article Published on 2022-06-292024-08-01 Journal: Nature Communications [Category] 말라리아, [키워드] malaria Parasite host response Respiratory distress syndrome [DOI] 10.1038/s41467-022-31301-8 PMC 바로가기