Development and validation of SCOPE score: A clinical score to predict COVID-19 pneumonia progression to severe respiratory failureSCOPE 점수의 개발 및 검증: COVID-19 폐렴이 중증 호흡부전으로 진행되는 것을 예측하기 위한 임상 점수Article Published on 2022-02-252022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, [키워드] Accuracy alternative Biomarkers C-reactive protein can be used circulating cohorts comparable Concentration COVID-19 D dimers death develop development disease Disease progression estimate excessive inflammatory response ferritin Hospital admission independent infected with SARS-CoV-2 interleukin interleukin-6 Invasive mechanical ventilation Mild MOST Most patients Non-invasive non-specific offer Patient plasma concentration Pneumonia predict prediction Predictive progression Receiver operator characteristic receiving receptor Respiratory failure SARS-CoV-2 SAVE-MORE study severe respiratory failure severe symptom severe symptoms soluble urokinase plasminogen activator receptor soluble urokinase plasminogen activator receptor. SRF suPAR Symptoms Treatment [DOI] 10.1016/j.xcrm.2022.100560 PMC 바로가기 [Article Type] Article
Chronic diseases, chest computed tomography, and laboratory tests as predictors of severe respiratory failure and death in elderly Brazilian patients hospitalized with COVID-19: a prospective cohort studyResearch Published on 2022-02-172022-10-27 Journal: BMC Geriatrics [Category] Coronavirus, COVID19(2023년), Fulltext, MERS, SARS, [키워드] adjusted adults hospitalized age Anemia association Atrial fibrillation C-reactive protein Cancer Chest computed tomography Chest CT chronic Chronic diseases collected COVID-19 CRP death determine Diseases elderly hemoglobin Hospitalization Hospitalized independent predictor independent risk factor Laboratory test Laboratory tests lung involvement mechanical ventilation men Mortality objective occurred Older patients hospitalized predictor progression prospective cohort prospective cohort study pulmonary involvement Regression analyses Respiratory failure Result risk factor severe respiratory failure Vitamin Vitamin D with COVID-19 [DOI] 10.1186/s12877-022-02776-3 PMC 바로가기 [Article Type] Research
COVID-19-Triggered Acute Exacerbation of IPF, an Underdiagnosed Clinical Entity With Two-Peaked Respiratory Failure: A Case Report and Literature ReviewMedicine Published on 2022-02-032022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute exacerbation Affect assumed Case report clinical Complication COVID-19 death develop entity Exacerbation high resolution CT scan high risk Idiopathic pulmonary fibrosis Interstitial lung disease IPF literature lung disorders Mild Moderate COVID-19 Patient patients with IPF pulmonary fibrosis recent report respiratory Respiratory failure Respiratory system respiratory viral infection review risk severe coronavirus disease severe respiratory failure thought triggered viral infection with COVID-19 [DOI] 10.3389/fmed.2022.815924 PMC 바로가기 [Article Type] Medicine
Recommendations for the management of critically ill patients with COVID-19 in Intensive Care UnitsResearch article Published on 2022-02-012022-10-05 Journal: Medicina intensiva [Category] COVID19(2023년), SARS, 바이오마커, [키워드] Admission China clinical trials COVID-19 COVID-19 drug treatment COVID-19 pandemic COVID-19 testing Critical Critical care Critically ill patient Diagnosis effort Evidence group ICU include intensive care unit intensive care units management methodological Patient patients patients with COVID-19 recommendation researchers SARS-CoV-2 SARS-COV-2 infection severe respiratory failure supported Treatment with COVID-19 working [DOI] 10.1016/j.medine.2021.11.019 [Article Type] Research article
Prognostic role of Interleukin-6/lymphocytes ratio in SARS-CoV2 related pneumoniaSARS-CoV2 관련 폐렴에서 인터루킨-6/림프구 비율의 예후 역할Article Published on 2022-02-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] 95% CI Admission age analyzed AUC Biomarker C-reactive protein collected COVID-19 COVID-19 patient CRP cytokine Cytokine storm D-dimer defined died dimer discharged Endpoint females fibrinogen High flow nasal cannula highest Hospital admission Hospital mortality Hospital stay ICU IL-6 in-hospital mortality independent Intensive intensive care unit interleukin interleukin-6 intubation invasive ventilation lymphocyte Lymphocytes material mean value Mortality multivariate multivariate logistic regression N/L nasal nasal cannula neutrophil no difference outcome Patient Pneumonia Prognosis prognostic required Respiratory failure SARS-CoV2 severe respiratory failure significantly higher significantly lower study population suffered tested [DOI] 10.1016/j.intimp.2021.108435 PMC 바로가기 [Article Type] Article
A 6-mRNA host response classifier in whole blood predicts outcomes in COVID-19 and other acute viral infectionsClinical Trial Published on 2022-01-182022-10-04 Journal: Scientific Reports [Category] 바이오마커, 임상, 진단, 치료제, [키워드] 30-Day mortality acute viral infection assist Care Classifier clinical study Cohort COVID-19 determine develop enrolled facilitate Gene Expression healthcare Host Host immune response host response illnesses implementation in viral independent Infection Infectious diseases Influenza isothermal Logistic Logistic regression machine learning management medical need Molecular medicine outcome Patient predict Prognostic markers reducing retrospective retrospective cohort risk RNA RNAs selected severe respiratory failure severity severity of COVID-19 Statistical methods training data transcriptomic Viral illness viral infection Whole blood [DOI] 10.1038/s41598-021-04509-9 PMC 바로가기 [Article Type] Clinical Trial
Longitudinally monitored immune biomarkers predict the timing of COVID-19 outcomes종 방향으로 모니터링 된 면역 바이오 마커는 Covid-19 결과의시기를 예측합니다.Research Article Published on 2022-01-182022-09-10 Journal: PLoS Computational Biology [Category] 바이오마커, 진단, [키워드] anti-SARS-CoV-2 Antibody titers assist Asymptomatic Biomarker Biomarkers blood cell Blood urea nitrogen build C-reactive protein Clinical data Clinical outcome clinical parameter Clinical parameters collected contribute COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity death Decision making Demographic and clinical data Disease progression Early detection Factors fatality feature Health Health care Health care worker health care workers health worker health workers healthcare high-risk patient High-risk patients Hospital admission Hospitalization hospitalized COVID-19 patients immune individuals information Kinetics lymphocyte lymphocyte counts machine machine learning machine learning models mind Mortality MOST neutrophil nitrogen outcome outcomes parameters Patient patient data post-symptom onset predict predicted Predictive Predictive model Predictive value Prevent profiles PSO resource Respiratory failure risk SARS-CoV-2 infected patient SARS-CoV-2 infected patients SARS-COV-2 infection severe respiratory failure severity Severity of disease Spike IgG titers Support Temporal analysis the timing therapeutic intervention therapeutic interventions urea urea nitrogen WBC White blood cell with COVID-19 [DOI] 10.1371/journal.pcbi.1009778 PMC 바로가기 [Article Type] Research Article
Cytokine Hemoadsorption as Rescue Therapy for Critically Ill Patients With SARS-CoV-2 Pneumonia With Severe Respiratory Failure and HypercytokinemiaMedicine Published on 2022-01-102022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] “cytokine storm” acute respiratory distress syndrome (ARDS) All the patient analyzed benefit Berlin C-reactive protein Case series clinical response clinically coronavirus 2019 disease COVID-19 Critically ill patient cytokine cytokine removal D-dimer death dysregulated Europe evaluate failure ferritin Germany hemoadsorption high risk hypercytokinemia ICU identifying IL-6 Ill improvement in-hospital mortality inflammatory biomarkers Inflammatory response intensive care interleukin-6 Invasive mechanical ventilation organ dysfunction Oxygenation PaO pathophysiology Patient plasma Prone position prone positioning reduction in rescue respiratory Respiratory failure Retrospective study SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pneumonia severe respiratory failure significant difference single center SOFA score Therapies therapy Treatment with COVID-19 [DOI] 10.3389/fmed.2021.779038 PMC 바로가기 [Article Type] Medicine
Circulating levels of calprotectin, a signature of neutrophil activation in prediction of severe respiratory failure in COVID-19 patients: a multicenter, prospective study (CalCov study)Observational Study Published on 2022-01-012022-10-05 Journal: Inflammation research : official journal of the Eu [Category] 임상, [키워드] Accuracy Activation Admission admitted to ICU adult COVID-19 patients Analysis blood sample calprotectin can be used characterized collected COVID-19 COVID-19 patients Critical dysregulated immune response evaluate ICU ICU admission ICU patient independent intensive care unit Intubated Invasive mechanical ventilation involved Laboratory tests multicenter neutrophil neutrophil activation Neutrophil activation. patients predict Primary outcome prospective observational study Prospective Study reflect required ROC AUC secondary outcome serum severe COVID-19 severe respiratory failure severity significantly higher [DOI] 10.1007/s00011-021-01516-4 PMC 바로가기 [Article Type] Observational Study
COVID-19 in Recent Lung Transplant Recipients: Clinical Outcomes and Management StrategiesArticle Published on 2022-01-012022-10-05 Journal: Transplantation proceedings [Category] COVID19(2023년), SARS, 바이오마커, 진단, 치료제, [키워드] advanced age antibody antiviral therapy cause change clinical Clinical course Cohort Comorbidity convalescent plasma COVID-19 COVID-19 infection death disease General population high risk Hospital stay immune incidence Infection infection with COVID-19 Laboratory lung lung transplant management medication Munich obesity one patient outcome outcomes Patient patients Premature receive recent recipient Remdesivir responsible Result risk factor SARS-COV-2 infection severe respiratory failure severity solid organ transplants Strategy suffered susceptible Symptoms the patient the SARS-CoV-2 Transplant Treatment viral infection [DOI] 10.1016/j.transproceed.2021.12.014 [Article Type] Article