S2 subunit – Page 3 – Communicable Diseases Research

Dromedary camel nanobodies broadly neutralize SARS-CoV-2 variants

단봉 낙타 나노바디는 SARS-CoV-2 변종을 광범위하게 중화시킵니다.

Article

Published on 2022-05-032022-09-11
Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종,

Peptides-based therapeutics: Emerging potential therapeutic agents for COVID-19

펩티드 기반 치료제: COVID-19에 대한 새로운 잠재적 치료제

Review

Published on 2022-05-012022-09-11
Journal: Thérapie [Category] Coronavirus, COVID19(2023년), SARS, 신약개발, 임상, 치료제,

[키워드] antimicrobial peptide antiviral activity Antiviral agents blocked causative agent cell membrane cleave clinical trials COVID-19 COVID-19 outbreak drug drugs feasibility form fusion hACE2 host cell host cell membrane Human humans In silico method inhibitor Interaction intestine intestines lactoferrin lung Lungs mechanism MERS outbreak pandemic peptide peptide-based peptides Peptides-based therapeutics positive-sense RNA virus potential therapeutic agent RNA virus S protein S protein-hACE2 interaction S1 subunit S2 subunit SARS-CoV-2 shown the S1 subunit the SARS-CoV-2 therapeutic viral envelope viral infection
[DOI] 10.1016/j.therap.2021.09.007 PMC 바로가기 [Article Type] Review

Neutralizing Monoclonal Antibodies Inhibit SARS-CoV-2 Infection through Blocking Membrane Fusion

중화 단일 클론 항체는 막 융합 차단을 통해 SARS-CoV-2 감염을 억제합니다

Article

Published on 2022-04-272022-09-11
Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단,

[키워드] Alpha antigenic epitope Antisera blocking cell membrane collected conserved COVID-19 therapeutics Delta Effectiveness epitope epitope peptide Epitopes Epsilon exhibited fusion Gamma immunized immunodominant Infection inhibit SARS-CoV-2 inhibited membrane membrane fusion mice MOST Mutation NAb NAbs Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody peptides Protein RBD RBD sequence RBD sequences Receptor binding Receptor binding domain reduced S protein S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants SARS-like coronaviruses sequence spike (S) protein the RBD the S protein the SARS-CoV-2 unique Vaccine Vaccines variants virus virus entry
[DOI] 10.1128/spectrum.01814-21 PMC 바로가기 [Article Type] Article

Longitudinal immune profiling reveals dominant epitopes mediating long-term humoral immunity in COVID-19-convalescent individuals

세로 방향 면역 프로파일링은 COVID-19 회복기 개인의 장기 체액성 면역을 매개하는 지배적인 에피토프를 나타냅니다

Article

Published on 2022-04-012022-09-11
Journal: The Journal of Allergy and Clinical Immunology [Category] COVID19(2023년), SARS, 변종, 진단,

[키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus Analysis antibody Antibody Response caused circulating variants concerning contagious coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients COVID-19-convalescent individual COVID-19-convalescent individuals cytokine cytokine production diagnostic disease onset dissect dominant dominant epitope early stage early stages endemic human coronavirus endemic human coronaviruses epitope Epitopes fatality feature global pandemic highly pathogenic humoral humoral immune responses Humoral immunity immune immune profiling immune response immune responses Immunity individual induce Kinetics long-term immune response long-term immune responses Longevity longitudinal longitudinal analysis mapped moderate moderate symptoms N-terminal domain Neutralizing antibodies neutralizing antibody ORF1ab path patients peptide peptide microarray performed Protein Proteins proteome proteome-wide peptide microarray. reactive respiratory responsible reveal S1 subunit S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein sequence homology sequence identity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown specific antibodies Spike protein sustained symptoms of COVID-19 the early SARS-CoV-2 the S1 subunit the SARS-CoV-2 Vaccine design Wuhan-Hu-1
[DOI] 10.1016/j.jaci.2022.01.005 PMC 바로가기 [Article Type] Article

The S1 Subunit of the SARS-CoV-2 Spike Protein Activates Human Monocytes to Produce Cytokines Linked to COVID-19: Relevance to Galectin-3

SARS-CoV-2 스파이크 단백질의 S1 서브유닛은 인간 단핵구를 활성화하여 COVID-19와 연결된 사이토카인을 생성합니다: 갈렉틴-3과의 관련성

Article

Published on 2022-03-222022-09-11
Journal: Frontiers in Immunology [Category] SARS, 변종,

[키워드] ACE2 activate Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 ARDS basophil basophils bind caused component coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CRS cytokine Cytokine release syndrome Cytokines dendritic dendritic cell disease dysregulated Efficacy epithelial cell epithelial cells Evidence facilitate feature fold galectin-3 Health human monocyte human monocytes immune cells Inflammation innate immune innate immune cell Innate immune cells innate immune response Innate immunity lectin Lung injury mechanism MERS Middle East Middle East respiratory syndrome monocyte Monocytes N-terminal domain novel vaccines NTD pandemic persistence pocket Produce Relevance reported respiratory respiratory distress Respiratory distress syndrome responsible S1 subunit S1-NTD S2 subunit SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus shown solid phase spike Spike protein stalk structural homology susceptible individuals syndrome synthesis the S1 subunit the SARS-CoV-2 the spike protein therapeutic interventions Therapeutics Vaccine variants virus while β-Coronaviruses
[DOI] 10.3389/fimmu.2022.831763 PMC 바로가기 [Article Type] Article

A Five-Helix-Based SARS-CoV-2 Fusion Inhibitor Targeting Heptad Repeat 2 Domain against SARS-CoV-2 and Its Variants of Concern

SARS-CoV-2 및 우려 변종에 대한 헵타드 반복 2 도메인을 표적으로 하는 5개 나선 기반 SARS-CoV-2 융합 억제제

Article

Published on 2022-03-132022-09-11
Journal: Viruses [Category] SARS, 변종,

[키워드] 5-Helix acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 cell-cell fusion concern conserved conserved region Coronavirus-2 COVID-19 vaccines Delta delta variant domain Efficacy fusion fusion inhibitor helix heptad repeat heptad repeat 1 heptad repeat 2 homologous Infection inhibited Lambda nCoV omicron Omicron variants pandemic Prevent Prophylactic Protective Protein pseudotyped SARS-CoV-2 Recombinant protein Repeat S-mediated cell-cell fusion S2 subunit SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 six-helix bundle targeting therapeutic treat variant variant of concern variants variants of concern variants of interest VoC VOCs wild-type
[DOI] 10.3390/v14030597 PMC 바로가기 [Article Type] Article

Carbohydrate Ligands for COVID-19 Spike Proteins

Article

Published on 2022-02-062022-10-28
Journal: Viruses [Category] COVID-19, COVID19(2023년), Fulltext, MERS, SARS,

SARS-CoV-2–Specific Vaccine Candidates; the Contribution of Structural Vaccinology

Review

Published on 2022-02-032022-10-28
Journal: Vaccines [Category] COVID-19,

Kinetics of immune responses to SARS-CoV-2 proteins in individuals with varying severity of infection and following a single dose of the AZD1222

감염 정도가 다양하고 AZD1222의 단일 투여 후 개인에서 SARS-CoV-2 단백질에 대한 면역 반응의 동역학

Research Article

Published on 2022-01-272022-09-12
Journal: Clinical and experimental immunology [Category] COVID19(2023년), MERS, SARS, 진단,

[키워드] ACE2 Alpha angiotensin antibody AZD1222 cohorts comparable country declined doses highest IgA IgA antibody IgA response IgG IgG antibody IgG response immune response immune responses individual individuals investigated Kinetics less mild illness N protein natural infection outbreak Patient Protein RBD receptor Receptor binding domain reduce reduced remained S2 subunit SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins Severity of infection significantly significantly lower single dose tested the antibody response the SARS-CoV-2 titre vaccination vaccinee vaccinees VOCs were assessed wild type
[DOI] 10.1093/cei/uxac009 PMC 바로가기 [Article Type] Research Article

Comprehensive characterization of the antibody responses to SARS-CoV-2 Spike protein finds additional vaccine-induced epitopes beyond those for mild infection

SARS-CoV-2 스파이크 단백질에 대한 항체 반응의 포괄적인 특성화는 경증 감염에 대한 것 이외의 추가 백신 유도 에피토프를 찾습니다.

Comparative Study

Published on 2022-01-242022-09-10
Journal: eLife [Category] 변종, 치료기술, 치료제,

[키워드] Affect affected age Alter Analysis antibodies antibody Antibody binding antibody epitope Antibody Response Antigen Bacteria binding C-terminal domain cause chair changes in complicate Comprehensive computing conserved Control covariate COVID-19 COVID-19 pandemic disease DNA fragment dose education effective epitope Epitopes escape escape mutations experiment exposure to faculty FAM feature finding focus foundation funding fusion peptide genetic code help Howard Hughe Howard Hughes Human Humoral response humoral responses identify immune Immune escape immune system implication individual infect infected individuals Infection Infrastructure interfere Laboratory Lower majority mild infection mRNA vaccination mRNA vaccine mutant Mutation mutations NIH not affect not altered occur offered overlapping pandemic pathway Pathways pattern peptide peptides phage phages population level portion Principal component principal component analysis produced producing PROTECT Protein RBD Region regions Research residue route S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 spike protein Scholar selected severe disease Severe infection shape small molecule Small molecules specific antibodies specific protein spike Spike protein spike-specific antibodies Spike-specific antibody Spread stick subsequent Support supported target the antibody the antibody response the RBD the S1 subunit the SARS-CoV-2 the Spike the spike protein thought triggering unique vaccinated individual vaccinated individuals vaccination Vaccine Vaccine development vaccine-induced antibodies vaccine-induced antibody variant Variation virus was performed while wild-type
[DOI] 10.7554/eLife.73490 PMC 바로가기 [Article Type] Comparative Study