Soluble TNF receptors predict acute kidney injury and mortality in critically ill COVID-19 patients: A prospective observational study가용성 TNF 수용체는 중환자 COVID-19 환자의 급성 신장 손상 및 사망률을 예측합니다: 전향적 관찰 연구Observational Study Published on 2022-01-012022-09-11 Journal: Cytokine [Category] SARS, 바이오마커, 임상, [키워드] 30-Day mortality Activation Acute kidney injury addition age AKI an area association Biomarker Biomarkers Blood donors characteristic collected Control control group coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical care Critically ill Critically ill patient critically ill patients cut-off demographic demographic data develop ferritin hallmark healthy blood donor ICU ICU admission IL-6 Illness severity immune cascade independent Inflammation Inflammatory inflammatory biomarkers Informed consent involved kidney Level Mortality multiple organ failure non-survivor Organ failure organs outcome Patient PCR-confirmed COVID-19 PCT plasma Plasma level Plasma levels Pneumonia predict prospective observational study quantified receiver receiver operating characteristic receptor receptors Respiratory failure Septic shock severe COVID-19 patient severe COVID-19 patients severe disease severity severity of illness SOFA sTNFR survival survivor systemic inflammatory processe TNF TNF receptors. TNFα were used with COVID-19 [DOI] 10.1016/j.cyto.2021.155727 PMC 바로가기 [Article Type] Observational Study
Comparison of initial clinic characteristics of hospitalized patients in Suzhou City during the COVID-19 Omicron wave with ancestral variant waveCOVID-19 오미크론 파동 동안 쑤저우시 입원 환자의 초기 임상 특성과 조상 변이 파동의 비교Comparative Study Published on 2022-01-012022-09-11 Journal: Therapeutic Advances in Respiratory Disease [Category] SARS, 변종, [키워드] Analysis assessment B.1.1.529 Characteristics chi-square test China city Clinical data clinical feature Cluster Cohort cohort study collected comparable comparison Comparisons Computed tomography COVID-19 crazy-paving pattern EHR Electronic health record failure Fever Fisher exact test GGOs Ground-glass opacities ground-glass opacity had more Health health record Hospitalized hospitalized COVID-19 patient hospitalized COVID-19 patients hospitalized patient Infection initial less Logistic regression analysis lower risk lung Mann-Whitney U test Multiple logistic regression analysis multivariable logistic regression Multivariable logistic regression analysis occurred omicron Omicron variant outbreak performed Pneumonia provided radiology reduced responsible risk SARS-CoV-2 variant severity SOFA suffered the epidemic the SARS-CoV-2 variant [DOI] 10.1177/17534666221110346 PMC 바로가기 [Article Type] Comparative Study
Sequential Organ Failure Assessment Outperforms Quantitative Chest CT Imaging Parameters for Mortality Prediction in COVID-19 ARDSArticle Published on 2021-12-222022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome Admission ARDS ARDS patient artificial intelligence assessment association AUC Chest Chest CT computed tomography scan COVID-19 COVID-19 disease COVID-19 patients Critically ill patient diagnostic diagnostic value evaluated failure high mortality ICU ICU admission imaging in-hospital mortality include Injury intensive care lung Lung compliance Lung injury lung involvement management mask ventilation mechanical ventilation moderate multi-organ dysfunction multi-organ failure Organ failure Oxygenation oxygenation index parameter Patient patient triage positive airway pressure predict prediction Predictive pulmonary hypertension resource resources respiratory insufficiency Retrospective study risk stratification ROC analysis severe ARDS Severity Score significantly single center SOFA SOFA score syndrome vessel were assessed [DOI] 10.3390/diagnostics12010010 PMC 바로가기 [Article Type] Article
Prevalence and Trajectory of COVID-19-Associated Hypercoagulability Using Serial Thromboelastography in a South African PopulationResearch Article Published on 2021-12-222022-10-31 Journal: Critical Care Research and Practice [Category] COVID-19, [키워드] 95% CI abnormality acute respiratory syndrome Admission African amplitude anticoagulation Black patients Coagulation Cohort conducted coronavirus COVID-19 disease Critically ill Cytokine storm Degradation difference elevated group hypercoagulability hypercoagulable hypoxia impairment Inflammation initial IQR majority median median age Mortality Observational cohort study Patient point-of-care Population Prevalence prevalent remained resulting SARS-CoV-2 significantly significantly higher significantly lower SOFA South South Africa subsequent the patient therapy thromboelastography Ventilated Whole blood women [DOI] 10.1155/2021/3935098 PMC 바로가기 [Article Type] Research Article
Lung histopathologic clusters in severe COVID-19: a link between clinical picture and tissue damageObservational Study Published on 2021-12-132022-10-04 Journal: Critical Care [Category] 임상, [키워드] affected analyzed applied Autopsies Clinical data clinical picture Cluster Clustering Clusters Comorbidity Complete conducted correlation COVID-19 COVID-19 patients described died Diffuse alveolar damage distribution Duration Evidence Hierarchical highlight histology hospitalized patient ICU Infectious disease Intervention Italy kidney knowledge large cohort long-lasting lung Lung histopathology Lung injury overlap pathophysiology Patient PEEP Pneumonia Positive end-expiratory pressure Positive-pressure ventilation proliferative Result retrospective cohort scored serum albumin severe COVID-19 patients severe SARS-CoV-2 SOFA supplementary material tissue damage Treatment Ventilation ventilatory [DOI] 10.1186/s13054-021-03846-5 PMC 바로가기 [Article Type] Observational Study
Outcome of Critically Ill COVID-19 Patients According to the Setting of Corticosteroid Initiation—A Retrospective Observational Cohort StudyArticle Published on 2021-12-132022-10-30 Journal: Journal of Personalized Medicine [Category] COVID-19, [키워드] Admission age all-cause mortality cohort study conducted Corticosteroid COVID-19 COVID-19 patient COVID-19 patients Critically ill death Deterioration determine Dexamethasone Factor hospital discharge Hospitalization ICU ICU admission Ill initiated intensive care intensive care unit Invasive mechanical ventilation investigated less Mortality multivariable analysis Odds ratio Organ failure outcome Patient propensity score matching receiving regimen setting significant difference SOFA survival transferred treated [DOI] 10.3390/jpm11121359 PMC 바로가기 [Article Type] Article
Thrombogenicity markers for early diagnosis and prognosis in COVID-19: a change from the current paradigm?COVID-19의 조기 진단 및 예후를 위한 thromogenicity markers: 현재 패러다임의 변화?Observational Study Published on 2021-12-012022-09-11 Journal: Blood coagulation & fibrinolysis : an internationa [Category] SARS, 바이오마커, 임상, 치료기술, [키워드] Admission African Americans Analysis Biomarker Comparisons composite endpoint COVID-19 COVID-19 diagnosis COVID-19 negative COVID-19 patient COVID-19 patients COVID-19 positive patient COVID-19 positive patients death diabete diabetes diagnostic early diagnosis FCS FDA FIBRIN fibrin clot fibrinogen functional Guidance Hospitalization hospitalized COVID-19 Hypothesis identify In-hospital less marker Metrics MOST Multivariate analysis Myocardial infarction negative patients observation observational study Occurrence on admission Organ failure outcome Patient patients positive positive patient positive patients Prognosis prognostic Prospective Study Sequential Organ Failure Assessment SOFA SOFA score Standard stroke suggested Support thromboelastography Thromboembolism thrombogenicity thrombotic thrombotic event Thrombotic events utility were recorded Whole blood with COVID-19 [DOI] 10.1097/MBC.0000000000001069 PMC 바로가기 [Article Type] Observational Study
Effect of anti-interleukin drugs in patients with COVID-19 and signs of cytokine release syndrome (COV-AID): a factorial, randomised, controlled trialCOVID-19 및 사이토카인 방출 증후군(COV-AID) 징후가 있는 환자에서 항인터루킨 약물의 효과: 요인, 무작위, 대조 시험Randomized Controlled Trial Published on 2021-12-012022-09-12 Journal: The Lancet. Respiratory Medicine [Category] Fulltext, SARS, 임상, 진단, [키워드] 95% CI assessment assigned baseline Belgium Block randomisation blockade C-reactive protein concentration center challenge Clinical improvement Complete Concentration Controlled trial COVID-19 Cytokine release syndrome D-dimer defined diagnosis of COVID-19 discharge drug Effect Efficacy Endpoint EudraCT evaluate Evidence factorial design failure ferritin fraction hazard ratio hospital hospitalised patient hypoxia hypoxic respiratory failure IL-1 IL-6 IL-6 blockade incidence intention-to-treat analysis intention-to-treat population interleukin International intravenously IQR lactate dehydrogenase less lymphopenia male mechanical ventilation median median age median time morbidity and mortality Mortality mortality risk Most patient multicentre Open-label oxygen PaO pathway Patient patients died patients with COVID-19 Primary outcome randomisation randomised Randomly receive Registered Safety safety population SARS-CoV-2 Serious Adverse Event serious infection serum single dose SOFA SOFA score Stratification study groups study outcome supplemental oxygen Symptom syndrome systemic cytokine therapeutic strategy Tocilizumab treatment group Trial were assessed with COVID-19 [DOI] 10.1016/S2213-2600(21)00377-5 PMC 바로가기 [Article Type] Randomized Controlled Trial
Comparison of mortality risk evaluation tools efficacy in critically ill COVID-19 patientsResearch Article Published on 2021-11-222022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] 4C mortality score 95% CI Accuracy Admission age Analysis APACHE II assessment AUC value average calculated can be used chronic Combination COVID-19 COVID-19 pandemic COVID-19 patient Critically ill demonstrated determine Efficacy failure Final hospital ICU ICU Patients increase in independent intensive care male Mortality mortality risk Non-survivors Patient Physiology predict Predictive predictor regression analysis Result Retrospective study risk score Risk scores score SOFA survivor treated was performed [DOI] 10.1186/s12879-021-06866-2 PMC 바로가기 [Article Type] Research Article
Kinetics of antibody response in critically ill patients with Middle East respiratory syndrome and association with mortality and viral clearanceArticle Published on 2021-11-192022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, [키워드] 95% CI Admission admitted to ICU antibody Antibody Response Antigen assessment association blood sample clearance coated with collected Corticosteroids Critically ill Critically ill patient Diseases ELISA enzyme-linked immunosorbent failure faster ICU IgG antibody immunology Immunotherapy implication invasive ventilation Kinetics lower mortality median MERS MERS patient MERS-CoV MERS-CoV RNA MERS-CoV S1 Middle East Mortality onset of symptom optical Pathogenesis Patient renal replacement therapy rRT-PCR significantly increased Signs and symptoms SOFA study cohort syndrome vasopressors viral clearance [DOI] 10.1038/s41598-021-01083-y PMC 바로가기 [Article Type] Article