serine 2 – Page 3 – Communicable Diseases Research

Host cell entry mediators implicated in the cellular tropism of SARS‑CoV‑2, the pathophysiology of COVID‑19 and the identification of microRNAs that can modulate the expression of these mediators (Review)

SARS-CoV-2의 세포 친화성, COVID-19의 병태생리학 및 이러한 매개체의 발현을 조절할 수 있는 microRNA의 식별에 연루된 숙주 세포 진입 매개체(검토)

Review

Published on 2022-02-012022-09-11
Journal: International journal of molecular medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘,

A New Butyrate Releaser Exerts a Protective Action against SARS-CoV-2 Infection in Human Intestine

새로운 부티레이트 방출제는 인간의 장에서 SARS-CoV-2 감염에 대한 보호 조치를 취합니다

Article

Published on 2022-01-272022-09-10
Journal: Molecules [Category] SARS, 유전자 메커니즘, 치료제,

[키워드] ACE2 Action Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration alteration angiotensin angiotensin-converting enzyme-2 Antiviral antiviral response butyramide Butyrate carbamoyl Characteristics coronavirus COVID-19 Cytokines Defense defense mechanisms Diseases enterocytes enzyme expression FBA functional Gut gut microbiome Host Human IL-15 infected cells Infection Infectious diseases intestinal models investigated involved limit MCP-1 mechanism metabolite Microbiome modulate monocyte monocyte chemoattractant protein-1 neuropilin Neuropilin-1 New NF-kB NRP1 nuclear oral administration Pathways Patient presenting pro-inflammatory cytokine pro-inflammatory cytokines protease Protective receptor reduce reduced reducing regulate Releaser reported respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected cells Serine serine 2 several gene several genes severe acute respiratory syndrome Coronavirus small intestinal biopsy small intestine TMPRSS2 TNF-α transmembrane transmembrane protease serine 2 up-regulation viral infection
[DOI] 10.3390/molecules27030862 PMC 바로가기 [Article Type] Article

Ozone exposure upregulates the expression of host susceptibility protein TMPRSS2 to SARS-CoV-2

Article

Published on 2022-01-252022-10-29
Journal: Scientific Reports [Category] COVID-19,

[키워드] ACE2 acute infection Acute inflammation Affect airway airways alveolar macrophage Alveolar macrophages ambient analyzed Angiotensin-converting enzyme binding cause cellular receptor clinical settings collected correlated dependent on detrimental effect elevated Environmental impact Epidemiology expression expression level health emergency Host host cell host susceptibility individual Infection Interaction lung tissue mice morbidity and mortality Mortality pandemic Pathogenesis priming proportion protease Protein proteolytic respiratory tract SARS-CoV-2 SARS-CoV-2 entry Scientific community serine 2 severe disease severe SARS-CoV-2 severity shown significantly subsequent susceptibility the SARS-CoV-2 TMPRSS2 TMPRSS2 protein transcript transmembrane upregulate upregulated virus while
[DOI] 10.1038/s41598-022-04906-8 PMC 바로가기 [Article Type] Article

Decreased TMPRSS2 expression by SARS-CoV-2 predicts the poor prognosis of lung cancer patients through metabolic pathways and immune infiltration

Research Paper

Published on 2022-01-152022-10-28
Journal: Aging (Albany NY) [Category] COVID-19,

[키워드] acute respiratory syndrome Algorithms Analysis cellular CIBERSORT clinicopathological parameter coronavirus correlated COVID-19 Cox regression Decreased DNA methylation drug target examined exhibited expression GEO global pandemic GSEA HPA immune Immune cell infiltration immune infiltration investigated KEGG lung cancer lung cancer patient lung cancer patients metabolic pathway molecular function mRNA mRNA expression outcome pathway Patient performed poor prognosis predict predictive power prognostic prognostic biomarker Prognostic value protease protein expression reduced SARS-CoV-2 SARS-CoV-infected cells serine 2 significantly Spread survival therapeutic target TMPRSS2 TMPRSS2 expression transmembrane was determined
[DOI] 10.18632/aging.203823 PMC 바로가기 [Article Type] Research Paper

Drug Repurposing for the Identification of Compounds with Anti-SARS-CoV-2 Capability via Multiple Targets

Article

Published on 2022-01-122022-10-28
Journal: Pharmaceutics [Category] COVID-19,

[키워드] 3C-like protease (3CL^pro/M^pro) 3CL pro accelerate acute respiratory syndrome addition anti-SARS-CoV-2 antiviral potency approved assays bioinformatics Compound coronavirus coronavirus disease COVID-19 docking simulation domain drug Drug screening enzyme activity evaluated feasible food identification infections inhibitory inhibitory effect Multiple other diseases Papain-like protease papain-like protease (PL^pro) protease RBD reduction repurposing SARS-CoV-2 serine 2 severe acute respiratory syndrome coronavirus 2 Tamoxifen target therapeutic potential these compound TMPRSS2 transmembrane transmembrane protease serine 2 (TMPRSS2) Treatment Vaccines
[DOI] 10.3390/pharmaceutics14010176 PMC 바로가기 [Article Type] Article

Exploring AyuGenomics approach for understanding COVID-19 predisposition and progression

Review article

Published on 2022-01-012022-10-05
Journal: Journal of Ayurveda and Integrative Medicine [Category] 신약개발, 유전자 메커니즘,

Immunoreactivity of the SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in murine models of hormonal manipulation, ageing, and cardiac injury

Article

Published on 2021-12-142022-10-29
Journal: Scientific Reports [Category] COVID-19,

[키워드] ACE-2 addition age Alter analyzed angiotensin-converting enzyme 2 association Cardiology cardiovascular disease Cell clinical study contrary correlation COVID-19 disease Diseases explain expression female gonadal hormone immunology immunostaining independent indicate Injury kidney liver lower expression Lung alveoli lung tissue Medical research men mice Molecular medicine Mouse models murine model myocardial injury protease Protein protein expression regulated respiratory tract SARS-CoV-2 virus serine 2 Sex Sex difference Sex hormones sinusoids the SARS-CoV-2 transmembrane variety of tissue
[DOI] 10.1038/s41598-021-03181-3 PMC 바로가기 [Article Type] Article

COVID-19 and gut immunomodulation

코로나19와 장 면역 조절

Review

Published on 2021-12-142022-09-12
Journal: World journal of gastroenterology [Category] SARS, 진단,

[키워드] acute respiratory syndrome Adaptive immune response addition angiotensin-converting enzyme-2 antibodies association calprotectin changes in clinically Comorbidities coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Cytokines dependent on direct infection disease disease severity Dysbiosis epithelial cell expresse Gastrointestinal gastrointestinal symptoms GI symptom GI symptoms GI Tract Gut gut microbiota Health heterogeneous hypoxia immune immune activation immune response Immunity immunoglobulin A impairment in vitro in vivo infect infected individual Infection Innate innate immune response intestinal epithelium observation organ organoids outcome Pathogenesis Patient positive Pre-existing diseases Probiotic Proinflammatory cytokine protease Protein reported required respiratory problems respiratory symptom Respiratory system rhesus SARS-CoV-2 serine 2 severe COVID-19 patient severe respiratory illness severity Stool supported Symptom symptomatic patient the disease therapeutic interventions Therapeutics transmembrane Viral RNA virus
[DOI] 10.3748/wjg.v27.i46.7925 PMC 바로가기 [Article Type] Review

Coronavirus Infection-Associated Cell Death Signaling and Potential Therapeutic Targets

코로나바이러스 감염 관련 세포 사멸 신호 및 잠재적 치료 표적

Review

Published on 2021-12-092022-09-10
Journal: Molecules [Category] SARS, 치료제,

[키워드] (RdRp 3CLpro ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplification angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-apoptotic Anti-inflammatory antiviral properties Apoptosis assembly autophagy BCL-2 can be used caused celastrol cell death cell death pathways Chloroquine chloroquine/hydroxychloroquine Compound coronavirus CoV infection COVID-19 COVID-19 treatment Critical Curcumin cysteine Cytokines death deaths Effect Efficacy enzyme expression FIVE flavonoids Frame group Helicase host cell Hydroxychloroquine induce Infection Inflammation inhibiting inhibitor Inhibitory effects interactions involved L-cysteine life cycle mechanism mitigate modify molecular target molecules MPro name natural natural compounds necroptosis NF-κB NF-κB signaling NLRP3 inflammasome non-structural protein nonstructural protein 1 nsp1 Nsp12 occurred Open reading frame ORF7a outcomes Papain play roles PLPro Potential progression proliferation promote Propagation protease Protein proteinase pyroptosis RdRP Regulated cell death Replication responsible RNA RNA dependent RNA polymerase RNA polymerase SARS-CoV infection SARS-CoV-2 SARS-CoV-2-infected patients Serine serine 2 severe acute respiratory syndrome Coronavirus Signaling small molecule specific inhibitor spike Spike protein survival target targeted therapy the disease therapeutic targeting TMPRSS2 TNF transmembrane transmembrane protease serine 2 Treatment variety Viral viral entry viral infection viral life cycle virions XIAP yielding
[DOI] 10.3390/molecules26247459 PMC 바로가기 [Article Type] Review

Nonmuscle myosin heavy chain IIA facilitates SARS-CoV-2 infection in human pulmonary cells

423

Published on 2021-12-062022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS,

[키워드] A549 ACE2 ACE2 receptors acute respiratory syndrome airways angiotensin-converting enzyme 2 APEX2 bind bypasse C-terminal domain Calu-3 calu-3 cells cathepsin B Cell cells cofactor contribute coronavirus coronavirus disease COVID-19 demonstrated ENhance experiment expression facilitate glycoprotein H1299 Host host cell host receptor human lung cells human tissues Infection inhibitor interact Intervention lung membrane membrane fusion MYH9 N-terminal domain overexpression pan-coronavirus pathway promote protease pseudovirus infection reduce reduced S1-NTD S2 subunit SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus infection SARS-CoV-2 S serine 2 Significance significantly subunit suggested target the SARS-CoV-2 TMPRSS2 transmembrane variety viral entry virus virus entry wild type
[DOI] 10.1073/pnas.2111011118 PMC 바로가기 [Article Type] 423