Reactive Centre Loop Mutagenesis of SerpinB3 to Target TMPRSS2 and Furin: Inhibition of SARS-CoV-2 Cell Entry and Replication
Article
Published on
Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료제,
Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료제,
[키워드] Alpha
Altered
Anti-viral
Anti-viral therapy
Antiviral
assays
biological molecules
cathepsin L
Cell
cell entry
cellular proteases
cleaved
designer serpin
effective
enzyme
expressing
facilitate
furin
generate
host cell protease
implicated
in vitro
infection with SARS-CoV-2
inhibit
inhibition
inhibitor
inhibitors
inhibitory
inhibitory activity
loop
membrane fusion
Mutagenesis
P681R
predicted
produced
protease
Protein
purified
rate constant
reactive
Recombinant protein
S protein cleavage
S1/S2 cleavage site
SARS-CoV-2
SARS-CoV-2 replication
SARS-CoV-2 viral replication
SARS-CoV-2 virus
serine 2
serine protease inhibitor
SerpinB3
shown
specificity
suppress
target
the Spike
the spike protein
TMPRSS2
transmembrane
variant
Vero E6 cell
[DOI] 10.3390/ijms232012522 PMC 바로가기
[DOI] 10.3390/ijms232012522 PMC 바로가기