Solid organ transplantation from donors with recent or current SARS-CoV-2 infection: A systematic review최근 또는 현재 SARS-CoV-2 감염이 있는 기증자의 고형 장기 이식: 체계적인 검토Review Published on 2022-08-012022-09-11 Journal: Anaesthesia, critical care & pain medicine [Category] COVID19(2023년), SARS, 치료기술, [키워드] anti-SARS-CoV-2 titer Cochrane COVID-19 Study Register complications COVID-19 COVID-19 symptoms cycle database died Donor donors dysfunction evaluate for inclusion heart Hospital stay IQR kidney kidneys liver lung median Mortality occurred organ Organ donation organ transplantation organs outcome Patient patients died positive recipient recipients rejection risk of transmission Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 viral Septic shock solid organ solid organ transplantation SOT Symptom symptomatic systematic review threshold Transmission Transplant two patients viral replication Viral transmission was performed Web of Science [DOI] 10.1016/j.accpm.2022.101098 PMC 바로가기 [Article Type] Review
RelCoVax®, a two antigen subunit protein vaccine candidate against SARS-CoV-2 induces strong immune responses in miceSARS-CoV-2에 대한 2개의 항원 소단위 단백질 백신 후보인 RelCoVax®는 마우스에서 강력한 면역 반응을 유도합니다Article Published on 2022-07-302022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료법, [키워드] adjuvant adjuvants Administered alum aluminum aluminum hydroxide Antibody titer Antibody titers Antigen antigen exposure Cell Cellular immune response cellular immune responses Combination contribute COVID-19 pandemic CpG Delta delta variant demonstrated develop dominant dose regimen dual E. coli effective vaccine elicited Emergency use authorization evade evidenced glycoprotein heterologous expression hydroxide IFN-γ immune responses immunize immunized immunized mice in vitro induce mammalian cell mammalian cells mice Mutation N protein N proteins neutralize Neutralizing antibodies neutralizing antibody nucleocapsid prime and boost Protein RBD Receptor binding domain Region RelCoVax® S protein Safe SARS-CoV-2 SARS-CoV-2 viral SARS-CoV-2 virus serum splenocyte splenocytes stimulated strain strong immune response subunit Subunit vaccine Th1 the SARS-CoV-2 virus vaccinated individuals Vaccine vaccine candidate vaccine candidates variants of SARS-CoV-2 viral strains virus entry [DOI] 10.1016/j.vaccine.2022.06.026 PMC 바로가기 [Article Type] Article
The short-term effect of different chlorhexidine forms versus povidone iodine mouth rinse in minimizing the oral SARS-CoV-2 viral load: An open label randomized controlled clinical trial studyRandomized Controlled Trial Published on 2022-07-292022-10-05 Journal: Medicine [Category] COVID19(2023년), SARS, 임상, [키워드] ARMS assigned baseline collected conducted control group Controlled clinical trial COVID-19 E gene Efficiency evaluated form four group group Intervention less male open label P-value participant Patient povidone randomization Randomized real time PCR recruited reduction S gene Saliva salivary SARS-CoV-2 SARS-CoV-2 viral second significant decrease statistically significant difference subject the SARS-CoV-2 threshold Viral load was collected was recorded [DOI] 10.1097/MD.0000000000028925 PMC 바로가기 [Article Type] Randomized Controlled Trial
Usefulness of real-time RT-PCR to understand the kinetics of SARS-CoV-2 in blood: A prospective study혈액 내 SARS-CoV-2의 동역학 이해를 위한 실시간 RT-PCR의 유용성: 전향적 연구Observational Study Published on 2022-07-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), SARS, 임상, 치료기술, [키워드] Admission approved blood sample Blood samples Care case sery clinical Clinical outcome collected conducted death defined detection diagnosis of SARS-CoV-2 discharge expressed hospitalisation hospitalised COVID-19 patient hospitalised COVID-19 patients intensive care unit intensive care unit admission Kinetics median time Mortality occurred outcome Patient patients persistent plasma Plasma viral-load Poor progressed Prospective Study Quantitative Range real time real-time RT-PCR risk RT-PCR RT-PCR assay SARS-CoV-2 SARS-CoV-2 viral SARS-CoV-2 viral load serum sample serum samples significantly higher Viral load Viremia Viremia-kinetics. was determined [DOI] 10.1016/j.jcv.2022.105166 PMC 바로가기 [Article Type] Observational Study
Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse originsBA.1 및 가능한 마우스 기원과 비교하여 Omicron BA.2 변이체의 증가된 감염성 및 면역 회피를 위한 구조적 및 생화학적 메커니즘Article Published on 2022-07-012022-09-11 Journal: Cell Research [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 binding addition antibody bind binding biochemical combating dominant effective Evolution exhibit high affinity high potency human ACE2 immune evasion implication infections infective inhibit interactions mechanism neutralization activity omicron open pathway RBDs Receptor-binding domain receptor-binding domains reveal SARS-CoV-2 viral shown spike trimer Strains Structure structures therapeutic trimer variant Viral viral infections wildtype WT spike [DOI] 10.1038/s41422-022-00672-4 PMC 바로가기 [Article Type] Article
Influence of SARS-CoV-2 inactivation by different chemical reagents on the humoral response evaluated in a murine model쥐 모델에서 평가된 체액 반응에 대한 다양한 화학 시약에 의한 SARS-CoV-2 비활성화의 영향Article Published on 2022-07-012022-09-12 Journal: Molecular immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] addition Administered anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Antigen antigenic biosafety Brazil cell culture supernatant Cytopathic effect ELISA ELISA assay evaluate evaluated expressive formaldehyde glutaraldehyde highest humoral IgG immunization immunized immunogen inactivated Inactivated virus inactivation influence mice murine model Neutralizing neutralizing antibody observation pandemic plaque polymerase chain PRNT PRNT(50) protocol purified quantification reagent real time risk RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 viral subsequent Test the SARS-CoV-2 Toxicity Treatment verification Vero cells Viral antigen viral inactivation Viral protein virus was performed [DOI] 10.1016/j.molimm.2022.05.012 PMC 바로가기 [Article Type] Article
In silico screening of some compounds derived from the desert medicinal plant Rhazya stricta for the potential treatment of COVID-19 Research Published on 2022-07-012022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 치료기술, 치료법, 치료제, [키워드] Acidic Analysis antiviral activity aromatic group average binding affinities binding affinity binding free energy binding interaction Ceftazidime Cell Compound coronavirus COVID-19 demonstrated docking exceptional exhibited FIVE fraction functional greater groups Health high stability HPLC Hydrogen bond in silico in vitro study Interaction less lowest MD simulation Molecular dynamics simulation occurred oxygen pandemic penetration Potential treatment predict Protein RBD RBD residue Receptor binding domain required retained SARS-CoV-2 SARS-CoV-2 viral selected similarity suggested the RBD the SARS-CoV-2 these compound Toxicity Treatment [DOI] 10.1038/s41598-022-15288-2 [Article Type] Research
Repurposing antiviral phytochemicals from the leaf extracts of Spondias mombin (Linn) towards the identification of potential SARSCOV-2 inhibitors잠재적인 SARSCOV-2 억제제의 식별을 위해 스폰디아스 몸빈(Spondias mombin, Linn)의 잎 추출물에서 항바이러스 파이토케미컬을 용도 변경Article Published on 2022-06-282022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료제, [키워드] 3CL pro absence acute respiratory symptoms acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Anti-viral Antiviral approved approved drug approved drugs binding free energy candidate Compound coronavirus 2 disease domain Dynamics exhibited free energy in vitro in vivo indicated inhibitor inhibitors investigated molecular dynamics molecular dynamics simulations momentum pattern persistence polymerase protease public health RBD Receptor-binding domain reported repurposing respiratory S-protein SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 viral Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spondia target the SARS-CoV-2 therapeutic Toxicity Vaccine vaccine availability Vaccine hesitancy viral mutation [DOI] 10.1038/s41598-022-14558-3 PMC 바로가기 [Article Type] Article
Host chitinase 3-like-1 is a universal therapeutic target for SARS-CoV-2 viral variants in COVID-19숙주 키티나제 3-유사-1은 COVID-19의 SARS-CoV-2 바이러스 변이체에 대한 보편적인 치료 표적입니다Article Published on 2022-06-232022-09-11 Journal: eLife [Category] COVID19(2023년), SARS, 변종, [키워드] accumulate ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Alpha anti-CHI3L1 antibody Antibody neutralization Beta breakthrough infections caused Cell CHI3L1 chitinase Concentration coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 defined Delta delta variant demonstrated determine effective inhibitor epithelial epithelial cell Express FRG genetic variability host tissue induce Infection Infectious disease inhibit inhibitor Intervention kasugamycin Laboratory lethal disease Microbiology morbidity and mortality neutralization omicron priming protease pseudovirus pseudoviruses S protein SARS-CoV-2 viral Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe disease spike stimulate strain susceptibility the disease therapeutic target Therapeutics Transmissibility variant variants variants of concern viral variant viruses VoC Waves worldwide pandemic [DOI] 10.7554/eLife.78273 PMC 바로가기 [Article Type] Article
Detection of SARS-CoV-2 RNA through tandem isothermal gene amplification without reverse transcription역전사 없이 탠덤 등온 유전자 증폭을 통한 SARS-CoV-2 RNA 검출Article Published on 2022-06-152022-09-11 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] Accuracy alternative amplification amplified Analysis cDNA complex composed COVID-19 COVID-19 epidemic Cycling detect detection diagnose Diagnosis DNA emission form G-quadruplex gene amplification generate hairpin structure isothermal Isothermal gene amplification linear primer Primers produced RCA repeated reverse transcription Rolling Rolling circle amplification SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 viral SARS-CoV-2 viral RNA sensitivity single-stranded DNA ssDNA strand Strand displacement amplification subsequent Thioflavin Thioflavin T. viral genes Viral RNA [DOI] 10.1016/j.aca.2022.339909 PMC 바로가기 [Article Type] Article