Potential Use of CRISPR/Cas13 Machinery in Understanding Virus–Host InteractionMicrobiology Published on 2021-11-262022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acquisition approaches Cas13 Cas9 class component CRISPR-Cas Degradation degrade diagnostics DNA effector elements Features Genetic identify immune system Interaction modulate Nuclease nucleases nucleic acid offer Palindromic phage plasmids Potential Prokaryote Protein Proteins recognizing Repeat Research RNA RNA interference RNA-labeling sequence spacer subsequent understanding variant Viral RNA Virological virus diagnosis virus interference virus resistance [DOI] 10.3389/fmicb.2021.743580 PMC 바로가기 [Article Type] Microbiology
Nucleic Acid-Based Treatments Against COVID-19: Potential Efficacy of Aptamers and siRNAsMicrobiology Published on 2021-11-082022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acting Against antiviral therapy approach approved aptamer aptamer–siRNA chimera candidate cleave COVID-19 disease drug effective Effectiveness genomic Infection inhibit limitations Pathogenesis Potential reduce Replication RNA interference siRNA siRNAs Stage subgenomic RNA the disease the SARS-CoV-2 these compound Treatment treatments for COVID-19 viral infections viral life cycle viral loads Virus neutralization virus-neutralizing [DOI] 10.3389/fmicb.2021.758948 PMC 바로가기 [Article Type] Microbiology
Dysregulation of RNA interference components in COVID-19 patientsResearch Note Published on 2021-10-292022-10-27 Journal: BMC Research Notes [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] acute respiratory syndrome Ago2 Antiviral China component coronavirus COVID-19 COVID-19 patient COVID-19 patients COVID-19patient Defense demonstrated DGCR8 Dicer Drosha dysregulated expression expression level Health healthy individuals healthy subjects inhibiting mechanism mRNA Novel coronavirus objective Post-transcriptional gene silencing Result RNA interference SARS-CoV-2 severe respiratory illness statistically suggested supplementary material Viral proteins virus virus replication Wuhan [DOI] 10.1186/s13104-021-05816-0 PMC 바로가기 [Article Type] Research Note
Dysregulation of RNA interference components in COVID-19 patientsCOVID-19 환자에서 RNA 간섭 성분의 조절 조절Research Note Published on 2021-10-292022-09-10 Journal: BMC Research Notes [Category] 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Ago2 Antiviral China component coronavirus COVID-19 COVID-19 patient COVID-19 patients COVID-19patient COVID-19patients Defense defense mechanisms demonstrated DGCR8 Dicer Drosha dysregulated expression expression level Health healthy individuals healthy subjects inhibiting mechanism mRNA mRNAs Novel coronavirus objective Post-transcriptional gene silencing respiratory Respiratory illness Result RNA interference RNAi SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 severe respiratory illness statistically suggested supplementary material Viral Viral proteins virus virus replication Wuhan [DOI] 10.1186/s13104-021-05816-0 PMC 바로가기 [Article Type] Research Note
Dysregulation of RNA interference components in COVID-19 patientsResearch Note Published on 2021-10-292022-10-27 Journal: BMC Research Notes [Category] COVID-19, [키워드] acute respiratory syndrome Ago2 Antiviral China component coronavirus COVID-19 COVID-19 patient COVID-19 patients COVID-19patient Defense demonstrated DGCR8 Dicer Drosha dysregulated expression expression level Health healthy individuals healthy subjects inhibiting mechanism mRNA Novel coronavirus objective Post-transcriptional gene silencing Result RNA interference SARS-CoV-2 severe respiratory illness statistically suggested supplementary material Viral proteins virus virus replication Wuhan [DOI] 10.1186/s13104-021-05816-0 PMC 바로가기 [Article Type] Research Note
SARS‐CoV‐2 targeting by RNAi and host complement inhibition: A two‐pronged subterfuge for COVID‐19 treatmentRNAi에 의한 SARS-CoV-2 표적화 및 숙주 보체 억제: COVID-19 치료를 위한 두 갈래의 속임수Review Published on 2021-10-132022-09-10 Journal: Immunity, Inflammation and Disease [Category] 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach C3a clinical manifestation clinical manifestations complement Complement inhibitor component conjunction coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 patients curtail cytokine Cytokine storm degrade detrimental Disease progression disease progression and severity downstream effective Evidence exacerbate gene regulation processes globe Host immune responses infections information inhibitor knowledge lack less Local mitigate molecules ORF Perspective preventive measure preventive measures progression Proinflammatory cytokine protective immunity Replication required respiratory Result RNA interference RNAi robust SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus severity Spread suppress symptomatic and asymptomatic systemic immune response systemic immune responses the cytokine storm transcript transmissible variant Treatment vaccinate Vaccine variants Viral viral spread viral/retroviral virus [DOI] 10.1002/iid3.549 PMC 바로가기 [Article Type] Review
Inhibition of SARS-CoV-2 Replication by a Small Interfering RNA Targeting the Leader Sequence리더 서열을 표적으로하는 작은 간섭 RNA에 의한 SARS-COV-2 복제의 억제Article Published on 2021-10-082022-09-10 Journal: Viruses [Category] MERS, SARS, 변종, 신약개발, 진단, 치료제, [키워드] 5′-UTR 5′-untranslated region 5′-UTR acute respiratory syndrome acute respiratory syndrome coronavirus Alpha analyzed assays conserved coronavirus COVID-19 Cytopathic effect death delta variant eight family member genomic highly active homology inhibition initial leader sequence magnitude means prevented reduced replication Replication reporter respiratory retained RNA RNA interference RNAi RNAi therapy SARS-CoV virus SARS-CoV viruses SARS-CoV-1 SARS-CoV-2 sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 siRNA siRNAs subgenomic RNAs suppress target targeting the SARS-CoV-2 Treatment Vaccine development variant Viral viral infection viral infections viral replication virus virus replication viruses [DOI] 10.3390/v13102030 PMC 바로가기 [Article Type] Article
AGO CLIP-based imputation of potent siRNA sequences targeting SARS-CoV-2 with antifibrotic miRNA-like activity항섬유증 miRNA 유사 활성을 가진 SARS-CoV-2를 표적으로 하는 강력한 siRNA 서열의 AGO CLIP 기반 전가Article Published on 2021-09-272022-09-10 Journal: Scientific Reports [Category] SARS, 변종, 유전자 메커니즘, 치료제, [키워드] (RdRp acting acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antifibrotic Argonaute binding calculate caused conserved coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 crosslinking fibrosis immunoprecipitation induce Local lung cell line lung cell lines microRNA MicroRNAs miRNA miRNAs non-structural protein Nsp12 parameter predict pulmonary fibrosis RdRP repressed respiratory RNA RNA interference RNA viruses RNA-dependent RNA polymerase RNAi therapy SARS-CoV-2 SARS-CoV-2 genome screened seed sequence Sequence annotation Sequencing severe acute respiratory syndrome Coronavirus siRNA siRNAs Small interfering RNA small interfering RNAs susceptible synthesised TGF-β the SARS-CoV-2 genome transcript Transcriptome transcriptomes treat utilised variants [DOI] 10.1038/s41598-021-98708-z PMC 바로가기 [Article Type] Article
The development and improvement of ribonucleic acid therapy strategiesReview article Published on 2021-09-142022-10-05 Journal: Molecular Therapy. Nucleic Acids [Category] 비임상, [키워드] activating addition Affect Antisense oligonucleotides AONs backbone binding affinity catalytic cellular chemical modification COVID-19 delivery vehicle drugs functions Gene Expression IMPROVE limitation microRNA miRNA miRNAs Modification oligonucleotide overcome regulate ribonucleic acid therapy RNA RNA interference RNA vaccine RNA vaccines siRNA siRNAs therapeutic therapeutic drug therapeutic mechanism therapy Toxicity Transcription translation [DOI] 10.1016/j.omtn.2021.09.002 [Article Type] Review article
Protease cleavage of RNF20 facilitates coronavirus replication via stabilization of SREBP1423 Published on 2021-09-142022-10-29 Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS, [키워드] addressed antiviral role Bioinformatics analysis catalytic activity caused Cell cleavage cleave cleaved complex conserved coronavirus Coronavirus replication COVID-19 decrease Degradation develop drug ENhance enzyme Evidence evidenced facilitate Factors finger global public health Host host antiviral response host protein identify inhibitor interferon interferon-stimulated gene ISGs knockdown M pro mutant nsp5 polyprotein Prevent promote protease provided Respiratory Coronavirus Ring risk RNA interference RNF20 RNF40 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 main protease SARS-CoV-2 replication Significance significantly SREBP1 stimulatory target treat viral replication [DOI] 10.1073/pnas.2107108118 PMC 바로가기 [Article Type] 423