Engineered disulfide reveals structural dynamics of locked SARS-CoV-2 spike설계된 이황화물은 잠긴 SARS-CoV-2 스파이크의 구조적 역학을 보여줍니다Article Published on 2022-07-292022-09-11 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, [키워드] Acidic Alter Analysis cellular compartment change changes in conformation conformational change conformations D614G D614G mutation Disulfide disulfide bond domain extracellular space functional high-resolution structure hinge interact modulate Mutation Neutral pre-fusion Protein provide RBD Receptor binding domain Regulation reveal SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 spike SARS-CoV-2 spikes sequence Structure structures transition variants of concern viral fitness virion virus wild-type SARS-CoV-2 [DOI] 10.1371/journal.ppat.1010583 PMC 바로가기 [Article Type] Article
Length-dependent motions of SARS-CoV-2 frameshifting RNA pseudoknot and alternative conformations suggest avenues for frameshifting suppressionSARS-CoV-2 frameshifting RNA pseudoknot 및 대체 형태의 길이 의존적 움직임은 frameshifting 억제를 위한 길을 제안합니다Article Published on 2022-07-252022-09-11 Journal: Nature Communications [Category] Coronavirus, COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] Analysis Anti-viral assumed build conformation conformational conserved experiments heterogeneous inhibit Interaction linear mechanism molecular molecular dynamics motif mRNA mutant observation pathway polyproteins required RNA SARS-CoV-2 structures therapeutic target translation [DOI] 10.1038/s41467-022-31353-w PMC 바로가기 [Article Type] Article
Nanoparticles in the diagnosis and treatment of vascular aging and related diseases Reviews Published on 2022-07-112022-10-05 Journal: Signal Transduction and Targeted Therapy [Category] 바이오마커, [키워드] advance adverse effect alteration cardiovascular diseases cellular cellular senescence cerebrovascular diseases chronic kidney diseases Diagnosis diagnostic disease Diseases Epigenetic events function knowledge less limitation mitochondrial dysfunction molecular Multiple nanoparticle Occurrence oxidative stress Phenotypes Prognosis structures therapeutic tissues Treatment Vascular vascular inflammation vasculature [DOI] 10.1038/s41392-022-01082-z [Article Type] Reviews
Structural and biochemical mechanism for increased infectivity and immune evasion of Omicron BA.2 variant compared to BA.1 and their possible mouse originsBA.1 및 가능한 마우스 기원과 비교하여 Omicron BA.2 변이체의 증가된 감염성 및 면역 회피를 위한 구조적 및 생화학적 메커니즘Article Published on 2022-07-012022-09-11 Journal: Cell Research [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2 binding addition antibody bind binding biochemical combating dominant effective Evolution exhibit high affinity high potency human ACE2 immune evasion implication infections infective inhibit interactions mechanism neutralization activity omicron open pathway RBDs Receptor-binding domain receptor-binding domains reveal SARS-CoV-2 viral shown spike trimer Strains Structure structures therapeutic trimer variant Viral viral infections wildtype WT spike [DOI] 10.1038/s41422-022-00672-4 PMC 바로가기 [Article Type] Article
The SARS-CoV-2 helicase as a target for antiviral therapy: Identification of potential small molecule inhibitors by in silico modelling항바이러스 치료의 표적으로서의 SARS-CoV-2 헬리카제: in silico 모델링을 통한 잠재적인 소분자 억제제 식별Article Published on 2022-07-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] Acetylcysteine active site acute respiratory syndrome addition anti-inflammatory property Antiviral antiviral activity antiviral therapeutics antivirals binding free energy clavulanic acid Compound coronavirus coronavirus disease COVID-19 DHX9 DNA DNA2 expected Fatty acid fatty acids free energies Helicase Hepatitis hepatitis C highlighting identification identify in silico include inhibitor inhibitory activity initial lead leads Ligand MERS-CoV molecular dynamics Molecular dynamics simulation molecular dynamics simulations non-structural protein nsp13 nucleoside performed reported Research respiratory SARS-CoV SARS-CoV-2 SARS-CoV-2 nsp13 selected sequence Severe acute respiratory syndrome small molecule inhibitor specific inhibitor specific inhibitors strain structural homology structural proteins Structure structures synthetic the SARS-CoV-2 utilised Vaccine variant was performed were used [DOI] 10.1016/j.jmgm.2022.108193 PMC 바로가기 [Article Type] Article
Structural basis of HIV inhibition by L-nucleosides: Opportunities for drug development and repurposingReview article Published on 2022-07-012022-10-05 Journal: Drug discovery today [Category] 신약개발, [키워드] active sites affecting AIDS binding both virus cause common drug complexes Diseases drug Drug development drug resistance drugs HBV hepatitis B virus polymerase HIV HIV-1 reverse transcriptase human liver immune system implication inhibitors L-nucleoside opportunity pathogen polymerase problem public health remained repurposing structures transcriptase virus with HIV [DOI] 10.1016/j.drudis.2022.02.016 [Article Type] Review article
The role of autologous micrografts injection from the scalp tissue in the treatment of COVID-19 associated telogen effluvium: Clinical and trichoscopic evaluationClinical Trial Published on 2022-07-012022-10-05 Journal: Dermatologic therapy [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory syndrome asymptomatic infection autologous autologous micrografts caused characterized clinical Coronavirus-2 COVID-19 COVID-19 infection epithelial evaluate evaluated Follow-up generate hair follicle hair follicles infected with SARS-CoV-2 injection life-threatening management manifestation multiorgan disease Patient SARS-CoV-2 stem cell stem cells structures suffered telogen effluvium therapeutic tissue Treatment [DOI] 10.1111/dth.15545 PMC 바로가기 [Article Type] Clinical Trial
Cryo-EM structures of SARS-CoV-2 Omicron BA.2 spikeSARS-CoV-2 Omicron BA.2 스파이크의 Cryo-EM 구조Article Published on 2022-06-282022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies antibody binding antibodies coronavirus CP: Microbiology cryo-EM Cryoelectron microscopy determine domain ectodomain epitope Epitopes functional fusion peptide hallmark immune immune evasion induce Interaction less Lineage Microbiology Microscopy Mutation neutralize omicron Omicron BA.2 Omicron variant peptide proportion Protein Pseudovirus neutralization assay RBD Receptor binding domain Region remodeling respiratory resulting S proteins SARS-CoV-2 SARS-CoV-2 spike severe acute respiratory syndrome Coronavirus Structure structures the RBD underlie variant Variation [DOI] 10.1016/j.celrep.2022.111009 PMC 바로가기 [Article Type] Article
CROMATIC: Cro ss-Relationship Ma p of Cavi ti es from C oronavirusesCHROMATIC: 코로나바이러스의 Cavi 시간 교차 관계 지도Article Published on 2022-06-272022-09-11 Journal: Journal of Chemical Information and Modeling [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus alterations Analysis conserved coronavirus COVID-19 disease database drug candidates effective etiologic agent help high resolution highlighting identify Interaction MERS MERS-CoV molecular interaction Mutation performed Protein protocols Repository SARS-CoV SARS-CoV-2 SARS-CoV-2 spike variants Scientific community sequence severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 similarity starting point Structure structures therapy Virtual screening X-ray [DOI] 10.1021/acs.jcim.2c00169 PMC 바로가기 [Article Type] Article
Olfactory dysfunction in COVID-19: pathology and long-term implications for brain healthReview article Published on 2022-06-202022-10-05 Journal: Trends in molecular medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute phase Anosmia Brain cognitive COVID-19 COVID-19 cases Decreased downregulation dysfunction Evidence Health implication Inflammation likelihood long-lasting Mortality MOST neurological deficits Neuropathology occur Olfaction olfactory olfactory dysfunction pathology pathophysiology Quality of life question receptor proteins SARS-CoV-2 Smell loss structures Taste the SARS-CoV-2 virus [DOI] 10.1016/j.molmed.2022.06.005 [Article Type] Review article