Seroprevalence of infection-induced SARS-CoV-2 antibodies among health care users of Northern Italy: results from two serosurveys (October-November 2019 and September-October 2021)Article Published on 2022-11-012022-11-15 Journal: International Journal of Infectious Diseases [Category] SARS, 진단, 치료기술, [키워드] 95% CI 95% confidence interval age anti-Nucleocapsid IgG antibodies antibody calculated Care circulating CIs conducted COVID-19 detect domains enzyme-linked immunosorbent enzyme-linked immunosorbent assay Gender groups Health Hypothesis IgG IgG antibody Immunoglobulin immunosorbent Italy multiplex nucleocapsid Piedmont positive test result prevalence rate proportion Receptor binding domain Result S1 and S2 S1 domain Sample SARS-CoV-2 SARS-CoV-2 antibody semiquantitative method sera Seroprevalence Serosurvey Support tested the spike protein Transmission dynamics virus [DOI] 10.1016/j.ijid.2022.09.017 PMC 바로가기
B-cell repopulation dynamics and drug pharmacokinetics impact SARS-CoV-2 vaccine efficacy in anti-CD20-treated multiple sclerosis patientsArticle Published on 2022-11-012022-11-15 Journal: European journal of neurology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] 95% CI 95% confidence interval Affect anti-CD20 anti-CD20 treatment antibody Antibody Response Antibody titers B cell B cells B-cell B-cell depletion Blood booster cellular response Cohort correlated detectable develop Efficacy Guidance humoral identify IgG^{+} interleukin-13 Logistic regression median memory multiple sclerosis naïve no correlation Odds ratio Patient patients predict predictor Probability recent rituximab S1 domain SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine Seroconversion T-cell Response treated Treatment turn vaccination vaccine responses [DOI] 10.1111/ene.15492 PMC 바로가기
An experimental test of the nicotinic hypothesis of COVID-19Article Published on 2022-11-012022-11-16 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acetylcholine receptors acute respiratory syndrome binding binding competition assays cells competing complex coronavirus COVID-19 disease ectodomain effort expressed Hypothesis Infection Ligand nicotinic receptors pathophysiological mechanism peptides performed Rabies virus receptor receptors S1 domain SARS-CoV-2 SARS-CoV-2 spike protein Spike protein suggested Symptom tested the SARS-CoV-2 unlikely virus [DOI] 10.1073/pnas.2204242119 PMC 바로가기
Insertion/deletion hotspots in the Nsp2, Nsp3, S1, and ORF8 genes of SARS-related coronavirusesArticle Published on 2022-10-282022-11-16 Journal: BMC Ecology and Evolution [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome animal hosts base bases bat bat coronavirus benefit Characteristics classical complex coronavirus determine Frame Future Genome genomic region hotspot Human human SARS-CoV-2 human SARS-CoV-2 strain INDEL Indel hotspot indels insertion/deletion insertion/deletion (indel). mechanism Multiple sequence alignment Mutation N-terminal domain Neutral non-structural protein Occurrence offer ORF8 ORF8 gene pangolin Pangolin coronavirus (PCoV) Point mutation RaTG13 Region reported RNA sequence S1 domain SARS-CoV SARS-CoV-2 SARS-related coronavirus SARS-related coronaviruses severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) survival the spike protein viral evolution virus viruses [DOI] 10.1186/s12862-022-02078-7 PMC 바로가기
Permissive omicron breakthrough infections in individuals with binding or neutralizing antibodies to ancestral SARS-CoV-2Article Published on 2022-09-292022-11-15 Journal: Vaccine [Category] SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome analyzed B.1.1.529 binding binding antibodies binding antibody breakthrough Breakthrough infection calibrated coronavirus correlated include individual Infection longitudinal cohort study marker Neutralizing activity Neutralizing antibodies neutralizing antibody occurred omicron Permissive Population ranged Recombinant spike protein S1 domain SARS-CoV-2 sequence sera Spike protein the spike protein vaccination rates variant WHO World Health Organization Wuhan-Hu-1 [DOI] 10.1016/j.vaccine.2022.08.058 PMC 바로가기
Isolation of a human SARS-CoV-2 neutralizing antibody from a synthetic phage library and its conversion to fluorescent biosensorsArticle Published on 2022-09-152022-11-15 Journal: Scientific Reports [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome addition angiotensin-converting enzyme 2 antibody antibody fragment antigen detection binding Clinical treatment clone coronavirus demonstrated diagnose effective Fab fluorescent Health help Human monoclonal antibody human SARS-CoV-2 IgG neutralize neutralizing antibody outbreak Prevent public health S protein S1 domain SARS-CoV-2 selected spike glycoprotein spread of COVID-19 viral infection viral infections virus detection [DOI] 10.1038/s41598-022-19699-z PMC 바로가기
Utility of in silico-identified-peptides in spike-S1 domain and nucleocapsid of SARS-CoV-2 for antibody detection in COVID-19 patients and antibody productionArticle Published on 2022-09-052022-11-15 Journal: Scientific Reports [Category] SARS, 변종, 진단, 치료기술, [키워드] 2D structure 3D structure analyzed antibody Antibody detection antibody production Antibody Response Antigen antigenic peptides changes in COVID-19 patient COVID-19 patients domain eight Evidence homology immunogenic in silico analysis limitation N protein New nucleocapsid peptide performed Proteins provide RBD Result S1 domain SARS-CoV-2 SARS-CoV-2 variant selected sequence serum serum sample Seven Standardization structural proteins the N protein the spike protein trimer virus viruses were used [DOI] 10.1038/s41598-022-18517-w PMC 바로가기
Probing structural basis for enhanced binding of SARS-CoV-2 P.1 variant spike protein with the human ACE2 receptorSARS-CoV-2 P.1 변이체 스파이크 단백질과 인간 ACE2 수용체의 향상된 결합을 위한 구조적 기초 조사Article Published on 2022-07-012022-09-11 Journal: Journal of cellular biochemistry [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding ACE2 receptor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affinity Analysis angiotensin angiotensin converting enzyme approach binding circulating commonality Comparative analysis complex conformational change Contact coronavirus COVID-19 cumulative cumulative effect demonstrated enzyme host receptor human ACE2 receptor Infection initial Interaction investigated molecular molecular dynamic simulation Mutation P.1 variant P.1 variants Probing Protein protein network analysis provide RBD RBD residue RBD residues RBD-ACE2 receptor Receptor binding domain reported responsible S1 domain SARS-CoV-2 severe acute respiratory syndrome Coronavirus Spike protein the RBD the spike protein unique variant variants virus transmission wild type [DOI] 10.1002/jcb.30276 PMC 바로가기 [Article Type] Article
Insertion-and-Deletion Mutations between the Genomes of SARS-CoV, SARS-CoV-2, and Bat Coronavirus RaTG13SARS-CoV, SARS-CoV-2 및 박쥐 코로나바이러스 RaTG13의 게놈 간의 삽입 및 삭제 돌연변이Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 base bases bat bat coronavirus RaTG13 Complete coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) developmental distribution FIVE Frame gene sequence Genome genome sequence Genome sequences genomes Inconclusive INDEL indels insertion insertion-and-deletion mutation mechanism MOST Mutation mutation rate mutations Noncoding region nonstructural protein 3 Open reading frame ORF ORF8 ORF8 gene ORF8 genes Point mutation point mutations protein 3 RaTG13 replaced REPLACED BY replacement S1 domain SARS-CoV SARS-CoV-2 SARS-CoV-2 genome sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus (SARS-CoV) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Spike protein the SARS-CoV-2 genome the spike protein viral genome virus [DOI] 10.1128/spectrum.00716-22 PMC 바로가기 [Article Type] Article
Immune Response after 2 Doses of BNT162b2 mRNA COVID-19 Vaccinations in Children and Adolescents with Cancer and Hematologic DiseasesArticle Published on 2022-06-012022-11-15 Journal: Asian Pacific Journal of Cancer Prevention : APJCP [Category] COVID19(2023년), SARS, 진단, [키워드] 95%CI Administered Adolescent analyzed anti-SARS-CoV-2 antibody blood sample BNT162b2 mRNA BNT162b2 vaccine Cancer children collected Complete COVID-19 COVID-19 infection COVID-19 vaccine defined Delta Delta strain disease dose enrolled evaluate GMT hematologic Hematologic malignancy high risk IgG immune response Immunocompromised patient immunogenicity Immunoglobulin immunosuppressive agent immunosuppressive drugs mRNA mRNA COVID-19 vaccine. of BNT162b2 offered Patient Patients with cancer pediatric pediatric cancer prospective cohort study RBD receive receiving Receptor binding domain response S-RBD S1 domain SARS-CoV-2 SARS-CoV-2 vaccine serum severe symptom solid tumor sVNT the spike protein Treatment vaccination viral neutralization was determined [DOI] 10.31557/APJCP.2022.23.6.2049 PMC 바로가기