Two-Component Nanoparticle Vaccine Displaying Glycosylated Spike S1 Domain Induces Neutralizing Antibody Response against SARS-CoV-2 VariantsResearch Article Published on 2021-10-122022-10-29 Journal: mBio [Category] COVID-19, MERS, SARS, [키워드] ACE2 receptor binding adenoviral vector alleviate Cell COVID-19 effective expression full-length S glycosylation help immunization insect cells mice mRNA nanoparticle Neutralizing antibody response pandemic platform produced Protein protein-based vaccine response robust S1 domain SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variants secreted spike subunit the SARS-CoV-2 Vaccine Vaccines variants VLP Wuhan [DOI] 10.1128/mBio.01813-21 PMC 바로가기 [Article Type] Research Article
Spike Proteins of SARS-CoV-2 Induce Pathological Changes in Molecular Delivery and Metabolic Function in the Brain Endothelial CellsSARS-COV-2의 스파이크 단백질은 뇌 내피 세포에서 분자 전달 및 대사 기능에서 병리학 적 변화를 유도한다.Article Published on 2021-10-082022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 BBB Blood–brain barrier Brain cause change changes in component components coronavirus coronavirus disease COVID-19 delivery dextran drastic Effect Endothelial cell endothelial cells enzyme Express function functional host cells induce infected with SARS-CoV-2 infecting infectious agent infectious agents marker mechanism metabolic metabolic function metabolism mitochondrial molecular neurological sign neurological signs Neurological symptom Neurological symptoms pathogenic pathological pathological mechanism permeability physiological RBD recent receptor Receptor-binding domain respiratory S1 domain SARS-CoV-2 SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown spike Spike protein the receptor-binding domain toxic effect toxic effects Transferrin Treatment trimer was increased [DOI] 10.3390/v13102021 PMC 바로가기 [Article Type] Article
Xeno-Nucleic Acid (XNA) 2’-Fluoro-Arabino Nucleic Acid (FANA) Aptamers to the Receptor-Binding Domain of SARS-CoV-2 S Protein Block ACE2 BindingArticle Published on 2021-10-022022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] ACE2 acid affinity Amino acid angiotensin-converting enzyme 2 aptamer bind binding binding affinity block Cell comparable COVID-19 demonstrated DNA ELISA assay Evolution FANA generate human host cells inhibited inhibition Interaction Ligand neutralizing antibody nucleotide platform RBD receptor S protein S1 domain S1 protein SARS virus SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 S selected specificity the RBD the receptor-binding domain trimeric S protein viral S protein was used XNA [DOI] 10.3390/v13101983 PMC 바로가기 [Article Type] Article
Longitudinal Analysis of Inflammatory Response to SARS-CoV-2 in the Upper Respiratory Tract Reveals an Association with Viral Load, Independent of Symptoms상부 호흡기에서 SARS-CoV-2에 대한 염증 반응의 종단 분석은 증상과 무관한 바이러스 부하와의 연관성을 보여줍니다Observational Study Published on 2021-09-282022-09-12 Journal: Journal of Clinical Immunology [Category] MERS, SARS, 임상, 진단, [키워드] Activation active site analyzed Anosmia antiviral response CCL2 collected conducted Control correlated COVID-19 cohort CXCL10 cytokine cytokine level cytokine levels cytokine response Cytokines different time point different time points dissemination elevated enrolled Geneva University Hospitals GM-CSF IgA IgG IL-6 immunological characteristics increase in Increases increases in independent of innate response intranasal load Local longitudinal Mild myeloid cells nasal Nasal cavity nasal epithelium Nasal wash observational study Patient produced recruitment remained respiratory response Result S1 domain Sample SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected patient SARS-CoV-2-infected patients serum serum cytokine levels specimen Spike protein subset supplementary material Switzerland Symptom symptom onset Symptoms the spike protein therapeutic approaches tract understanding upper upper respiratory tract Viral load Virological virological and immunological characteristics virus [DOI] 10.1007/s10875-021-01134-z PMC 바로가기 [Article Type] Observational Study
Immunogenicity and Reactogenicity After SARS-CoV-2 mRNA Vaccination in Kidney Transplant Recipients Taking Belatacept벨라타셉트를 복용하는 신장 이식 환자에서 SARS-CoV-2 mRNA 백신 접종 후 면역원성과 반응성Article Published on 2021-09-012022-09-11 Journal: Transplantation [Category] SARS, 치료기술, [키워드] analyzed anti-SARS-CoV-2 antibodies belatacept blood sample Blood samples calculate collected detectable dose Effectiveness enzyme enzyme immunoassay Fold change Humoral immunity immunoassay immunogenicity impair investigated kidney transplant recipient kidney transplant recipients measure mRNA mRNA vaccine participant Patient positive positive response Probability PROTECT Receptor-binding domain recipient recipients recruited S1 domain SARS-CoV-2 SARS-CoV-2 spike protein Spike protein Taking the receptor-binding domain the SARS-CoV-2 Transplant Treatment vaccination was used [DOI] 10.1097/TP.0000000000003824 PMC 바로가기 [Article Type] Article
The BNT162b2 mRNA COVID-19 vaccine in adolescents and young adults with cancer: A monocentric experience청소년 및 암에 걸린 젊은 성인을 위한 BNT162b2 mRNA COVID-19 백신: 단일 중심 경험Comparative Study Published on 2021-09-012022-09-12 Journal: European journal of cancer (Oxford, England : 1990 [Category] MERS, 신약개발, 진단, [키워드] Administered administration Affect antibody AYA BNT162b2 mRNA Cancer Care COVID COVID-19 COVID-19 infection COVID-19 vaccine Critical determine Efficacy IgG IgG antibody Immunoglobulin include infections injection Local mandatory median Mild neutralisation neutralisation test oncology one patient Paediatric oncology paediatric patient Pain Patient patients positive COVID-19 positive serology pre-vaccination progression reactivity Retrospective analysis S1 domain safety profile Seroconversion serology serology testing Side-effect solid tumour Symptom systemic symptom tested the spike protein the vaccine Treatment Tumours vaccination Vaccine vaccine injection was tested were given [DOI] 10.1016/j.ejca.2021.06.002 PMC 바로가기 [Article Type] Comparative Study
DNA Aptamers Block the Receptor Binding Domain at the Spike Protein of SARS-CoV-2Molecular Biosciences Published on 2021-08-122022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE2 ACE2 receptor affected Angiotensin converting enzyme-2 aptamer binding binding site block cell receptors conditions curative develop DNA DNA aptamers effective Evidence free energies genetic material host cell host cell membrane human ACE2 receptor human cells inaccessible Interaction membrane molecular molecular dynamics molecular simulations nucleotide Probability Proteins recognize recognizing reducing S-protein S1 domain SARS-CoV-2 sensitivity significantly single-stranded Spike protein subsequent the SARS-CoV-2 the Spike trimer virus [DOI] 10.3389/fmolb.2021.713003 PMC 바로가기 [Article Type] Molecular Biosciences
SARS-CoV-2 Spike Protein Extrapolation for COVID Diagnosis and Vaccine DevelopmentMolecular Biosciences Published on 2021-07-282022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] acute respiratory syndrome affecting alleviate antibody antigenic target antiviral therapeutics approach can be used cell lines clinical development conserved Coronaviral coronavirus coronavirus disease Coronavirus pandemic Coronavirus-2 COVID COVID-19 COVID-19 pandemic cross-react demonstrated detect development Diagnosis diagnosis of COVID-19 diagnostic diagnostics domain effective ELISA extrapolation facilitate host cell receptor Human IgM and IgG in vitro study Infection inhibiting interact Lateral flow immunoassays mAb mAbs molecular monoclonal antibody Mortality N-terminal domain neutralize Neutralizing neutralizing antibody pandemic platform polyclonal antibody Prevent Prophylaxis RBD Receptor binding domain Region researcher S-protein S1 and S2 S1 domain S2 domain SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection selection pressure sequence similarity Serological assay spike spike gene spike glycoprotein the RBD Treatment trimer Vaccine Vaccines Viral protein virus virus-cell membrane fusion [DOI] 10.3389/fmolb.2021.607886 PMC 바로가기 [Article Type] Molecular Biosciences
Impact of the Second Epidemic Wave of SARS-CoV-2: Increased Exposure of Young PeopleSARS-CoV-2의 두 번째 전염병 영향: 젊은이들의 노출 증가Public Health Published on 2021-07-262022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 진단, 치료기술, [키워드] age age and sex anti-SARS-CoV-2 IgG antibodies antibody Antibody titer borderline clinical laboratories Clinical management collected Corsica cross-sectional ELISA enzyme-linked immunosorbent assay Estimated estimates exposure First wave France Frequency herd immunity house IgG antibodies IgG antibody Impact Increased individual Laboratory men neutralization neutralization test Neutralizing antibodies Odds ratio P -value participant Patient positive produced profile proportion residual S1 domain Sample SARS-CoV-2 second second wave semi-quantitative sera serological surveillance seroneutralization Seroprevalence significantly significantly higher Spike protein tested Viral viral spike protein virus neutralization test VNT Wave women [DOI] 10.3389/fpubh.2021.715192 PMC 바로가기 [Article Type] Public Health
Binding of SARS-CoV-2 Fusion Peptide to Host Endosome and Plasma MembraneArticle Published on 2021-07-132022-10-29 Journal: The journal of physical chemistry. B [Category] COVID-19, SARS, [키워드] acting bind binding C-terminus cellular membrane cleavage Connected conserved Contact eight element endosome flexible linker function fusion fusion peptide Host host cell host cell receptor human host identify Infection initial insertion MD simulation membrane membrane fusion molecular Multiple N-terminus plasma membranes proceed promote Protein required S1 domain S2′ site SARS-CoV-2 second stability subsequent the SARS-CoV-2 the SARS-CoV-2 virus viral envelope viral membrane viral spike virion virus [DOI] 10.1021/acs.jpcb.1c04176 PMC 바로가기 [Article Type] Article