Surface plasmon resonance approach to study drug interactions with SARS-CoV-2 RNA-dependent RNA polymerase highlights treatment potential of suraminSARS-CoV-2 RNA 의존성 RNA 중합효소와의 약물 상호작용 연구를 위한 표면 플라즈몬 공명 접근법, 수라민의 치료 가능성 강조Article Published on 2021-12-012022-09-11 Journal: Journal of virological methods [Category] SARS, 치료제, [키워드] approach binding ChIP drug drug target Favipiravir highlight Interaction precluded RdRP real time ribavirin RNA RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RNA sofosbuvir study drug Suramin surface plasmon surface plasmon resonance Treatment virus replication [DOI] 10.1016/j.jviromet.2021.114283 PMC 바로가기 [Article Type] Article
Hepatitis B Surface Antigen Decline during Sofosbuvir and Ribavirin Therapy in Hepatitis B Inactive Carriers Who Were Co-infected with Hepatitis CArticle Published on 2021-11-152023-06-12 Journal: Internal medicine (Tokyo, Japan) [Category] B형 간염, [키워드] hepatitis B surface antigen Hepatitis B virus hepatitis C virus ribavirin sofosbuvir [DOI] 10.2169/internalmedicine.7337-21 PMC 바로가기
Asunaprevir, a Potent Hepatitis C Virus Protease Inhibitor, Blocks SARS-CoV-2 Propagation강력한 C형 간염 바이러스 프로테아제 억제제인 Asunaprevir, SARS-CoV-2 전파 차단Article Published on 2021-09-302022-09-11 Journal: Molecules and cells [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antiviral activity asunaprevir binding block blocked calu-3 cells candidate coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Cytopathic effect cytopathic effects daclatasvir direct-acting antiviral Drug repurposing evaluated Health hepatitis C hepatitis C virus human lung human lung Calu-3 cells include infected cells inhibited inhibitor life cycle NS5A pandemic potent Propagation Protease inhibitor protein level protein levels RNA RNA polymerase inhibitor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 propagation SARS-CoV-2 vaccine SARS-CoV-2-infected cells severe acute respiratory syndrome Coronavirus significantly sofosbuvir therapeutic agent Treatment vaccination Vero E6 VERO E6 cells viral life cycle virion [DOI] 10.14348/molcells.2021.0076 PMC 바로가기 [Article Type] Article
In silico analysis of RNA-dependent RNA polymerase of the SARS-CoV-2 and therapeutic potential of existing antiviral drugsSARS-CoV-2의 RNA 의존성 RNA 중합효소의 in silico 분석 및 기존 항바이러스제의 치료 가능성Article Published on 2021-08-012022-09-11 Journal: Computers in biology and medicine [Category] SARS, 치료제, [키워드] alteration Amino acid amino acids Analysis Antiviral antiviral drug antiviral drugs binding affinity cofactor complex Computational biology conserved coronavirus demonstrated effective highlight homologous hydrogen Hydrogen bond hydrogen bonds Infection Interaction interaction site Intervention involved mode Molecular modelling molecules Multiple Multiple sequence alignment mutable Nsp12 Nsp7 Organisms phylogenetic analyses Phylogenetic analysis RaTG13 RdRP reduced Region remained Remdesivir resulting RNA RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 virus selected selected drugs sequence Sequence alignment sofosbuvir subunit subunits sustained the binding affinity the SARS-CoV-2 the SARS-CoV-2 virus therapeutic potential therapeutic strategy uracil Viral RNA [DOI] 10.1016/j.compbiomed.2021.104591 PMC 바로가기 [Article Type] Article
Complex analysis of the personalized pharmacotherapy in the management of COVID-19 patients and suggestions for applications of predictive, preventive, and personalized medicine attitudeResearch Published on 2021-07-162022-10-31 Journal: The EPMA Journal [Category] COVID-19, [키워드] all ethnic groups alpha-2b analysed Analysis antiviral agent approach Biomarker calculated ceftriaxone Characteristics Chloroquine clinical Clinical practice clinical trial Colchicine collected Comorbidities comprehensive analysis Coronavirus disease 2019 COVID-19 COVID-19 patient daclatasvir defined Dexamethasone drug Drug efficacy Drug score drug therapy Drug-to-drug interaction drugs ethnic group Ethnicity-based differences evaluate facilitate Frequency functional Future healthcare Gene score generate genetic difference genetic differences genetic test HCQ highest human immunoglobulin human immunoglobulin G Hydroxychloroquine immune regulator indicated Individual outcomes individuals interferon interferon alpha-2b Interferon beta-1a levofloxacin Lopinavir losartan management molecular mechanisms Optimal medication patients with comorbidity performed Personalized medicine personalized treatment pharmacogenetic pharmacogenetics pharmacogenomics Predictive Predictive preventive personalized medicine (PPPM/3 PM) Prednisone Remdesivir reported Result ribavirin Ritonavir significantly sofosbuvir suggested supplementary material the patient translation Treatment Trial Variation variations Zinc [DOI] 10.1007/s13167-021-00247-0 PMC 바로가기 [Article Type] Research
A review on the interaction of nucleoside analogues with SARS-CoV-2 RNA dependent RNA polymerase뉴클레오사이드 유사체와 SARS-CoV-2 RNA 의존성 RNA 중합효소의 상호작용에 대한 고찰Review Published on 2021-06-302022-09-11 Journal: International journal of biological macromolecules [Category] SARS, 신약개발, 치료제, [키워드] Antiviral antiviral drugs approved clinical development computational analysis CoV COVID-19 CoVs drug Efficacy ExoN ExoN proofreading Favipiravir human CoV human CoVs Infection information inhibitor Interaction lack nucleoside nucleoside analogue Nucleoside analogues outbreak platform preserved RdRP Remdesivir Repurposed drug ribavirin RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 RNA Severe acute respiratory syndrome severe acute respiratory syndrome-coronavirus-2 sofosbuvir tenofovir Vaccine [DOI] 10.1016/j.ijbiomac.2021.03.112 PMC 바로가기 [Article Type] Review
SARS-CoV-2 RNA dependent RNA polymerase (RdRp) targeting: an in silico perspectiveSARS-CoV-2 RNA 의존성 RNA 중합효소(RdRp) 표적화: 인 실리코 관점Article Published on 2021-06-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, 치료제, [키워드] Affect anti-viral drug Anti-viral drugs approved drug binding binding affinity build cefuroxime clinically Compound COVID-19 derivative docking drug drug candidates Drug repurposing Effectiveness Efficacy Favipiravir Galidesivir Health Health crisis help Hydroxychloroquine IDX-184 in silico include inhibit SARS-CoV-2 inhibitor molecular molecular docking molecular dynamics Molecular dynamics simulation must New nucleotide Perspective Proteins punch RdRP reduce Remdesivir ribavirin RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 RdRp SARS-CoV-2 RNA Setrobuvir sofosbuvir tenofovir the SARS-CoV-2 Treatment viral infection viral infections Viral protein [DOI] 10.1080/07391102.2020.1761882 PMC 바로가기 [Article Type] Article
A computational approach to aid clinicians in selecting anti-viral drugs for COVID-19 trials임상의가 COVID-19 시험을 위한 항바이러스제를 선택하는 데 도움이 되는 컴퓨터 접근 방식Article Published on 2021-04-272022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, 신약개발, 임상, 치료제, [키워드] analysed anti-viral drug Antiviral antiviral treatments antivirals applied approach assist association best build Chemical structure Clinical research clinical trial clinical trials clinician Combination Computational biology and bioinformatics Computational drug computational method Computational methods Computational models coronavirus COVID-19 curated cure database death drug drug target Efficacy experimental protocol experimental protocols genomic help IMPROVE information interactions machine learning model machine learning models mutate mutated Older open positioning predict problems Prophylactic Remdesivir renal Research similarity sofosbuvir Stage Strains Symptoms sync tenofovir Tenofovir alafenamide tenofovir disoproxil the vaccine TRAIL Treatment treatment of COVID-19 Trial umifenovir vaccine efficacy Vaccines virus viruses [DOI] 10.1038/s41598-021-88153-3 PMC 바로가기 [Article Type] Article
Overcoming Culture Restriction for SARS-CoV-2 in Human Cells Facilitates the Screening of Compounds Inhibiting Viral ReplicationArticle Published on 2021-04-262023-06-15 Journal: Antimicrobial Agents and Chemotherapy [Category] MERS, SARS, [키워드] A549 cells coronavirus COVID-19 Galidesivir Huh7.5 cells molnupiravir nucleotide analogs Remdesivir sofosbuvir Virus evolution [DOI] 10.1128/AAC.00097-21 PMC 바로가기
Sofosbuvir/daclatasvir in the treatment of COVID-19 infection: A meta-analysisCOVID-19 감염 치료에서 Sofosbuvir/daclatasvir: 메타 분석Comment Published on 2021-04-012022-09-11 Journal: The Journal of Infection [Category] SARS, 치료제, [키워드] Abstract COVID-19 daclatasvir Meta-analysis SARS-CoV-2 sofosbuvir sofosbuvir/daclatasvir sofosbuvir/daclatasvir. Treatment [DOI] 10.1016/j.jinf.2020.12.021 PMC 바로가기 [Article Type] Comment