Propolis, Bee Honey, and Their Components Protect against Coronavirus Disease 2019 (COVID-19): A Review of In Silico, In Vitro, and Clinical Studies프로폴리스, 꿀벌 꿀 및 그 구성 요소는 코로나바이러스 질병 2019(COVID-19)로부터 보호합니다: In Silico, In Vitro 및 임상 연구에 대한 검토Review Published on 2021-02-252022-09-10 Journal: Molecules [Category] MERS, 임상, 치료제, [키워드] ACE-II activities Anti-inflammatory antioxidant Antiviral antiviral drug Antiviral effect Antiviral treatment bee bee honey bee products caffeic acid clinical Combination component Compound coronavirus disease Coronavirus disease 2019 Coronaviruses COVID -19 COVID-19 cytokine Cytokine storm discharge Effect Effects examined exhibited Express fatality flavonoids green Honey hospital hospitalized COVID-19 patient hospitalized COVID-19 patients host cells immune immunomodulatory in silico in vitro inhibit inhibited less Liposome Luteolin main protease molecular docking/biochemical modeling molecular simulations Mortality naringin natural Nigella Sativa non-structural protein non-structural proteins Prophylactic Propolis randomized clinical trials receiving Remdesivir respiratory review rutin SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome spike glycoprotein standard care Symptom the cytokine storm these compound these compounds Treatment treatment for COVID-19 Treatment outcome Trigger Vero E6 VERO E6 cells Viral viral clearance viral replication viral spike viral-host interaction virulence [DOI] 10.3390/molecules26051232 PMC 바로가기 [Article Type] Review
Network pharmacology for the identification of phytochemicals in traditional Chinese medicine for COVID-19 that may regulate interleukin-6인터루킨-6을 조절할 수 있는 COVID-19에 대한 중국 전통 의학의 파이토케미컬 식별을 위한 네트워크 약리학Bioinformatics Published on 2021-01-292022-08-31 Journal: Bioscience Reports [Category] 유전자 메커니즘, 치료제, [키워드] analyzed anti-inflammation effect approach approaches binding affinity biological processe biological processes Capsule Chinese collected Compound compounds construction core gene core genes coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment Cytoscape Decoction decrease docking result down-regulate effective evaluate excavation Formula gene cluster gene clusters Granule identify IL-6 indicated ingredient inhibit interleukin-6 Luteolin mechanism molecular molecular docking network network pharmacology pathway Pathways pharmacological positive potential mechanism potential mechanisms Protein–protein interaction quercetin regulate rehabilitation Research rutin screened TCM the binding affinity Traditional Chinese medicine Treatment ursolic acid was used [DOI] 10.1042/BSR20202583 PMC 바로가기 [Article Type] Bioinformatics
Optimization and evaluation of propolis liposomes as a promising therapeutic approach for COVID-19COVID-19에 대한 유망한 치료 접근법으로서 프로폴리스 리포솜의 최적화 및 평가Article Published on 2021-01-052022-09-11 Journal: International journal of pharmaceutics [Category] SARS, 치료제, [키워드] 3CL-protease anti-viral activity Antiviral approach Avigan caffeic acid comparable component COVID-19 determined by develop Docking studies docking study Efficiency encapsulation highest affinity Hydroxychloroquine IC50 inhibitory effect injection Liposome liposomes methodology optimization parameter Particle performed Propolis protease Protein released Remdesivir response Result RT-PCR rutin significantly spike Spike protein targets Therapeutic approach Treatment Viral viral replication [DOI] 10.1016/j.ijpharm.2020.120028 PMC 바로가기 [Article Type] Article
Traditional Chinese medicine network pharmacology study on exploring the mechanism of Xuebijing Injection in the treatment of coronavirus disease 20192019년 코로나바이러스 질병 치료에서 Xuebijing 주사의 메커니즘 탐구에 대한 중국 전통 의학 네트워크 약리학 연구Article Published on 2020-12-012022-08-31 Journal: Chinese journal of natural medicines [Category] MERS, SARS, 유전자 메커니즘, 치료제, [키워드] ACE2 Affect Analysis angiotensin Angiotensin-converting enzyme Anti-inflammatory Antiviral apigenin Chinese community-acquired pneumonia components Compound coronavirus disease Coronavirus disease 2019 COVID-19 Cytoscape database docked drug enrichment analysis Gene ontology help IL6 immune response indicated ingredient injection KEGG Kyoto Luteolin MAPK1 mechanism molecular docking multiple pathway multiple pathways network network pharmacology Ontology other compound other compounds overlapping Pathway enrichment analysis Perspective Pneumonia potential mechanism PPI network predict Proteins provided quercetin rutin S protein SALVIANOLIC ACID screened Sepsis Spike protein target target gene Target genes targets TCM TNF Traditional Chinese medicine treat Treatment with COVID-19 Xuebijing injection. [DOI] 10.1016/S1875-5364(20)60038-3 PMC 바로가기 [Article Type] Article
Potential bioactive glycosylated flavonoids as SARS-CoV-2 main protease inhibitors: A molecular docking and simulation studiesSARS-CoV-2 주요 프로테아제 억제제로서의 잠재적 생체 활성 글리코실화 플라보노이드: 분자 도킹 및 시뮬레이션 연구Research Article Published on 2020-10-152022-08-13 Journal: PLoS ONE [Category] Biochemistry, COVID-19, [키워드] 3CL pro 6LU7 Acute respiratory infection antiviral molecules approach AutoDock AutoDock vina best binding affinity chemical structures Chymotrypsin-like protease complex Consensus coronavirus docking experiments Docking studies docking study downloaded drug drug treatment evaluate flavonoids flavonoids chemical structure flavonoids chemical structures fruit glycosylated flavonoid glycosylated flavonoids glycosylated forms highest binding affinity in vitro in vivo experiment inhibit inhibitor inhibitors inhibitors of SARS-CoV-2 investigated limit MD simulation MD simulations molecular docking Molecular docking study natural phenolic compound natural phenolic compounds Novel coronavirus performed Perspective physiological activities plants Potential protease Protein Protein Data Bank Protein Data Bank site PubChem quercetin Quercetin-3-O-rhamnoside respiratory respiratory infection responsible rutin SARS-CoV SARS-CoV-2 main protease SARS-CoV-2 protease Simulation study Spread stability tested the SARS-CoV-2 Treatment virus virus expansion was performed [DOI] 10.1371/journal.pone.0240653 PMC 바로가기 [Article Type] Research Article
Flavonoid glycosides and their putative human metabolites as potential inhibitors of the SARS-CoV-2 main protease (Mpro) and RNA-dependent RNA polymerase (RdRp)Original Article Published on 2020-09-302022-10-29 Journal: Memórias do Instituto Oswaldo Cruz [Category] COVID-19, MERS, SARS, [키워드] 3CLpro active sites acute respiratory syndrome analysed approach approaches coronavirus Coronavirus disease 2019 COVID-19 cysteine protease derivative derivatives docking analysis docking result Dysphania ambrosioides evidenced flavonoid glucuronides glycoside human organism Hydrogen bond in silico in vitro in vivo experiments indicated Infection inhibitor Interaction metabolite molecular docking MPro nicotiflorin non-structural protein pandemic Phytomedicines predicted protease Proteins RdRP Region reported risk RNA-dependent RNA polymerase rutin SARS-CoV-2 stages target the binding affinity the SARS-CoV-2 viral replication Virtual screening WHO World Health Organization [DOI] 10.1590/0074-02760200207 PMC 바로가기 [Article Type] Original Article
Discovery of Potential Flavonoid Inhibitors Against COVID-19 3CL Proteinase Based on Virtual Screening StrategyMolecular Biosciences Published on 2020-09-292022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] 2019 novel coronavirus 3CL accounted Accuracy Against approved Area AUC binding affinity caused Compound Comprehensive coronavirus inhibitor COVID-19 COVID-19 3CL proteinase Curve dataset drug Drug discovery exhibited flavonoid flavonoids machine learning molecular docking NMPA other compounds outbreak Potential product proteinase public health reached Regression resolved ROC rutin screened Screening Strategy Virtual screening [DOI] 10.3389/fmolb.2020.556481 PMC 바로가기 [Article Type] Molecular Biosciences
Possible SARS-coronavirus 2 inhibitor revealed by simulated molecular docking to viral main protease and host toll-like receptorResearch Article Published on 2020-06-122022-10-31 Journal: Future Virology [Category] COVID-19, [키워드] adopted Analysis Antiviral applied binding energy COVID-19 determine enrichment functional protein GO and KEGG enrichment analysis Host Inflammatory inhibitor Interaction material metabolic process metabolism molecular docking MPro plants protease Protein rutin SARS-coronavirus SARS-CoV-2 main protease selected target therapeutic TLR TLR2 TLR6 TLR7 TLRs Toll-like receptor Toll-like receptors traditional antiviral medicinal plants [DOI] 10.2217/fvl-2020-0099 PMC 바로가기 [Article Type] Research Article
Regulated rutin co-administration reverses mitochondrial-mediated apoptosis in Plasmodium berghei-infected miceArticle Published on 2020-02-052024-08-28 Journal: Biochemical and Biophysical Research Communications [Category] 말라리아, [키워드] Apoptosis artesunate-mefloquine Dihydroartemisinin-piperaquine Malarial Infection Mitochondria rutin